Chromosome stability protein 9

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination."
    Serrentino M.E., Chaplais E., Sommermeyer V., Borde V.
    PLoS Genet 9:e1003416-e1003416(2013) [PubMed] [Europe PMC] [Abstract]
• SUMO transferase activity Source: SGDInferred from direct assayⁱ
  • "SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae."
    Cheng C.H., Lo Y.H., Liang S.S., Ti S.C., Lin F.M., Yeh C.H., Huang H.Y., Wang T.F.
    Genes Dev 20:2067-2081(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• DNA repair Source: UniProtKB-KW
• homologous chromosome pairing at meiosis Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.7

    "Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast."
    Peoples-Holst T.L., Burgess S.M.
    Genes Dev. 19:863-874(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION OF THE SIC COMPLEX.
• protein sumoylation Source: SGDInferred from direct assayⁱ
  • "SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae."
    Cheng C.H., Lo Y.H., Liang S.S., Ti S.C., Lin F.M., Yeh C.H., Huang H.Y., Wang T.F.
    Genes Dev 20:2067-2081(2006) [PubMed] [Europe PMC] [Abstract]
• reciprocal meiotic recombination Source: SGDInferred from mutant phenotypeⁱ
  • "Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis."
    Borner G.V., Kleckner N., Hunter N.
    Cell 117:29-45(2004) [PubMed] [Europe PMC] [Abstract]
  • "Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination."
    Serrentino M.E., Chaplais E., Sommermeyer V., Borde V.
    PLoS Genet 9:e1003416-e1003416(2013) [PubMed] [Europe PMC] [Abstract]
• synaptonemal complex assembly Source: SGDInferred from mutant phenotypeⁱ
  • Ref.4

    "Zip3 provides a link between recombination enzymes and synaptonemal complex proteins."
    Agarwal S., Roeder G.S.
    Cell 102:245-255(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SIC COMPLEX, INTERACTION WITH ZIP1; MRE11; RAD51 AND RAD57.
  • "SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae."
    Cheng C.H., Lo Y.H., Liang S.S., Ti S.C., Lin F.M., Yeh C.H., Huang H.Y., Wang T.F.
    Genes Dev 20:2067-2081(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGGYLAIVFI PQTNTKSMRE KKQKCLKQVR RLSLISPKKY IMPDSIFEQP 
        60         70         80         90        100
FVYCGVCHRR TSHGDPLRLT SCAHILCSQH SPLTSKVCPI CRSSDISIIN 
       110        120        130        140        150
LVESKQLPTD IRIFFEPLPP LLESLYNVSQ FQLNGLSKQC QYYQNHCLKL 
       160        170        180        190        200
REKCARQQQL LYQAKIELDS MAILKKRIQE LESVLNHNNV SSMSVGVLPT 
       210        220        230        240        250
RNSHQNHYQP PPTVDLTVDD NSLEEFEAKS FIKKLKKNSS LRNSSKNNNG 
       260        270        280        290        300
TVTPSTSGRV NKNQPLFMET LNNPNRNSIP PPGMNPNANS NLPNISTIAE 
       310        320        330        340        350
STNLNRFSFS PVRVAKGFDG KLPNLDILTN NGSVSSKNIS RLSSASLQPS 
       360        370        380        390        400
SPLSSSSNRL ILPNSNLKEL HHSNTPLTST STQFPSALEK LKITRKRNNT 
       410        420        430        440        450
ISGSNRITHN LSSHVRSSGL AFSSSSNSLQ QSKLPKSNIL KRSNSTQQLT 
       460        470        480 
NTHLKSDNHL PPRSSNTVLG SSKKNNKFRR IR                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XII
   Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names