UniProtKB - Q06032 (CST9_YEAST)
Protein
Chromosome stability protein 9
Gene
CST9
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the synapsis initiation complex (SIC) necessary for the synaptonemal complex assembly. Stabilizes the ZIP2 component to the chromosomes. The SIC complex loads onto chromosomes and nucleates ZIP1 polymerization, a molecular zipper that acts to bring homologous chromosomes in close apposition, which is required for meiotic crossover. May also be involved in double strand break repair.5 Publications
GO - Molecular functioni
- chromatin binding Source: SGD
- SUMO transferase activity Source: SGD
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- homologous chromosome pairing at meiosis Source: SGD
- protein sumoylation Source: SGD
- reciprocal meiotic recombination Source: SGD
- synaptonemal complex assembly Source: SGD
Keywordsi
Biological process | DNA damage, DNA repair, Meiosis |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosome stability protein 9Alternative name(s): Molecular zipper protein 3 |
Gene namesi | Name:CST9 Synonyms:ZIP3 Ordered Locus Names:YLR394W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YLR394W |
SGDi | S000004386, CST9 |
Subcellular locationi
Nucleus
Other locations
Note: Synapsed meiotic chromosomes.
Nucleus
- condensed nuclear chromosome Source: SGD
- nuclear chromosome Source: SGD
- synaptonemal complex Source: GO_Central
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232995 | 1 – 482 | Chromosome stability protein 9Add BLAST | 482 |
Proteomic databases
PaxDbi | Q06032 |
Expressioni
Inductioni
Expressed during meiosis.1 Publication
Interactioni
Subunit structurei
Component of the synapsis initiation complex composed of at least ZIP2, ZIP3, MSH4 and MSH5.
Interacts also with ZIP1, MRE11, RAD51 and RAD53.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 31653, 237 interactors |
ComplexPortali | CPX-1386, Synapsis initiation complex |
DIPi | DIP-5875N |
IntActi | Q06032, 8 interactors |
STRINGi | 4932.YLR394W |
Miscellaneous databases
RNActi | Q06032, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 333 – 445 | Ser-richAdd BLAST | 113 |
Phylogenomic databases
eggNOGi | KOG4739, Eukaryota |
HOGENOMi | CLU_051887_0_0_1 |
InParanoidi | Q06032 |
OMAi | QPLFMET |
Family and domain databases
InterProi | View protein in InterPro IPR042123, Zip3/RNF212-like IPR001841, Znf_RING |
PANTHERi | PTHR22663, PTHR22663, 1 hit |
Pfami | View protein in Pfam PF14634, zf-RING_5, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06032-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGYLAIVFI PQTNTKSMRE KKQKCLKQVR RLSLISPKKY IMPDSIFEQP
60 70 80 90 100
FVYCGVCHRR TSHGDPLRLT SCAHILCSQH SPLTSKVCPI CRSSDISIIN
110 120 130 140 150
LVESKQLPTD IRIFFEPLPP LLESLYNVSQ FQLNGLSKQC QYYQNHCLKL
160 170 180 190 200
REKCARQQQL LYQAKIELDS MAILKKRIQE LESVLNHNNV SSMSVGVLPT
210 220 230 240 250
RNSHQNHYQP PPTVDLTVDD NSLEEFEAKS FIKKLKKNSS LRNSSKNNNG
260 270 280 290 300
TVTPSTSGRV NKNQPLFMET LNNPNRNSIP PPGMNPNANS NLPNISTIAE
310 320 330 340 350
STNLNRFSFS PVRVAKGFDG KLPNLDILTN NGSVSSKNIS RLSSASLQPS
360 370 380 390 400
SPLSSSSNRL ILPNSNLKEL HHSNTPLTST STQFPSALEK LKITRKRNNT
410 420 430 440 450
ISGSNRITHN LSSHVRSSGL AFSSSSNSLQ QSKLPKSNIL KRSNSTQQLT
460 470 480
NTHLKSDNHL PPRSSNTVLG SSKKNNKFRR IR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19729 Genomic DNA Translation: AAB82346.1 BK006945 Genomic DNA Translation: DAA09695.1 |
PIRi | S55950 |
RefSeqi | NP_013498.3, NM_001182282.3 |
Genome annotation databases
EnsemblFungii | YLR394W_mRNA; YLR394W; YLR394W |
GeneIDi | 851110 |
KEGGi | sce:YLR394W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19729 Genomic DNA Translation: AAB82346.1 BK006945 Genomic DNA Translation: DAA09695.1 |
PIRi | S55950 |
RefSeqi | NP_013498.3, NM_001182282.3 |
3D structure databases
SMRi | Q06032 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31653, 237 interactors |
ComplexPortali | CPX-1386, Synapsis initiation complex |
DIPi | DIP-5875N |
IntActi | Q06032, 8 interactors |
STRINGi | 4932.YLR394W |
Proteomic databases
PaxDbi | Q06032 |
Genome annotation databases
EnsemblFungii | YLR394W_mRNA; YLR394W; YLR394W |
GeneIDi | 851110 |
KEGGi | sce:YLR394W |
Organism-specific databases
EuPathDBi | FungiDB:YLR394W |
SGDi | S000004386, CST9 |
Phylogenomic databases
eggNOGi | KOG4739, Eukaryota |
HOGENOMi | CLU_051887_0_0_1 |
InParanoidi | Q06032 |
OMAi | QPLFMET |
Miscellaneous databases
PROi | PR:Q06032 |
RNActi | Q06032, protein |
Family and domain databases
InterProi | View protein in InterPro IPR042123, Zip3/RNF212-like IPR001841, Znf_RING |
PANTHERi | PTHR22663, PTHR22663, 1 hit |
Pfami | View protein in Pfam PF14634, zf-RING_5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CST9_YEAST | |
Accessioni | Q06032Primary (citable) accession number: Q06032 Secondary accession number(s): D6VZ29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD