UniProtKB - Q05KR1 (Q05KR1_RAT)
Protein
Submitted name:
Interleukin 1 bete receptor type 1 long transmembrane form
Gene
Il1r1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- interleukin-1, type I, activating receptor activity Source: InterPro
- interleukin-1 binding Source: Ensembl
- platelet-derived growth factor receptor binding Source: Ensembl
- protease binding Source: Ensembl
GO - Biological processi
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
- positive regulation of neutrophil extravasation Source: Ensembl
- positive regulation of T-helper 1 cell cytokine production Source: Ensembl
- regulation of inflammatory response Source: Ensembl
Keywordsi
Molecular function | ReceptorImported |
Ligand | NADARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Interleukin 1 bete receptor type 1 long transmembrane formImportedSubmitted name: Interleukin 1 receptor, type I, isoform CRA_aImportedSubmitted name: Interleukin-1 receptor type 1Imported |
Gene namesi | ORF Names:rCG_22481Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2892, Il1r1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 354 – 376 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_5014102182 | 34 – 590 | Sequence analysisAdd BLAST | 557 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014504, Expressed in liver and 19 other tissues |
Interactioni
GO - Molecular functioni
- interleukin-1 binding Source: Ensembl
- platelet-derived growth factor receptor binding Source: Ensembl
- protease binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 129 | Ig-likeInterPro annotationAdd BLAST | 100 | |
Domaini | 135 – 231 | Ig-likeInterPro annotationAdd BLAST | 97 | |
Domaini | 243 – 345 | Ig-likeInterPro annotationAdd BLAST | 103 | |
Domaini | 400 – 558 | TIRInterPro annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the interleukin-1 receptor family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT01000000214361 |
HOGENOMi | CLU_025552_3_0_1 |
OMAi | EISGFSW |
OrthoDBi | 1109920at2759 |
TreeFami | TF325519 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR004076, IL-1_rcpt_I-typ IPR004074, IL-1_rcpt_I/II-typ IPR041416, IL-1RAcP-like_ig IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF18452, Ig_6, 1 hit PF01582, TIR, 1 hit |
PRINTSi | PR01538, INTRLEUKN1R1 PR01536, INTRLKN1R12F |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS50104, TIR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q05KR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPRLVTSSA KSSILENMKV LLGFICLIVP LLSLETDKCT EYPNEVISFS
60 70 80 90 100
SVNEIDIRSC PLTPNEMHGG TIIWYKNDSK TPISADKDSR IHQQNEHLWF
110 120 130 140 150
VPAKMEDSGY YYCIMRNSTY CLKTKITMSV LENDPGLCYN TQASFIQRLH
160 170 180 190 200
VAGDGSLVCP YLDFFKDENN ELPKVQWYKN CKPLPLDDGN FFGFKNKLMV
210 220 230 240 250
MNVAEEHRGN YTCRTSYTYQ GKQYPVTRVI TFITIDDSKR DRPVIMSPRN
260 270 280 290 300
ETMEADPGST IQLICNVTGQ FTDLVYWKWN GSEIEWDDPI LAEDYQFLEH
310 320 330 340 350
PSAKRKYTLI TTLNVSEVKS QFYRYPFICF VKNTHILETA HVRLVYPVPD
360 370 380 390 400
FKNYLIGGFA IFTATAVFCA CIYKVFKVDI VLWYRDSCSD FLPPKASDGK
410 420 430 440 450
TYDAYVLYPK TYGEGSFAYL DTFVFKLLPE VLEGQFGYKL FICGRDDYVG
460 470 480 490 500
EDTIEVTNEN VKRSRRLIII LVRDMGSFSC LGQSSEEQIA IYDALIREGI
510 520 530 540 550
KIILLELEKI QDYEKMPESI QFIKQKHGAI CWSGDFKERP QSAKTRFWKN
560 570 580 590
LRYQMPAQRR SPLSKHHLLT LDPVLDTKEK LQAETHLPLG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ02955 | IL1R1_RAT | Interleukin-1 receptor type 1 | Il1r1 Il1ra | 576 | Annotation score: | ||
Q05KR0 | Q05KR0_RAT | Interleukin 1 beta receptor type 1 ... | Il1r1 il1r1 | 573 | Annotation score: | ||
A0A0G2K6N4 | A0A0G2K6N4_RAT | Interleukin 1 receptor, type I, iso... | Il1r1 rCG_22481 | 576 | Annotation score: | ||
A0A0G2K2H8 | A0A0G2K2H8_RAT | Interleukin-1 receptor type 1 | Il1r1 | 525 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07067457 Genomic DNA No translation available. AABR07067458 Genomic DNA No translation available. AB112437 mRNA Translation: BAF34664.1 CH473965 Genomic DNA Translation: EDL99179.1 |
RefSeqi | NP_037255.3, NM_013123.3 XP_006244808.1, XM_006244746.3 XP_006244809.1, XM_006244747.3 |
Genome annotation databases
Ensembli | ENSRNOT00000019673; ENSRNOP00000019673; ENSRNOG00000014504 |
GeneIDi | 25663 |
KEGGi | rno:25663 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07067457 Genomic DNA No translation available. AABR07067458 Genomic DNA No translation available. AB112437 mRNA Translation: BAF34664.1 CH473965 Genomic DNA Translation: EDL99179.1 |
RefSeqi | NP_037255.3, NM_013123.3 XP_006244808.1, XM_006244746.3 XP_006244809.1, XM_006244747.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSRNOT00000019673; ENSRNOP00000019673; ENSRNOG00000014504 |
GeneIDi | 25663 |
KEGGi | rno:25663 |
Organism-specific databases
CTDi | 3554 |
RGDi | 2892, Il1r1 |
Phylogenomic databases
GeneTreei | ENSGT01000000214361 |
HOGENOMi | CLU_025552_3_0_1 |
OMAi | EISGFSW |
OrthoDBi | 1109920at2759 |
TreeFami | TF325519 |
Gene expression databases
Bgeei | ENSRNOG00000014504, Expressed in liver and 19 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR004076, IL-1_rcpt_I-typ IPR004074, IL-1_rcpt_I/II-typ IPR041416, IL-1RAcP-like_ig IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF18452, Ig_6, 1 hit PF01582, TIR, 1 hit |
PRINTSi | PR01538, INTRLEUKN1R1 PR01536, INTRLKN1R12F |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q05KR1_RAT | |
Accessioni | Q05KR1Primary (citable) accession number: Q05KR1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 14, 2006 |
Last sequence update: | November 14, 2006 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |