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Entry version 75 (12 Aug 2020)
Sequence version 1 (14 Nov 2006)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Carsonella ruddii (strain PV)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta (EC:2.7.7.6)
Short name:
RNAP subunit beta
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpoB
Ordered Locus Names:CRP_162
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCarsonella ruddii (strain PV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri387662 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeZymobacter groupCandidatus Carsonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000777 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003002961 – 1267DNA-directed RNA polymerase subunit betaAdd BLAST1267

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q05FH8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000524_4_0_6

KEGG Orthology (KO)

More...
KOi
K03043

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIKVMCE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00653, RNA_pol_B_RPB2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.270.10, 2 hits
2.40.50.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR010243, RNA_pol_bsu_bac
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR20856, PTHR20856, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04565, RNA_pol_Rpb2_3, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02013, rpoB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05FH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINYLKFNRF CFSKKKFFHK CNLPYLLHNQ IGSYNSFLSS KYNSLFSIKK
60 70 80 90 100
VLKQYFPLIC NNKNIFIKLK KIELLEPCNT EKYTKIRNLH LFSTLYMYIS
110 120 130 140 150
IYVINKNLNV YKKIFLGNIP SMTKKGNFII NGIDRILISQ FTKSYGIYFY
160 170 180 190 200
TEKKKKKCII IPLKGSWLEF IITNNFLIVF DKKINFEINV FLICLGYNKK
210 220 230 240 250
YFFNFFFFKI KIKIIRGKKR IFFLLNKKKY FYKIYNKYIC ISIKKILGKL
260 270 280 290 300
FGKNYFLKKN TFLKFNIIDI NKVNLILNYP IYFFFIIFLK KIINLNYLIY
310 320 330 340 350
IYKNFKLKIN KELLQYKKGY IINFFRNLFY KKKYFYSLIG AKRIFKRLFL
360 370 380 390 400
KKNNKLTIYL EIIKKILKFI KFNIQNDNFD NLENKLILNC GKLLSIKFDF
410 420 430 440 450
LFKKVIKFIN YKMNNFKKYK DLDFIVNSDI ITIGLKDYFC NNELSQFLDQ
460 470 480 490 500
NNPLAEISHN RKISLISGIG IEKENCGFDI RDIHYSHYCK VCPIDTPEGH
510 520 530 540 550
NIGLINSLAY LSKVNKYNFI STIYKISILG KILGITFLDN KFDKHKFIVN
560 570 580 590 600
FNSTIETIYG EIFRSPYFEA RKTNYYYYKK FLNIDLIEIC GDQIISVGAS
610 620 630 640 650
LIPFLSHNDA NRCLMGSNMQ RQAVPLIDSE NPIVGTGNEL EIGLNSNYNI
660 670 680 690 700
LSDLNGYVLY SDNYKIIIKN NNFIKTYFLE KYTRTNQNTI LNQYTKVLKG
710 720 730 740 750
DFVKVGNIIA DSNSTKNGEI SLGKNLRVAF MSWYGYNFED SILLSSSILN
760 770 780 790 800
KNNFNSIHIY EFITVLKYNE NGFEIVSNEC FGSNEKIKNK VKNGIIKIGE
810 820 830 840 850
FVFSKDVIVG KMIPKKKRKF SPEEKLFKIV FSESNFNYYE QPLTVPKNIK
860 870 880 890 900
GTIIAVNDFK IFYFKNKIFK LLKFEQLNYT CKNINNFFYE TFNYYLTKIK
910 920 930 940 950
KLLFNNKITI KKKRINSYNI NINNIFKIKC FNKKINFKLN IFKNIISNEL
960 970 980 990 1000
LKKKNIFVYK KINFIKHDDF ENSIIRIIKI KIAVKKQIAI GDKMSGRHGN
1010 1020 1030 1040 1050
KGVVSNIIDY ENMPYDKFGN KIDLILNPLG VPSRMNVGQL LEVFLAGSLN
1060 1070 1080 1090 1100
LIKSFFLKIK NLNKISYFKM KLFIKIIFKC IYDKNINLNI FNNSLVLKIF
1110 1120 1130 1140 1150
KNIKNQLNVC VHNFYNFNVN KVNNIIKTIG INKNCELLLF DGITGKRYLQ
1160 1170 1180 1190 1200
LVNVGYIYFM KLNHLVIDKI YSRSIGPYSI VTQQPLGGKS NLGGQRLGEM
1210 1220 1230 1240 1250
EVWALEAYGA AFLLKEMLTI KSDDILGRIE LYKNIIKGIN DANSGIPESF
1260
QVLMKEIQSL CFDIKIL
Length:1,267
Mass (Da):149,255
Last modified:November 14, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95F0479F8F734266
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP009180 Genomic DNA Translation: BAF35193.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAF35193; BAF35193; CRP_162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
crp:CRP_162

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009180 Genomic DNA Translation: BAF35193.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ05FH8

Genome annotation databases

EnsemblBacteriaiBAF35193; BAF35193; CRP_162
KEGGicrp:CRP_162

Phylogenomic databases

HOGENOMiCLU_000524_4_0_6
KOiK03043
OMAiTIKVMCE

Family and domain databases

CDDicd00653, RNA_pol_B_RPB2, 1 hit
Gene3Di2.40.270.10, 2 hits
2.40.50.150, 1 hit
InterProiView protein in InterPro
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR010243, RNA_pol_bsu_bac
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856, PTHR20856, 1 hit
PfamiView protein in Pfam
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04565, RNA_pol_Rpb2_3, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit
TIGRFAMsiTIGR02013, rpoB, 1 hit
PROSITEiView protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOB_CARRP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05FH8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: August 12, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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