Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deuterosome assembly protein 1

Gene

DEUP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).By similarity

Miscellaneous

CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Deuterosome assembly protein 1Imported
Alternative name(s):
Coiled-coil domain-containing protein 67
Gene namesi
Name:DEUP1Imported
Synonyms:CCDC67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165325.13
HGNCiHGNC:26344 DEUP1
neXtProtiNX_Q05D60

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi159989
OpenTargetsiENSG00000165325
PharmGKBiPA143485419

Polymorphism and mutation databases

BioMutaiCCDC67
DMDMi156630476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002978291 – 604Deuterosome assembly protein 1Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei547PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ05D60
MaxQBiQ05D60
PaxDbiQ05D60
PeptideAtlasiQ05D60
PRIDEiQ05D60
ProteomicsDBi58400
58401 [Q05D60-2]

PTM databases

iPTMnetiQ05D60
PhosphoSitePlusiQ05D60

Expressioni

Gene expression databases

BgeeiENSG00000165325 Expressed in 110 organ(s), highest expression level in testis
CleanExiHS_CCDC67
ExpressionAtlasiQ05D60 baseline and differential
GenevisibleiQ05D60 HS

Organism-specific databases

HPAiHPA010986

Interactioni

Subunit structurei

Interacts with CEP152; the interaction is mutually exclusive with CEP63.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127746, 56 interactors
IntActiQ05D60, 47 interactors
MINTiQ05D60
STRINGi9606.ENSP00000298050

Structurei

3D structure databases

ProteinModelPortaliQ05D60
SMRiQ05D60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili14 – 59Sequence analysisAdd BLAST46
Coiled coili85 – 197Sequence analysisAdd BLAST113
Coiled coili226 – 278Sequence analysisAdd BLAST53
Coiled coili336 – 399Sequence analysisAdd BLAST64
Coiled coili558 – 601Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the CEP63 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIW9 Eukaryota
ENOG4111S30 LUCA
GeneTreeiENSGT00530000063797
HOGENOMiHOG000111430
HOVERGENiHBG107618
InParanoidiQ05D60
OMAiWANQNTY
OrthoDBiEOG091G0LBG
PhylomeDBiQ05D60
TreeFamiTF330595

Family and domain databases

InterProiView protein in InterPro
IPR031470 Cep63/Deup1_N
IPR029611 Deup1
PANTHERiPTHR18875:SF5 PTHR18875:SF5, 1 hit
PfamiView protein in Pfam
PF17045 CEP63, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05D60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENQAHNTMG TSPCEAELQE LMEQIDIMVS NKKMDWERKM RALETRLDLR
60 70 80 90 100
DQELANAQTC LDQKGQEVGL LRQKLDSLEK CNLAMTQNYE GQLQSLKAQF
110 120 130 140 150
SKLTNNFEKL RLHQMKQNKV PRKELPHLKE EIPFELSNLN QKLEEFRAKS
160 170 180 190 200
REWDKQEILY QTHLISLDAQ QKLLSEKCNQ FQKQAQSYQT QLNGKKQCLE
210 220 230 240 250
DSSSEIPRLI CDPDPNCEIN ERDEFIIEKL KSAVNEIALS RNKLQDENQK
260 270 280 290 300
LLQELKMYQR QCQAMEAGLS EVKSELQSRD DLLRIIEMER LQLHRELLKI
310 320 330 340 350
GECQNAQGNK TRLESSYLPS IKEPERKIKE LFSVMQDQPN HEKELNKIRS
360 370 380 390 400
QLQQVEEYHN SEQERMRNEI SDLTEELHQK EITIATVTKK AALLEKQLKM
410 420 430 440 450
ELEIKEKMLA KQKVSDMKYK AVRTENTHLK GMMGDLDPGE YMSMDFTNRE
460 470 480 490 500
QSRHTSINKL QYENERLRND LAKLHVNGKS TWTNQNTYEE TGRYAYQSQI
510 520 530 540 550
KVEQNEERLS HDCEPNRSTM PPLPPSTFQA KEMTSPLVSD DDVFPLSPPD
560 570 580 590 600
MSFPASLAAQ HFLLEEEKRA KELEKLLNTH IDELQRHTEF TLNKYSKLKQ

NRHI
Length:604
Mass (Da):70,977
Last modified:August 21, 2007 - v2
Checksum:i0BC0B1C207D2EA2A
GO
Isoform 2 (identifier: Q05D60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-263: Q → M

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):40,111
Checksum:iEA6CD8113D15980E
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIY2E9PIY2_HUMAN
Deuterosome assembly protein 1
DEUP1
553Annotation score:
E9PLX9E9PLX9_HUMAN
Deuterosome assembly protein 1
DEUP1
346Annotation score:
E9PPB2E9PPB2_HUMAN
Deuterosome assembly protein 1
DEUP1
329Annotation score:
A0A087WVI3A0A087WVI3_HUMAN
Deuterosome assembly protein 1
DEUP1
599Annotation score:
A0A0A0MTD8A0A0A0MTD8_HUMAN
Deuterosome assembly protein 1
DEUP1
348Annotation score:
A0A088AWP1A0A088AWP1_HUMAN
Deuterosome assembly protein 1
DEUP1
445Annotation score:
E9PMP4E9PMP4_HUMAN
Deuterosome assembly protein 1
DEUP1
106Annotation score:
E9PLL9E9PLL9_HUMAN
Deuterosome assembly protein 1
DEUP1
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440E → R in BAB71673 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050759175S → F. Corresponds to variant dbSNP:rs34205920Ensembl.1
Natural variantiVAR_059601440E → G. Corresponds to variant dbSNP:rs12282288Ensembl.1
Natural variantiVAR_050760440E → Q. Corresponds to variant dbSNP:rs12288277Ensembl.1
Natural variantiVAR_050761504Q → K1 PublicationCorresponds to variant dbSNP:rs2259633Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273671 – 262Missing in isoform 2. 1 PublicationAdd BLAST262
Alternative sequenceiVSP_027368263Q → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003969 Genomic DNA No translation available.
AP004242 Genomic DNA No translation available.
BC017929 mRNA Translation: AAH17929.1 Sequence problems.
BC031247 mRNA Translation: AAH31247.2
AK058122 mRNA Translation: BAB71673.1 Sequence problems.
CCDSiCCDS44707.1 [Q05D60-1]
RefSeqiNP_857596.2, NM_181645.3 [Q05D60-1]
XP_005273859.1, XM_005273802.1 [Q05D60-1]
UniGeneiHs.436625

Genome annotation databases

EnsembliENST00000298050; ENSP00000298050; ENSG00000165325 [Q05D60-1]
GeneIDi159989
KEGGihsa:159989
UCSCiuc001pdq.5 human [Q05D60-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003969 Genomic DNA No translation available.
AP004242 Genomic DNA No translation available.
BC017929 mRNA Translation: AAH17929.1 Sequence problems.
BC031247 mRNA Translation: AAH31247.2
AK058122 mRNA Translation: BAB71673.1 Sequence problems.
CCDSiCCDS44707.1 [Q05D60-1]
RefSeqiNP_857596.2, NM_181645.3 [Q05D60-1]
XP_005273859.1, XM_005273802.1 [Q05D60-1]
UniGeneiHs.436625

3D structure databases

ProteinModelPortaliQ05D60
SMRiQ05D60
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127746, 56 interactors
IntActiQ05D60, 47 interactors
MINTiQ05D60
STRINGi9606.ENSP00000298050

PTM databases

iPTMnetiQ05D60
PhosphoSitePlusiQ05D60

Polymorphism and mutation databases

BioMutaiCCDC67
DMDMi156630476

Proteomic databases

EPDiQ05D60
MaxQBiQ05D60
PaxDbiQ05D60
PeptideAtlasiQ05D60
PRIDEiQ05D60
ProteomicsDBi58400
58401 [Q05D60-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298050; ENSP00000298050; ENSG00000165325 [Q05D60-1]
GeneIDi159989
KEGGihsa:159989
UCSCiuc001pdq.5 human [Q05D60-1]

Organism-specific databases

CTDi159989
DisGeNETi159989
EuPathDBiHostDB:ENSG00000165325.13
GeneCardsiDEUP1
HGNCiHGNC:26344 DEUP1
HPAiHPA010986
neXtProtiNX_Q05D60
OpenTargetsiENSG00000165325
PharmGKBiPA143485419
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIW9 Eukaryota
ENOG4111S30 LUCA
GeneTreeiENSGT00530000063797
HOGENOMiHOG000111430
HOVERGENiHBG107618
InParanoidiQ05D60
OMAiWANQNTY
OrthoDBiEOG091G0LBG
PhylomeDBiQ05D60
TreeFamiTF330595

Miscellaneous databases

GenomeRNAii159989
PROiPR:Q05D60

Gene expression databases

BgeeiENSG00000165325 Expressed in 110 organ(s), highest expression level in testis
CleanExiHS_CCDC67
ExpressionAtlasiQ05D60 baseline and differential
GenevisibleiQ05D60 HS

Family and domain databases

InterProiView protein in InterPro
IPR031470 Cep63/Deup1_N
IPR029611 Deup1
PANTHERiPTHR18875:SF5 PTHR18875:SF5, 1 hit
PfamiView protein in Pfam
PF17045 CEP63, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEUP1_HUMAN
AccessioniPrimary (citable) accession number: Q05D60
Secondary accession number(s): E9PJR5, Q8NEF1, Q96LL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again