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Protein

CTD small phosphatase-like protein 2

Gene

CTDSPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable phosphatase.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q05D32

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CTD small phosphatase-like protein 2 (EC:3.1.3.-)
Short name:
CTDSP-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTDSPL2
ORF Names:HSPC058, HSPC129
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137770.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26936 CTDSPL2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05D32

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000137770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672063

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTDSPL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187471086

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314641 – 466CTD small phosphatase-like protein 2Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26N6-acetyllysineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei86PhosphothreonineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q05D32

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05D32

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05D32

PeptideAtlas

More...
PeptideAtlasi
Q05D32

PRoteomics IDEntifications database

More...
PRIDEi
Q05D32

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58398
58399 [Q05D32-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q05D32

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05D32

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05D32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137770 Expressed in 195 organ(s), highest expression level in stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_CTDSPL2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q05D32 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q05D32 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040763
HPA062198

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PDIK1LQ8N1654EBI-10039222,EBI-6423298

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119571, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q05D32, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260327

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q05D32

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05D32

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini283 – 442FCP1 homologyPROSITE-ProRule annotationAdd BLAST160

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CTDSPL2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1605 Eukaryota
COG5190 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00910000144223

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107781

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05D32

KEGG Orthology (KO)

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KOi
K17616

Identification of Orthologs from Complete Genome Data

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OMAi
MRLRMRK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GO9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05D32

TreeFam database of animal gene trees

More...
TreeFami
TF354278

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03031 NIF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00577 CPDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02251 HIF-SF_euk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50969 FCP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05D32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLRTRKASQ QSNQIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS
60 70 80 90 100
SIKKFIKGST PKEERENPSK RSRIERDIDN NLITSTPRAG EKPNKQISRV
110 120 130 140 150
RRKSQVNGEA GSYEMTNQHV KQNGKLEDNP SSGSPPRTTL LGTIFSPVFN
160 170 180 190 200
FFSPANKNGT SGSDSPGQAV EAEEIVKQLD MEQVDEITTS TTTSTNGAAY
210 220 230 240 250
SNQAVQVRPS LNNGLEEAEE TVNRDIPPLT APVTPDSGYS SAHAEATYEE
260 270 280 290 300
DWEVFDPYYF IKHVPPLTEE QLNRKPALPL KTRSTPEFSL VLDLDETLVH
310 320 330 340 350
CSLNELEDAA LTFPVLFQDV IYQVYVRLRP FFREFLERMS QMYEIILFTA
360 370 380 390 400
SKKVYADKLL NILDPKKQLV RHRLFREHCV CVQGNYIKDL NILGRDLSKT
410 420 430 440 450
IIIDNSPQAF AYQLSNGIPI ESWFMDKNDN ELLKLIPFLE KLVELNEDVR
460
PHIRDRFRLH DLLPPD
Length:466
Mass (Da):52,999
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8BA6911EBD4B332
GO
Isoform 2 (identifier: Q05D32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-230: Missing.

Show »
Length:394
Mass (Da):45,424
Checksum:iA1E6F3A0FBFCD13B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNU2H0YNU2_HUMAN
CTD small phosphatase-like protein ...
CTDSPL2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMH7H0YMH7_HUMAN
CTD small phosphatase-like protein ...
CTDSPL2
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNW9H0YNW9_HUMAN
CTD small phosphatase-like protein ...
CTDSPL2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMB4H0YMB4_HUMAN
CTD small phosphatase-like protein ...
CTDSPL2
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29030 differs from that shown. Reason: Frameshift at positions 84 and 95.Curated
The sequence AAH18623 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91664 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107 – 110NGEA → MEKL in AAF29093 (PubMed:11042152).Curated4
Sequence conflicti228P → T in AAF29030 (PubMed:11042152).Curated1
Sequence conflicti321I → V in AAQ76796 (PubMed:16533400).Curated1
Sequence conflicti321I → V in BAA91664 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042886244A → V. Corresponds to variant dbSNP:rs871923Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033218159 – 230Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY364237 mRNA Translation: AAQ76796.1
DQ128104 mRNA Translation: AAZ42188.1
AF161543 mRNA Translation: AAF29030.1 Frameshift.
AF161478 mRNA Translation: AAF29093.1
AK001385 mRNA Translation: BAA91664.1 Different initiation.
AK291230 mRNA Translation: BAF83919.1
CR627421 mRNA Translation: CAH10508.1
CH471082 Genomic DNA Translation: EAW77265.1
BC018623 mRNA Translation: AAH18623.1 Sequence problems.
BC035744 mRNA Translation: AAH35744.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10110.1 [Q05D32-1]

NCBI Reference Sequences

More...
RefSeqi
NP_057480.2, NM_016396.2 [Q05D32-1]
XP_005254498.1, XM_005254441.2 [Q05D32-1]
XP_006720628.1, XM_006720565.2 [Q05D32-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.497967

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260327; ENSP00000260327; ENSG00000137770 [Q05D32-1]
ENST00000558373; ENSP00000453051; ENSG00000137770 [Q05D32-2]
ENST00000558966; ENSP00000452837; ENSG00000137770 [Q05D32-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51496

UCSC genome browser

More...
UCSCi
uc001ztr.4 human [Q05D32-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364237 mRNA Translation: AAQ76796.1
DQ128104 mRNA Translation: AAZ42188.1
AF161543 mRNA Translation: AAF29030.1 Frameshift.
AF161478 mRNA Translation: AAF29093.1
AK001385 mRNA Translation: BAA91664.1 Different initiation.
AK291230 mRNA Translation: BAF83919.1
CR627421 mRNA Translation: CAH10508.1
CH471082 Genomic DNA Translation: EAW77265.1
BC018623 mRNA Translation: AAH18623.1 Sequence problems.
BC035744 mRNA Translation: AAH35744.1
CCDSiCCDS10110.1 [Q05D32-1]
RefSeqiNP_057480.2, NM_016396.2 [Q05D32-1]
XP_005254498.1, XM_005254441.2 [Q05D32-1]
XP_006720628.1, XM_006720565.2 [Q05D32-1]
UniGeneiHs.497967

3D structure databases

ProteinModelPortaliQ05D32
SMRiQ05D32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119571, 26 interactors
IntActiQ05D32, 15 interactors
STRINGi9606.ENSP00000260327

PTM databases

DEPODiQ05D32
iPTMnetiQ05D32
PhosphoSitePlusiQ05D32

Polymorphism and mutation databases

BioMutaiCTDSPL2
DMDMi187471086

Proteomic databases

EPDiQ05D32
MaxQBiQ05D32
PaxDbiQ05D32
PeptideAtlasiQ05D32
PRIDEiQ05D32
ProteomicsDBi58398
58399 [Q05D32-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51496
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260327; ENSP00000260327; ENSG00000137770 [Q05D32-1]
ENST00000558373; ENSP00000453051; ENSG00000137770 [Q05D32-2]
ENST00000558966; ENSP00000452837; ENSG00000137770 [Q05D32-1]
GeneIDi51496
KEGGihsa:51496
UCSCiuc001ztr.4 human [Q05D32-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51496
EuPathDBiHostDB:ENSG00000137770.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTDSPL2
HGNCiHGNC:26936 CTDSPL2
HPAiHPA040763
HPA062198
neXtProtiNX_Q05D32
OpenTargetsiENSG00000137770
PharmGKBiPA142672063

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00910000144223
HOVERGENiHBG107781
InParanoidiQ05D32
KOiK17616
OMAiMRLRMRK
OrthoDBiEOG091G0GO9
PhylomeDBiQ05D32
TreeFamiTF354278

Enzyme and pathway databases

SIGNORiQ05D32

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTDSPL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51496

Protein Ontology

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PROi
PR:Q05D32

Gene expression databases

BgeeiENSG00000137770 Expressed in 195 organ(s), highest expression level in stomach
CleanExiHS_CTDSPL2
ExpressionAtlasiQ05D32 baseline and differential
GenevisibleiQ05D32 HS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTSL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05D32
Secondary accession number(s): Q3ZTU1
, Q6AI06, Q8IYI9, Q9NVT2, Q9NZX8, Q9P030
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 5, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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