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Protein

Solute carrier organic anion transporter family member

Gene

SLCO1B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family memberUniRule annotation
Gene namesi
Name:SLCO1B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 48HelicalUniRule annotationAdd BLAST20
Transmembranei68 – 89HelicalUniRule annotationAdd BLAST22
Transmembranei96 – 117HelicalUniRule annotationAdd BLAST22
Transmembranei170 – 195HelicalUniRule annotationAdd BLAST26
Transmembranei207 – 230HelicalUniRule annotationAdd BLAST24
Transmembranei258 – 279HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134865839

PTM / Processingi

Proteomic databases

PeptideAtlasiQ05CV5

Expressioni

Gene expression databases

GenevisibleiQ05CV5 HS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 296MFSInterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
HOVERGENiHBG063896
KOiK05043

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF03137 OATP, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Fragment.

Q05CV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS
60 70 80 90 100
SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL
160 170 180 190 200
NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA
210 220 230 240 250
KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT
260 270 280 290
DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKKK KKKKKK
Length:296
Mass (Da):32,903
Last modified:November 14, 2006 - v1
Checksum:i31DD44FCCB6A0912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei296Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020696 mRNA Translation: AAH20696.1
RefSeqiNP_006437.3, NM_006446.4
UniGeneiHs.449738

Genome annotation databases

GeneIDi10599
KEGGihsa:10599

Similar proteinsi

Entry informationi

Entry nameiQ05CV5_HUMAN
AccessioniPrimary (citable) accession number: Q05CV5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: January 31, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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