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Entry version 130 (17 Jun 2020)
Sequence version 3 (25 Nov 2008)
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Protein

Echinoderm microtubule-associated protein-like 5

Gene

EML5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q05BV3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 5
Short name:
EMAP-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EML5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165521.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18197 EML5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618119 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05BV3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
161436

Open Targets

More...
OpenTargetsi
ENSG00000165521

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134894613

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q05BV3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EML5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274143

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002843951 – 1969Echinoderm microtubule-associated protein-like 5Add BLAST1969

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q05BV3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q05BV3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05BV3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05BV3

PeptideAtlas

More...
PeptideAtlasi
Q05BV3

PRoteomics IDEntifications database

More...
PRIDEi
Q05BV3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58380 [Q05BV3-1]
58381 [Q05BV3-2]
58382 [Q05BV3-4]
58383 [Q05BV3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05BV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05BV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165521 Expressed in left ovary and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q05BV3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q05BV3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165521 Tissue enhanced (brain, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127791, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q05BV3, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000451998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q05BV3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05BV3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati59 – 100WD 1Add BLAST42
Repeati104 – 145WD 2Add BLAST42
Repeati148 – 187WD 3Add BLAST40
Repeati195 – 233WD 4Add BLAST39
Repeati235 – 273WD 5Add BLAST39
Repeati280 – 321WD 6Add BLAST42
Repeati323 – 362WD 7Add BLAST40
Repeati406 – 445WD 8Add BLAST40
Repeati449 – 488WD 9Add BLAST40
Repeati561 – 601WD 10Add BLAST41
Repeati725 – 766WD 11Add BLAST42
Repeati770 – 811WD 12Add BLAST42
Repeati814 – 853WD 13Add BLAST40
Repeati861 – 900WD 14Add BLAST40
Repeati901 – 940WD 15Add BLAST40
Repeati996 – 1035WD 16Add BLAST40
Repeati1038 – 1077WD 17Add BLAST40
Repeati1080 – 1120WD 18Add BLAST41
Repeati1236 – 1276WD 19Add BLAST41
Repeati1412 – 1463WD 20Add BLAST52
Repeati1467 – 1508WD 21Add BLAST42
Repeati1511 – 1550WD 22Add BLAST40
Repeati1560 – 1598WD 23Add BLAST39
Repeati1600 – 1646WD 24Add BLAST47
Repeati1691 – 1731WD 25Add BLAST41
Repeati1733 – 1774WD 26Add BLAST42
Repeati1775 – 1814WD 27Add BLAST40
Repeati1887 – 1926WD 28Add BLAST40
Repeati1932 – 1969WD 29Add BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2106 Eukaryota
ENOG410XNTQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156613

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001930_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05BV3

KEGG Orthology (KO)

More...
KOi
K18597

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEPEGHR

Database of Orthologous Groups

More...
OrthoDBi
97584at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05BV3

TreeFam database of animal gene trees

More...
TreeFami
TF317832

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR005108 HELP
IPR011041 Quinoprot_gluc/sorb_DH
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894 ANAPC4_WD40, 2 hits
PF03451 HELP, 3 hits
PF00400 WD40, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 28 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50952 SSF50952, 1 hit
SSF50978 SSF50978, 3 hits
SSF50998 SSF50998, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05BV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR
60 70 80 90 100
EHRQKFYRGH SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV
110 120 130 140 150
LKDVHTHGIA CLAFDLDGQR LVSVGLDSKN AVCVWDWKRG KMLSMAPGHT
160 170 180 190 200
DRIFDISWDL YQPNKLVSCG VKHIKFWSLC GNALTPKRGV FGKTGDLQTI
210 220 230 240 250
LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHAAGI FSMNACEEGF
260 270 280 290 300
ATGGRDGCIR LWDLTFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
310 320 330 340 350
QDSEIFEIVV QERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR
360 370 380 390 400
IWSLVDHALI ARCNMEEPIR CAAVNADGIH LALGMKDGSF TVLRVRDMTE
410 420 430 440 450
VVHIKDRKEA IHELKYSPDG TYLAVGCNDS SVDIYGVAQR YKKVGECLGS
460 470 480 490 500
LSFITHLDWS SDSRYLQTND GNGKRLFYRM PGGKEVTSTE EIKGVHWASW
510 520 530 540 550
TCVSGLEVNG IWPKYSDIND INSVDGNYIG QVLVTADDYG IIKLFRYPCL
560 570 580 590 600
RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
610 620 630 640 650
DAVHIAPQES LADSHSDESD SDLSDVPELD SEIEQETQLT YRRQVYKEDL
660 670 680 690 700
PQLKEQCKEK QKSATSKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQIG
710 720 730 740 750
EIVYHVAAVG VIYNRQQNTQ RFYLGHDDDI LCLTIHPLKD YVATGQVGRD
760 770 780 790 800
PSIHIWDTET IKPLSILKGH HQYGVSAVDF SADGKRLASV GIDDSHTVVL
810 820 830 840 850
WDWKKGEKLS IARGSKDKIF VVKMNPYVPD KLITAGIKHM KFWRKAGGGL
860 870 880 890 900
IGRKGYIGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDIFLVKTVK
910 920 930 940 950
AHDGPVFSMH ALEKGFVTGG KDGIVALWDD SFERCLKTYA IKRAALAPGS
960 970 980 990 1000
KGLLLEDNPS IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE
1010 1020 1030 1040 1050
VWGLATHPYL PICATVSDDK TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP
1060 1070 1080 1090 1100
DGKALAVGLN DGSFLMANAD TLEDLVSFHH RKDMISDIRF SPGSGKYLAV
1110 1120 1130 1140 1150
ASHDSFIDIY NVMSSKRVGI CKGATSYITH IDWDIRGKLL QVNTGAKEQL
1160 1170 1180 1190 1200
FFEAPRGKKQ TIPSVEVEKI AWASWTSVLG LCCEGIWPVI GEVTDVTASC
1210 1220 1230 1240 1250
LTSDKMVLAT GDDLGFVKLF RYPTKGKFGK FKRYVAHSTH VTNVRWTYDD
1260 1270 1280 1290 1300
SMLVTLGGTD MSLMVWTNEM EGYREKRPCD SEESDIDSEE DGGYDSDVTR
1310 1320 1330 1340 1350
ENEISYTIRA LSTNIRPMLG IKPHLQQKEP SIDERPPVSR APPQPEKLQT
1360 1370 1380 1390 1400
NNVGKKKRPI EDLVLELIFG YRGRDCRNNV HYLNDGDDII YHTASVGILH
1410 1420 1430 1440 1450
NVATGSQSFY QEHNDDILCL TVNQHPKFIN IVATGQVGDS ADMSATAPSI
1460 1470 1480 1490 1500
HIWDAMNKQT LSILRCYHSK GVCSVSFSAT GKLLLSVGLD PEHTITIWRW
1510 1520 1530 1540 1550
QEGAKIASRA GHNQRIFVAE FRPDSDTQFV SVGVKHVKFW TLAGRALLSK
1560 1570 1580 1590 1600
KGLLSTLEDA RMQTMLAIAF GANNLTFTGT ISGDVCVWKD HILCRIVARA
1610 1620 1630 1640 1650
HNGPVFAMYT TLRDGLIVTG GKERPSKEGG AVKLWDQELR RCRAFRLETG
1660 1670 1680 1690 1700
QATDCVRSVC RGKGKILVGT RNAEIIEVGE KNAACNILVN GHVDGPIWGL
1710 1720 1730 1740 1750
ATHPSRDFFL SAAEDGTVRL WDIADKKMLN KVNLGHAART VCYSPEGDMV
1760 1770 1780 1790 1800
AIGMKNGEFI ILLVSSLKIW GKKRDRRCAI HDIRFSPDSR YLAVGSSENS
1810 1820 1830 1840 1850
VDFYDLTLGP TLNRISYCKD IPSFVIQMDF SADSSYLQVS SGCYKRHVYE
1860 1870 1880 1890 1900
VPSGKHLMDH AAIDRITWAT WTSILGDEVL GIWSRHAEKA DVNCACVSHS
1910 1920 1930 1940 1950
GISLVTGDDF GMVKLFDFPC PEKFAKHKRF LGHSPHVTNI RFTSGDRHVV
1960
SAGGDDCSLF VWKCVHTPH
Length:1,969
Mass (Da):219,427
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB105BD33557F500D
GO
Isoform 2 (identifier: Q05BV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1137-1144: GKLLQVNT → AFTGQHWC
     1145-1969: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,144
Mass (Da):127,821
Checksum:iF882D3A33FB66378
GO
Isoform 4 (identifier: Q05BV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-622: ESLADSHSDESDSD → GYIHLYLHRHLNLM
     623-1969: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:622
Mass (Da):70,003
Checksum:iECEFB08803C581CE
GO
Isoform 5 (identifier: Q05BV3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1334-1334: E → ERQGVVRGS

Show »
Length:1,977
Mass (Da):220,267
Checksum:iD928D4A079974647
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJS1H0YJS1_HUMAN
Echinoderm microtubule-associated p...
EML5
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ79H0YJ79_HUMAN
Echinoderm microtubule-associated p...
EML5
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJX1H0YJX1_HUMAN
Echinoderm microtubule-associated p...
EML5
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32685 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC86793 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC87266 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAI46257 differs from that shown. The sequence differs from that shown in N-terminus because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti317F → S in AAH32685 (PubMed:15489334).Curated1
Sequence conflicti1402V → A in BAC86793 (PubMed:14702039).Curated1
Sequence conflicti1804Y → C in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1814R → G in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1823S → G in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1827Q → R in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1928K → R in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1940I → V in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1963K → R in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1967T → A in AAI50640 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031730269I → V. Corresponds to variant dbSNP:rs17188228Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041258609 – 622ESLAD…ESDSD → GYIHLYLHRHLNLM in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_041259623 – 1969Missing in isoform 4. 1 PublicationAdd BLAST1347
Alternative sequenceiVSP_0412601137 – 1144GKLLQVNT → AFTGQHWC in isoform 2. 1 Publication8
Alternative sequenceiVSP_0412611145 – 1969Missing in isoform 2. 1 PublicationAdd BLAST825
Alternative sequenceiVSP_0406451334E → ERQGVVRGS in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK127024 mRNA Translation: BAC86793.1 Sequence problems.
AK128086 mRNA Translation: BAC87266.1 Sequence problems.
AL121768 Genomic DNA No translation available.
AL162171 Genomic DNA No translation available.
BC032685 mRNA Translation: AAH32685.1 Sequence problems.
BC150639 mRNA Translation: AAI50640.1
AY357725 mRNA Translation: AAQ62653.1
CR933726 Transcribed RNA Translation: CAI46257.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS45148.1 [Q05BV3-5]

NCBI Reference Sequences

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RefSeqi
NP_899243.1, NM_183387.2 [Q05BV3-5]
XP_006720133.1, XM_006720070.3 [Q05BV3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380664; ENSP00000370039; ENSG00000165521 [Q05BV3-1]
ENST00000554922; ENSP00000451998; ENSG00000165521 [Q05BV3-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
161436

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:161436

UCSC genome browser

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UCSCi
uc059edd.1 human [Q05BV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127024 mRNA Translation: BAC86793.1 Sequence problems.
AK128086 mRNA Translation: BAC87266.1 Sequence problems.
AL121768 Genomic DNA No translation available.
AL162171 Genomic DNA No translation available.
BC032685 mRNA Translation: AAH32685.1 Sequence problems.
BC150639 mRNA Translation: AAI50640.1
AY357725 mRNA Translation: AAQ62653.1
CR933726 Transcribed RNA Translation: CAI46257.1 Sequence problems.
CCDSiCCDS45148.1 [Q05BV3-5]
RefSeqiNP_899243.1, NM_183387.2 [Q05BV3-5]
XP_006720133.1, XM_006720070.3 [Q05BV3-1]

3D structure databases

SMRiQ05BV3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127791, 7 interactors
IntActiQ05BV3, 7 interactors
STRINGi9606.ENSP00000451998

PTM databases

iPTMnetiQ05BV3
PhosphoSitePlusiQ05BV3

Polymorphism and mutation databases

BioMutaiEML5
DMDMi215274143

Proteomic databases

jPOSTiQ05BV3
MassIVEiQ05BV3
MaxQBiQ05BV3
PaxDbiQ05BV3
PeptideAtlasiQ05BV3
PRIDEiQ05BV3
ProteomicsDBi58380 [Q05BV3-1]
58381 [Q05BV3-2]
58382 [Q05BV3-4]
58383 [Q05BV3-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47387 35 antibodies

Genome annotation databases

EnsembliENST00000380664; ENSP00000370039; ENSG00000165521 [Q05BV3-1]
ENST00000554922; ENSP00000451998; ENSG00000165521 [Q05BV3-5]
GeneIDi161436
KEGGihsa:161436
UCSCiuc059edd.1 human [Q05BV3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
161436
DisGeNETi161436
EuPathDBiHostDB:ENSG00000165521.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EML5
HGNCiHGNC:18197 EML5
HPAiENSG00000165521 Tissue enhanced (brain, ovary)
MIMi618119 gene
neXtProtiNX_Q05BV3
OpenTargetsiENSG00000165521
PharmGKBiPA134894613

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2106 Eukaryota
ENOG410XNTQ LUCA
GeneTreeiENSGT00940000156613
HOGENOMiCLU_001930_0_0_1
InParanoidiQ05BV3
KOiK18597
OMAiHEPEGHR
OrthoDBi97584at2759
PhylomeDBiQ05BV3
TreeFamiTF317832

Enzyme and pathway databases

SignaLinkiQ05BV3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
161436 2 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EML5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
161436
PharosiQ05BV3 Tdark

Protein Ontology

More...
PROi
PR:Q05BV3
RNActiQ05BV3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165521 Expressed in left ovary and 111 other tissues
ExpressionAtlasiQ05BV3 baseline and differential
GenevisibleiQ05BV3 HS

Family and domain databases

Gene3Di2.130.10.10, 6 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR005108 HELP
IPR011041 Quinoprot_gluc/sorb_DH
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 2 hits
PF03451 HELP, 3 hits
PF00400 WD40, 8 hits
SMARTiView protein in SMART
SM00320 WD40, 28 hits
SUPFAMiSSF50952 SSF50952, 1 hit
SSF50978 SSF50978, 3 hits
SSF50998 SSF50998, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMAL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05BV3
Secondary accession number(s): B9EK59
, Q5H9N6, Q6UYC9, Q6ZRP3, Q6ZT03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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