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Entry version 114 (13 Nov 2019)
Sequence version 2 (15 Jan 2008)
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Protein

MBT domain-containing protein 1

Gene

MBTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri45 – 80FCS-typePROSITE-ProRule annotationAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MBT domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBTD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19866 MBTD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05BQ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MBTD1 is a cause of acute poorly differentiated myeloid leukemia. Translocation (10;17)(p15;q21) with ZMYND11.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
54799

Open Targets

More...
OpenTargetsi
ENSG00000011258

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938339

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q05BQ5

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1287625

DrugCentral

More...
DrugCentrali
Q05BQ5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MBTD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166232936

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003137171 – 628MBT domain-containing protein 1Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei115N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q05BQ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q05BQ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q05BQ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05BQ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05BQ5

PeptideAtlas

More...
PeptideAtlasi
Q05BQ5

PRoteomics IDEntifications database

More...
PRIDEi
Q05BQ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58373 [Q05BQ5-1]
58374 [Q05BQ5-2]
58375 [Q05BQ5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05BQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05BQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000011258 Expressed in 215 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q05BQ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q05BQ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021876

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120158, 33 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-978 NuA4 histone acetyltransferase complex

Protein interaction database and analysis system

More...
IntActi
Q05BQ5, 31 interactors

Molecular INTeraction database

More...
MINTi
Q05BQ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000468304

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q05BQ5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1628
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05BQ5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q05BQ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati141 – 245MBT 1Add BLAST105
Repeati253 – 350MBT 2Add BLAST98
Repeati351 – 456MBT 3Add BLAST106
Repeati464 – 560MBT 4Add BLAST97

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri45 – 80FCS-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMEY Eukaryota
ENOG410ZCJZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153840

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231220

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05BQ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNHGFHV

Database of Orthologous Groups

More...
OrthoDBi
1334498at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05BQ5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.60.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02820 MBT, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00561 MBT, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05BQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFDGYDSCSE DTSSSSSSEE SEEEVAPLPS NLPIIKNNGQ VYTYPDGKSG
60 70 80 90 100
MATCEMCGMV GVRDAFYSKT KRFCSVSCSR SYSSNSKKAS ILARLQGKPP
110 120 130 140 150
TKKAKVLQKQ PLVAKLAAYA QYQATLQNQA KTKAAVSMEG FSWGNYINSN
160 170 180 190 200
SFIAAPVTCF KHAPMGTCWG DISENVRVEV PNTDCSLPTK VFWIAGIVKL
210 220 230 240 250
AGYNALLRYE GFENDSGLDF WCNICGSDIH PVGWCAASGK PLVPPRTIQH
260 270 280 290 300
KYTNWKAFLV KRLTGAKTLP PDFSQKVSES MQYPFKPCMR VEVVDKRHLC
310 320 330 340 350
RTRVAVVESV IGGRLRLVYE ESEDRTDDFW CHMHSPLIHH IGWSRSIGHR
360 370 380 390 400
FKRSDITKKQ DGHFDTPPHL FAKVKEVDQS GEWFKEGMKL EAIDPLNLST
410 420 430 440 450
ICVATIRKVL ADGFLMIGID GSEAADGSDW FCYHATSPSI FPVGFCEINM
460 470 480 490 500
IELTPPRGYT KLPFKWFDYL RETGSIAAPV KLFNKDVPNH GFRVGMKLEA
510 520 530 540 550
VDLMEPRLIC VATVTRIIHR LLRIHFDGWE EEYDQWVDCE SPDLYPVGWC
560 570 580 590 600
QLTGYQLQPP ASQSSRENQS ASSKQKKKAK SQQYKGHKKM TTLQLKEELL
610 620
DGEDYNFLQG ASDQESNGSA NFYIKQEP
Length:628
Mass (Da):70,547
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D2E6C7EF5C5D8AA
GO
Isoform 2 (identifier: Q05BQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-169: APMGTCW → GRRVAPR
     170-628: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:169
Mass (Da):18,381
Checksum:i8C3D0A97AABAAA82
GO
Isoform 3 (identifier: Q05BQ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     564-628: SSRENQSASS...SANFYIKQEP → CKLVYRKGVLL

Show »
Length:410
Mass (Da):46,717
Checksum:i6E9C09639AC02CF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ11K7EQ11_HUMAN
MBT domain-containing protein 1
MBTD1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85763 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti575Q → K in AAH34364 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0301151 – 164Missing in isoform 3. 2 PublicationsAdd BLAST164
Alternative sequenceiVSP_042701163 – 169APMGTCW → GRRVAPR in isoform 2. 1 Publication7
Alternative sequenceiVSP_042702170 – 628Missing in isoform 2. 1 PublicationAdd BLAST459
Alternative sequenceiVSP_030118564 – 628SSREN…IKQEP → CKLVYRKGVLL in isoform 3. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000062 mRNA Translation: BAA90919.1
AK124061 mRNA Translation: BAC85763.1 Sequence problems.
AC005839 Genomic DNA No translation available.
AC006141 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94562.1
BC034364 mRNA Translation: AAH34364.1
BC101736 mRNA Translation: AAI01737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11581.2 [Q05BQ5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060113.2, NM_017643.2 [Q05BQ5-1]
XP_011523238.1, XM_011524936.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376381; ENSP00000365561; ENSG00000011258 [Q05BQ5-3]
ENST00000405860; ENSP00000386072; ENSG00000011258 [Q05BQ5-2]
ENST00000415868; ENSP00000403946; ENSG00000011258 [Q05BQ5-1]
ENST00000586178; ENSP00000468304; ENSG00000011258 [Q05BQ5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54799

UCSC genome browser

More...
UCSCi
uc002itp.5 human [Q05BQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000062 mRNA Translation: BAA90919.1
AK124061 mRNA Translation: BAC85763.1 Sequence problems.
AC005839 Genomic DNA No translation available.
AC006141 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94562.1
BC034364 mRNA Translation: AAH34364.1
BC101736 mRNA Translation: AAI01737.1
CCDSiCCDS11581.2 [Q05BQ5-1]
RefSeqiNP_060113.2, NM_017643.2 [Q05BQ5-1]
XP_011523238.1, XM_011524936.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FEOX-ray2.50A/B130-566[»]
4C5IX-ray2.59A/B130-566[»]
6NFXX-ray1.95A140-562[»]
SMRiQ05BQ5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120158, 33 interactors
ComplexPortaliCPX-978 NuA4 histone acetyltransferase complex
IntActiQ05BQ5, 31 interactors
MINTiQ05BQ5
STRINGi9606.ENSP00000468304

Chemistry databases

BindingDBiQ05BQ5
ChEMBLiCHEMBL1287625
DrugCentraliQ05BQ5

PTM databases

iPTMnetiQ05BQ5
PhosphoSitePlusiQ05BQ5

Polymorphism and mutation databases

BioMutaiMBTD1
DMDMi166232936

Proteomic databases

EPDiQ05BQ5
jPOSTiQ05BQ5
MassIVEiQ05BQ5
MaxQBiQ05BQ5
PaxDbiQ05BQ5
PeptideAtlasiQ05BQ5
PRIDEiQ05BQ5
ProteomicsDBi58373 [Q05BQ5-1]
58374 [Q05BQ5-2]
58375 [Q05BQ5-3]

Genome annotation databases

EnsembliENST00000376381; ENSP00000365561; ENSG00000011258 [Q05BQ5-3]
ENST00000405860; ENSP00000386072; ENSG00000011258 [Q05BQ5-2]
ENST00000415868; ENSP00000403946; ENSG00000011258 [Q05BQ5-1]
ENST00000586178; ENSP00000468304; ENSG00000011258 [Q05BQ5-1]
GeneIDi54799
KEGGihsa:54799
UCSCiuc002itp.5 human [Q05BQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54799
DisGeNETi54799

GeneCards: human genes, protein and diseases

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GeneCardsi
MBTD1
HGNCiHGNC:19866 MBTD1
HPAiHPA021876
neXtProtiNX_Q05BQ5
OpenTargetsiENSG00000011258
PharmGKBiPA134938339

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IMEY Eukaryota
ENOG410ZCJZ LUCA
GeneTreeiENSGT00940000153840
HOGENOMiHOG000231220
InParanoidiQ05BQ5
OMAiPNHGFHV
OrthoDBi1334498at2759
PhylomeDBiQ05BQ5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MBTD1 human
EvolutionaryTraceiQ05BQ5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54799
PharosiQ05BQ5

Protein Ontology

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PROi
PR:Q05BQ5

Gene expression databases

BgeeiENSG00000011258 Expressed in 215 organ(s), highest expression level in forebrain
ExpressionAtlasiQ05BQ5 baseline and differential
GenevisibleiQ05BQ5 HS

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PfamiView protein in Pfam
PF02820 MBT, 4 hits
SMARTiView protein in SMART
SM00561 MBT, 4 hits
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBTD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05BQ5
Secondary accession number(s): Q6ZVU7, Q9NXU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 13, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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