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Entry version 81 (07 Oct 2020)
Sequence version 1 (14 Nov 2006)
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Protein
Submitted name:

TP53BP2 protein

Gene

TP53BP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TP53BP2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TP53BP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q05BL1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q05BL1
With#Exp.IntAct
ADAMTS12 - isoform 3 [P58397-3]3EBI-11952721,EBI-12048761
APPL1 [Q9UKG1]3EBI-11952721,EBI-741243
ARHGAP45 [Q92619]3EBI-11952721,EBI-2825900
ARHGEF6 [Q15052]3EBI-11952721,EBI-1642523
AXIN1 [A0A0S2Z4M1]3EBI-11952721,EBI-16429430
BAG3 [O95817]3EBI-11952721,EBI-747185
BAIAP2 - isoform 6 [Q9UQB8-6]3EBI-11952721,EBI-9092016
BCAS2 [O75934]3EBI-11952721,EBI-1050106
CCDC13 [Q8IYE1]3EBI-11952721,EBI-10961312
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-11952721,EBI-10961624
CCDC85A [Q96PX6]4EBI-11952721,EBI-7257229
CDC5L [Q99459]3EBI-11952721,EBI-374880
CEP55 [Q53EZ4]3EBI-11952721,EBI-747776
CEP95 [Q96GE4]3EBI-11952721,EBI-372775
CGN [B9EK46]3EBI-11952721,EBI-14314072
CRK [P46108]3EBI-11952721,EBI-886
DDX6 [P26196]3EBI-11952721,EBI-351257
DIRAS1 [O95057]3EBI-11952721,EBI-11993172
EFHC1 [Q5JVL4]3EBI-11952721,EBI-743105
ELOA [Q14241]3EBI-11952721,EBI-742350
GCC1 [Q96CN9]3EBI-11952721,EBI-746252
GEM [P55040]3EBI-11952721,EBI-744104
GFAP [P14136]3EBI-11952721,EBI-744302
GOLGA1 [Q92805]3EBI-11952721,EBI-6164177
GPS2 [Q13227]3EBI-11952721,EBI-713355
H2BC9 [Q93079]3EBI-11952721,EBI-352469
hCG_2042749 [A0A024R4Z4]3EBI-11952721,EBI-14231181
HHEX [Q03014]3EBI-11952721,EBI-747421
HSF2BP [O75031]3EBI-11952721,EBI-7116203
INSYN2A [Q6ZSG2]3EBI-11952721,EBI-12146621
IQUB [Q8NA54]3EBI-11952721,EBI-10220600
KDM1A [O60341]3EBI-11952721,EBI-710124
LHX4 [A0A0S2Z5S9]3EBI-11952721,EBI-16429099
LMNB1 [P20700]3EBI-11952721,EBI-968218
LMNB2 [Q03252]3EBI-11952721,EBI-2830427
MOS [P00540]3EBI-11952721,EBI-1757866
MTMR14 [Q8NCE2]3EBI-11952721,EBI-5658424
MTURN [Q8N3F0]3EBI-11952721,EBI-11980301
NAP1L2 [Q9ULW6]3EBI-11952721,EBI-3911716
NDC80 [O14777]3EBI-11952721,EBI-715849
NEDD4 - isoform 3 [P46934-3]3EBI-11952721,EBI-11980721
NHSL2 [Q5HYW2]3EBI-11952721,EBI-2859639
OTUB2 [Q96DC9]3EBI-11952721,EBI-746259
PHF1 [O43189]3EBI-11952721,EBI-530034
PIBF1 [Q4G0R1]3EBI-11952721,EBI-14066006
PLEKHF2 [Q9H8W4]3EBI-11952721,EBI-742388
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-11952721,EBI-12014286
PPP1CA [P62136]3EBI-11952721,EBI-357253
PPP1CB [P62140]3EBI-11952721,EBI-352350
PPP1CC [P36873]3EBI-11952721,EBI-356283
PRAM1 [Q96QH2]3EBI-11952721,EBI-2860740
PRPF31 [Q8WWY3]3EBI-11952721,EBI-1567797
RALBP1 [Q15311]3EBI-11952721,EBI-749285
RASAL3 [Q86YV0]3EBI-11952721,EBI-3437896
RASSF10 [A6NK89]3EBI-11952721,EBI-6912267
RASSF8 - isoform 2 [Q8NHQ8-2]3EBI-11952721,EBI-10976415
RGMA - isoform 2 [Q96B86-3]3EBI-11952721,EBI-14497860
RXRB - isoform 2 [P28702-3]3EBI-11952721,EBI-16429492
SCNM1 [Q9BWG6]3EBI-11952721,EBI-748391
SETD5 - isoform 3 [Q9C0A6-3]3EBI-11952721,EBI-12233047
SH3KBP1 [Q96B97]3EBI-11952721,EBI-346595
SHTN1 - isoform 4 [A0MZ66-4]3EBI-11952721,EBI-12097232
TARS3 [A2RTX5]3EBI-11952721,EBI-1056629
TROAP [Q12815]3EBI-11952721,EBI-2349743
TSGA10 [Q9BZW7]3EBI-11952721,EBI-744794
TXLNA [P40222]3EBI-11952721,EBI-359793
TYK2 [P29597]3EBI-11952721,EBI-1383454
UBASH3A - isoform 2 [P57075-2]3EBI-11952721,EBI-7353612
UBASH3B [Q8TF42]3EBI-11952721,EBI-1380492
UBTD1 [Q9HAC8]3EBI-11952721,EBI-745871
YOD1 [Q5VVQ6]3EBI-11952721,EBI-2510804
ZBTB4 [Q9P1Z0]3EBI-11952721,EBI-2564133
ZGPAT [A0A0S2Z6H0]3EBI-11952721,EBI-16428984
ZGPAT - isoform 2 [Q8N5A5-2]6EBI-11952721,EBI-10183064
ZNF438 [Q7Z4V0]3EBI-11952721,EBI-11962468
ZNF552 [Q9H707]3EBI-11952721,EBI-2555731
ZNF575 [Q86XF7]3EBI-11952721,EBI-14069183

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q05BL1, 79 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini845 – 943ANK_REP_REGIONInterPro annotationAdd BLAST99
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati878 – 910ANKPROSITE-ProRule annotationAdd BLAST33
Repeati911 – 943ANKPROSITE-ProRule annotationAdd BLAST33
Domaini977 – 1039SH3InterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 42DisorderedSequence analysisAdd BLAST42
Regioni242 – 261DisorderedSequence analysisAdd BLAST20
Regioni414 – 518DisorderedSequence analysisAdd BLAST105
Regioni575 – 626DisorderedSequence analysisAdd BLAST52
Regioni644 – 668DisorderedSequence analysisAdd BLAST25
Regioni722 – 829DisorderedSequence analysisAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili48 – 123Sequence analysisAdd BLAST76
Coiled coili127 – 161Sequence analysisAdd BLAST35
Coiled coili180 – 214Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi242 – 259PolarSequence analysisAdd BLAST18
Compositional biasi430 – 459PolarSequence analysisAdd BLAST30
Compositional biasi474 – 494PolarSequence analysisAdd BLAST21
Compositional biasi575 – 601PolarSequence analysisAdd BLAST27
Compositional biasi785 – 799Pro-richSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05BL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAPLAGTLV VSGPRSQDPS LKRNGVKVPG EYRRKENGVN SPRMDLTLAE
60 70 80 90 100
LQEMASRQQQ QIEAQQQLLA TKEQRLKFLK QQDQRQQQQV AEQEKLKRLK
110 120 130 140 150
EIAENQEAKL KKVRALKGHV EQKRLSNGKL VEEIEQMNNL FQQKQRELVL
160 170 180 190 200
AVSKVEELTR QLEMLKNGRI DSHHDNQSAV AELDRLYKEL QLRNKLNQEQ
210 220 230 240 250
NAKLQQQREC LNKRNSEVAV MDKRVNELRD RLWKKKAALQ QKENLPVSSD
260 270 280 290 300
GNLPQQAASA PSRVAAVGPY IQSSTMPRMP SRPELLVKPA LPDGSLVIQA
310 320 330 340 350
SEGPMKIQTL PNMRSGAASQ TKGSKIHPVG PDWSPSNADL FPSQGSASVP
360 370 380 390 400
QSTGNALDQV DDGEVPLREK EKKVRPFSMF DAVDQSNAPP SFGTLRKNQS
410 420 430 440 450
SEDILRDAQV ANKNVAKVPP PVPTKPKQIN LPYFGQTNQP PSDIKPDGSS
460 470 480 490 500
QQLSTVVPSM GTKPKPAGQQ PRVLLSPSIP SVGQDQTLSP GSKQESPPAA
510 520 530 540 550
AVRPFTPQPS KDTLLPPFRK PQTVAASSIY SMYTQQQAPG KNFQQAVQSA
560 570 580 590 600
LTKTHTRGPH FSSVYGKPVI AAAQNQQQHP ENIYSNSQGK PGSPEPETEP
610 620 630 640 650
VSSVQENHEN ERIPRPLSPT KLLPFLSNPY RNQSDADLEA LRKKLSNAPR
660 670 680 690 700
PLKKRSSITE PEGPNGPNIQ KLLYQRTTIA AMETISVPSY PSKSASVTAS
710 720 730 740 750
SESPVEIQNP YLHVEPEKEV VSLVPESLSP EDVGNASTEN SDMPAPSPGL
760 770 780 790 800
DYEPEGVPDN SPNLQNNPEE PNPEAPHVLD VYLEEYPPYP PPPYPSGEPE
810 820 830 840 850
GPGEDSVSMR PPEITGQVSL PPGKRTNLRK TGSERIAHGM RVKFNPLALL
860 870 880 890 900
LDSSLEGEFD LVQRIIYEVD DPSLPNDEGI TALHNAVCAG HTEIVKFLVQ
910 920 930 940 950
FGVNVNAADS DGWTPLHCAA SCNNVQVCKF LVESGAAVFA MTYSDMQTAA
960 970 980 990 1000
DKCEEMEEGY TQCSQFLYGV QEKMGIMNKG VIYALWDYEP QNDDELPMKE
1010 1020 1030 1040
GDCMTIIHRE DEDEIEWWWA RLNDKEGYVP RNLLGLYPRI KPRQRSLA
Length:1,048
Mass (Da):116,047
Last modified:November 14, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F71BECEFA1B9D27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC040247 mRNA Translation: AAH40247.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040247 mRNA Translation: AAH40247.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ05BL1, 79 interactors

Proteomic databases

PeptideAtlasiQ05BL1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TP53BP2, human

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ05BL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05BL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: October 7, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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