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Protein

CDGSH iron-sulfur domain-containing protein 2

Gene

CISD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity).By similarity

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi101Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi110Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi114Iron-sulfur (2Fe-2S); via pros nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CDGSH iron-sulfur domain-containing protein 2
Gene namesi
Name:CISD2
Synonyms:CDGSH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:27372 CISD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37LumenalSequence analysisAdd BLAST37
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 135CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160041 – 135CDGSH iron-sulfur domain-containing protein 2Add BLAST135

Proteomic databases

PaxDbiQ05B71
PRIDEiQ05B71

Expressioni

Gene expression databases

BgeeiENSBTAG00000027630 Expressed in 10 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Homodimer. Interacts with BCL2; the interaction is direct and disrupted by BIK interaction with BCL2. Interacts with BCL2L1. Interacts with ITPR1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039580

Structurei

3D structure databases

ProteinModelPortaliQ05B71
SMRiQ05B71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CISD protein family. CISD2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3461 Eukaryota
ENOG41122II LUCA
GeneTreeiENSGT00390000001233
HOGENOMiHOG000242301
HOVERGENiHBG052444
InParanoidiQ05B71
OMAiTGYLAFC
OrthoDBiEOG091G0XB4
TreeFamiTF324661

Family and domain databases

InterProiView protein in InterPro
IPR018967 FeS-contain_CDGSH-typ
IPR019610 FeS-contain_mitoNEET_N
PfamiView protein in Pfam
PF10660 MitoNEET_N, 1 hit
PF09360 zf-CDGSH, 1 hit
SMARTiView protein in SMART
SM00704 ZnF_CDGSH, 1 hit

Sequencei

Sequence statusi: Complete.

Q05B71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLESVARIV KVQLPAYLKR LPVPESITGF ARLTVSEWLR LLPFLGVLAL
60 70 80 90 100
LGYLAVRPFL PKKKQQKDSL INLKIQKENP KVVNEINIED LCLTKAAYCR
110 120 130
CWRSKTFPAC DGSHNKHNEL TGDNVGPLIL KKKEV
Length:135
Mass (Da):15,278
Last modified:November 14, 2006 - v1
Checksum:i44AD1817D6C536D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122676 mRNA Translation: AAI22677.1
RefSeqiNP_001073807.1, NM_001080338.1
UniGeneiBt.28419

Genome annotation databases

EnsembliENSBTAT00000039792; ENSBTAP00000039580; ENSBTAG00000027630
GeneIDi781260
KEGGibta:781260

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122676 mRNA Translation: AAI22677.1
RefSeqiNP_001073807.1, NM_001080338.1
UniGeneiBt.28419

3D structure databases

ProteinModelPortaliQ05B71
SMRiQ05B71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039580

Proteomic databases

PaxDbiQ05B71
PRIDEiQ05B71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039792; ENSBTAP00000039580; ENSBTAG00000027630
GeneIDi781260
KEGGibta:781260

Organism-specific databases

CTDi493856
VGNCiVGNC:27372 CISD2

Phylogenomic databases

eggNOGiKOG3461 Eukaryota
ENOG41122II LUCA
GeneTreeiENSGT00390000001233
HOGENOMiHOG000242301
HOVERGENiHBG052444
InParanoidiQ05B71
OMAiTGYLAFC
OrthoDBiEOG091G0XB4
TreeFamiTF324661

Gene expression databases

BgeeiENSBTAG00000027630 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR018967 FeS-contain_CDGSH-typ
IPR019610 FeS-contain_mitoNEET_N
PfamiView protein in Pfam
PF10660 MitoNEET_N, 1 hit
PF09360 zf-CDGSH, 1 hit
SMARTiView protein in SMART
SM00704 ZnF_CDGSH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCISD2_BOVIN
AccessioniPrimary (citable) accession number: Q05B71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 12, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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