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UniProtKB - Q05B60 (NUD14_BOVIN)
Protein
Uridine diphosphate glucose pyrophosphatase NUDT14
Gene
NUDT14
Organism
Bos taurus (Bovine)
Status
Functioni
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).
By similarityCatalytic activityi
- UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate. EC:3.6.1.45
Cofactori
Mg2+By similarity
GO - Molecular functioni
- ADP-ribose diphosphatase activity Source: Ensembl
- identical protein binding Source: Ensembl
- metal ion binding Source: InterPro
- UDP-sugar diphosphatase activity Source: GO_Central
GO - Biological processi
- nucleoside phosphate metabolic process Source: GO_Central
- ribose phosphate metabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium |
Enzyme and pathway databases
Reactomei | R-BTA-480985, Synthesis of dolichyl-phosphate-glucose |
Names & Taxonomyi
Protein namesi | Recommended name: Uridine diphosphate glucose pyrophosphatase NUDT14 (EC:3.6.1.45)Short name: UDPG pyrophosphatase Short name: UGPPase Alternative name(s): Nucleoside diphosphate-linked moiety X motif 14 Short name: Nudix motif 14 |
Gene namesi | Name:NUDT14 Synonyms:UGPP |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000048010 |
VGNCi | VGNC:32328, NUDT14 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000282602 | 1 – 222 | Uridine diphosphate glucose pyrophosphatase NUDT14Add BLAST | 222 |
Proteomic databases
PaxDbi | Q05B60 |
PRIDEi | Q05B60 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000048010, Expressed in pons and 94 other tissues |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000055697 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 206 | Nudix hydrolasePROSITE-ProRule annotationAdd BLAST | 169 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 111 – 129 | Nudix boxAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the Nudix hydrolase family.Curated
Phylogenomic databases
eggNOGi | KOG4432, Eukaryota |
GeneTreei | ENSGT00940000154045 |
HOGENOMi | CLU_062658_1_0_1 |
InParanoidi | Q05B60 |
OMAi | YTYELCA |
OrthoDBi | 1164318at2759 |
TreeFami | TF313661 |
Family and domain databases
InterProi | View protein in InterPro IPR004385, NDP_pyrophosphatase IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
SUPFAMi | SSF55811, SSF55811, 1 hit |
TIGRFAMsi | TIGR00052, TIGR00052, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q05B60-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS
60 70 80 90 100
SRRSLVLVKQ FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT
110 120 130 140 150
YELCAGLLDQ PGLSLEEVAC KEAWEECGYR LAPSDLRRVT SYKSGVGLTG
160 170 180 190 200
SSQTMFYAEV TDAQRGSPGG GLAEEGELIE VVHLPLDGAR TFADDPDVPK
210 220
TLGVIFGISW FFSCVAPGLG LQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC122769 mRNA Translation: AAI22770.1 |
RefSeqi | NP_001099122.1, NM_001105652.2 |
Genome annotation databases
Ensembli | ENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010 |
GeneIDi | 100126049 |
KEGGi | bta:100126049 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC122769 mRNA Translation: AAI22770.1 |
RefSeqi | NP_001099122.1, NM_001105652.2 |
3D structure databases
AlphaFoldDBi | Q05B60 |
SMRi | Q05B60 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000055697 |
Proteomic databases
PaxDbi | Q05B60 |
PRIDEi | Q05B60 |
Genome annotation databases
Ensembli | ENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010 |
GeneIDi | 100126049 |
KEGGi | bta:100126049 |
Organism-specific databases
CTDi | 256281 |
VEuPathDBi | HostDB:ENSBTAG00000048010 |
VGNCi | VGNC:32328, NUDT14 |
Phylogenomic databases
eggNOGi | KOG4432, Eukaryota |
GeneTreei | ENSGT00940000154045 |
HOGENOMi | CLU_062658_1_0_1 |
InParanoidi | Q05B60 |
OMAi | YTYELCA |
OrthoDBi | 1164318at2759 |
TreeFami | TF313661 |
Enzyme and pathway databases
Reactomei | R-BTA-480985, Synthesis of dolichyl-phosphate-glucose |
Gene expression databases
Bgeei | ENSBTAG00000048010, Expressed in pons and 94 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004385, NDP_pyrophosphatase IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
SUPFAMi | SSF55811, SSF55811, 1 hit |
TIGRFAMsi | TIGR00052, TIGR00052, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NUD14_BOVIN | |
Accessioni | Q05B60Primary (citable) accession number: Q05B60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | November 14, 2006 | |
Last modified: | May 25, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families