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Protein

Fatty-acid amide hydrolase 2-B

Gene

faah2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Anandamide + H2O = arachidonic acid + ethanolamine.
Oleamide + H2O = oleic acid + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Charge relay systemBy similarity1
Active sitei203Charge relay systemBy similarity1
Active sitei227Acyl-ester intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty-acid amide hydrolase 2-B (EC:3.5.1.99)
Gene namesi
Name:faah2b
ORF Names:zgc:153568
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061027-358 faah2b

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919951 – 526Fatty-acid amide hydrolase 2-BAdd BLAST526

Proteomic databases

PaxDbiQ05AM4
PRIDEiQ05AM4

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071507

Structurei

3D structure databases

ProteinModelPortaliQ05AM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1212 Eukaryota
COG0154 LUCA
HOGENOMiHOG000116697
HOVERGENiHBG101001
InParanoidiQ05AM4
KOiK19176
PhylomeDBiQ05AM4

Family and domain databases

Gene3Di3.90.1300.10, 1 hit
InterProiView protein in InterPro
IPR020556 Amidase_CS
IPR023631 Amidase_dom
IPR036928 AS_sf
PfamiView protein in Pfam
PF01425 Amidase, 1 hit
SUPFAMiSSF75304 SSF75304, 1 hit
PROSITEiView protein in PROSITE
PS00571 AMIDASES, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q05AM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLTLGERVQ HCLLVLVSGL FLALFRLLSP GTKRPKHLPP ITNPLLTLSA
60 70 80 90 100
VQLAEKIRRG EVSSVEVVQA YIDRIQEVNP LLNALIKDRF SAALLEAARA
110 120 130 140 150
DKLIKEENGG EEVLRNQFPL LGVPMSVKES FGLQGMPNSG GLKSRGKVLA
160 170 180 190 200
SVDAPPVALL KRAGAIPLGV TNTSELCMWM ESNNHLYGIT SNPYNLERIC
210 220 230 240 250
GGSSGGEGSI IGGGASVFGI GSDIGGSIRM PCFFNGIFGH KPSRGVVSND
260 270 280 290 300
NQFPRCSGLQ NEYTGSGPMC RYAEDLLPLL KIMAGPTADK LTLSKAVDLK
310 320 330 340 350
KLRFFTIVDD GGSPLTSPVD RQLVEVQKRV AARLEADLGV TVQEVNFPQL
360 370 380 390 400
KYSYQIWDTF LALPDKDGKP PEAFVELMAD GGSVWPVWEL IKRIFGRSEH
410 420 430 440 450
TVAAIGLALM ESSHSSKSSE FILKQKEDLQ REMEDLLGTD GVLLYPSHPL
460 470 480 490 500
LAPKHHHPLF MPFNFSYTGI LNILGLPVTQ CPLGLSKERL PLGVQVVAGL
510 520
CQDHLTLAMA LYLEKAFGGW VDPGVV
Length:526
Mass (Da):57,026
Last modified:November 14, 2006 - v1
Checksum:i271E1756BABDDA86
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QM44F1QM44_DANRE
Fatty-acid amide hydrolase 2-B
faah2b
526Annotation score:
A0A2R8PZX1A0A2R8PZX1_DANRE
Fatty-acid amide hydrolase 2-B
faah2b
524Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124392 mRNA Translation: AAI24393.1
RefSeqiNP_001070930.1, NM_001077462.1
UniGeneiDr.81626

Genome annotation databases

GeneIDi768298
KEGGidre:768298

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124392 mRNA Translation: AAI24393.1
RefSeqiNP_001070930.1, NM_001077462.1
UniGeneiDr.81626

3D structure databases

ProteinModelPortaliQ05AM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071507

Proteomic databases

PaxDbiQ05AM4
PRIDEiQ05AM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi768298
KEGGidre:768298

Organism-specific databases

CTDi768298
ZFINiZDB-GENE-061027-358 faah2b

Phylogenomic databases

eggNOGiKOG1212 Eukaryota
COG0154 LUCA
HOGENOMiHOG000116697
HOVERGENiHBG101001
InParanoidiQ05AM4
KOiK19176
PhylomeDBiQ05AM4

Miscellaneous databases

PROiPR:Q05AM4

Family and domain databases

Gene3Di3.90.1300.10, 1 hit
InterProiView protein in InterPro
IPR020556 Amidase_CS
IPR023631 Amidase_dom
IPR036928 AS_sf
PfamiView protein in Pfam
PF01425 Amidase, 1 hit
SUPFAMiSSF75304 SSF75304, 1 hit
PROSITEiView protein in PROSITE
PS00571 AMIDASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAH2B_DANRE
AccessioniPrimary (citable) accession number: Q05AM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 14, 2006
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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