GATA-binding protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes."
    Lyons S.E., Lawson N.D., Lei L., Bennett P.E., Weinstein B.M., Liu P.P.
    Proc Natl Acad Sci U S A 99:5454-5459(2002) [PubMed] [Europe PMC] [Abstract]
  • "Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish."
    Belele C.L., English M.A., Chahal J., Burnetti A., Finckbeiner S.M., Gibney G., Kirby M., Sood R., Liu P.P.
    Blood 114:5162-5172(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: ZFINInferred from direct assayⁱ
  • "A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes."
    Lyons S.E., Lawson N.D., Lei L., Bennett P.E., Weinstein B.M., Liu P.P.
    Proc Natl Acad Sci U S A 99:5454-5459(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: ZFINInferred from direct assayⁱ
  • "Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish."
    Belele C.L., English M.A., Chahal J., Burnetti A., Finckbeiner S.M., Gibney G., Kirby M., Sood R., Liu P.P.
    Blood 114:5162-5172(2009) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• cardiac muscle tissue development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chordate embryonic development Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants."
    Traver D., Paw B.H., Poss K.D., Penberthy W.T., Lin S., Zon L.I.
    Nat Immunol 4:1238-1246(2003) [PubMed] [Europe PMC] [Abstract]
• embryonic hemopoiesis Source: ZFINInferred from mutant phenotypeⁱ
  • "A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes."
    Lyons S.E., Lawson N.D., Lei L., Bennett P.E., Weinstein B.M., Liu P.P.
    Proc Natl Acad Sci U S A 99:5454-5459(2002) [PubMed] [Europe PMC] [Abstract]
• erythrocyte development Source: ZFINInferred from mutant phenotypeⁱ
  • "Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart."
    Vermot J., Forouhar A.S., Liebling M., Wu D., Plummer D., Gharib M., Fraser S.E.
    PLoS Biol 7:e1000246-e1000246(2009) [PubMed] [Europe PMC] [Abstract]
• erythrocyte differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants."
    Traver D., Paw B.H., Poss K.D., Penberthy W.T., Lin S., Zon L.I.
    Nat Immunol 4:1238-1246(2003) [PubMed] [Europe PMC] [Abstract]
  • "Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development."
    Woo A.J., Moran T.B., Schindler Y.L., Choe S.K., Langer N.B., Sullivan M.R., Fujiwara Y., Paw B.H., Cantor A.B.
    Mol Cell Biol 28:2675-2689(2008) [PubMed] [Europe PMC] [Abstract]
• macrophage differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish."
    Belele C.L., English M.A., Chahal J., Burnetti A., Finckbeiner S.M., Gibney G., Kirby M., Sood R., Liu P.P.
    Blood 114:5162-5172(2009) [PubMed] [Europe PMC] [Abstract]
• monocyte differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish."
    Belele C.L., English M.A., Chahal J., Burnetti A., Finckbeiner S.M., Gibney G., Kirby M., Sood R., Liu P.P.
    Blood 114:5162-5172(2009) [PubMed] [Europe PMC] [Abstract]
• myeloid cell differentiation Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis."
    Kitaguchi T., Kawakami K., Kawahara A.
    Mech Dev 126:314-323(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: ZFINInferred from mutant phenotypeⁱ
  • "Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos."
    Galloway J.L., Wingert R.A., Thisse C., Thisse B., Zon L.I.
    Dev Cell 8:109-116(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: ZFINInferred from mutant phenotypeⁱ
  • "Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis."
    Kitaguchi T., Kawakami K., Kawahara A.
    Mech Dev 126:314-323(2009) [PubMed] [Europe PMC] [Abstract]
• neutrophil differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish."
    Glenn N.O., Schumacher J.A., Kim H.J., Zhao E.J., Skerniskyte J., Sumanas S.
    Dev Biol 393:149-159(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: ZFINInferred from mutant phenotypeⁱ
  • "Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish embryos."
    Kobayashi M., Nishikawa K., Yamamoto M.
    Development 128:2341-2350(2001) [PubMed] [Europe PMC] [Abstract]
• primitive hemopoiesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish."
    Belele C.L., English M.A., Chahal J., Burnetti A., Finckbeiner S.M., Gibney G., Kirby M., Sood R., Liu P.P.
    Blood 114:5162-5172(2009) [PubMed] [Europe PMC] [Abstract]
  • "Hematopoietic mutations in the zebrafish."
    Weinstein B.M., Schier A.F., Abdelilah S., Malicki J., Solnica-Krezel L., Stemple D.L., Stainier D.Y., Zwartkruis F., Driever W., Fishman M.C.
    Development 123:303-309(1996) [PubMed] [Europe PMC] [Abstract]
• regulation of myeloid cell differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish."
    Rhodes J., Hagen A., Hsu K., Deng M., Liu T.X., Look A.T., Kanki J.P.
    Dev Cell 8:97-108(2005) [PubMed] [Europe PMC] [Abstract]
  • "Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos."
    Galloway J.L., Wingert R.A., Thisse C., Thisse B., Zon L.I.
    Dev Cell 8:109-116(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MENSSEPSRW VSPGLLSPDP LVNYTTDSGL LPPVDVDEPF YSSSETDLLP 
        60         70         80         90        100
SYYSTSVQSR ASSSYRHSPV RQVYSSQSIL GNIQWLDNSA GHSLNSPYNP 
       110        120        130        140        150
TSTVWSSSPF AKTPLHSHTS TSIYQNTATP SFTSPKEGFP SPSRDGKDSP 
       160        170        180        190        200
RLQEVLKAER LSPMSGSGSS FLNLSSATGG VYGPSPHMLS PYGSYMSTSQ 
       210        220        230        240        250
DYSSAALYST GGPWMSPSSY SPKLRNKMRL SPPEARECVN CGATATPLWR 
       260        270        280        290        300
RDGTGHYLCN ACGLYHKMNG QNRPLIRPKK RLIVSKRAGT QCANCHTSTT 
       310        320        330        340        350
TLWRRNASGE PVCNACGLYF KLHNVNRPLT MKKDGIQTRN RKVSNRNKKG 
       360        370        380        390        400
KKNAASEVYP DMSHMAPPDE HVGAYSLNPG PLLSYSHPAH LLPTSTLHSS 
       410 
TTLPYTHHPN SGMMPTLV                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ