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UniProtKB - Q05AA6 (DRP2_MOUSE)
Protein
Dystrophin-related protein 2
Gene
Drp2
Organism
Mus musculus (Mouse)
Status
Functioni
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells (PubMed:22764250).
Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane (PubMed:22764250).
Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 610 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 613 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 634 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 637 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 605 – 661 | ZZ-type; degeneratePROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
GO - Biological processi
- central nervous system development Source: InterPro
- synapse organization Source: MGI
- synaptic signaling Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Dystrophin-related protein 2Short name: DRP-2 |
Gene namesi | Name:Drp2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107432, Drp2 |
VEuPathDBi | HostDB:ENSMUSG00000000223 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Peripheral membrane protein 1 Publication
Other locations
- postsynaptic density By similarity
- dendrite By similarity
- Perikaryon By similarity
Note: Detected in Schwann cells at periaxonal myelin membranes.1 Publication
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- dendrite Source: MGI
- glutamatergic synapse Source: MGI
- membrane Source: MGI
- perikaryon Source: UniProtKB-SubCell
- postsynaptic density Source: MGI
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, SynapsePathology & Biotechi
Disruption phenotypei
Mice with a Schwann cell-specific gene disruption show no obvious impairment of nerve conduction velocity and display no visible defects of their motor skills. After six months, about 6% of their nerve fibers present myelination defects, including myelin outfoldings, focal hypermyelination, and onion bulbs with thin myelin and supernumerary Schwann cells. At the molecular level, Schwann cell-specific gene disruption impairs formation of Cajal bands and location of Prx in patches that colocalize with appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Cytoplasm from mutant Schwann cells forms an annulus under the cell membrane, insted of being strictly compartmentalized. Besides, mutant nerves display increased numbers of Schmidt-Lanterman incisures.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000345015 | 1 – 957 | Dystrophin-related protein 2Add BLAST | 957 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 748 | Phosphoserine1 Publication | 1 | |
Modified residuei | 910 | Phosphothreonine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q05AA6 |
PaxDbi | Q05AA6 |
PRIDEi | Q05AA6 |
ProteomicsDBi | 277499 |
PTM databases
iPTMneti | Q05AA6 |
PhosphoSitePlusi | Q05AA6 |
Expressioni
Tissue specificityi
Detected in quadriceps nerve Schwann cells (PubMed:22764250). Detected in sciatic nerve (PubMed:11430802, PubMed:22764250). Detected in trigeminal nerve Schwann cells (at protein level) (PubMed:11430802). Detected in brain and spinal cord (PubMed:8640231).3 Publications
Gene expression databases
Bgeei | ENSMUSG00000000223, Expressed in sciatic nerve and 214 other tissues |
ExpressionAtlasi | Q05AA6, baseline and differential |
Genevisiblei | Q05AA6, MM |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 199313, 4 interactors |
CORUMi | Q05AA6 |
STRINGi | 10090.ENSMUSP00000115246 |
Miscellaneous databases
RNActi | Q05AA6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 102 – 179 | Spectrin 1Add BLAST | 78 | |
Repeati | 231 – 337 | Spectrin 2Add BLAST | 107 | |
Domaini | 358 – 383 | WWPROSITE-ProRule annotationAdd BLAST | 26 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 876 – 923 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 879 – 898 | Polar residuesSequence analysisAdd BLAST | 20 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 605 – 661 | ZZ-type; degeneratePROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4286, Eukaryota |
GeneTreei | ENSGT00940000153467 |
HOGENOMi | CLU_001187_0_0_1 |
InParanoidi | Q05AA6 |
OMAi | QADHVMD |
TreeFami | TF337303 |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR017433, Dystrophin-related_2 IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat IPR001202, WW_dom IPR036020, WW_dom_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00435, Spectrin, 2 hits PF00397, WW, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF038205, Dystrophin-related_p2, 1 hit |
SMARTi | View protein in SMART SM00150, SPEC, 2 hits SM00456, WW, 1 hit SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q05AA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPLVMQGCP YTLPRCHEWH AADRFHHSSS LRNTCPQPQV RAAVTIPAPP
60 70 80 90 100
WDGAGDPCLS PKLLNGTVGA TGPLEPSAMN LCWNEIKKKS HNLRARLEAF
110 120 130 140 150
SDLSGKLQLP LREIIDWLSQ KDEELSAQLP LQGDVALVQQ EKETHAAFME
160 170 180 190 200
EVKSKGPYIS SVLESAQAFL SQHPFEELEE SQSESKDTSP RQRIQNLSRF
210 220 230 240 250
VWKQATVASE LWEKLTARCV DQHRHIEHTL EHLLEIQGAM EELSSTLTQA
260 270 280 290 300
EGVRATWEPI GDLFIDSLPE HIQAIKLFKE EFSPVKDGVK LVNDLAHQLA
310 320 330 340 350
ISDVHLSMEN SRALEQINIR WKQLQVSVAE RLKQLQDAHR DFGPGSQHFL
360 370 380 390 400
STSVQVPWER AISPNKVPYY INHQAQTTCW DHPKMTELYQ TLADLNNIKF
410 420 430 440 450
SAYRTAMKLR RVQKALRLDL VTLTTALEIF NEHDLQASEH VMDVVEVIHC
460 470 480 490 500
LTALYERLEE ERGILVNVPL CVDMSLNWLL NVFDSGRSGK MRALSFKTGI
510 520 530 540 550
ACLCGTEVKE KLQYLFSQVA NSGSQCDQRH LGALLHEAIQ VPRQLGEVAA
560 570 580 590 600
FGGSNVEPSV RSCFRFSTGK PVIEASQFLE WVNLEPQSMV WLAVLHRVTI
610 620 630 640 650
AEQVKHQTKC SICRQCPIKG FRYRSLKQFN VDICQTCFLT GRASKGNKLH
660 670 680 690 700
YPIMEYYTPT TSSENMRDFA TTLKNKFRSK QYFSKHPQRG YLPVQSVLES
710 720 730 740 750
DCSETPASSP MLPHADTHSR IEHFASRLAE MESQNCSFFN DSLSPDDSID
760 770 780 790 800
EDQYLLRHSS PITDREPAFG QQAPCSMATE SKGELEKILA HLEDENRILQ
810 820 830 840 850
GELRRLKWQH EEAAEAPTLV EGSAEATPDH RNEELLAEAR ILRQHKSRLE
860 870 880 890 900
TRMQILEDHN KQLESQLQRL RELLLQPPSE SDGNGSAGSS LASSPRQSEG
910 920 930 940 950
SHPREKGQTT PDTEVADDVG SKSQDVSLCL EDIMEKLRHA FPSVRSSDVT
ANTLLAS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AV35 | B1AV35_MOUSE | Dystrophin-related protein 2 | Drp2 | 981 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 362 | I → F in BAC38217 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 598 | V → VLHRV in AAC52607 (PubMed:8640231).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK081426 mRNA Translation: BAC38217.1 AL672064 Genomic DNA No translation available. BC125345 mRNA Translation: AAI25346.1 BC125347 mRNA Translation: AAI25348.1 U43520 mRNA Translation: AAC52607.1 |
CCDSi | CCDS30394.1 |
RefSeqi | NP_034208.2, NM_010078.3 |
Genome annotation databases
Ensembli | ENSMUST00000113226; ENSMUSP00000108852; ENSMUSG00000000223 ENSMUST00000113228; ENSMUSP00000108854; ENSMUSG00000000223 ENSMUST00000153424; ENSMUSP00000115246; ENSMUSG00000000223 |
GeneIDi | 13497 |
KEGGi | mmu:13497 |
UCSCi | uc009uga.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK081426 mRNA Translation: BAC38217.1 AL672064 Genomic DNA No translation available. BC125345 mRNA Translation: AAI25346.1 BC125347 mRNA Translation: AAI25348.1 U43520 mRNA Translation: AAC52607.1 |
CCDSi | CCDS30394.1 |
RefSeqi | NP_034208.2, NM_010078.3 |
3D structure databases
SMRi | Q05AA6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199313, 4 interactors |
CORUMi | Q05AA6 |
STRINGi | 10090.ENSMUSP00000115246 |
PTM databases
iPTMneti | Q05AA6 |
PhosphoSitePlusi | Q05AA6 |
Proteomic databases
MaxQBi | Q05AA6 |
PaxDbi | Q05AA6 |
PRIDEi | Q05AA6 |
ProteomicsDBi | 277499 |
Protocols and materials databases
Antibodypediai | 506, 67 antibodies from 17 providers |
DNASUi | 13497 |
Genome annotation databases
Ensembli | ENSMUST00000113226; ENSMUSP00000108852; ENSMUSG00000000223 ENSMUST00000113228; ENSMUSP00000108854; ENSMUSG00000000223 ENSMUST00000153424; ENSMUSP00000115246; ENSMUSG00000000223 |
GeneIDi | 13497 |
KEGGi | mmu:13497 |
UCSCi | uc009uga.2, mouse |
Organism-specific databases
CTDi | 1821 |
MGIi | MGI:107432, Drp2 |
VEuPathDBi | HostDB:ENSMUSG00000000223 |
Phylogenomic databases
eggNOGi | KOG4286, Eukaryota |
GeneTreei | ENSGT00940000153467 |
HOGENOMi | CLU_001187_0_0_1 |
InParanoidi | Q05AA6 |
OMAi | QADHVMD |
TreeFami | TF337303 |
Miscellaneous databases
BioGRID-ORCSi | 13497, 0 hits in 63 CRISPR screens |
ChiTaRSi | Drp2, mouse |
PROi | PR:Q05AA6 |
RNActi | Q05AA6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000223, Expressed in sciatic nerve and 214 other tissues |
ExpressionAtlasi | Q05AA6, baseline and differential |
Genevisiblei | Q05AA6, MM |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR017433, Dystrophin-related_2 IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat IPR001202, WW_dom IPR036020, WW_dom_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00435, Spectrin, 2 hits PF00397, WW, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF038205, Dystrophin-related_p2, 1 hit |
SMARTi | View protein in SMART SM00150, SPEC, 2 hits SM00456, WW, 1 hit SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DRP2_MOUSE | |
Accessioni | Q05AA6Primary (citable) accession number: Q05AA6 Secondary accession number(s): Q61095, Q8C4R1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | November 14, 2006 | |
Last modified: | February 23, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot