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Protein

Dynein light chain 1, axonemal

Gene

Dnal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity).By similarity

Miscellaneous

Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.By similarity

GO - Molecular functioni

  • alpha-tubulin binding Source: MGI
  • dynein heavy chain binding Source: MGI
  • motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, axonemal
Gene namesi
Name:Dnal1
Synonyms:Dnalc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921462 Dnal1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002811312 – 190Dynein light chain 1, axonemalAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ05A62
PaxDbiQ05A62
PRIDEiQ05A62

PTM databases

iPTMnetiQ05A62
PhosphoSitePlusiQ05A62

Expressioni

Tissue specificityi

Expressed in the respiratory epithelium of the upper airways and the ependymal cells lining the brain ventricles.1 Publication

Gene expression databases

BgeeiENSMUSG00000042523 Expressed in 232 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_DNALC1
ExpressionAtlasiQ05A62 baseline and differential
GenevisibleiQ05A62 MM

Interactioni

Subunit structurei

Interacts with ZMYND10 (via C-terminus). Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222746, 1 interactor
STRINGi10090.ENSMUSP00000121038

Structurei

3D structure databases

ProteinModelPortaliQ05A62
SMRiQ05A62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 70LRR 1Add BLAST22
Repeati71 – 92LRR 2Add BLAST22
Repeati94 – 115LRR 3Add BLAST22
Repeati116 – 137LRR 4Add BLAST22
Domaini150 – 190LRRCTAdd BLAST41

Sequence similaritiesi

Belongs to the dynein light chain LC1-type family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00390000016904
HOGENOMiHOG000230603
HOVERGENiHBG081457
InParanoidiQ05A62
KOiK10411
OMAiLWISYNN
OrthoDBiEOG091G0P8H
PhylomeDBiQ05A62
TreeFamiTF323974

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05A62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKATTIKEA LSRWEEKTGQ KPSDAKEIKL YAQIPPIEKM DASLSTLGNC
60 70 80 90 100
EKLSLSTNCI EKIANLNGLK NLRILSLGRN NIKNLNGLEA VGETLEELWI
110 120 130 140 150
SYNFIEKLKG IHVMKKLKIL YMSNNLVKDW AEFLKLAELP CLEDLVFVGN
160 170 180 190
PLEEKHSAEG NWIDEATKRV PKLKKLDGTP VIKEDEEEES
Length:190
Mass (Da):21,465
Last modified:March 20, 2007 - v2
Checksum:i7052EB49CDCE4A0B
GO
Isoform 2 (identifier: Q05A62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-14: Missing.
     15-15: E → M

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,010
Checksum:iDB170C2A3B075B4B
GO
Isoform 3 (identifier: Q05A62-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:151
Mass (Da):17,054
Checksum:iC239D4222AB5681A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYU7D3YYU7_MOUSE
Dynein light chain 1, axonemal
Dnal1 Dnalc1
103Annotation score:
D3YTL1D3YTL1_MOUSE
Dynein light chain 1, axonemal
Dnal1 Dnalc1
81Annotation score:
D6RHN1D6RHN1_MOUSE
Dynein light chain 1, axonemal
Dnal1 Dnalc1
73Annotation score:

Sequence cautioni

The sequence AAI25395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147F → L in BAB24259 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0239851 – 39Missing in isoform 3. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_0239842 – 14Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_02398315E → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005826 mRNA Translation: BAB24259.1
BC125392 mRNA Translation: AAI25393.1
BC125394 mRNA Translation: AAI25395.2 Different initiation.
BG916281 mRNA No translation available.
CCDSiCCDS26039.2 [Q05A62-1]
CCDS83987.1 [Q05A62-3]
RefSeqiNP_001333457.1, NM_001346528.1 [Q05A62-3]
NP_083097.2, NM_028821.3 [Q05A62-1]
UniGeneiMm.101525

Genome annotation databases

EnsembliENSMUST00000046340; ENSMUSP00000037076; ENSMUSG00000042523 [Q05A62-3]
ENSMUST00000123491; ENSMUSP00000121038; ENSMUSG00000042523 [Q05A62-1]
GeneIDi105000
KEGGimmu:105000
UCSCiuc007oek.2 mouse [Q05A62-1]
uc011yot.1 mouse [Q05A62-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005826 mRNA Translation: BAB24259.1
BC125392 mRNA Translation: AAI25393.1
BC125394 mRNA Translation: AAI25395.2 Different initiation.
BG916281 mRNA No translation available.
CCDSiCCDS26039.2 [Q05A62-1]
CCDS83987.1 [Q05A62-3]
RefSeqiNP_001333457.1, NM_001346528.1 [Q05A62-3]
NP_083097.2, NM_028821.3 [Q05A62-1]
UniGeneiMm.101525

3D structure databases

ProteinModelPortaliQ05A62
SMRiQ05A62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222746, 1 interactor
STRINGi10090.ENSMUSP00000121038

PTM databases

iPTMnetiQ05A62
PhosphoSitePlusiQ05A62

Proteomic databases

MaxQBiQ05A62
PaxDbiQ05A62
PRIDEiQ05A62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046340; ENSMUSP00000037076; ENSMUSG00000042523 [Q05A62-3]
ENSMUST00000123491; ENSMUSP00000121038; ENSMUSG00000042523 [Q05A62-1]
GeneIDi105000
KEGGimmu:105000
UCSCiuc007oek.2 mouse [Q05A62-1]
uc011yot.1 mouse [Q05A62-2]

Organism-specific databases

CTDi83544
MGIiMGI:1921462 Dnal1

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00390000016904
HOGENOMiHOG000230603
HOVERGENiHBG081457
InParanoidiQ05A62
KOiK10411
OMAiLWISYNN
OrthoDBiEOG091G0P8H
PhylomeDBiQ05A62
TreeFamiTF323974

Miscellaneous databases

PROiPR:Q05A62
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042523 Expressed in 232 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_DNALC1
ExpressionAtlasiQ05A62 baseline and differential
GenevisibleiQ05A62 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDNAL1_MOUSE
AccessioniPrimary (citable) accession number: Q05A62
Secondary accession number(s): A0JLX1, Q9DAH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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