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Entry version 159 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Thiamine transporter

Gene

THI7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for intake of thiamine.

Miscellaneous

Present with 3120 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.39.4.1, the nucleobase:cation symporter-1 (ncs1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiamine transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THI7
Synonyms:THI10
Ordered Locus Names:YLR237W
ORF Names:L8083.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004227, THI7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YLR237W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 73ExtracellularSequence analysisAdd BLAST11
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 111CytoplasmicSequence analysisAdd BLAST17
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 173ExtracellularSequence analysisAdd BLAST41
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 197CytoplasmicSequence analysis3
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 240ExtracellularSequence analysisAdd BLAST22
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 274CytoplasmicSequence analysisAdd BLAST13
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 332ExtracellularSequence analysisAdd BLAST37
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 371CytoplasmicSequence analysisAdd BLAST18
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 394ExtracellularSequence analysis2
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 446CytoplasmicSequence analysisAdd BLAST31
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 483ExtracellularSequence analysisAdd BLAST16
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 598CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001979261 – 598Thiamine transporterAdd BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei560PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05998

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05998

PRoteomics IDEntifications database

More...
PRIDEi
Q05998

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05998

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31504, 106 interactors

Database of interacting proteins

More...
DIPi
DIP-4784N

Protein interaction database and analysis system

More...
IntActi
Q05998, 3 interactors

Molecular INTeraction database

More...
MINTi
Q05998

STRING: functional protein association networks

More...
STRINGi
4932.YLR237W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q05998, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni574 – 598DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi576 – 590Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2466, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021555_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05998

Identification of Orthologs from Complete Genome Data

More...
OMAi
STKAWAW

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012681, NCS1
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00800, ncs1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05998-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFGSKVSRA LRFLEIPVKD RASVSFLKNP DLQPIKSANQ TWGFWSNFAY
60 70 80 90 100
WGVMSFSVGT WMSASSALGV GLSYPETIGT FIVGDVLTII FTLANSCPGY
110 120 130 140 150
DWKVGFTLAQ RFVFGIYGSA FGIIIRILMS IVNYGSNAWV GGLCINMILD
160 170 180 190 200
SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HVLTAFCYLM KPYHMNYILI
210 220 230 240 250
WSCVATFFSM LGMVIYLAKQ AHGVGELFTS TKSTATGSTK AWAWVYMISY
260 270 280 290 300
WFGSVSPGST NQSDYSRFGS SNWAIWAGTI CALLIPTTLI PVFGVIGAST
310 320 330 340 350
CDKLYGEQYW MPMDIFNHWL TTNYSAGARA GAFFCGLSFV LSQMSYTISN
360 370 380 390 400
CGFASGMDLA GLLPKYVDIK RGALFAACVS WACLPWNFYN SSSTFLTVMS
410 420 430 440 450
SFGVVMTPII SVMICDNFLI RKRQYSITNA FILKGEYYFT KGVNWRAIVA
460 470 480 490 500
WVCGMTPGLP GIAWEVNNDY FHNTGIVNFF YGDSFFSFLI SFFVYWGLCL
510 520 530 540 550
LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGEGYT
560 570 580 590
TGHEYRPEGS DDEIPELVKT SSENTNEFEI VHHKNNEKQS STASEKAA
Length:598
Mass (Da):66,904
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5160ADCAFC68A39E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19027 Genomic DNA Translation: AAB67405.1
D55634 Genomic DNA Translation: BAA09504.1
BK006945 Genomic DNA Translation: DAA09551.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51456

NCBI Reference Sequences

More...
RefSeqi
NP_013338.1, NM_001182124.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR237W_mRNA; YLR237W; YLR237W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR237W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA Translation: AAB67405.1
D55634 Genomic DNA Translation: BAA09504.1
BK006945 Genomic DNA Translation: DAA09551.1
PIRiS51456
RefSeqiNP_013338.1, NM_001182124.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31504, 106 interactors
DIPiDIP-4784N
IntActiQ05998, 3 interactors
MINTiQ05998
STRINGi4932.YLR237W

Protein family/group databases

TCDBi2.A.39.4.1, the nucleobase:cation symporter-1 (ncs1) family

PTM databases

iPTMnetiQ05998

Proteomic databases

MaxQBiQ05998
PaxDbiQ05998
PRIDEiQ05998

Genome annotation databases

EnsemblFungiiYLR237W_mRNA; YLR237W; YLR237W
GeneIDi850938
KEGGisce:YLR237W

Organism-specific databases

SGDiS000004227, THI7
VEuPathDBiFungiDB:YLR237W

Phylogenomic databases

eggNOGiKOG2466, Eukaryota
GeneTreeiENSGT00940000176299
HOGENOMiCLU_021555_3_0_1
InParanoidiQ05998
OMAiSTKAWAW

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q05998
RNActiQ05998, protein

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681, NCS1
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133, Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800, ncs1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHI7_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05998
Secondary accession number(s): D6VYN5, P87335
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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