Nucleoside diphosphate kinase A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• a 2'-deoxyribonucleoside 5'-diphosphate

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  + ATP

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  = a 2'-deoxyribonucleoside 5'-triphosphate

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  + ADP

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  EC:2.7.4.6
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  Source: Rhea

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  a 2'-deoxyribonucleoside 5'-diphosphate

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  zoom

  +

  ATP

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  =

  a 2'-deoxyribonucleoside 5'-triphosphate

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  +

  ADP

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• a ribonucleoside 5'-diphosphate

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  + ATP

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  = a ribonucleoside 5'-triphosphate

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  + ADP

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  EC:2.7.4.6
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  • See the description of this EC number in ENZYME.
  Source: Rhea

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  a ribonucleoside 5'-diphosphate

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  ATP

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  =

  a ribonucleoside 5'-triphosphate

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  ADP

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<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• deoxyribonuclease activity Source: Ensembl
• enzyme binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo."
    Jovanovic S., Jovanovic A., Crawford R.M.
    J. Mol. Biol. 371:349-361(2007) [PubMed] [Europe PMC] [Abstract]
• gamma-tubulin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome."
    Roymans D., Vissenberg K., De Jonghe C., Willems R., Engler G., Kimura N., Grobben B., Claes P., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 262:145-153(2001) [PubMed] [Europe PMC] [Abstract]
• GTP binding Source: Ensembl
• identical protein binding Source: Ensembl
• intermediate filament binding Source: RGDInferred from physical interactionⁱ
  • "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma."
    Roymans D., Willems R., Vissenberg K., De Jonghe C., Grobben B., Claes P., Lascu I., Van Bockstaele D., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 261:127-138(2000) [PubMed] [Europe PMC] [Abstract]
• magnesium ion binding Source: Ensembl
• nucleoside diphosphate kinase activity Source: RGDInferred from direct assayⁱ
  • "Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome."
    Roymans D., Vissenberg K., De Jonghe C., Willems R., Engler G., Kimura N., Grobben B., Claes P., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 262:145-153(2001) [PubMed] [Europe PMC] [Abstract]
• ribosomal small subunit binding Source: Ensembl
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1)."
    Cheng S., Alfonso-Jaume M.A., Mertens P.R., Lovett D.H.
    Biochem. J. 366:807-816(2002) [PubMed] [Europe PMC] [Abstract]
• single-stranded DNA binding Source: RGDInferred from direct assayⁱ
  • "Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1)."
    Cheng S., Alfonso-Jaume M.A., Mertens P.R., Lovett D.H.
    Biochem. J. 366:807-816(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to drug Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma."
    Roymans D., Willems R., Vissenberg K., De Jonghe C., Grobben B., Claes P., Lascu I., Van Bockstaele D., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 261:127-138(2000) [PubMed] [Europe PMC] [Abstract]
• cellular response to fatty acid Source: RGDInferred from expression patternⁱ
  • "Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity."
    Veluthakal R., Suresh M.V., Kowluru A.
    Mol. Cell. Biochem. 329:121-129(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to glucose stimulus Source: RGDInferred from expression patternⁱ
  • "Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity."
    Veluthakal R., Suresh M.V., Kowluru A.
    Mol. Cell. Biochem. 329:121-129(2009) [PubMed] [Europe PMC] [Abstract]
• CTP biosynthetic process Source: InterPro
• endocytosis Source: UniProtKB-KW
• GTP biosynthetic process Source: InterPro
• hippocampus development Source: RGDInferred from expression patternⁱ
  • "Changes of hippocampal signaling protein levels during postnatal brain development in the rat."
    Weitzdorfer R., Hoger H., Shim K.S., Cekici L., Pollak A., Lubec G.
    Hippocampus 18:807-813(2008) [PubMed] [Europe PMC] [Abstract]
• lactation Source: Ensembl
• negative regulation of gene expression Source: RGDInferred from direct assayⁱ
  • "Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1)."
    Cheng S., Alfonso-Jaume M.A., Mertens P.R., Lovett D.H.
    Biochem. J. 366:807-816(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of myeloid leukocyte differentiation Source: RGDInferred from direct assayⁱ
  • "A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it's kinase activity."
    Okabe-Kado J., Kasukabe T., Hozumi M., Honma Y., Kimura N., Baba H., Urano T., Shiku H.
    FEBS Lett. 363:311-315(1995) [PubMed] [Europe PMC] [Abstract]
• nucleoside diphosphate phosphorylation Source: RGDInferred from direct assayⁱ
  • "Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome."
    Roymans D., Vissenberg K., De Jonghe C., Willems R., Engler G., Kimura N., Grobben B., Claes P., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 262:145-153(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA binding Source: Ensembl
• positive regulation of epithelial cell proliferation Source: Ensembl
• positive regulation of neuron projection development Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells."
    Ishijima Y., Shimada N., Fukuda M., Miyazaki H., Orlov N.Y., Orlova T.G., Yamada T., Kimura N.
    FEBS Lett. 445:155-159(1999) [PubMed] [Europe PMC] [Abstract]
• purine nucleotide metabolic process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pyrimidine nucleotide metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to amine Source: RGDInferred from expression patternⁱ
  • "Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination."
    Boyiri T., Somiari R.I., Russell S., Aliaga C., El-Bayoumy K.
    Int. J. Oncol. 35:559-567(2009) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: RGDInferred from expression patternⁱ
  • "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma."
    Roymans D., Willems R., Vissenberg K., De Jonghe C., Grobben B., Claes P., Lascu I., Van Bockstaele D., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 261:127-138(2000) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma."
    Roymans D., Willems R., Vissenberg K., De Jonghe C., Grobben B., Claes P., Lascu I., Van Bockstaele D., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 261:127-138(2000) [PubMed] [Europe PMC] [Abstract]
• response to testosterone Source: RGDInferred from expression patternⁱ
  • "Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination."
    Boyiri T., Somiari R.I., Russell S., Aliaga C., El-Bayoumy K.
    Int. J. Oncol. 35:559-567(2009) [PubMed] [Europe PMC] [Abstract]
• UTP biosynthetic process Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: RGDInferred from physical interactionⁱ
  • "M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo."
    Jovanovic S., Jovanovic A., Crawford R.M.
    J. Mol. Biol. 371:349-361(2007) [PubMed] [Europe PMC] [Abstract]
• gamma-tubulin binding Source: RGDInferred from direct assayⁱ
  • "Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome."
    Roymans D., Vissenberg K., De Jonghe C., Willems R., Engler G., Kimura N., Grobben B., Claes P., Verbelen J.P., Van Broeckhoven C., Slegers H.
    Exp. Cell Res. 262:145-153(2001) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MANSERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF IQASEDLLKE 
        60         70         80         90        100
HYIDLKDRPF FSGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK 
       110        120        130        140        150
PGTIRGDFCI QVGRNIIHGS DSVESAEKEI SLWFQPEELV DYKSCAQNWI 

YE                                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families