UniProtKB - Q05979 (KYNU_YEAST)
Protein
Kynureninase
Gene
BNA5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation1 Publication
Miscellaneous
Present with 3060 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Cofactori
pyridoxal 5'-phosphateUniRule annotation
: L-kynurenine degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation1 PublicationProteins known to be involved in this subpathway in this organism are:
- Kynureninase (BNA5)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.
Pathwayi: NAD(+) biosynthesis
This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation1 PublicationProteins known to be involved in the 3 steps of the subpathway in this organism are: This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 111 | Pyridoxal phosphate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 112 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 196 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 226 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 229 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 251 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 286 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 314 | Pyridoxal phosphateUniRule annotation | 1 |
GO - Molecular functioni
- kynureninase activity Source: SGD
- pyridoxal phosphate binding Source: UniProtKB-UniRule
GO - Biological processi
- 'de novo' NAD biosynthetic process from tryptophan Source: SGD
- anthranilate metabolic process Source: GO_Central
- L-kynurenine catabolic process Source: UniProtKB-UniPathway
- quinolinate biosynthetic process Source: UniProtKB-UniRule
- tryptophan catabolic process to kynurenine Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Pyridine nucleotide biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | MetaCyc:YLR231C-MONOMER |
Reactomei | R-SCE-71240, Tryptophan catabolism |
UniPathwayi | UPA00253;UER00329 UPA00334;UER00455 |
Names & Taxonomyi
Protein namesi | Recommended name: KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)Alternative name(s): Biosynthesis of nicotinic acid protein 5UniRule annotation L-kynurenine hydrolaseUniRule annotation |
Gene namesi | Name:BNA5UniRule annotation Ordered Locus Names:YLR231C ORF Names:L8083.14 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004221, BNA5 |
VEuPathDBi | FungiDB:YLR231C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218665 | 1 – 453 | KynureninaseAdd BLAST | 453 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 252 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Proteomic databases
MaxQBi | Q05979 |
PaxDbi | Q05979 |
PRIDEi | Q05979 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationBinary interactionsi
Q05979
With | #Exp. | IntAct |
---|---|---|
RSP5 [P39940] | 2 | EBI-10016,EBI-16219 |
Protein-protein interaction databases
BioGRIDi | 31501, 58 interactors |
DIPi | DIP-6518N |
IntActi | Q05979, 7 interactors |
MINTi | Q05979 |
STRINGi | 4932.YLR231C |
Miscellaneous databases
RNActi | Q05979, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 139 – 142 | Pyridoxal phosphate bindingUniRule annotation | 4 |
Sequence similaritiesi
Belongs to the kynureninase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG3846, Eukaryota |
GeneTreei | ENSGT00390000008033 |
HOGENOMi | CLU_003433_4_0_1 |
InParanoidi | Q05979 |
OMAi | AGWWGHD |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_01970, Kynureninase, 1 hit |
InterProi | View protein in InterPro IPR000192, Aminotrans_V_dom IPR010111, Kynureninase IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR14084, PTHR14084, 1 hit |
Pfami | View protein in Pfam PF00266, Aminotran_5, 1 hit |
PIRSFi | PIRSF038800, KYNU, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01814, kynureninase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q05979-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKALELDGE YPESLRDEFN IPTFKSMGLS SDDKPVTYLC GNSLGLMPKS
60 70 80 90 100
TRNSINAELD AWSDCAVESH FKHPEEARGK VPWVSIDLPI LPLLAPIVGA
110 120 130 140 150
QENEVAVMNS LTANLNSLLI TFYKPTEKRF KILFEKGSFP SDYYAFYNQC
160 170 180 190 200
KIHGISEPEN VFIQIEPREG ETYIRTQDIL DTIEVNQDEL ALVCLSGVQY
210 220 230 240 250
YTGQYFDIGR ITSFAHQFPD ILVGWDLAHA VGNVPLQLHD WGVDFACWCS
260 270 280 290 300
YKYLNAGPGG IGGLFVHSKH TKPDPAKESL PRLAGWWGND PAKRFQMLEV
310 320 330 340 350
FEPIPGALGF RQSNPSVIDT VALRSSLELF AKFNGINEVR KRSLLLTNYM
360 370 380 390 400
TELLEASKYY KHPLRIEKLP CFFTILTPTS TDEEHGAQLS LYFDSDTGKE
410 420 430 440 450
DIMPKVFQYL HDHGVIGDAR RPNVIRLAPA PLYNTFSDVY IAVNALNEAM
DKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19027 Genomic DNA Translation: AAB67417.1 BK006945 Genomic DNA Translation: DAA09548.1 |
PIRi | S51453 |
RefSeqi | NP_013332.1, NM_001182118.1 |
Genome annotation databases
EnsemblFungii | YLR231C_mRNA; YLR231C; YLR231C |
GeneIDi | 850933 |
KEGGi | sce:YLR231C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19027 Genomic DNA Translation: AAB67417.1 BK006945 Genomic DNA Translation: DAA09548.1 |
PIRi | S51453 |
RefSeqi | NP_013332.1, NM_001182118.1 |
3D structure databases
SMRi | Q05979 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31501, 58 interactors |
DIPi | DIP-6518N |
IntActi | Q05979, 7 interactors |
MINTi | Q05979 |
STRINGi | 4932.YLR231C |
Proteomic databases
MaxQBi | Q05979 |
PaxDbi | Q05979 |
PRIDEi | Q05979 |
Genome annotation databases
EnsemblFungii | YLR231C_mRNA; YLR231C; YLR231C |
GeneIDi | 850933 |
KEGGi | sce:YLR231C |
Organism-specific databases
SGDi | S000004221, BNA5 |
VEuPathDBi | FungiDB:YLR231C |
Phylogenomic databases
eggNOGi | KOG3846, Eukaryota |
GeneTreei | ENSGT00390000008033 |
HOGENOMi | CLU_003433_4_0_1 |
InParanoidi | Q05979 |
OMAi | AGWWGHD |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00329 UPA00334;UER00455 |
BioCyci | MetaCyc:YLR231C-MONOMER |
Reactomei | R-SCE-71240, Tryptophan catabolism |
Miscellaneous databases
PROi | PR:Q05979 |
RNActi | Q05979, protein |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_01970, Kynureninase, 1 hit |
InterProi | View protein in InterPro IPR000192, Aminotrans_V_dom IPR010111, Kynureninase IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR14084, PTHR14084, 1 hit |
Pfami | View protein in Pfam PF00266, Aminotran_5, 1 hit |
PIRSFi | PIRSF038800, KYNU, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01814, kynureninase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KYNU_YEAST | |
Accessioni | Q05979Primary (citable) accession number: Q05979 Secondary accession number(s): D6VYN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families