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Protein

ADP/ATP translocase 1

Gene

Slc25a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: GO_Central
  • enzyme binding Source: RGD

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:Slc25a4
Synonyms:Ant1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620352 Slc25a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000905772 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei7PhosphoserineCombined sources1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei149PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei160S-nitrosocysteineCombined sources1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiQ05962
PRIDEiQ05962

PTM databases

CarbonylDBiQ05962
iPTMnetiQ05962
PhosphoSitePlusiQ05962

Expressioni

Tissue specificityi

In heart, skeletal muscle and to a lesser extent, in brain and kidney.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250085, 2 interactors
CORUMiQ05962
IntActiQ05962, 4 interactors
MINTiQ05962
STRINGi10116.ENSRNOP00000014704

Structurei

3D structure databases

ProteinModelPortaliQ05962
SMRiQ05962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiQ05962
KOiK05863
PhylomeDBiQ05962

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q05962-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDQALSFLK DFLAGGIAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGSS
160 170 180 190 200
QREFNGLGDC LTKIFKSDGL KGLYQGFSVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGRKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Length:298
Mass (Da):32,989
Last modified:January 23, 2007 - v3
Checksum:i66704FF78C6BC320
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P9Y4Q6P9Y4_RAT
ADP/ATP translocase 1
Slc25a4 rCG_58997
298Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61667 Genomic DNA Translation: CAA43842.1
D12770 mRNA Translation: BAA02237.1
PIRiI60173
RefSeqiNP_445967.1, NM_053515.1
UniGeneiRn.4092

Genome annotation databases

GeneIDi85333
KEGGirno:85333

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61667 Genomic DNA Translation: CAA43842.1
D12770 mRNA Translation: BAA02237.1
PIRiI60173
RefSeqiNP_445967.1, NM_053515.1
UniGeneiRn.4092

3D structure databases

ProteinModelPortaliQ05962
SMRiQ05962
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250085, 2 interactors
CORUMiQ05962
IntActiQ05962, 4 interactors
MINTiQ05962
STRINGi10116.ENSRNOP00000014704

PTM databases

CarbonylDBiQ05962
iPTMnetiQ05962
PhosphoSitePlusiQ05962

Proteomic databases

PaxDbiQ05962
PRIDEiQ05962

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85333
KEGGirno:85333

Organism-specific databases

CTDi291
RGDi620352 Slc25a4

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiQ05962
KOiK05863
PhylomeDBiQ05962

Miscellaneous databases

PROiPR:Q05962

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiADT1_RAT
AccessioniPrimary (citable) accession number: Q05962
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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