UniProtKB - Q05946 (UTP13_YEAST)
Protein
U3 small nucleolar RNA-associated protein 13
Gene
UTP13
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication
Miscellaneous
Present with 8070 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- U3 snoRNA binding Source: SGD
GO - Biological processi
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- rRNA methylation Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein |
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
Reactomei | R-SCE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 13Short name: U3 snoRNA-associated protein 13 Alternative name(s): U three protein 13 |
Gene namesi | Name:UTP13 Ordered Locus Names:YLR222C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YLR222C |
SGDi | S000004212, UTP13 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: SGD
- nucleoplasm Source: Reactome
- Pwp2p-containing subcomplex of 90S preribosome Source: SGD
Other locations
- 90S preribosome Source: SGD
- small-subunit processome Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051320 | 1 – 817 | U3 small nucleolar RNA-associated protein 13Add BLAST | 817 |
Proteomic databases
MaxQBi | Q05946 |
PaxDbi | Q05946 |
PRIDEi | Q05946 |
PTM databases
iPTMneti | Q05946 |
Interactioni
Subunit structurei
Interacts with snoRNA U3.
Interacts with MPP10.
Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 31489, 307 interactors |
ComplexPortali | CPX-1410, UTP-B complex |
DIPi | DIP-4790N |
IntActi | Q05946, 43 interactors |
MINTi | Q05946 |
STRINGi | 4932.YLR222C |
Miscellaneous databases
RNActi | Q05946, protein |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 59 – 100 | WD 1Add BLAST | 42 | |
Repeati | 102 – 139 | WD 2Add BLAST | 38 | |
Repeati | 142 – 187 | WD 3Add BLAST | 46 | |
Repeati | 191 – 233 | WD 4Add BLAST | 43 | |
Repeati | 238 – 280 | WD 5Add BLAST | 43 | |
Repeati | 386 – 425 | WD 6Add BLAST | 40 | |
Repeati | 432 – 476 | WD 7Add BLAST | 45 | |
Repeati | 489 – 528 | WD 8Add BLAST | 40 | |
Repeati | 531 – 572 | WD 9Add BLAST | 42 | |
Repeati | 573 – 614 | WD 10Add BLAST | 42 | |
Repeati | 616 – 654 | WD 11Add BLAST | 39 | |
Repeati | 664 – 705 | WD 12Add BLAST | 42 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0319, Eukaryota |
GeneTreei | ENSGT00940000157651 |
HOGENOMi | CLU_009276_0_0_1 |
InParanoidi | Q05946 |
OMAi | PYVQRHF |
Family and domain databases
Gene3Di | 2.130.10.10, 4 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR013934, SSU_processome_Utp13 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08625, Utp13, 1 hit PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 11 hits |
SUPFAMi | SSF50978, SSF50978, 2 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q05946-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLKTSYKGI SLNPIYAGSS AVATVSENGK ILATPVLDEI NIIDLTPGSR
60 70 80 90 100
KILHKISNED EQEITALKLT PDGQYLTYVS QAQLLKIFHL KTGKVVRSMK
110 120 130 140 150
ISSPSYILDA DSTSTLLAVG GTDGSIIVVD IENGYITHSF KGHGGTISSL
160 170 180 190 200
KFYGQLNSKI WLLASGDTNG MVKVWDLVKR KCLHTLQEHT SAVRGLDIIE
210 220 230 240 250
VPDNDEPSLN LLSGGRDDII NLWDFNMKKK CKLLKTLPVN QQVESCGFLK
260 270 280 290 300
DGDGKRIIYT AGGDAIFQLI DSESGSVLKR TNKPIEELFI IGVLPILSNS
310 320 330 340 350
QMFLVLSDQT LQLINVEEDL KNDEDTIQVT SSIAGNHGII ADMRYVGPEL
360 370 380 390 400
NKLALATNSP SLRIIPVPDL SGPEASLPLD VEIYEGHEDL LNSLDATEDG
410 420 430 440 450
LWIATASKDN TAIVWRYNEN SCKFDIYAKY IGHSAAVTAV GLPNIVSKGY
460 470 480 490 500
PEFLLTASND LTIKKWIIPK PTASMDVQII KVSEYTRHAH EKDINALSVS
510 520 530 540 550
PNDSIFATAS YDKTCKIWNL ENGELEATLA NHKRGLWDVS FCQYDKLLAT
560 570 580 590 600
SSGDKTVKIW SLDTFSVMKT LEGHTNAVQR CSFINKQKQL ISCGADGLIK
610 620 630 640 650
IWDCSSGECL KTLDGHNNRL WALSTMNDGD MIVSADADGV FQFWKDCTEQ
660 670 680 690 700
EIEEEQEKAK LQVEQEQSLQ NYMSKGDWTN AFLLAMTLDH PMRLFNVLKR
710 720 730 740 750
ALGESRSRQD TEEGKIEVIF NEELDQAISI LNDEQLILLM KRCRDWNTNA
760 770 780 790 800
KTHTIAQRTI RCILMHHNIA KLSEIPGMVK IVDAIIPYTQ RHFTRVDNLV
810
EQSYILDYAL VEMDKLF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19027 Genomic DNA Translation: AAB67411.1 BK006945 Genomic DNA Translation: DAA09538.1 |
PIRi | S51445 |
RefSeqi | NP_013323.1, NM_001182109.1 |
Genome annotation databases
EnsemblFungii | YLR222C_mRNA; YLR222C; YLR222C |
GeneIDi | 850919 |
KEGGi | sce:YLR222C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19027 Genomic DNA Translation: AAB67411.1 BK006945 Genomic DNA Translation: DAA09538.1 |
PIRi | S51445 |
RefSeqi | NP_013323.1, NM_001182109.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5WLC | electron microscopy | 3.80 | LR | 648-817 | [»] | |
5WYJ | electron microscopy | 8.70 | BC | 1-817 | [»] | |
5WYK | electron microscopy | 4.50 | BC | 1-817 | [»] | |
6KE6 | electron microscopy | 3.40 | B3 | 1-817 | [»] | |
6ND4 | electron microscopy | 4.30 | R | 648-817 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31489, 307 interactors |
ComplexPortali | CPX-1410, UTP-B complex |
DIPi | DIP-4790N |
IntActi | Q05946, 43 interactors |
MINTi | Q05946 |
STRINGi | 4932.YLR222C |
PTM databases
iPTMneti | Q05946 |
Proteomic databases
MaxQBi | Q05946 |
PaxDbi | Q05946 |
PRIDEi | Q05946 |
Genome annotation databases
EnsemblFungii | YLR222C_mRNA; YLR222C; YLR222C |
GeneIDi | 850919 |
KEGGi | sce:YLR222C |
Organism-specific databases
EuPathDBi | FungiDB:YLR222C |
SGDi | S000004212, UTP13 |
Phylogenomic databases
eggNOGi | KOG0319, Eukaryota |
GeneTreei | ENSGT00940000157651 |
HOGENOMi | CLU_009276_0_0_1 |
InParanoidi | Q05946 |
OMAi | PYVQRHF |
Enzyme and pathway databases
Reactomei | R-SCE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
PROi | PR:Q05946 |
RNActi | Q05946, protein |
Family and domain databases
Gene3Di | 2.130.10.10, 4 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR013934, SSU_processome_Utp13 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08625, Utp13, 1 hit PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 11 hits |
SUPFAMi | SSF50978, SSF50978, 2 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UTP13_YEAST | |
Accessioni | Q05946Primary (citable) accession number: Q05946 Secondary accession number(s): D6VYM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD