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Entry version 182 (22 Apr 2020)
Sequence version 2 (01 Oct 1996)
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Protein

Synaptic vesicular amine transporter

Gene

SLC18A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q05940

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.2.29 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptic vesicular amine transporter
Alternative name(s):
Monoamine transporter
Solute carrier family 18 member 2
Vesicular amine transporter 2
Short name:
VAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC18A2
Synonyms:SVMT, VMAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10935 SLC18A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
193001 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05940

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 129Lumenal, vesicleSequence analysisAdd BLAST88
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 159CytoplasmicSequence analysis9
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 189Lumenal, vesicleSequence analysis9
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 219CytoplasmicSequence analysis9
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Topological domaini243 – 248Lumenal, vesicleSequence analysis6
Transmembranei249 – 271HelicalSequence analysisAdd BLAST23
Topological domaini272 – 291CytoplasmicSequence analysisAdd BLAST20
Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
Topological domaini312 – 328Lumenal, vesicleSequence analysisAdd BLAST17
Transmembranei329 – 352HelicalSequence analysisAdd BLAST24
Topological domaini353 – 357CytoplasmicSequence analysis5
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 389Lumenal, vesicleSequence analysisAdd BLAST11
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Topological domaini411 – 414CytoplasmicSequence analysis4
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 440Lumenal, vesicleSequence analysis5
Transmembranei441 – 462HelicalSequence analysisAdd BLAST22
Topological domaini463 – 514CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinsonism-dystonia, infantile, 2 (PKDYS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by infantile onset of abnormal movements, including parkinsonism, dystonia, and poor fine motor skills, as well as autonomic dysfunction, including abnormal sweating, cold extremities, and poor sleep. Some patients have variable degrees of developmental delay.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081069387P → L in PKDYS2; strong decrease in serotonin transport. 1 PublicationCorresponds to variant dbSNP:rs1392638187EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dystonia, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
6571

MalaCards human disease database

More...
MalaCardsi
SLC18A2
MIMi618049 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000165646

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
352649 Brain dopamine-serotonin vesicular transport disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA325

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q05940 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1893

Drug and drug target database

More...
DrugBanki
DB01472 4-Methoxyamphetamine
DB00182 Amphetamine
DB00865 Benzphetamine
DB01089 Deserpidine
DB12161 Deutetrabenazine
DB01576 Dextroamphetamine
DB00988 Dopamine
DB01363 Ephedra sinica root
DB01364 Ephedrine
DB00502 Haloperidol
DB05381 Histamine
DB06706 Isometheptene
DB00579 Mazindol
DB01577 Metamfetamine
DB01454 Midomafetamine
DB01442 MMDA
DB04821 Nomifensine
DB00368 Norepinephrine
DB06714 Propylhexedrine
DB09363 Rauwolfia serpentina root
DB00206 Reserpine
DB08839 Serotonin
DB04844 Tetrabenazine

DrugCentral

More...
DrugCentrali
Q05940

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1012

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC18A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1722742

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001275141 – 514Synaptic vesicular amine transporterAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi117 ↔ 3241 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei511PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q05940

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q05940

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q05940

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05940

PeptideAtlas

More...
PeptideAtlasi
Q05940

PRoteomics IDEntifications database

More...
PRIDEi
Q05940

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58362 [Q05940-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05940

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05940

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165646 Expressed in substantia nigra and 142 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q05940 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165646 Tissue enhanced (blood, brain, cervix, uterine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SLC6A3.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112459, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q05940, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298472

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q05940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q05940 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3764 Eukaryota
ENOG410XW69 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157593

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_10_9_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05940

KEGG Orthology (KO)

More...
KOi
K08155

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIYGRDR

Database of Orthologous Groups

More...
OrthoDBi
956763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05940

TreeFam database of animal gene trees

More...
TreeFami
TF313494

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q05940-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSELALVR WLQESRRSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS
60 70 80 90 100
IKHEKNATEI QTARPVHTAS ISDSFQSIFS YYDNSTMVTG NATRDLTLHQ
110 120 130 140 150
TATQHMVTNA SAVPSDCPSE DKDLLNENVQ VGLLFASKAT VQLITNPFIG
160 170 180 190 200
LLTNRIGYPI PIFAGFCIMF VSTIMFAFSS SYAFLLIARS LQGIGSSCSS
210 220 230 240 250
VAGMGMLASV YTDDEERGNV MGIALGGLAM GVLVGPPFGS VLYEFVGKTA
260 270 280 290 300
PFLVLAALVL LDGAIQLFVL QPSRVQPESQ KGTPLTTLLK DPYILIAAGS
310 320 330 340 350
ICFANMGIAM LEPALPIWMM ETMCSRKWQL GVAFLPASIS YLIGTNIFGI
360 370 380 390 400
LAHKMGRWLC ALLGMIIVGV SILCIPFAKN IYGLIAPNFG VGFAIGMVDS
410 420 430 440 450
SMMPIMGYLV DLRHVSVYGS VYAIADVAFC MGYAIGPSAG GAIAKAIGFP
460 470 480 490 500
WLMTIIGIID ILFAPLCFFL RSPPAKEEKM AILMDHNCPI KTKMYTQNNI
510
QSYPIGEDEE SESD
Length:514
Mass (Da):55,713
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42EA91A225485DB2
GO
Isoform 2 (identifier: Q05940-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-209: MGMLAS → RCGMPE
     210-514: Missing.

Show »
Length:209
Mass (Da):22,980
Checksum:iE5C6638E4F86FF66
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB19009 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17R → H in CAA50489 (PubMed:8373557).Curated1
Sequence conflicti302C → S in AAA59877 (PubMed:8095030).Curated1
Sequence conflicti354K → T in AAA59877 (PubMed:8095030).Curated1
Sequence conflicti378A → P in AAA59877 (PubMed:8095030).Curated1
Sequence conflicti395I → N in AAA59877 (PubMed:8095030).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081069387P → L in PKDYS2; strong decrease in serotonin transport. 1 PublicationCorresponds to variant dbSNP:rs1392638187EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057151204 – 209MGMLAS → RCGMPE in isoform 2. 1 Publication6
Alternative sequenceiVSP_057152210 – 514Missing in isoform 2. 1 PublicationAdd BLAST305

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L09118 mRNA Translation: AAA59877.1
L23205 mRNA Translation: AAA61290.1
L14269 mRNA Translation: AAA91853.1
X71354 mRNA Translation: CAA50489.1
AB044401 Genomic DNA Translation: BAB19009.1 Sequence problems.
AK314997 mRNA Translation: BAG37493.1
AL391988 Genomic DNA No translation available.
AL731557 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49428.1
CH471066 Genomic DNA Translation: EAW49429.1
BC030593 mRNA Translation: AAH30593.1
BC108927 mRNA Translation: AAI08928.1
BC108928 mRNA Translation: AAI08929.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7599.1 [Q05940-1]

Protein sequence database of the Protein Information Resource

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PIRi
A49368
S29810

NCBI Reference Sequences

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RefSeqi
NP_003045.2, NM_003054.4 [Q05940-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000644641; ENSP00000496339; ENSG00000165646 [Q05940-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6571

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6571

UCSC genome browser

More...
UCSCi
uc001ldd.3 human [Q05940-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Vesicular monoamine transporter entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09118 mRNA Translation: AAA59877.1
L23205 mRNA Translation: AAA61290.1
L14269 mRNA Translation: AAA91853.1
X71354 mRNA Translation: CAA50489.1
AB044401 Genomic DNA Translation: BAB19009.1 Sequence problems.
AK314997 mRNA Translation: BAG37493.1
AL391988 Genomic DNA No translation available.
AL731557 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49428.1
CH471066 Genomic DNA Translation: EAW49429.1
BC030593 mRNA Translation: AAH30593.1
BC108927 mRNA Translation: AAI08928.1
BC108928 mRNA Translation: AAI08929.1
CCDSiCCDS7599.1 [Q05940-1]
PIRiA49368
S29810
RefSeqiNP_003045.2, NM_003054.4 [Q05940-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112459, 2 interactors
IntActiQ05940, 10 interactors
STRINGi9606.ENSP00000298472

Chemistry databases

BindingDBiQ05940
ChEMBLiCHEMBL1893
DrugBankiDB01472 4-Methoxyamphetamine
DB00182 Amphetamine
DB00865 Benzphetamine
DB01089 Deserpidine
DB12161 Deutetrabenazine
DB01576 Dextroamphetamine
DB00988 Dopamine
DB01363 Ephedra sinica root
DB01364 Ephedrine
DB00502 Haloperidol
DB05381 Histamine
DB06706 Isometheptene
DB00579 Mazindol
DB01577 Metamfetamine
DB01454 Midomafetamine
DB01442 MMDA
DB04821 Nomifensine
DB00368 Norepinephrine
DB06714 Propylhexedrine
DB09363 Rauwolfia serpentina root
DB00206 Reserpine
DB08839 Serotonin
DB04844 Tetrabenazine
DrugCentraliQ05940
GuidetoPHARMACOLOGYi1012

Protein family/group databases

TCDBi2.A.1.2.29 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ05940
PhosphoSitePlusiQ05940

Polymorphism and mutation databases

BioMutaiSLC18A2
DMDMi1722742

Proteomic databases

EPDiQ05940
jPOSTiQ05940
MassIVEiQ05940
PaxDbiQ05940
PeptideAtlasiQ05940
PRIDEiQ05940
ProteomicsDBi58362 [Q05940-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2802 381 antibodies

Genome annotation databases

EnsembliENST00000644641; ENSP00000496339; ENSG00000165646 [Q05940-1]
GeneIDi6571
KEGGihsa:6571
UCSCiuc001ldd.3 human [Q05940-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6571
DisGeNETi6571

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC18A2
HGNCiHGNC:10935 SLC18A2
HPAiENSG00000165646 Tissue enhanced (blood, brain, cervix, uterine)
MalaCardsiSLC18A2
MIMi193001 gene
618049 phenotype
neXtProtiNX_Q05940
OpenTargetsiENSG00000165646
Orphaneti352649 Brain dopamine-serotonin vesicular transport disease
PharmGKBiPA325

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3764 Eukaryota
ENOG410XW69 LUCA
GeneTreeiENSGT00940000157593
HOGENOMiCLU_001265_10_9_1
InParanoidiQ05940
KOiK08155
OMAiLIYGRDR
OrthoDBi956763at2759
PhylomeDBiQ05940
TreeFamiTF313494

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
SIGNORiQ05940

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC18A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Vesicular_monoamine_transporter_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6571
PharosiQ05940 Tclin

Protein Ontology

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PROi
PR:Q05940
RNActiQ05940 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165646 Expressed in substantia nigra and 142 other tissues
GenevisibleiQ05940 HS

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVMAT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05940
Secondary accession number(s): B2RC96
, D3DRC4, Q15876, Q4G147, Q5VW49, Q9H3P6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1996
Last modified: April 22, 2020
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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