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Protein

Dual specificity protein phosphatase 2

Gene

DUSP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei257Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkiQ05923
SIGNORiQ05923

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 2 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity protein phosphatase PAC-1
Gene namesi
Name:DUSP2
Synonyms:PAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000158050.4
HGNCiHGNC:3068 DUSP2
MIMi603068 gene
neXtProtiNX_Q05923

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1844
OpenTargetsiENSG00000158050
PharmGKBiPA27525

Chemistry databases

ChEMBLiCHEMBL2157858

Polymorphism and mutation databases

BioMutaiDUSP2
DMDMi464334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947931 – 314Dual specificity protein phosphatase 2Add BLAST314

Proteomic databases

PaxDbiQ05923
PeptideAtlasiQ05923
PRIDEiQ05923
ProteomicsDBi58356

PTM databases

DEPODiQ05923
iPTMnetiQ05923
PhosphoSitePlusiQ05923

Expressioni

Tissue specificityi

Expressed in hematopoietic tissues.

Inductioni

By mitogens.

Gene expression databases

BgeeiENSG00000158050 Expressed in 153 organ(s), highest expression level in urinary bladder
CleanExiHS_DUSP2
GenevisibleiQ05923 HS

Organism-specific databases

HPAiHPA071920

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108177, 24 interactors
IntActiQ05923, 1 interactor
MINTiQ05923
STRINGi9606.ENSP00000288943

Chemistry databases

BindingDBiQ05923

Structurei

Secondary structure

1314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ05923
SMRiQ05923
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05923

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 144RhodanesePROSITE-ProRule annotationAdd BLAST122
Domaini237 – 302Tyrosine-protein phosphataseAdd BLAST66

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294080
HOVERGENiHBG007347
InParanoidiQ05923
KOiK04459
OMAiGFQACCP
OrthoDBiEOG091G0249
PhylomeDBiQ05923
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q05923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLEAARELE CAALGTLLRD PREAERTLLL DCRPFLAFCR RHVRAARPVP
60 70 80 90 100
WNALLRRRAR GPPAAVLACL LPDRALRTRL VRGELARAVV LDEGSASVAE
110 120 130 140 150
LRPDSPAHVL LAALLHETRA GPTAVYFLRG GFDGFQGCCP DLCSEAPAPA
160 170 180 190 200
LPPTGDKTSR SDSRAPVYDQ GGPVEILPYL FLGSCSHSSD LQGLQACGIT
210 220 230 240 250
AVLNVSASCP NHFEGLFRYK SIPVEDNQMV EISAWFQEAI GFIDWVKNSG
260 270 280 290 300
GRVLVHCQAG ISRSATICLA YLMQSRRVRL DEAFDFVKQR RGVISPNFSF
310
MGQLLQFETQ VLCH
Length:314
Mass (Da):34,400
Last modified:February 1, 1994 - v1
Checksum:iFDD3543C6DE10CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11329 mRNA Translation: AAA50779.1
U23853 Genomic DNA Translation: AAA86112.1
AC012307 Genomic DNA Translation: AAY24222.1
CH471207 Genomic DNA Translation: EAW71385.1
BC007771 mRNA Translation: AAH07771.1
CCDSiCCDS2016.1
PIRiA57126
RefSeqiNP_004409.1, NM_004418.3
UniGeneiHs.1183

Genome annotation databases

EnsembliENST00000288943; ENSP00000288943; ENSG00000158050
GeneIDi1844
KEGGihsa:1844
UCSCiuc002svk.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11329 mRNA Translation: AAA50779.1
U23853 Genomic DNA Translation: AAA86112.1
AC012307 Genomic DNA Translation: AAY24222.1
CH471207 Genomic DNA Translation: EAW71385.1
BC007771 mRNA Translation: AAH07771.1
CCDSiCCDS2016.1
PIRiA57126
RefSeqiNP_004409.1, NM_004418.3
UniGeneiHs.1183

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M3GNMR-A170-314[»]
ProteinModelPortaliQ05923
SMRiQ05923
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108177, 24 interactors
IntActiQ05923, 1 interactor
MINTiQ05923
STRINGi9606.ENSP00000288943

Chemistry databases

BindingDBiQ05923
ChEMBLiCHEMBL2157858

PTM databases

DEPODiQ05923
iPTMnetiQ05923
PhosphoSitePlusiQ05923

Polymorphism and mutation databases

BioMutaiDUSP2
DMDMi464334

Proteomic databases

PaxDbiQ05923
PeptideAtlasiQ05923
PRIDEiQ05923
ProteomicsDBi58356

Protocols and materials databases

DNASUi1844
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288943; ENSP00000288943; ENSG00000158050
GeneIDi1844
KEGGihsa:1844
UCSCiuc002svk.5 human

Organism-specific databases

CTDi1844
DisGeNETi1844
EuPathDBiHostDB:ENSG00000158050.4
GeneCardsiDUSP2
HGNCiHGNC:3068 DUSP2
HPAiHPA071920
MIMi603068 gene
neXtProtiNX_Q05923
OpenTargetsiENSG00000158050
PharmGKBiPA27525
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294080
HOVERGENiHBG007347
InParanoidiQ05923
KOiK04459
OMAiGFQACCP
OrthoDBiEOG091G0249
PhylomeDBiQ05923
TreeFamiTF105122

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkiQ05923
SIGNORiQ05923

Miscellaneous databases

EvolutionaryTraceiQ05923
GeneWikiiDUSP2
GenomeRNAii1844
PROiPR:Q05923
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158050 Expressed in 153 organ(s), highest expression level in urinary bladder
CleanExiHS_DUSP2
GenevisibleiQ05923 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS2_HUMAN
AccessioniPrimary (citable) accession number: Q05923
Secondary accession number(s): Q53T45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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