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Protein

Homeobox protein engrailed-2

Gene

EN2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi200 – 259HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: UniProtKB
  • negative regulation of neuron death Source: ParkinsonsUK-UCL
  • positive regulation of phosphorylation Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-2
Short name:
Gg-En-2
Short name:
Homeobox protein en-2
Gene namesi
Name:EN2
Synonyms:EN-2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960691 – 289Homeobox protein engrailed-2Add BLAST289

Expressioni

Gene expression databases

BgeeiENSGALG00000023430 Expressed in 2 organ(s), highest expression level in cerebellum

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ05917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 106Poly-Gly9

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG005975
InParanoidiQ05917
KOiK09319
OMAiKDAGTCC
OrthoDBiEOG091G0XBB

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR019549 Homeobox-engrailed_C-terminal
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000747 Homeobox_engrailed
IPR020479 Homeobox_metazoa
IPR019737 Homoebox-engrailed_CS
IPR000047 HTH_motif
PfamiView protein in Pfam
PF10525 Engrail_1_C_sig, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00026 ENGRAILED
PR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00033 ENGRAILED, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q05917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGGRSPRE EAAEPQESGG DAEPGGGRRA LLLPPGDPPH PHPHPHRITN
60 70 80 90 100
FFIDNILRPE FGRRKEAGGT AGEPRRPGAE SRRSPAAAAP APGAPVPGGG
110 120 130 140 150
GGGGGGSPGR GEGGPAALAL HGAAKKGGDP AALEAALKAR GLSGAELSVS
160 170 180 190 200
SDSDSSQAGS NAGNQPMLWP AWVYCTRYSD RPSSGPRSRK PKKKNPNKED
210 220 230 240 250
KRPRTAFTAE QLQRLKAEFQ TNRYLTEQRR QSLAQELGLN ESQIKIWFQN
260 270 280
KRAKIKKATG SKNSLAVHLM AQGLYNHSTT AKDGKSDSE
Length:289
Mass (Da):30,507
Last modified:September 5, 2012 - v2
Checksum:iC5EF48F9F160AA2A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PIF3A0A1D5PIF3_CHICK
Homeobox protein engrailed-like
EN2
104Annotation score:

Sequence cautioni

The sequence AAA53437 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA53438 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12696 Genomic DNA Translation: AAA53437.1 Sequence problems.
L12697 Genomic DNA Translation: AAA53438.1 Sequence problems.
PIRiF48423
RefSeqiNP_001254648.1, NM_001267719.1
UniGeneiGga.56328

Genome annotation databases

GeneIDi100859435
KEGGigga:100859435

Similar proteinsi

Entry informationi

Entry nameiHME2_CHICK
AccessioniPrimary (citable) accession number: Q05917
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 5, 2012
Last modified: September 12, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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