UniProtKB - Q05901 (ACHB3_HUMAN)
Protein
Neuronal acetylcholine receptor subunit beta-3
Gene
CHRNB3
Organism
Homo sapiens (Human)
Status
Functioni
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
GO - Molecular functioni
- acetylcholine binding Source: Ensembl
- acetylcholine-gated cation-selective channel activity Source: ProtInc
- channel activity Source: ProtInc
- neurotransmitter receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to nicotine Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, cholinergic Source: GO_Central
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q05901 |
Reactomei | R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal acetylcholine receptor subunit beta-3 |
Gene namesi | Name:CHRNB3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1963, CHRNB3 |
MIMi | 118508, gene |
neXtProti | NX_Q05901 |
VEuPathDBi | HostDB:ENSG00000147432.6 |
Subcellular locationi
Plasma Membrane
- acetylcholine-gated channel complex Source: ProtInc
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- dopaminergic synapse Source: Ensembl
- integral component of membrane Source: UniProtKB
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 232 | ExtracellularSequence analysisAdd BLAST | 208 | |
Transmembranei | 233 – 257 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 265 – 282 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 299 – 320 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 321 – 428 | CytoplasmicSequence analysisAdd BLAST | 108 | |
Transmembranei | 429 – 447 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 1142 |
OpenTargetsi | ENSG00000147432 |
PharmGKBi | PA26495 |
Miscellaneous databases
Pharosi | Q05901, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2109233 |
DrugBanki | DB00237, Butabarbital DB00898, Ethanol DB00184, Nicotine |
DrugCentrali | Q05901 |
Genetic variation databases
BioMutai | CHRNB3 |
DMDMi | 2506128 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000000383 | 25 – 458 | Neuronal acetylcholine receptor subunit beta-3Add BLAST | 434 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 153 ↔ 167 | By similarity | ||
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q05901 |
MaxQBi | Q05901 |
PaxDbi | Q05901 |
PeptideAtlasi | Q05901 |
PRIDEi | Q05901 |
ProteomicsDBi | 58355 |
PTM databases
GlyGeni | Q05901, 3 sites |
PhosphoSitePlusi | Q05901 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147432, Expressed in substantia nigra and 48 other tissues |
ExpressionAtlasi | Q05901, baseline and differential |
Genevisiblei | Q05901, HS |
Organism-specific databases
HPAi | ENSG00000147432, Tissue enhanced (brain, pancreas, testis) |
Interactioni
Subunit structurei
Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.
Protein-protein interaction databases
BioGRIDi | 107564, 5 interactors |
ComplexPortali | CPX-2192, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 |
IntActi | Q05901, 3 interactors |
STRINGi | 9606.ENSP00000289957 |
Chemistry databases
BindingDBi | Q05901 |
Miscellaneous databases
RNActi | Q05901, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000156892 |
HOGENOMi | CLU_018074_1_0_1 |
InParanoidi | Q05901 |
OMAi | RRDEVYW |
OrthoDBi | 381858at2759 |
PhylomeDBi | Q05901 |
TreeFami | TF315605 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 2 hits |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q05901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS
60 70 80 90 100
NDTIKVYFGL KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI
110 120 130 140 150
HSIKVPSESL WLPDIVLFEN ADGRFEGSLM TKVIVKSNGT VVWTPPASYK
160 170 180 190 200
SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM VDLILINENV DRKDFFDNGE
210 220 230 240 250
WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL IIPCLGLSFL
260 270 280 290 300
TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL
310 320 330 340 350
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK
360 370 380 390 400
DHVDRYSSPE KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR
410 420 430 440 450
YISRHVKKEH FISQVVQDWK FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL
KMWLHSYH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RMT8 | A0A1D5RMT8_HUMAN | Neuronal acetylcholine receptor sub... | CHRNB3 | 9 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 – 38 | LFQ → EWK in CAA47851 (PubMed:7690916).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048173 | 451 | K → E. Corresponds to variant dbSNP:rs35327613EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62438 mRNA Translation: AAB40116.1 Y08417 mRNA Translation: CAA69694.1 AF140765 , AF140760, AF140761, AF140762, AF140763, AF140764 Genomic DNA Translation: AAD33063.1 BC069681 mRNA Translation: AAH69681.1 BC069703 mRNA Translation: AAH69703.1 BC069788 mRNA Translation: AAH69788.1 X67513 mRNA Translation: CAA47851.1 |
CCDSi | CCDS6134.1 |
PIRi | I38056 |
RefSeqi | NP_000740.1, NM_000749.4 |
Genome annotation databases
Ensembli | ENST00000289957; ENSP00000289957; ENSG00000147432 |
GeneIDi | 1142 |
KEGGi | hsa:1142 |
UCSCi | uc003xpi.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62438 mRNA Translation: AAB40116.1 Y08417 mRNA Translation: CAA69694.1 AF140765 , AF140760, AF140761, AF140762, AF140763, AF140764 Genomic DNA Translation: AAD33063.1 BC069681 mRNA Translation: AAH69681.1 BC069703 mRNA Translation: AAH69703.1 BC069788 mRNA Translation: AAH69788.1 X67513 mRNA Translation: CAA47851.1 |
CCDSi | CCDS6134.1 |
PIRi | I38056 |
RefSeqi | NP_000740.1, NM_000749.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107564, 5 interactors |
ComplexPortali | CPX-2192, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 |
IntActi | Q05901, 3 interactors |
STRINGi | 9606.ENSP00000289957 |
Chemistry databases
BindingDBi | Q05901 |
ChEMBLi | CHEMBL2109233 |
DrugBanki | DB00237, Butabarbital DB00898, Ethanol DB00184, Nicotine |
DrugCentrali | Q05901 |
PTM databases
GlyGeni | Q05901, 3 sites |
PhosphoSitePlusi | Q05901 |
Genetic variation databases
BioMutai | CHRNB3 |
DMDMi | 2506128 |
Proteomic databases
MassIVEi | Q05901 |
MaxQBi | Q05901 |
PaxDbi | Q05901 |
PeptideAtlasi | Q05901 |
PRIDEi | Q05901 |
ProteomicsDBi | 58355 |
Protocols and materials databases
Antibodypediai | 11480, 167 antibodies |
DNASUi | 1142 |
Genome annotation databases
Ensembli | ENST00000289957; ENSP00000289957; ENSG00000147432 |
GeneIDi | 1142 |
KEGGi | hsa:1142 |
UCSCi | uc003xpi.2, human |
Organism-specific databases
CTDi | 1142 |
DisGeNETi | 1142 |
GeneCardsi | CHRNB3 |
HGNCi | HGNC:1963, CHRNB3 |
HPAi | ENSG00000147432, Tissue enhanced (brain, pancreas, testis) |
MIMi | 118508, gene |
neXtProti | NX_Q05901 |
OpenTargetsi | ENSG00000147432 |
PharmGKBi | PA26495 |
VEuPathDBi | HostDB:ENSG00000147432.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000156892 |
HOGENOMi | CLU_018074_1_0_1 |
InParanoidi | Q05901 |
OMAi | RRDEVYW |
OrthoDBi | 381858at2759 |
PhylomeDBi | Q05901 |
TreeFami | TF315605 |
Enzyme and pathway databases
PathwayCommonsi | Q05901 |
Reactomei | R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Miscellaneous databases
BioGRID-ORCSi | 1142, 0 hits in 871 CRISPR screens |
ChiTaRSi | CHRNB3, human |
GeneWikii | CHRNB3 |
GenomeRNAii | 1142 |
Pharosi | Q05901, Tchem |
PROi | PR:Q05901 |
RNActi | Q05901, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147432, Expressed in substantia nigra and 48 other tissues |
ExpressionAtlasi | Q05901, baseline and differential |
Genevisiblei | Q05901, HS |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 2 hits |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACHB3_HUMAN | |
Accessioni | Q05901Primary (citable) accession number: Q05901 Secondary accession number(s): Q15827 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families