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Protein

Neuronal acetylcholine receptor subunit beta-3

Gene

CHRNB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit beta-3
Gene namesi
Name:CHRNB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147432.6
HGNCiHGNC:1963 CHRNB3
MIMi118508 gene
neXtProtiNX_Q05901

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 232ExtracellularSequence analysisAdd BLAST208
Transmembranei233 – 257HelicalSequence analysisAdd BLAST25
Transmembranei265 – 282HelicalSequence analysisAdd BLAST18
Transmembranei299 – 320HelicalSequence analysisAdd BLAST22
Topological domaini321 – 428CytoplasmicSequence analysisAdd BLAST108
Transmembranei429 – 447HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi1142
OpenTargetsiENSG00000147432
PharmGKBiPA26495

Chemistry databases

ChEMBLiCHEMBL2109233
DrugBankiDB00898 Ethanol
DB00674 Galantamine
DB00184 Nicotine

Polymorphism and mutation databases

BioMutaiCHRNB3
DMDMi2506128

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000038325 – 458Neuronal acetylcholine receptor subunit beta-3Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 167By similarity
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ05901
PaxDbiQ05901
PRIDEiQ05901
ProteomicsDBi58355

PTM databases

PhosphoSitePlusiQ05901

Expressioni

Gene expression databases

BgeeiENSG00000147432 Expressed in 38 organ(s), highest expression level in substantia nigra
CleanExiHS_CHRNB3
ExpressionAtlasiQ05901 baseline and differential
GenevisibleiQ05901 HS

Organism-specific databases

HPAiHPA045555

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.

Protein-protein interaction databases

BioGridi107564, 3 interactors
ComplexPortaliCPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
STRINGi9606.ENSP00000289957

Chemistry databases

BindingDBiQ05901

Structurei

3D structure databases

ProteinModelPortaliQ05901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ05901
KOiK04814
OMAiLLCMKGH
OrthoDBiEOG091G0R20
PhylomeDBiQ05901
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q05901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS
60 70 80 90 100
NDTIKVYFGL KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI
110 120 130 140 150
HSIKVPSESL WLPDIVLFEN ADGRFEGSLM TKVIVKSNGT VVWTPPASYK
160 170 180 190 200
SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM VDLILINENV DRKDFFDNGE
210 220 230 240 250
WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL IIPCLGLSFL
260 270 280 290 300
TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL
310 320 330 340 350
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK
360 370 380 390 400
DHVDRYSSPE KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR
410 420 430 440 450
YISRHVKKEH FISQVVQDWK FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL

KMWLHSYH
Length:458
Mass (Da):52,729
Last modified:November 1, 1997 - v2
Checksum:iD6E919E53CBD21F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RMT8A0A1D5RMT8_HUMAN
Neuronal acetylcholine receptor sub...
CHRNB3
9Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 38LFQ → EWK in CAA47851 (PubMed:7690916).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048173451K → E. Corresponds to variant dbSNP:rs35327613Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62438 mRNA Translation: AAB40116.1
Y08417 mRNA Translation: CAA69694.1
AF140765
, AF140760, AF140761, AF140762, AF140763, AF140764 Genomic DNA Translation: AAD33063.1
BC069681 mRNA Translation: AAH69681.1
BC069703 mRNA Translation: AAH69703.1
BC069788 mRNA Translation: AAH69788.1
X67513 mRNA Translation: CAA47851.1
CCDSiCCDS6134.1
PIRiI38056
RefSeqiNP_000740.1, NM_000749.4
UniGeneiHs.654576

Genome annotation databases

EnsembliENST00000289957; ENSP00000289957; ENSG00000147432
GeneIDi1142
KEGGihsa:1142
UCSCiuc003xpi.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62438 mRNA Translation: AAB40116.1
Y08417 mRNA Translation: CAA69694.1
AF140765
, AF140760, AF140761, AF140762, AF140763, AF140764 Genomic DNA Translation: AAD33063.1
BC069681 mRNA Translation: AAH69681.1
BC069703 mRNA Translation: AAH69703.1
BC069788 mRNA Translation: AAH69788.1
X67513 mRNA Translation: CAA47851.1
CCDSiCCDS6134.1
PIRiI38056
RefSeqiNP_000740.1, NM_000749.4
UniGeneiHs.654576

3D structure databases

ProteinModelPortaliQ05901
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107564, 3 interactors
ComplexPortaliCPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
STRINGi9606.ENSP00000289957

Chemistry databases

BindingDBiQ05901
ChEMBLiCHEMBL2109233
DrugBankiDB00898 Ethanol
DB00674 Galantamine
DB00184 Nicotine

PTM databases

PhosphoSitePlusiQ05901

Polymorphism and mutation databases

BioMutaiCHRNB3
DMDMi2506128

Proteomic databases

MaxQBiQ05901
PaxDbiQ05901
PRIDEiQ05901
ProteomicsDBi58355

Protocols and materials databases

DNASUi1142
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289957; ENSP00000289957; ENSG00000147432
GeneIDi1142
KEGGihsa:1142
UCSCiuc003xpi.2 human

Organism-specific databases

CTDi1142
DisGeNETi1142
EuPathDBiHostDB:ENSG00000147432.6
GeneCardsiCHRNB3
HGNCiHGNC:1963 CHRNB3
HPAiHPA045555
MIMi118508 gene
neXtProtiNX_Q05901
OpenTargetsiENSG00000147432
PharmGKBiPA26495
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ05901
KOiK04814
OMAiLLCMKGH
OrthoDBiEOG091G0R20
PhylomeDBiQ05901
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

ChiTaRSiCHRNB3 human
GeneWikiiCHRNB3
GenomeRNAii1142
PROiPR:Q05901
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147432 Expressed in 38 organ(s), highest expression level in substantia nigra
CleanExiHS_CHRNB3
ExpressionAtlasiQ05901 baseline and differential
GenevisibleiQ05901 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHB3_HUMAN
AccessioniPrimary (citable) accession number: Q05901
Secondary accession number(s): Q15827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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