CHRNB3

Functionⁱ

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functionⁱ

acetylcholine-gated cation-selective channel activity
Source: ProtInc
Traceable author statementⁱ
- 7690916
channel activity
Source: ProtInc
Traceable author statementⁱ
- 7690916
ligand-gated ion channel activity Source: Reactome
transmembrane signaling receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nervous system process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuromuscular synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of membrane potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of synaptic vesicle exocytosis Source: Ensembl
response to nicotine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic transmission, cholinergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal acetylcholine receptor subunit beta-3
Gene namesⁱ	Name:CHRNB3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147432.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1963 CHRNB3
MIMⁱ	118508 gene
neXtProtⁱ	NX_Q05901

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 232	ExtracellularSequence analysisAdd BLAST	208
Transmembraneⁱ	233 – 257	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	265 – 282	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	299 – 320	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	321 – 428	CytoplasmicSequence analysisAdd BLAST	108
Transmembraneⁱ	429 – 447	HelicalSequence analysisAdd BLAST	19

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1142
Open Targets More...OpenTargetsⁱ	ENSG00000147432
PharmGKBⁱ	PA26495

Chemistry databases

ChEMBLⁱ	CHEMBL2109233
Drug and drug target database More...DrugBankⁱ	DB00898 Ethanol DB00674 Galantamine DB00184 Nicotine

Polymorphism and mutation databases

BioMutaⁱ	CHRNB3
DMDMⁱ	2506128

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_0000000383	25 – 458	Neuronal acetylcholine receptor subunit beta-3Add BLAST		434

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	138	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	153 ↔ 167	By similarity
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q05901
PaxDbⁱ	Q05901
PRIDEⁱ	Q05901
ProteomicsDBⁱ	58355

PTM databases

PhosphoSitePlusⁱ	Q05901

PhosphoSitePlusⁱ

Q05901

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000147432 Expressed in 38 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_CHRNB3
ExpressionAtlasⁱ	Q05901 baseline and differential
Genevisibleⁱ	Q05901 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045555

HPAⁱ

HPA045555

Interactionⁱ

Subunit structureⁱ

Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.

Protein-protein interaction databases

BioGridⁱ	107564, 3 interactors
ComplexPortalⁱ	CPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
STRINGⁱ	9606.ENSP00000289957

Chemistry databases

BindingDBⁱ

Q05901

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q05901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	Q05901
KEGG Orthology (KO) More...KOⁱ	K04814
OMAⁱ	LLCMKGH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	Q05901
TreeFamⁱ	TF315605

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 2 hits
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q05901-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS 
        60         70         80         90        100
NDTIKVYFGL KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI 
       110        120        130        140        150
HSIKVPSESL WLPDIVLFEN ADGRFEGSLM TKVIVKSNGT VVWTPPASYK 
       160        170        180        190        200
SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM VDLILINENV DRKDFFDNGE 
       210        220        230        240        250
WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL IIPCLGLSFL 
       260        270        280        290        300
TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL 
       310        320        330        340        350
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK 
       360        370        380        390        400
DHVDRYSSPE KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR 
       410        420        430        440        450
YISRHVKKEH FISQVVQDWK FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL 

KMWLHSYH

Length:458

Mass (Da):52,729

Last modified:November 1, 1997 - v2

Checksum:ⁱD6E919E53CBD21F8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1D5RMT8	A0A1D5RMT8_HUMAN		Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit beta-3	CHRNB3	9	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	36 – 38	LFQ → EWK in CAA47851 (PubMed:7690916).Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048173	451	K → E. Corresponds to variant dbSNP:rs35327613Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62438 mRNA Translation: AAB40116.1 Y08417 mRNA Translation: CAA69694.1 AF140765 AF140764 Genomic DNA Translation: AAD33063.1 BC069681 mRNA Translation: AAH69681.1 BC069703 mRNA Translation: AAH69703.1 BC069788 mRNA Translation: AAH69788.1 X67513 mRNA Translation: CAA47851.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6134.1
PIRⁱ	I38056
NCBI Reference Sequences More...RefSeqⁱ	NP_000740.1, NM_000749.4
UniGeneⁱ	Hs.654576

Genome annotation databases

Ensemblⁱ	ENST00000289957; ENSP00000289957; ENSG00000147432
GeneIDⁱ	1142
KEGGⁱ	hsa:1142
UCSC genome browser More...UCSCⁱ	uc003xpi.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q05901	Neuronal acetylcholine receptor subunit beta-3		PANTR		458	UniRef100_Q05901
UPI00024D0126		HUMAN		384
CHRNB3 isoform 1		PANTR		458
UPI0005D00DF0		HUMAN		329

Protein	Similar proteins		Species	Score	Length	Source
Q05901	Neuronal acetylcholine receptor subunit beta-3		PANTR		458	UniRef90_Q05901
Cholinergic receptor nicotinic beta 3 subunit		CHLSB		462
Cholinergic receptor nicotinic beta 3 subunit		HORSE		459
Uncharacterized protein		RHIRO		458
Uncharacterized protein		NOMLE		458
+30

Protein	Similar proteins		Species	Score	Length	Source
Q05901	Neuronal acetylcholine receptor subunit alpha-5		HUMAN		468	UniRef50_P30532
Neuronal acetylcholine receptor subunit alpha-5		PANTR		468
Neuronal acetylcholine receptor subunit non-alpha-3		CARAU		466
Neuronal acetylcholine receptor subunit alpha-5		MOUSE		467
Neuronal acetylcholine receptor subunit alpha-5		RAT		452
+548

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62438 mRNA Translation: AAB40116.1 Y08417 mRNA Translation: CAA69694.1 AF140765 AF140764 Genomic DNA Translation: AAD33063.1 BC069681 mRNA Translation: AAH69681.1 BC069703 mRNA Translation: AAH69703.1 BC069788 mRNA Translation: AAH69788.1 X67513 mRNA Translation: CAA47851.1
CCDSⁱ	CCDS6134.1
PIRⁱ	I38056
RefSeqⁱ	NP_000740.1, NM_000749.4
UniGeneⁱ	Hs.654576

3D structure databases

ProteinModelPortalⁱ	Q05901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107564, 3 interactors
ComplexPortalⁱ	CPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
STRINGⁱ	9606.ENSP00000289957

Chemistry databases

BindingDBⁱ	Q05901
ChEMBLⁱ	CHEMBL2109233
DrugBankⁱ	DB00898 Ethanol DB00674 Galantamine DB00184 Nicotine

PTM databases

PhosphoSitePlusⁱ	Q05901

PhosphoSitePlusⁱ

Q05901

Polymorphism and mutation databases

BioMutaⁱ	CHRNB3
DMDMⁱ	2506128

Proteomic databases

MaxQBⁱ	Q05901
PaxDbⁱ	Q05901
PRIDEⁱ	Q05901
ProteomicsDBⁱ	58355

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1142
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000289957; ENSP00000289957; ENSG00000147432
GeneIDⁱ	1142
KEGGⁱ	hsa:1142
UCSCⁱ	uc003xpi.2 human

Organism-specific databases

CTDⁱ	1142
DisGeNETⁱ	1142
EuPathDBⁱ	HostDB:ENSG00000147432.6
GeneCardsⁱ	CHRNB3
HGNCⁱ	HGNC:1963 CHRNB3
HPAⁱ	HPA045555
MIMⁱ	118508 gene
neXtProtⁱ	NX_Q05901
OpenTargetsⁱ	ENSG00000147432
PharmGKBⁱ	PA26495
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	Q05901
KOⁱ	K04814
OMAⁱ	LLCMKGH
OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	Q05901
TreeFamⁱ	TF315605

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

ChiTaRSⁱ	CHRNB3 human
GeneWikiⁱ	CHRNB3
GenomeRNAiⁱ	1142
Protein Ontology More...PROⁱ	PR:Q05901
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147432 Expressed in 38 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_CHRNB3
ExpressionAtlasⁱ	Q05901 baseline and differential
Genevisibleⁱ	Q05901 HS

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 2 hits
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACHB3_HUMAN
Accessionⁱ	Q05901Primary (citable) accession number: Q05901 Secondary accession number(s): Q15827
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - Q05901 (ACHB3_HUMAN)

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Neuronal acetylcholine receptor subunit beta-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ