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UniProtKB - Q05854 (YL278_YEAST)

Entry version 150 (25 May 2022)
Sequence version 1 (01 Nov 1997)
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Protein

Uncharacterized transcriptional regulatory protein YLR278C

Gene

YLR278C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi41 – 68Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized transcriptional regulatory protein YLR278C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YLR278C
ORF Names:L8003.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004268, YLR278C

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YLR278C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001150031 – 1341Uncharacterized transcriptional regulatory protein YLR278CAdd BLAST1341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1143PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q05854

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q05854

PRoteomics IDEntifications database

More...PRIDEi		Q05854

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q05854

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		31546, 160 interactors

Database of interacting proteins

More...DIPi		DIP-7433N

Protein interaction database and analysis system

More...IntActi		Q05854, 4 interactors

Molecular INTeraction database

More...MINTi		Q05854

STRING: functional protein association networks

More...STRINGi		4932.YLR278C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q05854, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q05854

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q05854

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 100DisorderedSequence analysisAdd BLAST29
Regioni770 – 804DisorderedSequence analysisAdd BLAST35
Regioni864 – 971DisorderedSequence analysisAdd BLAST108
Regioni1031 – 1116DisorderedSequence analysisAdd BLAST86
Regioni1220 – 1240DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 91Polar residuesSequence analysisAdd BLAST20
Compositional biasi770 – 797Polar residuesSequence analysisAdd BLAST28

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS9Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176304

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004038_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q05854

Identification of Orthologs from Complete Genome Data

More...OMAi		AHDMINN

Family and domain databases

Conserved Domains Database

More...CDDi		cd00067, GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00906, Fungal_trans, 1 hit
SM00066, GAL4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57701, SSF57701, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRPRKNVSQ EKIQQLKREL ELAGNRTDVL LQDKKGRSRS CLLCRRRKQR 
        60         70         80         90        100
CDHKLPSCTA CLKAGIKCVQ PSKYSSSTSN SNTNNNTPTA GTVPPTPHPV 
       110        120        130        140        150
IKRELQDSSI GAGAGAATSL NDMTIIKPIS TSNSNVDAGD ANEFRKTIKS 
       160        170        180        190        200
VTTNSNPNLM RQDKDQYTIF LEKKLKSLET LLDLSPGCNQ YNYELSQYKK 
       210        220        230        240        250
VSHLFSNNTS DYSRPNSSNM VILPLPSPSN KPLENTNNNG SNVNAATNDT 
       260        270        280        290        300
SASTNNINNN NAICQSASLL NDPLETLDFT KCIFAKYNLK KEFLMYDPIF 
       310        320        330        340        350
ELNEKLSRSF LDTFFTRLQF KYPILDEQEI YTFYDHYLHN KILIPPSSPA 
       360        370        380        390        400
TSSAAPPSNS HSYSEIEFHF LSGRMWLVFS ISAYLLMTTG KYKGFPPHRY 
       410        420        430        440        450
FSTAIRHITK CGLHLNYVQQ IELLTLLVLY IIRTDRDSLI LYDIIKDVMG 
       460        470        480        490        500
ISKKKLHLNQ WYPNDPFANK KLRLFWCVYL LERMICVAVG KPYTIKESEI 
       510        520        530        540        550
NLPLFNNDSF YTKGVHAAAP STNDHGVQFI NQSLKLRRIE SQFVETLQLL 
       560        570        580        590        600
KNDSRSVKQS IDQLPLVRKF FEDLEVWRKS YSTLDVKNFE NETLKLYYYR 
       610        620        630        640        650
SVRLLIQPYL EFFAPEDRLF RECQAAAGQI CQLYKIFHQK TLNGHSTPAV 
       660        670        680        690        700
HTVFVAGVTL IYCMWLARNF DDQRRKKLGD ASKHTRPLIS ASLFSTMDDL 
       710        720        730        740        750
RACSVCLYVM TERSNFARTF RDTFDQLMNA TVGNLIERCG PDSSELIFMA 
       760        770        780        790        800
SSVAKRTEPK NINDEANKAI SSGDTLHDSN SANAANLSNS NDKNISHNGG 
       810        820        830        840        850
MPPAVARIFG KGQAEEHAGF VENSQVDLAE QEKFKKKQGV LEKTSVPKSL 
       860        870        880        890        900
AHLLTKMDDR SRISNSSMSY TTSSSSSSSS SSSSSTLSFP SSQEKNLKIN 
       910        920        930        940        950
VNNDNNGMTI SSVNREHNNN HNNNNDNNNN NNNNNNNSNN NNNVNNNDNE 
       960        970        980        990       1000
SNSRSTTNNS CNNGNNSQYV RNNNVTMEND VERPIQDQYI VKKPTNQTEF 
      1010       1020       1030       1040       1050
DWQVFQQQAF LQQQLAQHNL QAYLSSLNTD TMTNRSPSKS SSISTASSHS 
      1060       1070       1080       1090       1100
DPIPIAMTQS PTPYPQTSNM LPQQHVSRPL PQQQREQPQQ HITSPQRFSE 
      1110       1120       1130       1140       1150
SNFTNQLNNG MINSNPLQSA IFSNHTSENK QLRDVEESNF STSPLRADYG 
      1160       1170       1180       1190       1200
NNIISSIPAS FTSNSIPVSV KQARNGSSSG DILFSNGAHD MINNISTWTN 
      1210       1220       1230       1240       1250
NSVLDALNSK SILQTIFPQS QEPSSLSMDK QQQQHQQQNM CSENNVTANN 
      1260       1270       1280       1290       1300
FQQTQNDPSY NRNLFMMSNQ EGVQYNLDET EKNGPKTQVE ANTSANLHFD 
      1310       1320       1330       1340 
NVIPTVTNAD IRKKRSNWDN MMTSGPVEDF WTINDDYGFL T
Length:1,341
Mass (Da):151,279
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94201F3964500EEF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U17243 Genomic DNA Translation: AAB67326.1
U17245 Genomic DNA Translation: AAB67370.1
BK006945 Genomic DNA Translation: DAA09591.1

Protein sequence database of the Protein Information Resource

More...PIRi		S50366

NCBI Reference Sequences

More...RefSeqi		NP_013380.1, NM_001182165.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YLR278C_mRNA; YLR278C; YLR278C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850984

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YLR278C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17243 Genomic DNA Translation: AAB67326.1
U17245 Genomic DNA Translation: AAB67370.1
BK006945 Genomic DNA Translation: DAA09591.1
PIRiS50366
RefSeqiNP_013380.1, NM_001182165.1

3D structure databases

AlphaFoldDBiQ05854
SMRiQ05854
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi31546, 160 interactors
DIPiDIP-7433N
IntActiQ05854, 4 interactors
MINTiQ05854
STRINGi4932.YLR278C

PTM databases

iPTMnetiQ05854

Proteomic databases

MaxQBiQ05854
PaxDbiQ05854
PRIDEiQ05854

Genome annotation databases

EnsemblFungiiYLR278C_mRNA; YLR278C; YLR278C
GeneIDi850984
KEGGisce:YLR278C

Organism-specific databases

SGDiS000004268, YLR278C
VEuPathDBiFungiDB:YLR278C

Phylogenomic databases

eggNOGiENOG502QS9Q, Eukaryota
GeneTreeiENSGT00940000176304
HOGENOMiCLU_004038_1_0_1
InParanoidiQ05854
OMAiAHDMINN

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q05854
RNActiQ05854, protein

Family and domain databases

CDDicd00067, GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906, Fungal_trans, 1 hit
SM00066, GAL4, 1 hit
SUPFAMiSSF57701, SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYL278_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05854
Secondary accession number(s): D6VYS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 25, 2022
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
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