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Protein

Ribonuclease 3

Gene

rnc

Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41MagnesiumUniRule annotation1
Active sitei45UniRule annotation1
Metal bindingi114MagnesiumUniRule annotation1
Active sitei117UniRule annotation1
Metal bindingi117MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciBAPH372461:G1GK7-168-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:BCc_163
OrganismiBuchnera aphidicola subsp. Cinara cedri (strain Cc)
Taxonomic identifieri372461 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000669 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000757311 – 226Ribonuclease 3Add BLAST226

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi372461.BCc_163

Structurei

3D structure databases

ProteinModelPortaliQ057R4
SMRiQ057R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 128RNase IIIUniRule annotationAdd BLAST123
Domaini155 – 225DRBMUniRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q057R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPIVMKKLQ KFIGYTFTNI TLLKHALTHR SASSQHNERL EFLGDSILSF
60 70 80 90 100
IIAKALYHHF PKMNEGGMSR MRATLVRGNT LAEIATEFSL GKYLQLGQGE
110 120 130 140 150
KKSGGFKRES ILANAIEAII ASIFLDSNIY TVERIILYWY KNRFKKMNPT
160 170 180 190 200
GTKKDPKTRL QEYLQSKHFS LPIYSIGQIY GEAHNQIFTI YCKIDGLSEL
210 220
LIGIGASRRK AEQDAAQNAL IRLEVE
Length:226
Mass (Da):25,705
Last modified:November 14, 2006 - v1
Checksum:i0C88BF51C2CB931E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000263 Genomic DNA Translation: ABJ90635.1
RefSeqiWP_011672554.1, NC_008513.1

Genome annotation databases

EnsemblBacteriaiABJ90635; ABJ90635; BCc_163
KEGGibcc:BCc_163

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000263 Genomic DNA Translation: ABJ90635.1
RefSeqiWP_011672554.1, NC_008513.1

3D structure databases

ProteinModelPortaliQ057R4
SMRiQ057R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi372461.BCc_163

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ90635; ABJ90635; BCc_163
KEGGibcc:BCc_163

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Enzyme and pathway databases

BioCyciBAPH372461:G1GK7-168-MONOMER

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNC_BUCCC
AccessioniPrimary (citable) accession number: Q057R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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