UniProtKB - Q05718 (IBP6_BOVIN)
Protein
Insulin-like growth factor-binding protein 6
Gene
IGFBP6
Organism
Bos taurus (Bovine)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.By similarity
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- cell migration Source: UniProtKB
Keywordsi
Molecular function | Growth factor binding |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 6Short name: IBP-6 Short name: IGF-binding protein 6 Short name: IGFBP-6 |
Gene namesi | Name:IGFBP6 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000152776 | 26 – 237 | Insulin-like growth factor-binding protein 6Add BLAST | 212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 30 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 42 | PROSITE-ProRule annotation | ||
Disulfide bondi | 55 ↔ 61 | PROSITE-ProRule annotation | ||
Disulfide bondi | 69 ↔ 82 | PROSITE-ProRule annotation | ||
Disulfide bondi | 76 ↔ 102 | PROSITE-ProRule annotation | ||
Disulfide bondi | 159 ↔ 186 | PROSITE-ProRule annotation | ||
Disulfide bondi | 197 ↔ 208 | PROSITE-ProRule annotation | ||
Disulfide bondi | 210 ↔ 231 | PROSITE-ProRule annotation |
Post-translational modificationi
O-glycosylated.Curated
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q05718 |
PRIDEi | Q05718 |
Interactioni
Subunit structurei
Interacts (via C-terminal domain) with PHB2.
By similarityGO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000028615 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 105 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 156 – 231 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 76 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QV3Q, Eukaryota |
InParanoidi | Q05718 |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022326, IGFBP-6 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF14, PTHR11551:SF14, 1 hit |
Pfami | View protein in Pfam PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01982, IGFBPFAMILY6 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q05718-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPHRLLPPL LLTLLLAARP GGALARCPGC GQGVSAGCPG GCAEEEDGGP
60 70 80 90 100
AAEGCAEAGG CLRREGQQCG VYTPNCAPGL QCQPPEKEDL PLRALLQGRG
110 120 130 140 150
RCGRARTPSG ENPKESKPQA GTARSQDVNR RDQQRNSGTS TTPSRSNSGG
160 170 180 190 200
VQDTEMGPCR KHLDSVLQQL QTEVFRGAHT LYVPNCDHRG FYRKRQCRSS
210 220 230
QGQRRGPCWC VERMGQPLPG SSEGGDGSSL CPTGSSG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 188 | H → Q in AAI10142 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110141 mRNA Translation: AAI10142.1 S52774 mRNA Translation: AAB24875.2 AY197339 Genomic DNA Translation: AAO45612.1 |
PIRi | C45403 T01404 |
RefSeqi | NP_001035585.1, NM_001040495.2 |
Genome annotation databases
GeneIDi | 404186 |
KEGGi | bta:404186 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110141 mRNA Translation: AAI10142.1 S52774 mRNA Translation: AAB24875.2 AY197339 Genomic DNA Translation: AAO45612.1 |
PIRi | C45403 T01404 |
RefSeqi | NP_001035585.1, NM_001040495.2 |
3D structure databases
SMRi | Q05718 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000028615 |
Protein family/group databases
MEROPSi | I31.952 |
Proteomic databases
PaxDbi | Q05718 |
PRIDEi | Q05718 |
Genome annotation databases
GeneIDi | 404186 |
KEGGi | bta:404186 |
Organism-specific databases
CTDi | 3489 |
Phylogenomic databases
eggNOGi | ENOG502QV3Q, Eukaryota |
InParanoidi | Q05718 |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022326, IGFBP-6 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF14, PTHR11551:SF14, 1 hit |
Pfami | View protein in Pfam PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01982, IGFBPFAMILY6 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP6_BOVIN | |
Accessioni | Q05718Primary (citable) accession number: Q05718 Secondary accession number(s): Q2YDN5, Q865L3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | May 30, 2006 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |