IGFBP5

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

fibronectin binding Source: Ensembl
insulin-like growth factor I binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to cAMP Source: Ensembl
female pregnancy Source: Ensembl
glucose homeostasis Source: Ensembl
hair follicle morphogenesis Source: Ensembl
lung alveolus development Source: Ensembl
mammary gland involution Source: Ensembl
negative regulation of growth Source: Ensembl
negative regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
negative regulation of muscle tissue development Source: Ensembl
negative regulation of osteoblast differentiation Source: Ensembl
negative regulation of skeletal muscle hypertrophy Source: Ensembl
negative regulation of smooth muscle cell migration Source: Ensembl
negative regulation of smooth muscle cell proliferation Source: Ensembl
negative regulation of translation Source: Ensembl
osteoblast differentiation Source: Ensembl
positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
positive regulation of vascular associated smooth muscle cell migration Source: Ensembl
positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
regulation of cell growth Source: Ensembl
response to growth hormone
Source: AgBase
Inferred from direct assayⁱ
- "Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells."
  Sakamoto K., Yano T., Kobayashi T., Hagino A., Aso H., Obara Y.
  Domest. Anim. Endocrinol. 32:260-272(2007) [PubMed] [Europe PMC] [Abstract]
striated muscle cell differentiation Source: Ensembl
type B pancreatic cell proliferation Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-BTA-8957275, Post-translational protein phosphorylation

Reactomeⁱ

R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-8957275, Post-translational protein phosphorylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 5 Short name: IBP-5 Short name: IGF-binding protein 5 Short name: IGFBP-5
Gene namesⁱ	Name:IGFBP5
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 2

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000152775	20 – 271	Insulin-like growth factor-binding protein 5Add BLAST		252

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	44 ↔ 58	PROSITE-ProRule annotation
Disulfide bondⁱ	66 ↔ 79	PROSITE-ProRule annotation
Modified residueⁱ	115	PhosphoserineBy similarity	1
Disulfide bondⁱ	191 ↔ 218	PROSITE-ProRule annotation
Disulfide bondⁱ	229 ↔ 240	PROSITE-ProRule annotation
Disulfide bondⁱ	242 ↔ 262	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q05717

PaxDbⁱ

Q05717

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000007062, Expressed in adult mammalian kidney and 18 other tissues

Bgeeⁱ

ENSBTAG00000007062, Expressed in adult mammalian kidney and 18 other tissues

Interactionⁱ

GO - Molecular functionⁱ

fibronectin binding Source: Ensembl
insulin-like growth factor I binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000009285

STRINGⁱ

9913.ENSBTAP00000009285

Structureⁱ

3D structure databases

SMRⁱ	Q05717
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 102	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		81
Domainⁱ	188 – 262	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		75

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG502QUPK, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155890
HOGENOMⁱ	CLU_070833_1_1_1
InParanoidⁱ	Q05717
KEGG Orthology (KO) More...KOⁱ	K23577
OMAⁱ	YTERCAL
Database of Orthologous Groups More...OrthoDBⁱ	979270at2759
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191, TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012213, IGFBP-5 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551:SF4, PTHR11551:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976, IGFBPFAMILY PR01981, IGFBPFAMILY5
SMARTⁱ	View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit
SUPFAMⁱ	SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q05717-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLTAVLLLL AACAGSAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP 
        60         70         80         90        100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL 
       110        120        130        140        150
NEKSYREQAK IERDSREHEE PTTSEMAEET YSPKIFRPKH TRISELKAEA 
       160        170        180        190        200
VKKDRRKKLT QSKFVGGAEN TAHPRVISAP EMRQKSEQGP CRRHMEASLQ 
       210        220        230        240        250
ELKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL 
       260        270 
PGMEYVDGDF QCHTFDSSNV E

Length:271

Mass (Da):30,314

Last modified:July 24, 2007 - v2

Checksum:ⁱA4CD8756DD64133D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DN511652 mRNA No translation available. BC149394 mRNA Translation: AAI49395.1 S52657 mRNA Translation: AAB24874.1
PIRⁱ	B45403
NCBI Reference Sequences More...RefSeqⁱ	NP_001098797.1, NM_001105327.2

Genome annotation databases

Ensemblⁱ	ENSBTAT00000078855; ENSBTAP00000061830; ENSBTAG00000054218
GeneIDⁱ	404185
KEGGⁱ	bta:404185

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q05717	Insulin-like growth factor-binding protein 5		PIG		271	UniRef90_Q05717
Insulin-like growth factor-binding protein 5		MONDO		310
Insulin-like growth factor-binding protein 5		PROCO		272
Insulin-like growth factor-binding protein 5		BUBBU		271
Insulin-like growth factor-binding protein 5		PHYMC		271
+39

Protein	Similar proteins		Species	Score	Length	Source
Q05717	Insulin-like growth factor-binding protein 5	)	HUMAN		272	UniRef50_P24593
Insulin-like growth factor-binding protein 5		MOUSE		271
Insulin-like growth factor-binding protein 5		RAT		271
Insulin-like growth factor-binding protein 5		PIG		271
Insulin-like growth factor-binding protein 5		CALJA		275
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DN511652 mRNA No translation available. BC149394 mRNA Translation: AAI49395.1 S52657 mRNA Translation: AAB24874.1
PIRⁱ	B45403
RefSeqⁱ	NP_001098797.1, NM_001105327.2

3D structure databases

SMRⁱ	Q05717
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000009285

STRINGⁱ

9913.ENSBTAP00000009285

Proteomic databases

PaxDbⁱ	Q05717

PaxDbⁱ

Q05717

Genome annotation databases

Ensemblⁱ	ENSBTAT00000078855; ENSBTAP00000061830; ENSBTAG00000054218
GeneIDⁱ	404185
KEGGⁱ	bta:404185

Organism-specific databases

CTDⁱ	3488

CTDⁱ

3488

Phylogenomic databases

eggNOGⁱ	ENOG502QUPK, Eukaryota
GeneTreeⁱ	ENSGT00940000155890
HOGENOMⁱ	CLU_070833_1_1_1
InParanoidⁱ	Q05717
KOⁱ	K23577
OMAⁱ	YTERCAL
OrthoDBⁱ	979270at2759
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-BTA-8957275, Post-translational protein phosphorylation

Reactomeⁱ

R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-8957275, Post-translational protein phosphorylation

Gene expression databases

Bgeeⁱ	ENSBTAG00000007062, Expressed in adult mammalian kidney and 18 other tissues

Bgeeⁱ

ENSBTAG00000007062, Expressed in adult mammalian kidney and 18 other tissues

Family and domain databases

CDDⁱ	cd00191, TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012213, IGFBP-5 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551:SF4, PTHR11551:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976, IGFBPFAMILY PR01981, IGFBPFAMILY5
SMARTⁱ	View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit
SUPFAMⁱ	SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP5_BOVIN
Accessionⁱ	Q05717Primary (citable) accession number: Q05717 Secondary accession number(s): A6QPM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	July 24, 2007
	Last modified:	October 7, 2020
	This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q05717 (IBP5_BOVIN)

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Insulin-like growth factor-binding protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ