UniProtKB - Q05716 (IBP4_BOVIN)
Protein
Insulin-like growth factor-binding protein 4
Gene
IGFBP4
Organism
Bos taurus (Bovine)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
GO - Biological processi
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Growth factor binding |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 4Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4 |
Gene namesi | Name:IGFBP4 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:30086, IGFBP4 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000014381 | 22 – 258 | Insulin-like growth factor-binding protein 4Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 53 | PROSITE-ProRule annotation | ||
Disulfide bondi | 30 ↔ 55 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 44 ↔ 56 | PROSITE-ProRule annotation | ||
Disulfide bondi | 67 ↔ 80 | PROSITE-ProRule annotation | ||
Disulfide bondi | 74 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 131 ↔ 138 | PROSITE-ProRule annotation | ||
Disulfide bondi | 174 ↔ 204 | PROSITE-ProRule annotation | ||
Disulfide bondi | 215 ↔ 226 | PROSITE-ProRule annotation | ||
Disulfide bondi | 228 ↔ 249 | PROSITE-ProRule annotation | ||
Modified residuei | 255 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q05716 |
PRIDEi | Q05716 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000008611, Expressed in liver and 18 other tissues |
ExpressionAtlasi | Q05716, baseline and differential |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
By similarityGO - Molecular functioni
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000011361 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 103 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 171 – 249 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | Q05716 |
OMAi | GLCMELA |
OrthoDBi | 979270at2759 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q05716-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSLCLMAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGKGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLVHGQGVC
110 120 130 140 150
MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRKCLQ KHLAKIRDRS
160 170 180 190 200
TSGGKMKVIG APREEARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP
210 220 230 240 250
IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH
QLADSFRE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1M0K0 | A0A3Q1M0K0_BOVIN | Insulin-like growth factor-binding ... | IGFBP4 | 290 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S52770 mRNA Translation: AAB24873.1 BC140688 mRNA Translation: AAI40689.1 |
PIRi | A45403 |
RefSeqi | NP_776982.1, NM_174557.4 |
Genome annotation databases
Ensembli | ENSBTAT00000011361; ENSBTAP00000011361; ENSBTAG00000008611 |
GeneIDi | 282262 |
KEGGi | bta:282262 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S52770 mRNA Translation: AAB24873.1 BC140688 mRNA Translation: AAI40689.1 |
PIRi | A45403 |
RefSeqi | NP_776982.1, NM_174557.4 |
3D structure databases
SMRi | Q05716 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000011361 |
Protein family/group databases
MEROPSi | I31.952 |
Proteomic databases
PaxDbi | Q05716 |
PRIDEi | Q05716 |
Genome annotation databases
Ensembli | ENSBTAT00000011361; ENSBTAP00000011361; ENSBTAG00000008611 |
GeneIDi | 282262 |
KEGGi | bta:282262 |
Organism-specific databases
CTDi | 3487 |
VGNCi | VGNC:30086, IGFBP4 |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | Q05716 |
OMAi | GLCMELA |
OrthoDBi | 979270at2759 |
TreeFami | TF331211 |
Gene expression databases
Bgeei | ENSBTAG00000008611, Expressed in liver and 18 other tissues |
ExpressionAtlasi | Q05716, baseline and differential |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP4_BOVIN | |
Accessioni | Q05716Primary (citable) accession number: Q05716 Secondary accession number(s): A5D7U8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |