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UniProtKB - Q05707 (COEA1_HUMAN)

Entry version 171 (10 Feb 2021)
Sequence version 3 (06 Feb 2007)
Previous versions | rss
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Protein

Collagen alpha-1(XIV) chain

Gene

COL14A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q05707

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1442490, Collagen degradation
R-HSA-1650814, Collagen biosynthesis and modifying enzymes
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-8948216, Collagen chain trimerization

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q05707

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XIV) chain
Alternative name(s):
Undulin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL14A1Imported
Synonyms:UND
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2191, COL14A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		120324, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q05707

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187955.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7373

MalaCards human disease database

More...MalaCardsi		COL14A1

Open Targets

More...OpenTargetsi		ENSG00000187955

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79501, Punctate palmoplantar keratoderma type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26707

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q05707, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COL14A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		125987815

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000578529 – 1796Collagen alpha-1(XIV) chainAdd BLAST1768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1384N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1388N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14674-hydroxyproline1 Publication1
Modified residuei14704-hydroxyproline; partial1 Publication1
Modified residuei14765-hydroxylysine; alternate1 Publication1
Glycosylationi1476O-linked (Gal...) hydroxylysine; alternate1 Publication1
Modified residuei14824-hydroxyproline1 Publication1
Modified residuei14855-hydroxylysine; partial1 Publication1
Glycosylationi1485O-linked (Gal...) hydroxylysine; partial1 Publication1
Modified residuei14974-hydroxyproline1 Publication1
Modified residuei15034-hydroxyproline1 Publication1
Modified residuei15174-hydroxyproline1 Publication1
Modified residuei15204-hydroxyproline1 Publication1
Modified residuei15235-hydroxylysine; partial1 Publication1
Glycosylationi1523O-linked (Gal...) hydroxylysine; partial1 Publication1
Modified residuei15265-hydroxylysine; partial1 Publication1
Glycosylationi1526O-linked (Gal...) hydroxylysine; partial1 Publication1
Modified residuei15324-hydroxyproline1 Publication1
Modified residuei15384-hydroxyproline1 Publication1
Modified residuei15444-hydroxyproline1 Publication1
Modified residuei15504-hydroxyproline1 Publication1
Modified residuei15564-hydroxyproline1 Publication1
Modified residuei15654-hydroxyproline1 Publication1
Modified residuei15684-hydroxyproline1 Publication1
Modified residuei15744-hydroxyproline1 Publication1
Modified residuei15774-hydroxyproline1 Publication1
Modified residuei15804-hydroxyproline1 Publication1
Modified residuei15954-hydroxyproline1 Publication1
Modified residuei15984-hydroxyproline1 Publication1
Modified residuei16015-hydroxylysine; alternate1 Publication1
Glycosylationi1601O-linked (Gal...) hydroxylysine; alternate1 Publication1
Modified residuei16434-hydroxyproline; partial1 Publication1
Modified residuei16564-hydroxyproline1 Publication1
Modified residuei16594-hydroxyproline1 Publication1
Modified residuei16624-hydroxyproline1 Publication1
Modified residuei16654-hydroxyproline1 Publication1
Modified residuei16684-hydroxyproline1 Publication1
Modified residuei16744-hydroxyproline1 Publication1
Modified residuei16774-hydroxyproline1 Publication1
Modified residuei16804-hydroxyproline1 Publication1
Modified residuei16864-hydroxyproline1 Publication1
Modified residuei16894-hydroxyproline1 Publication1
Modified residuei16985-hydroxylysine; alternate1 Publication1
Glycosylationi1698O-linked (Gal...) hydroxylysine; alternate1 Publication1
Modified residuei17015-hydroxylysine; alternate1 Publication1
Glycosylationi1701O-linked (Gal...) hydroxylysine; alternate1 Publication1
Modified residuei17044-hydroxyproline1 Publication1
Modified residuei17154-hydroxyproline1 Publication1
Modified residuei17264-hydroxyproline; partial1 Publication1
Modified residuei17294-hydroxyproline1 Publication1
Modified residuei17324-hydroxyproline1 Publication1
Modified residuei17354-hydroxyproline1 Publication1
Modified residuei17414-hydroxyproline1 Publication1
Modified residuei17474-hydroxyproline1 Publication1
Modified residuei17564-hydroxyproline1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity
May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q05707

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q05707

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q05707

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q05707

PeptideAtlas

More...PeptideAtlasi		Q05707

PRoteomics IDEntifications database

More...PRIDEi		Q05707

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58350 [Q05707-1]
58351 [Q05707-2]
58352 [Q05707-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1132, 18 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q05707, 18 sites, 7 O-linked glycans (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q05707

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q05707

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187955, Expressed in descending thoracic aorta and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q05707, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q05707, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187955, Tissue enhanced (enhanced)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113219, 51 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1755, Collagen type XIV trimer

Protein interaction database and analysis system

More...IntActi		Q05707, 34 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297848

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q05707, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q05707

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 122Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini158 – 330VWFA 1PROSITE-ProRule annotationAdd BLAST173
Domaini355 – 444Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini445 – 536Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini537 – 626Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini627 – 715Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST89
Domaini737 – 829Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST93
Domaini831 – 921Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST91
Domaini922 – 1010Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST89
Domaini1032 – 1205VWFA 2PROSITE-ProRule annotationAdd BLAST174
Domaini1229 – 1424Laminin G-likeAdd BLAST196
Domaini1462 – 1510Collagen-like 1Add BLAST49
Domaini1514 – 1570Collagen-like 2Add BLAST57
Domaini1571 – 1609Collagen-like 3Add BLAST39
Domaini1653 – 1705Collagen-like 4Add BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1217 – 1458Nonhelical region (NC4)Add BLAST242
Regioni1459 – 1610Triple-helical region 1 (COL2)Add BLAST152
Regioni1654 – 1779Triple-helical region 2 (COL1)Add BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1607 – 1609Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.Sequence analysis

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3544, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002527_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q05707

Identification of Orthologs from Complete Genome Data

More...OMAi		TPGFRMM

Database of Orthologous Groups

More...OrthoDBi		67372at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q05707

TreeFam database of animal gene trees

More...TreeFami		TF329914

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 8 hits
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR001791, Laminin_G
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391, Collagen, 4 hits
PF00041, fn3, 8 hits
PF00092, VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 8 hits
SM00210, TSPN, 1 hit
SM00327, VWA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 5 hits
SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 8 hits
PS50234, VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q05707-1) [UniParc]FASTAAdd to basket
Also known as: Undulin 11 Publication, Un11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW 
        60         70         80         90        100
KAPRGKFGGY KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII 
       110        120        130        140        150
AYNKDKESKP AQGQFRIKDL EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV 
       160        170        180        190        200
CQTPAIADIV ILVDGSWSIG RFNFRLVRHF LENLVTAFDV GSEKTRIGLA 
       210        220        230        240        250
QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA LNYIFENSFK 
       260        270        280        290        300
PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN 
       310        320        330        340        350
ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH 
       360        370        380        390        400
AITGPPTELI TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV 
       410        420        430        440        450
DGTVSSTVLK NLMSLTEYQI AVFAIYAHTA SEGLRGTETT LALPMASDLL 
       460        470        480        490        500
LYDVTENSMR VKWDAVPGAS GYLILYAPLT EGLAGDEKEM KIGETHTDIE 
       510        520        530        540        550
LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN LRISNVGSNS 
       560        570        580        590        600
ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT 
       610        620        630        640        650
IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD 
       660        670        680        690        700
EGLHKLMWIP VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG 
       710        720        730        740        750
SESEVVTAVG TTLDSFWTEP ATTIVPTTSV TSVFQTGIRN LVVGDETTSS 
       760        770        780        790        800
LRVKWDISDS DVQQFRVTYM TAQGDPEEEV IGTVMVPGSQ NNLLLKPLLP 
       810        820        830        840        850
DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE WYNRLRITWD 
       860        870        880        890        900
PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF 
       910        920        930        940        950
ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV 
       960        970        980        990       1000
VIESLQDRQK QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS 
      1010       1020       1030       1040       1050
IMEKTQSLPT RPPTFPPTIP PAKEVCKAAK ADLVFMVDGS WSIGDENFNK 
      1060       1070       1080       1090       1100
IISFLYSTVG ALNKIGTDGT QVAMVQFTDD PRTEFKLNAY KTKETLLDAI 
      1110       1120       1130       1140       1150
KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV ITDGRSQDDV 
      1160       1170       1180       1190       1200
NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK 
      1210       1220       1230       1240       1250
IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS 
      1260       1270       1280       1290       1300
MEPGTFNVFP CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ 
      1310       1320       1330       1340       1350
EPFALWEILN KNSDPLVGVI LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR 
      1360       1370       1380       1390       1400
KIFYGSFHKL HIVVSETLVK VVIDCKQVGE KAMNASANIT SDGVEVLGKM 
      1410       1420       1430       1440       1450
VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD DESCPDLPHS 
      1460       1470       1480       1490       1500
CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ 
      1510       1520       1530       1540       1550
GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP 
      1560       1570       1580       1590       1600
GQRGLPGKDG SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA 
      1610       1620       1630       1640       1650
KGERGERGDL QSQAMVRSVA RQVCEQLIQS HMARYTAILN QIPSHSSSIR 
      1660       1670       1680       1690       1700
TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP GNAGVPGTPG ERGLTGIKGE 
      1710       1720       1730       1740       1750
KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP PGHLGVPGPQ 
      1760       1770       1780       1790 
GPSGQPGYCD PSSCSAYGVR APHPDQPEFT PVQDELEAME LWGPGV
Length:1,796
Mass (Da):193,515
Last modified:February 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30A72F6E2CC07F70
GO
Isoform 21 Publication (identifier: Q05707-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1771-1796: APHPDQPEFTPVQDELEAMELWGPGV → DLIPYNDYQH

Show »
Length:1,780
Mass (Da):191,903
Checksum:iD0818CA6359B66D4
GO
Isoform 31 Publication (identifier: Q05707-3) [UniParc]FASTAAdd to basket
Also known as: Undulin 21 Publication, Un21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     197-291: Missing.

Show »
Length:1,701
Mass (Da):183,154
Checksum:i351A5F24379FEDF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQT7A0A0A0MQT7_HUMAN
Collagen alpha-1(XIV) chain
COL14A1
757Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT75J3QT75_HUMAN
Collagen alpha-1(XIV) chain
COL14A1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4G0W3Q4G0W3_HUMAN
COL14A1 protein
COL14A1
534Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT83J3QT83_HUMAN
Collagen alpha-1(XIV) chain
COL14A1
843Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBB2H0YBB2_HUMAN
Collagen alpha-1(XIV) chain
COL14A1
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36795 differs from that shown.Curated
The sequence AAH14640 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti616T → I in AAA36794 (PubMed:15489334).Curated1
Sequence conflicti1025V → G in AAA36794 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048772563N → H. Corresponds to variant dbSNP:rs4870723Ensembl.1
Natural variantiVAR_061113636T → A. Corresponds to variant dbSNP:rs56815167Ensembl.1
Natural variantiVAR_048773855P → L. Corresponds to variant dbSNP:rs2305606EnsemblClinVar.1
Natural variantiVAR_048774922V → I. Corresponds to variant dbSNP:rs11774228EnsemblClinVar.1
Natural variantiVAR_0487751342V → L1 PublicationCorresponds to variant dbSNP:rs17833992Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051653197 – 291Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0516541771 – 1796APHPD…WGPGV → DLIPYNDYQH in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC020603 Genomic DNA No translation available.
AC090735 Genomic DNA No translation available.
AC107877 Genomic DNA No translation available.
BC014640 mRNA Translation: AAH14640.1 Frameshift.
BC083495 mRNA Translation: AAH83495.1
BC140893 mRNA Translation: AAI40894.1
Y11709 mRNA Translation: CAA72401.1
Y11710 mRNA Translation: CAA72402.1
Y11711 mRNA Translation: CAA72403.1
M64108 mRNA Translation: AAA36794.1
M64109 mRNA Translation: AAA36795.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34938.1 [Q05707-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A40970
B40970
S37749
S46657

NCBI Reference Sequences

More...RefSeqi		NP_066933.1, NM_021110.3 [Q05707-1]
XP_005251116.1, XM_005251059.3
XP_006716714.1, XM_006716651.3 [Q05707-1]
XP_016869298.1, XM_017013809.1 [Q05707-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297848; ENSP00000297848; ENSG00000187955 [Q05707-1]
ENST00000309791; ENSP00000311809; ENSG00000187955 [Q05707-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7373

UCSC genome browser

More...UCSCi		uc003yox.5, human [Q05707-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020603 Genomic DNA No translation available.
AC090735 Genomic DNA No translation available.
AC107877 Genomic DNA No translation available.
BC014640 mRNA Translation: AAH14640.1 Frameshift.
BC083495 mRNA Translation: AAH83495.1
BC140893 mRNA Translation: AAI40894.1
Y11709 mRNA Translation: CAA72401.1
Y11710 mRNA Translation: CAA72402.1
Y11711 mRNA Translation: CAA72403.1
M64108 mRNA Translation: AAA36794.1
M64109 mRNA Translation: AAA36795.1 Sequence problems.
CCDSiCCDS34938.1 [Q05707-1]
PIRiA40970
B40970
S37749
S46657
RefSeqiNP_066933.1, NM_021110.3 [Q05707-1]
XP_005251116.1, XM_005251059.3
XP_006716714.1, XM_006716651.3 [Q05707-1]
XP_016869298.1, XM_017013809.1 [Q05707-1]

3D structure databases

SMRiQ05707
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113219, 51 interactors
ComplexPortaliCPX-1755, Collagen type XIV trimer
IntActiQ05707, 34 interactors
STRINGi9606.ENSP00000297848

PTM databases

GlyConnecti1132, 18 N-Linked glycans (4 sites)
GlyGeniQ05707, 18 sites, 7 O-linked glycans (6 sites)
iPTMnetiQ05707
PhosphoSitePlusiQ05707

Genetic variation databases

BioMutaiCOL14A1
DMDMi125987815

Proteomic databases

jPOSTiQ05707
MassIVEiQ05707
MaxQBiQ05707
PaxDbiQ05707
PeptideAtlasiQ05707
PRIDEiQ05707
ProteomicsDBi58350 [Q05707-1]
58351 [Q05707-2]
58352 [Q05707-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13712, 107 antibodies

Genome annotation databases

EnsembliENST00000297848; ENSP00000297848; ENSG00000187955 [Q05707-1]
ENST00000309791; ENSP00000311809; ENSG00000187955 [Q05707-2]
GeneIDi7373
KEGGihsa:7373
UCSCiuc003yox.5, human [Q05707-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7373
DisGeNETi7373

GeneCards: human genes, protein and diseases

More...GeneCardsi		COL14A1
HGNCiHGNC:2191, COL14A1
HPAiENSG00000187955, Tissue enhanced (enhanced)
MalaCardsiCOL14A1
MIMi120324, gene
neXtProtiNX_Q05707
OpenTargetsiENSG00000187955
Orphaneti79501, Punctate palmoplantar keratoderma type 1
PharmGKBiPA26707
VEuPathDBiHostDB:ENSG00000187955.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000153769
HOGENOMiCLU_002527_2_0_1
InParanoidiQ05707
OMAiTPGFRMM
OrthoDBi67372at2759
PhylomeDBiQ05707
TreeFamiTF329914

Enzyme and pathway databases

PathwayCommonsiQ05707
ReactomeiR-HSA-1442490, Collagen degradation
R-HSA-1650814, Collagen biosynthesis and modifying enzymes
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-8948216, Collagen chain trimerization
SIGNORiQ05707

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7373, 5 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COL14A1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Collagen,_type_XIV,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7373
PharosiQ05707, Tbio

Protein Ontology

More...PROi		PR:Q05707
RNActiQ05707, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187955, Expressed in descending thoracic aorta and 210 other tissues
ExpressionAtlasiQ05707, baseline and differential
GenevisibleiQ05707, HS

Family and domain databases

CDDicd00063, FN3, 8 hits
Gene3Di2.60.40.10, 8 hits
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR001791, Laminin_G
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF01391, Collagen, 4 hits
PF00041, fn3, 8 hits
PF00092, VWA, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 8 hits
SM00210, TSPN, 1 hit
SM00327, VWA, 2 hits
SUPFAMiSSF49265, SSF49265, 5 hits
SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 8 hits
PS50234, VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOEA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05707
Secondary accession number(s): B2RU07
, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67, Q9UDF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 6, 2007
Last modified: February 10, 2021
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with genetic variants
    List of human entries with genetic variants
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