UniProtKB - Q05707 (COEA1_HUMAN)
Protein
Collagen alpha-1(XIV) chain
Gene
COL14A1
Organism
Homo sapiens (Human)
Status
Functioni
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).By similarity1 Publication
GO - Molecular functioni
- collagen binding Source: UniProtKB
- extracellular matrix structural constituent Source: UniProtKB
- extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
- protein-macromolecule adaptor activity Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- cell-cell adhesion Source: UniProtKB
- collagen fibril organization Source: UniProtKB
- extracellular matrix organization Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q05707 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1650814, Collagen biosynthesis and modifying enzymes R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-8948216, Collagen chain trimerization |
SIGNORi | Q05707 |
Names & Taxonomyi
Protein namesi | Recommended name: Collagen alpha-1(XIV) chainAlternative name(s): Undulin |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2191, COL14A1 |
MIMi | 120324, gene |
neXtProti | NX_Q05707 |
VEuPathDBi | HostDB:ENSG00000187955.11 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- collagen type XIV trimer Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
- interstitial matrix Source: GO_Central
Other locations
- collagen trimer Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 7373 |
MalaCardsi | COL14A1 |
OpenTargetsi | ENSG00000187955 |
Orphaneti | 79501, Punctate palmoplantar keratoderma type 1 |
PharmGKBi | PA26707 |
Miscellaneous databases
Pharosi | Q05707, Tbio |
Genetic variation databases
BioMutai | COL14A1 |
DMDMi | 125987815 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000005785 | 29 – 1796 | Collagen alpha-1(XIV) chainAdd BLAST | 1768 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 94 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 372 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1384 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1388 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 1467 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1470 | 4-hydroxyproline; partial1 Publication | 1 | |
Modified residuei | 1476 | 5-hydroxylysine; alternate1 Publication | 1 | |
Glycosylationi | 1476 | O-linked (Gal...) hydroxylysine; alternate1 Publication | 1 | |
Modified residuei | 1482 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1485 | 5-hydroxylysine; partial1 Publication | 1 | |
Glycosylationi | 1485 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 | |
Modified residuei | 1497 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1503 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1517 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1520 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1523 | 5-hydroxylysine; partial1 Publication | 1 | |
Glycosylationi | 1523 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 | |
Modified residuei | 1526 | 5-hydroxylysine; partial1 Publication | 1 | |
Glycosylationi | 1526 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 | |
Modified residuei | 1532 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1538 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1544 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1550 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1556 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1565 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1568 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1574 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1577 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1580 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1595 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1598 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1601 | 5-hydroxylysine; alternate1 Publication | 1 | |
Glycosylationi | 1601 | O-linked (Gal...) hydroxylysine; alternate1 Publication | 1 | |
Modified residuei | 1643 | 4-hydroxyproline; partial1 Publication | 1 | |
Modified residuei | 1656 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1659 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1662 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1665 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1668 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1674 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1677 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1680 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1686 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1689 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1698 | 5-hydroxylysine; alternate1 Publication | 1 | |
Glycosylationi | 1698 | O-linked (Gal...) hydroxylysine; alternate1 Publication | 1 | |
Modified residuei | 1701 | 5-hydroxylysine; alternate1 Publication | 1 | |
Glycosylationi | 1701 | O-linked (Gal...) hydroxylysine; alternate1 Publication | 1 | |
Modified residuei | 1704 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1715 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1726 | 4-hydroxyproline; partial1 Publication | 1 | |
Modified residuei | 1729 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1732 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1735 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1741 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1747 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 1756 | 4-hydroxyproline1 Publication | 1 |
Post-translational modificationi
Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity
May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
jPOSTi | Q05707 |
MassIVEi | Q05707 |
MaxQBi | Q05707 |
PaxDbi | Q05707 |
PeptideAtlasi | Q05707 |
PRIDEi | Q05707 |
ProteomicsDBi | 58350 [Q05707-1] 58351 [Q05707-2] 58352 [Q05707-3] |
PTM databases
GlyConnecti | 1132, 18 N-Linked glycans (4 sites) |
GlyGeni | Q05707, 18 sites, 7 O-linked glycans (6 sites) |
iPTMneti | Q05707 |
PhosphoSitePlusi | Q05707 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187955, Expressed in descending thoracic aorta and 210 other tissues |
ExpressionAtlasi | Q05707, baseline and differential |
Genevisiblei | Q05707, HS |
Organism-specific databases
HPAi | ENSG00000187955, Tissue enhanced (enhanced) |
Interactioni
Subunit structurei
Homotrimer.
By similarityProtein-protein interaction databases
BioGRIDi | 113219, 51 interactors |
ComplexPortali | CPX-1755, Collagen type XIV trimer |
IntActi | Q05707, 34 interactors |
STRINGi | 9606.ENSP00000297848 |
Miscellaneous databases
RNActi | Q05707, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 122 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 158 – 330 | VWFA 1PROSITE-ProRule annotationAdd BLAST | 173 | |
Domaini | 355 – 444 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 445 – 536 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 537 – 626 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 627 – 715 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 737 – 829 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 831 – 921 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 922 – 1010 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 1032 – 1205 | VWFA 2PROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 1229 – 1424 | Laminin G-likeAdd BLAST | 196 | |
Domaini | 1462 – 1510 | Collagen-like 1Add BLAST | 49 | |
Domaini | 1514 – 1570 | Collagen-like 2Add BLAST | 57 | |
Domaini | 1571 – 1609 | Collagen-like 3Add BLAST | 39 | |
Domaini | 1653 – 1705 | Collagen-like 4Add BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1217 – 1458 | Nonhelical region (NC4)Add BLAST | 242 | |
Regioni | 1459 – 1610 | Triple-helical region 1 (COL2)Add BLAST | 152 | |
Regioni | 1654 – 1779 | Triple-helical region 2 (COL1)Add BLAST | 126 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1607 – 1609 | Cell attachment siteSequence analysis | 3 |
Sequence similaritiesi
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.Sequence analysis
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000153769 |
HOGENOMi | CLU_002527_2_0_1 |
InParanoidi | Q05707 |
OMAi | TPGFRMM |
OrthoDBi | 67372at2759 |
PhylomeDBi | Q05707 |
TreeFami | TF329914 |
Family and domain databases
CDDi | cd00063, FN3, 8 hits |
Gene3Di | 2.60.40.10, 8 hits 3.40.50.410, 2 hits |
InterProi | View protein in InterPro IPR008160, Collagen IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR001791, Laminin_G IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF01391, Collagen, 4 hits PF00041, fn3, 8 hits PF00092, VWA, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 8 hits SM00210, TSPN, 1 hit SM00327, VWA, 2 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF49899, SSF49899, 1 hit SSF53300, SSF53300, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 8 hits PS50234, VWFA, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q05707-1) [UniParc]FASTAAdd to basket
Also known as: Undulin 11 Publication, Un11 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW
60 70 80 90 100
KAPRGKFGGY KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII
110 120 130 140 150
AYNKDKESKP AQGQFRIKDL EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV
160 170 180 190 200
CQTPAIADIV ILVDGSWSIG RFNFRLVRHF LENLVTAFDV GSEKTRIGLA
210 220 230 240 250
QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA LNYIFENSFK
260 270 280 290 300
PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN
310 320 330 340 350
ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH
360 370 380 390 400
AITGPPTELI TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV
410 420 430 440 450
DGTVSSTVLK NLMSLTEYQI AVFAIYAHTA SEGLRGTETT LALPMASDLL
460 470 480 490 500
LYDVTENSMR VKWDAVPGAS GYLILYAPLT EGLAGDEKEM KIGETHTDIE
510 520 530 540 550
LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN LRISNVGSNS
560 570 580 590 600
ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT
610 620 630 640 650
IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD
660 670 680 690 700
EGLHKLMWIP VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG
710 720 730 740 750
SESEVVTAVG TTLDSFWTEP ATTIVPTTSV TSVFQTGIRN LVVGDETTSS
760 770 780 790 800
LRVKWDISDS DVQQFRVTYM TAQGDPEEEV IGTVMVPGSQ NNLLLKPLLP
810 820 830 840 850
DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE WYNRLRITWD
860 870 880 890 900
PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF
910 920 930 940 950
ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV
960 970 980 990 1000
VIESLQDRQK QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS
1010 1020 1030 1040 1050
IMEKTQSLPT RPPTFPPTIP PAKEVCKAAK ADLVFMVDGS WSIGDENFNK
1060 1070 1080 1090 1100
IISFLYSTVG ALNKIGTDGT QVAMVQFTDD PRTEFKLNAY KTKETLLDAI
1110 1120 1130 1140 1150
KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV ITDGRSQDDV
1160 1170 1180 1190 1200
NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK
1210 1220 1230 1240 1250
IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS
1260 1270 1280 1290 1300
MEPGTFNVFP CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ
1310 1320 1330 1340 1350
EPFALWEILN KNSDPLVGVI LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR
1360 1370 1380 1390 1400
KIFYGSFHKL HIVVSETLVK VVIDCKQVGE KAMNASANIT SDGVEVLGKM
1410 1420 1430 1440 1450
VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD DESCPDLPHS
1460 1470 1480 1490 1500
CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ
1510 1520 1530 1540 1550
GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP
1560 1570 1580 1590 1600
GQRGLPGKDG SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA
1610 1620 1630 1640 1650
KGERGERGDL QSQAMVRSVA RQVCEQLIQS HMARYTAILN QIPSHSSSIR
1660 1670 1680 1690 1700
TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP GNAGVPGTPG ERGLTGIKGE
1710 1720 1730 1740 1750
KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP PGHLGVPGPQ
1760 1770 1780 1790
GPSGQPGYCD PSSCSAYGVR APHPDQPEFT PVQDELEAME LWGPGV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MQT7 | A0A0A0MQT7_HUMAN | Collagen alpha-1(XIV) chain | COL14A1 | 757 | Annotation score: | ||
J3QT75 | J3QT75_HUMAN | Collagen alpha-1(XIV) chain | COL14A1 | 149 | Annotation score: | ||
Q4G0W3 | Q4G0W3_HUMAN | COL14A1 protein | COL14A1 | 534 | Annotation score: | ||
J3QT83 | J3QT83_HUMAN | Collagen alpha-1(XIV) chain | COL14A1 | 843 | Annotation score: | ||
H0YBB2 | H0YBB2_HUMAN | Collagen alpha-1(XIV) chain | COL14A1 | 336 | Annotation score: |
Sequence cautioni
The sequence AAA36795 differs from that shown.Curated
The sequence AAH14640 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 616 | T → I in AAA36794 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1025 | V → G in AAA36794 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048772 | 563 | N → H. Corresponds to variant dbSNP:rs4870723Ensembl. | 1 | |
Natural variantiVAR_061113 | 636 | T → A. Corresponds to variant dbSNP:rs56815167Ensembl. | 1 | |
Natural variantiVAR_048773 | 855 | P → L. Corresponds to variant dbSNP:rs2305606EnsemblClinVar. | 1 | |
Natural variantiVAR_048774 | 922 | V → I. Corresponds to variant dbSNP:rs11774228EnsemblClinVar. | 1 | |
Natural variantiVAR_048775 | 1342 | V → L1 PublicationCorresponds to variant dbSNP:rs17833992Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051653 | 197 – 291 | Missing in isoform 3. 1 PublicationAdd BLAST | 95 | |
Alternative sequenceiVSP_051654 | 1771 – 1796 | APHPD…WGPGV → DLIPYNDYQH in isoform 2. 1 PublicationAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020603 Genomic DNA No translation available. AC090735 Genomic DNA No translation available. AC107877 Genomic DNA No translation available. BC014640 mRNA Translation: AAH14640.1 Frameshift. BC083495 mRNA Translation: AAH83495.1 BC140893 mRNA Translation: AAI40894.1 Y11709 mRNA Translation: CAA72401.1 Y11710 mRNA Translation: CAA72402.1 Y11711 mRNA Translation: CAA72403.1 M64108 mRNA Translation: AAA36794.1 M64109 mRNA Translation: AAA36795.1 Sequence problems. |
CCDSi | CCDS34938.1 [Q05707-1] |
PIRi | A40970 B40970 S37749 S46657 |
RefSeqi | NP_066933.1, NM_021110.3 [Q05707-1] XP_005251116.1, XM_005251059.3 XP_006716714.1, XM_006716651.3 [Q05707-1] XP_016869298.1, XM_017013809.1 [Q05707-1] |
Genome annotation databases
Ensembli | ENST00000297848; ENSP00000297848; ENSG00000187955 [Q05707-1] ENST00000309791; ENSP00000311809; ENSG00000187955 [Q05707-2] |
GeneIDi | 7373 |
KEGGi | hsa:7373 |
UCSCi | uc003yox.5, human [Q05707-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020603 Genomic DNA No translation available. AC090735 Genomic DNA No translation available. AC107877 Genomic DNA No translation available. BC014640 mRNA Translation: AAH14640.1 Frameshift. BC083495 mRNA Translation: AAH83495.1 BC140893 mRNA Translation: AAI40894.1 Y11709 mRNA Translation: CAA72401.1 Y11710 mRNA Translation: CAA72402.1 Y11711 mRNA Translation: CAA72403.1 M64108 mRNA Translation: AAA36794.1 M64109 mRNA Translation: AAA36795.1 Sequence problems. |
CCDSi | CCDS34938.1 [Q05707-1] |
PIRi | A40970 B40970 S37749 S46657 |
RefSeqi | NP_066933.1, NM_021110.3 [Q05707-1] XP_005251116.1, XM_005251059.3 XP_006716714.1, XM_006716651.3 [Q05707-1] XP_016869298.1, XM_017013809.1 [Q05707-1] |
3D structure databases
SMRi | Q05707 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113219, 51 interactors |
ComplexPortali | CPX-1755, Collagen type XIV trimer |
IntActi | Q05707, 34 interactors |
STRINGi | 9606.ENSP00000297848 |
PTM databases
GlyConnecti | 1132, 18 N-Linked glycans (4 sites) |
GlyGeni | Q05707, 18 sites, 7 O-linked glycans (6 sites) |
iPTMneti | Q05707 |
PhosphoSitePlusi | Q05707 |
Genetic variation databases
BioMutai | COL14A1 |
DMDMi | 125987815 |
Proteomic databases
jPOSTi | Q05707 |
MassIVEi | Q05707 |
MaxQBi | Q05707 |
PaxDbi | Q05707 |
PeptideAtlasi | Q05707 |
PRIDEi | Q05707 |
ProteomicsDBi | 58350 [Q05707-1] 58351 [Q05707-2] 58352 [Q05707-3] |
Protocols and materials databases
Antibodypediai | 13712, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000297848; ENSP00000297848; ENSG00000187955 [Q05707-1] ENST00000309791; ENSP00000311809; ENSG00000187955 [Q05707-2] |
GeneIDi | 7373 |
KEGGi | hsa:7373 |
UCSCi | uc003yox.5, human [Q05707-1] |
Organism-specific databases
CTDi | 7373 |
DisGeNETi | 7373 |
GeneCardsi | COL14A1 |
HGNCi | HGNC:2191, COL14A1 |
HPAi | ENSG00000187955, Tissue enhanced (enhanced) |
MalaCardsi | COL14A1 |
MIMi | 120324, gene |
neXtProti | NX_Q05707 |
OpenTargetsi | ENSG00000187955 |
Orphaneti | 79501, Punctate palmoplantar keratoderma type 1 |
PharmGKBi | PA26707 |
VEuPathDBi | HostDB:ENSG00000187955.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000153769 |
HOGENOMi | CLU_002527_2_0_1 |
InParanoidi | Q05707 |
OMAi | TPGFRMM |
OrthoDBi | 67372at2759 |
PhylomeDBi | Q05707 |
TreeFami | TF329914 |
Enzyme and pathway databases
PathwayCommonsi | Q05707 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1650814, Collagen biosynthesis and modifying enzymes R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-8948216, Collagen chain trimerization |
SIGNORi | Q05707 |
Miscellaneous databases
BioGRID-ORCSi | 7373, 5 hits in 875 CRISPR screens |
ChiTaRSi | COL14A1, human |
GeneWikii | Collagen,_type_XIV,_alpha_1 |
GenomeRNAii | 7373 |
Pharosi | Q05707, Tbio |
PROi | PR:Q05707 |
RNActi | Q05707, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187955, Expressed in descending thoracic aorta and 210 other tissues |
ExpressionAtlasi | Q05707, baseline and differential |
Genevisiblei | Q05707, HS |
Family and domain databases
CDDi | cd00063, FN3, 8 hits |
Gene3Di | 2.60.40.10, 8 hits 3.40.50.410, 2 hits |
InterProi | View protein in InterPro IPR008160, Collagen IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR001791, Laminin_G IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF01391, Collagen, 4 hits PF00041, fn3, 8 hits PF00092, VWA, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 8 hits SM00210, TSPN, 1 hit SM00327, VWA, 2 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF49899, SSF49899, 1 hit SSF53300, SSF53300, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 8 hits PS50234, VWFA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COEA1_HUMAN | |
Accessioni | Q05707Primary (citable) accession number: Q05707 Secondary accession number(s): B2RU07 Q9UDF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 10, 2021 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants