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Protein

Folate receptor beta

Gene

Folr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95FolateBy similarity1
Binding sitei99FolateBy similarity1
Binding sitei188FolateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-196757 Metabolism of folate and pterines

Names & Taxonomyi

Protein namesi
Recommended name:
Folate receptor beta
Short name:
FR-beta
Alternative name(s):
Folate receptor 2
Folate-binding protein 2
Gene namesi
Name:Folr2
Synonyms:Fbp2, Folbp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95569 Folr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000880821 – 227Folate receptor betaAdd BLAST207
PropeptideiPRO_0000008809228 – 251Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi50 ↔ 97By similarity
Disulfide bondi59 ↔ 101By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 167By similarity
Disulfide bondi88 ↔ 138By similarity
Disulfide bondi127 ↔ 201By similarity
Disulfide bondi131 ↔ 181By similarity
Disulfide bondi144 ↔ 161By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi227GPI-anchor amidated serineSequence analysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ05685
PaxDbiQ05685
PRIDEiQ05685

Expressioni

Gene expression databases

BgeeiENSMUSG00000032725 Expressed in 104 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_FBP2
MM_FOLR2
ExpressionAtlasiQ05685 baseline and differential
GenevisibleiQ05685 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091692

Structurei

3D structure databases

ProteinModelPortaliQ05685
SMRiQ05685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 120Folate bindingBy similarity5
Regioni149 – 154Folate bindingBy similarity6

Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiQ05685
KOiK13649
OMAiELYGQCS
OrthoDBiEOG091G0GIA
PhylomeDBiQ05685
TreeFamiTF328532

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032937 FOLR2
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF8 PTHR10517:SF8, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q05685-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWKQTPLLL LVYMVTTGSG RDRTDLLNVC MDAKHHKTKP GPEDKLHDQC
60 70 80 90 100
SPWKKNACCS VNTSQELHKA DSRLYFNWDH CGKMEPACKS HFIQDSCLYE
110 120 130 140 150
CSPNLGPWIQ QVDQSWRKER FLDVPLCKED CHQWWEACRT SFTCKRDWHK
160 170 180 190 200
GWDWSSGINK CPNTAPCHTF EYYFPTPASL CEGLWSHSYK VSNYSRGSGR
210 220 230 240 250
CIQMWFDSTQ GNPNEDVVKF YASFMTSGTV PHAAVLLVPS LAPVLSLWLP

G
Length:251
Mass (Da):28,821
Last modified:June 1, 1994 - v1
Checksum:i8404EACEB1BFECC7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSV4A0A1B0GSV4_MOUSE
Folate receptor beta
Folr2
177Annotation score:
A0A1B0GQW7A0A1B0GQW7_MOUSE
Folate receptor beta
Folr2
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64817 mRNA Translation: AAA37599.1
BC022108 mRNA Translation: AAH22108.1
L25338 Genomic DNA Translation: AAA37594.1
CCDSiCCDS21516.1
PIRiB40969
RefSeqiNP_001290160.1, NM_001303231.1
NP_001290168.1, NM_001303239.1
NP_032061.1, NM_008035.2
UniGeneiMm.439666

Genome annotation databases

EnsembliENSMUST00000094141; ENSMUSP00000091692; ENSMUSG00000032725
ENSMUST00000210598; ENSMUSP00000147920; ENSMUSG00000032725
GeneIDi14276
KEGGimmu:14276
UCSCiuc009ipk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64817 mRNA Translation: AAA37599.1
BC022108 mRNA Translation: AAH22108.1
L25338 Genomic DNA Translation: AAA37594.1
CCDSiCCDS21516.1
PIRiB40969
RefSeqiNP_001290160.1, NM_001303231.1
NP_001290168.1, NM_001303239.1
NP_032061.1, NM_008035.2
UniGeneiMm.439666

3D structure databases

ProteinModelPortaliQ05685
SMRiQ05685
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091692

Proteomic databases

MaxQBiQ05685
PaxDbiQ05685
PRIDEiQ05685

Protocols and materials databases

DNASUi14276
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094141; ENSMUSP00000091692; ENSMUSG00000032725
ENSMUST00000210598; ENSMUSP00000147920; ENSMUSG00000032725
GeneIDi14276
KEGGimmu:14276
UCSCiuc009ipk.2 mouse

Organism-specific databases

CTDi2350
MGIiMGI:95569 Folr2

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiQ05685
KOiK13649
OMAiELYGQCS
OrthoDBiEOG091G0GIA
PhylomeDBiQ05685
TreeFamiTF328532

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-196757 Metabolism of folate and pterines

Miscellaneous databases

PROiPR:Q05685
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032725 Expressed in 104 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_FBP2
MM_FOLR2
ExpressionAtlasiQ05685 baseline and differential
GenevisibleiQ05685 MM

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032937 FOLR2
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF8 PTHR10517:SF8, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOLR2_MOUSE
AccessioniPrimary (citable) accession number: Q05685
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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