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Protein

Caldesmon

Gene

CALD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: ProtInc
  • cadherin binding Source: BHF-UCL
  • calmodulin binding Source: ProtInc
  • myosin binding Source: InterPro
  • tropomyosin binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Muscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-445355 Smooth Muscle Contraction

SIGNOR Signaling Network Open Resource

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SIGNORi
Q05682

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caldesmon
Short name:
CDM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALD1
Synonyms:CAD, CDM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000122786.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1441 CALD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
114213 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05682

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
800

Open Targets

More...
OpenTargetsi
ENSG00000122786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26034

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CALD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
338817891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892881 – 793CaldesmonAdd BLAST793

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei129PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki459Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei643PhosphoserineCombined sources1
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei656PhosphoserineCombined sources1
Modified residuei724PhosphoserineCombined sources1
Modified residuei730PhosphothreonineCombined sources1
Modified residuei753PhosphothreonineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei789PhosphoserineCombined sources1
Isoform 3 (identifier: Q05682-3)
Modified residuei12PhosphoserineCombined sources1
Modified residuei21PhosphotyrosineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Isoform 5 (identifier: Q05682-5)
Modified residuei12PhosphoserineCombined sources1
Modified residuei21PhosphotyrosineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q05682-2)
Modified residuei202PhosphoserineCombined sources1
Isoform 4 (identifier: Q05682-4)
Modified residuei202PhosphoserineCombined sources1
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 6 (identifier: Q05682-6)
Modified residuei202PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q05682

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05682

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05682

PeptideAtlas

More...
PeptideAtlasi
Q05682

PRoteomics IDEntifications database

More...
PRIDEi
Q05682

ProteomicsDB human proteome resource

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ProteomicsDBi
58344
58345 [Q05682-2]
58346 [Q05682-3]
58347 [Q05682-4]
58348 [Q05682-5]
58349 [Q05682-6]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q05682

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05682

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05682

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q05682

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122786 Expressed in 244 organ(s), highest expression level in cauda epididymis

CleanEx database of gene expression profiles

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CleanExi
HS_CAD
HS_CALD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q05682 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q05682 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000006
HPA008066
HPA017330

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-1642116,EBI-717399

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107251, 49 interactors

Protein interaction database and analysis system

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IntActi
Q05682, 31 interactors

Molecular INTeraction database

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MINTi
Q05682

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354826

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q05682

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati319 – 3321Add BLAST14
Repeati333 – 3462Add BLAST14
Repeati347 – 3603Add BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 207Myosin and calmodulin-bindingBy similarityAdd BLAST182
Regioni319 – 3753 X 14 AA tandem repeats of E-E-E-K-R-A-A-E-E-R-Q-R-I-KAdd BLAST57
Regioni564 – 621Tropomyosin-bindingSequence analysisAdd BLAST58
Regioni653 – 686Strong actin-bindingBy similarityAdd BLAST34
Regioni664 – 674Tropomyosin-bindingSequence analysisAdd BLAST11
Regioni716 – 722Calmodulin-bindingBy similarity7
Regioni768 – 793Weak actin-bindingBy similarityAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 46Poly-Arg8
Compositional biasi81 – 86Poly-Thr6
Compositional biasi189 – 196Poly-Glu8
Compositional biasi376 – 379Poly-Glu4
Compositional biasi540 – 543Poly-Arg4
Compositional biasi580 – 583Poly-Glu4
Compositional biasi597 – 600Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the caldesmon family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH1F Eukaryota
ENOG410ZMZI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013012

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050785

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q05682

KEGG Orthology (KO)

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KOi
K12327

Identification of Orthologs from Complete Genome Data

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OMAi
SYQRNNW

Database of Orthologous Groups

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OrthoDBi
EOG091G0I0H

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05682

TreeFam database of animal gene trees

More...
TreeFami
TF331771

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006017 Caldesmon
IPR006018 Caldesmon_LSP

The PANTHER Classification System

More...
PANTHERi
PTHR18949 PTHR18949, 1 hit
PTHR18949:SF0 PTHR18949:SF0, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02029 Caldesmon, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01076 CALDESMON

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05682-1) [UniParc]FASTAAdd to basket
Also known as: H-CAD

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDFERRREL RRQKREEMRL EAERIAYQRN DDDEEEAARE RRRRARQERL
60 70 80 90 100
RQKQEEESLG QVTDQVEVNA QNSVPDEEAK TTTTNTQVEG DDEAAFLERL
110 120 130 140 150
ARREERRQKR LQEALERQKE FDPTITDASL SLPSRRMQND TAENETTEKE
160 170 180 190 200
EKSESRQERY EIEETETVTK SYQKNDWRDA EENKKEDKEK EEEEEEKPKR
210 220 230 240 250
GSIGENQVEV MVEEKTTESQ EETVVMSLKN GQISSEEPKQ EEEREQGSDE
260 270 280 290 300
ISHHEKMEEE DKERAEAERA RLEAEERERI KAEQDKKIAD ERARIEAEEK
310 320 330 340 350
AAAQERERRE AEERERMREE EKRAAEERQR IKEEEKRAAE ERQRIKEEEK
360 370 380 390 400
RAAEERQRIK EEEKRAAEER QRARAEEEEK AKVEEQKRNK QLEEKKHAMQ
410 420 430 440 450
ETKIKGEKVE QKIEGKWVNE KKAQEDKLQT AVLKKQGEEK GTKVQAKREK
460 470 480 490 500
LQEDKPTFKK EEIKDEKIKK DKEPKEEVKS FMDRKKGFTE VKSQNGEFMT
510 520 530 540 550
HKLKHTENTF SRPGGRASVD TKEAEGAPQV EAGKRLEELR RRRGETESEE
560 570 580 590 600
FEKLKQKQQE AALELEELKK KREERRKVLE EEEQRRKQEE ADRKLREEEE
610 620 630 640 650
KRRLKEEIER RRAEAAEKRQ KMPEDGLSDD KKPFKCFTPK GSSLKIEERA
660 670 680 690 700
EFLNKSVQKS SGVKSTHQAA IVSKIDSRLE QYTSAIEGTK SAKPTKPAAS
710 720 730 740 750
DLPVPAEGVR NIKSMWEKGN VFSSPTAAGT PNKETAGLKV GVSSRINEWL
760 770 780 790
TKTPDGNKSP APKPSDLRPG DVSSKRNLWE KQSVDKVTSP TKV
Length:793
Mass (Da):93,231
Last modified:June 28, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7468E2C3E40BF697
GO
Isoform 2 (identifier: Q05682-2) [UniParc]FASTAAdd to basket
Also known as: WI-38 L-CAD I

The sequence of this isoform differs from the canonical sequence as follows:
     208-436: Missing.

Show »
Length:564
Mass (Da):65,707
Checksum:i57791B75720D2902
GO
Isoform 3 (identifier: Q05682-3) [UniParc]FASTAAdd to basket
Also known as: HELA L-CAD I

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MDDFERRRELRRQKREEMRLEAER → MLGGSGSHGRRSLAALSQ
     208-436: Missing.

Show »
Length:558
Mass (Da):64,256
Checksum:iAA511974B9C483DC
GO
Isoform 4 (identifier: Q05682-4) [UniParc]FASTAAdd to basket
Also known as: WI-38 L-CAD II, 1-CAD

The sequence of this isoform differs from the canonical sequence as follows:
     208-462: Missing.

Show »
Length:538
Mass (Da):62,663
Checksum:i7EBF78B53217E77A
GO
Isoform 5 (identifier: Q05682-5) [UniParc]FASTAAdd to basket
Also known as: HELA L-CAD II

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MDDFERRRELRRQKREEMRLEAER → MLGGSGSHGRRSLAALSQ
     208-462: Missing.

Show »
Length:532
Mass (Da):61,213
Checksum:i2A222B2C1AD79975
GO
Isoform 6 (identifier: Q05682-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-436: Missing.
     660-660: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:563
Mass (Da):65,620
Checksum:iFF15BFCFCF19C248
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX44E7EX44_HUMAN
Caldesmon
CALD1
557Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J813C9J813_HUMAN
Caldesmon
CALD1
459Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGZ1E9PGZ1_HUMAN
Caldesmon
CALD1
536Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE61F8WE61_HUMAN
Caldesmon
CALD1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEK3C9JEK3_HUMAN
Caldesmon
CALD1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JE79C9JE79_HUMAN
Caldesmon
CALD1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti530V → M in AAA35636 (PubMed:1885618).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065254397H → R1 PublicationCorresponds to variant dbSNP:rs6973420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0041541 – 24MDDFE…LEAER → MLGGSGSHGRRSLAALSQ in isoform 3 and isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_004156208 – 462Missing in isoform 4 and isoform 5. 4 PublicationsAdd BLAST255
Alternative sequenceiVSP_004155208 – 436Missing in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST229
Alternative sequenceiVSP_043292660Missing in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M64110 mRNA Translation: AAA35636.1
M83216 mRNA Translation: AAA58420.1
M83216 mRNA Translation: AAA58419.1
D90452 mRNA Translation: BAA14418.1
D90453 mRNA Translation: BAA14419.1
AK289686 mRNA Translation: BAF82375.1
AC019014 Genomic DNA No translation available.
AC083870 Genomic DNA No translation available.
BC040354 mRNA Translation: AAH40354.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47716.1 [Q05682-3]
CCDS47717.1 [Q05682-5]
CCDS5834.1 [Q05682-4]
CCDS5835.1 [Q05682-1]
CCDS5836.2 [Q05682-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
JH0628

NCBI Reference Sequences

More...
RefSeqi
NP_004333.1, NM_004342.6 [Q05682-4]
NP_149129.2, NM_033138.3 [Q05682-1]
NP_149130.1, NM_033139.3 [Q05682-3]
NP_149131.1, NM_033140.3 [Q05682-5]
NP_149347.2, NM_033157.3 [Q05682-6]
XP_016868140.1, XM_017012651.1
XP_016868141.1, XM_017012652.1 [Q05682-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.490203

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361675; ENSP00000354826; ENSG00000122786 [Q05682-1]
ENST00000361901; ENSP00000354513; ENSG00000122786 [Q05682-4]
ENST00000393118; ENSP00000376826; ENSG00000122786 [Q05682-3]
ENST00000417172; ENSP00000398826; ENSG00000122786 [Q05682-4]
ENST00000422748; ENSP00000395710; ENSG00000122786 [Q05682-6]
ENST00000424922; ENSP00000393621; ENSG00000122786 [Q05682-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
800

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:800

UCSC genome browser

More...
UCSCi
uc003vrz.4 human [Q05682-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64110 mRNA Translation: AAA35636.1
M83216 mRNA Translation: AAA58420.1
M83216 mRNA Translation: AAA58419.1
D90452 mRNA Translation: BAA14418.1
D90453 mRNA Translation: BAA14419.1
AK289686 mRNA Translation: BAF82375.1
AC019014 Genomic DNA No translation available.
AC083870 Genomic DNA No translation available.
BC040354 mRNA Translation: AAH40354.1
CCDSiCCDS47716.1 [Q05682-3]
CCDS47717.1 [Q05682-5]
CCDS5834.1 [Q05682-4]
CCDS5835.1 [Q05682-1]
CCDS5836.2 [Q05682-6]
PIRiJH0628
RefSeqiNP_004333.1, NM_004342.6 [Q05682-4]
NP_149129.2, NM_033138.3 [Q05682-1]
NP_149130.1, NM_033139.3 [Q05682-3]
NP_149131.1, NM_033140.3 [Q05682-5]
NP_149347.2, NM_033157.3 [Q05682-6]
XP_016868140.1, XM_017012651.1
XP_016868141.1, XM_017012652.1 [Q05682-4]
UniGeneiHs.490203

3D structure databases

ProteinModelPortaliQ05682
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107251, 49 interactors
IntActiQ05682, 31 interactors
MINTiQ05682
STRINGi9606.ENSP00000354826

PTM databases

iPTMnetiQ05682
PhosphoSitePlusiQ05682
SwissPalmiQ05682

Polymorphism and mutation databases

BioMutaiCALD1
DMDMi338817891

2D gel databases

OGPiQ05682

Proteomic databases

EPDiQ05682
MaxQBiQ05682
PaxDbiQ05682
PeptideAtlasiQ05682
PRIDEiQ05682
ProteomicsDBi58344
58345 [Q05682-2]
58346 [Q05682-3]
58347 [Q05682-4]
58348 [Q05682-5]
58349 [Q05682-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
800
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361675; ENSP00000354826; ENSG00000122786 [Q05682-1]
ENST00000361901; ENSP00000354513; ENSG00000122786 [Q05682-4]
ENST00000393118; ENSP00000376826; ENSG00000122786 [Q05682-3]
ENST00000417172; ENSP00000398826; ENSG00000122786 [Q05682-4]
ENST00000422748; ENSP00000395710; ENSG00000122786 [Q05682-6]
ENST00000424922; ENSP00000393621; ENSG00000122786 [Q05682-5]
GeneIDi800
KEGGihsa:800
UCSCiuc003vrz.4 human [Q05682-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
800
DisGeNETi800
EuPathDBiHostDB:ENSG00000122786.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CALD1
HGNCiHGNC:1441 CALD1
HPAiCAB000006
HPA008066
HPA017330
MIMi114213 gene
neXtProtiNX_Q05682
OpenTargetsiENSG00000122786
PharmGKBiPA26034

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH1F Eukaryota
ENOG410ZMZI LUCA
GeneTreeiENSGT00940000153901
HOGENOMiHOG000013012
HOVERGENiHBG050785
InParanoidiQ05682
KOiK12327
OMAiSYQRNNW
OrthoDBiEOG091G0I0H
PhylomeDBiQ05682
TreeFamiTF331771

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
SIGNORiQ05682

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CALD1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Caldesmon

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
800

Protein Ontology

More...
PROi
PR:Q05682

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122786 Expressed in 244 organ(s), highest expression level in cauda epididymis
CleanExiHS_CAD
HS_CALD1
ExpressionAtlasiQ05682 baseline and differential
GenevisibleiQ05682 HS

Family and domain databases

InterProiView protein in InterPro
IPR006017 Caldesmon
IPR006018 Caldesmon_LSP
PANTHERiPTHR18949 PTHR18949, 1 hit
PTHR18949:SF0 PTHR18949:SF0, 1 hit
PfamiView protein in Pfam
PF02029 Caldesmon, 2 hits
PRINTSiPR01076 CALDESMON

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCALD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05682
Secondary accession number(s): A8K0X1
, Q13978, Q13979, Q14741, Q14742, Q9UD91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 28, 2011
Last modified: December 5, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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