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Entry version 55 (22 Apr 2020)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Erythrocyte-binding antigen-175

Gene

EBA-175

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Erythrocyte-binding antigen-175Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EBA-175Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416457722 – 1421Sequence analysisAdd BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 189Combined sources
Disulfide bondi169 ↔ 180Combined sources
Disulfide bondi232 ↔ 310Combined sources
Disulfide bondi346 ↔ 359Combined sources
Disulfide bondi355 ↔ 427Combined sources
Disulfide bondi363 ↔ 425Combined sources
Disulfide bondi462 ↔ 497Combined sources
Disulfide bondi476 ↔ 488Combined sources
Disulfide bondi540 ↔ 615Combined sources
Disulfide bondi638 ↔ 718Combined sources
Disulfide bondi652 ↔ 662Combined sources
Disulfide bondi666 ↔ 739Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05644

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1336 – 1415EBA-175_VIInterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni756 – 1102DisorderedSequence analysisAdd BLAST347
Regioni1115 – 1170DisorderedSequence analysisAdd BLAST56
Regioni1278 – 1297DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1333 – 1353Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi767 – 789PolyampholyteSequence analysisAdd BLAST23
Compositional biasi790 – 804PolarSequence analysisAdd BLAST15
Compositional biasi856 – 871PolyampholyteSequence analysisAdd BLAST16
Compositional biasi882 – 897PolyampholyteSequence analysisAdd BLAST16
Compositional biasi898 – 925PolarSequence analysisAdd BLAST28
Compositional biasi926 – 940PolyampholyteSequence analysisAdd BLAST15
Compositional biasi976 – 999PolarSequence analysisAdd BLAST24
Compositional biasi1002 – 1019PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1037 – 1063PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1064 – 1084PolarSequence analysisAdd BLAST21
Compositional biasi1085 – 1102PolyampholyteSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K5CB Eukaryota
ENOG4110H8V LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1740.170, 1 hit
1.20.1310.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042202 Duffy-ag-bd_sf
IPR008602 Duffy-antigen-binding
IPR021620 EBA-175_C
IPR043057 EBA-175_C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05424 Duffy_binding, 2 hits
PF11556 EBA-175_VI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q05644-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCNISIYFF ASFFVLYFAK ARNEYDIKEN EKFLDVYKEK FNELDKKKYG
60 70 80 90 100
NVQKTDKKIF TFIENKLDIL NNSKFNKRWK SYGTPDNIDK NMSLINKHNN
110 120 130 140 150
EEMFNNNYQS FLSTSSLIKQ NKYVPINAVR VSRILSFLDS RINNGRNTSS
160 170 180 190 200
NNEVLSNCRE KRKGMKWDCK KKNDRSNYVC IPDRRIQLCI VNLSIIKTYT
210 220 230 240 250
KETMKDHFIE ASKKESQLLL KKNDNKYNSK FCNDLKNSFL DYGHLAMGND
260 270 280 290 300
MDFGGYSTKA ENKIQEVFKG AHGEISEHKI KNFRKKWWNE FREKLWEAML
310 320 330 340 350
SEHKNNINNC KNIPQEELQI TQWIKEWHGE FLLERDNRSK LPKSKCKNNT
360 370 380 390 400
LYEACEKECI DPCMKYRDWI IRSKFEWHTL SKEYETQKVP KENAENYLIK
410 420 430 440 450
ISENKNDAKV SLLLNNCDAE YSKYCDCKHT TTLVKSVLNG NDNTIKEKRE
460 470 480 490 500
HIDLDDFSKF GCDKNSVDTN TKVWECKKPY KLSTKDVCVP PRRQELCLGN
510 520 530 540 550
IDRIYDKNLL MIKEHILAIA IYESRILKRK YKNKDDKEVC KIINKTFADI
560 570 580 590 600
RDIIGGTDYW NDLSNRKLVG KINTNSNYVH RNKQNDKLFR DEWWKVIKKD
610 620 630 640 650
VWNVISWVFK DKTVCKEDDI ENIPQFFRWF SEWGDDYCQD KTKMIETLKV
660 670 680 690 700
ECKEKPCEDD NCKRKCNSYK EWISKKKEEY NKQAKQYQEY QKGNNYKMYS
710 720 730 740 750
EFKSIKPEVY LKKYSEKCSN LNFEDEFKEE LHSDYKNKCT MCPEVKDVPI
760 770 780 790 800
SIIRNNEQTS QEAVPEESTE IAHRTETRTD ERKNQEPANK DLKNPQQSVG
810 820 830 840 850
ENGTKDLLQE DLGGSRSEDE VTQEFGVNHG IPKGEDQTLG KSDAIPNIGE
860 870 880 890 900
PETGISTTEE SRHEEGHNKQ ALSTSVDEPE LSDTLQLHED TKENDKLPLE
910 920 930 940 950
SSTITSPTES GSSDTEETPS ISEGPKGNEQ KKRDDDSLSK ISVSPENSRP
960 970 980 990 1000
ETDAKDTSNL LKLKGDVDIS MPKAVIGSSP NDNINVTEQG DNISGVNSKP
1010 1020 1030 1040 1050
LSDDVRPDKN HEEVKEHTSN SDNVQQSGGI VNMNVEKELK DTLENPSSSL
1060 1070 1080 1090 1100
DEGKAHEELS EPNLSSDQDM SNTPGPLDNT SEETTERISN NEYKVNEREG
1110 1120 1130 1140 1150
ERTLTKEYED IVLKSHMNRE SDDGELYDEN SDLSTVNDES EDAEAKMKGN
1160 1170 1180 1190 1200
DTSEMSHNSS QHIESDQQKN DMKTVGDLGT THVQNEISVP VTGEIDEKLR
1210 1220 1230 1240 1250
ESKESKIHKA EEERLSHTDI HKINPEDRNS NTLHLKDIRN EENERHLTNQ
1260 1270 1280 1290 1300
NINISQERDL QKHGFHTMNN LHGDGVSERS QINHSHHGNR QDRGGNSGNV
1310 1320 1330 1340 1350
LNMRSNNNNF NNIPSRYNLY DKKLDLDLYE NRNDSTTKEL IKKLAEINKC
1360 1370 1380 1390 1400
ENEISVKYCD HMIHEEIPLK TCTKEKTRNL CCAVSDYCMS YFTYDSEEYY
1410 1420
NCTKREFDDP SYTCFRKEAF S
Length:1,421
Mass (Da):165,332
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BE8DDFA07CEE771
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1421Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32207 Genomic DNA Translation: AAA75179.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32207 Genomic DNA Translation: AAA75179.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QEXX-ray4.50A/B145-746[»]
SMRiQ05644
ModBaseiSearch...
PDBe-KBiSearch...

Phylogenomic databases

eggNOGiENOG410K5CB Eukaryota
ENOG4110H8V LUCA

Family and domain databases

Gene3Di1.10.1740.170, 1 hit
1.20.1310.20, 2 hits
InterProiView protein in InterPro
IPR042202 Duffy-ag-bd_sf
IPR008602 Duffy-antigen-binding
IPR021620 EBA-175_C
IPR043057 EBA-175_C_sf
PfamiView protein in Pfam
PF05424 Duffy_binding, 2 hits
PF11556 EBA-175_VI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ05644_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05644
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 22, 2020
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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