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Protein

Dihydropteroate synthase

Gene

Cbei_0206

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (Cbei_0206)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21MagnesiumBy similarity1
Binding sitei616-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei956-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1146-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1786-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2146-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCBEI290402:G1G93-240-MONOMER
UniPathwayi
UPA00077;UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Ordered Locus Names:Cbei_0206
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000565 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682061 – 269Dihydropteroate synthaseAdd BLAST269

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_0206

Structurei

3D structure databases

ProteinModelPortaliQ05621
SMRiQ05621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 261Pterin-bindingPROSITE-ProRule annotationAdd BLAST248

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni249 – 2516-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
HOGENOMiHOG000217509
KOiK00796
OMAiWAVRVHD
OrthoDBiPOG091H00BJ

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q05621-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIGSKEFNI GERTYIMGIL NFTPDSFSDG GKFNDIDVAV KHVKEMIDNG
60 70 80 90 100
ADIIDVGGES TRPGYEIVSE EEEISRVVPI IKAIKEDFDI PVSIDTYKAK
110 120 130 140 150
VAEQAIEAGA NLINDIWGFK KDKDMAKVAA KYNVPCCLMH NRDNTEYKNL
160 170 180 190 200
MEDILNDLKE CINIAKDAGV KDENIILDPG IGFGKTYEQN LEAMNNLERI
210 220 230 240 250
KELGYPILLG TSRKSMIGLA LNLPVEERIE GTVATTVIGI MKDACDFVRV
260
HDVLENSRAA KMTDIIVRR
Length:269
Mass (Da):29,948
Last modified:February 26, 2008 - v2
Checksum:iB66922317A603123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA Translation: ABR32396.1
L04468 Genomic DNA Translation: AAA52083.1
RefSeqiWP_011967558.1, NC_009617.1

Genome annotation databases

EnsemblBacteriaiABR32396; ABR32396; Cbei_0206
KEGGicbe:Cbei_0206

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA Translation: ABR32396.1
L04468 Genomic DNA Translation: AAA52083.1
RefSeqiWP_011967558.1, NC_009617.1

3D structure databases

ProteinModelPortaliQ05621
SMRiQ05621
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290402.Cbei_0206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR32396; ABR32396; Cbei_0206
KEGGicbe:Cbei_0206

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
HOGENOMiHOG000217509
KOiK00796
OMAiWAVRVHD
OrthoDBiPOG091H00BJ

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00156

BioCyciCBEI290402:G1G93-240-MONOMER

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHPS_CLOB8
AccessioniPrimary (citable) accession number: Q05621
Secondary accession number(s): A6LPW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 26, 2008
Last modified: February 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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