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Protein

Serine/threonine-protein kinase CTR1

Gene

CTR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator in the ethylene response pathway (PubMed:8431946). Phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene (PubMed:23132950).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei578ATPPROSITE-ProRule annotation1
Active sitei676Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi557 – 565ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine/tyrosine kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processEthylene signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 399

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase CTR11 Publication (EC:2.7.11.1Curated)
Alternative name(s):
Protein CONSTITUTIVE TRIPLE RESPONSE11 Publication
Gene namesi
Name:CTR11 Publication
Ordered Locus Names:At5g03730Imported
ORF Names:F17C15_150Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G03730
TAIRilocus:2144613 AT5G03730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Mutants display ethylene-treated phenotypes, resulting in plants with small, unexpanded leaves and whose seed cotyledon growth is impaired.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi596E → K in ctr1-4; exhibits ethylene-treated phenotype. 1 Publication1
Mutagenesisi694D → E in ctr1-1; exhibits ethylene-treated phenotype. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859071 – 821Serine/threonine-protein kinase CTR1Add BLAST821

Proteomic databases

PaxDbiQ05609
PRIDEiQ05609

PTM databases

iPTMnetiQ05609

Expressioni

Tissue specificityi

Expressed in both seedlings and adult plants.1 Publication

Gene expression databases

ExpressionAtlasiQ05609 baseline and differential
GenevisibleiQ05609 AT

Interactioni

Subunit structurei

Interacts with EIN2 (via C-terminus).1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi17024, 8 interactors
IntActiQ05609, 5 interactors
STRINGi3702.AT5G03730.1

Structurei

Secondary structure

1821
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ05609
SMRiQ05609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini551 – 809Protein kinasePROSITE-ProRule annotationAdd BLAST259

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 69Poly-Gly5
Compositional biasi135 – 141Poly-Gly7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOGENOMiHOG000239752
InParanoidiQ05609
KOiK14510
OMAiRISPIGH
OrthoDBiEOG09360753
PhylomeDBiQ05609

Family and domain databases

InterProiView protein in InterPro
IPR028324 CTR1
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR44329:SF1 PTHR44329:SF1, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q05609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMPGRRSNY TLLSQFSDDQ VSVSVTGAPP PHYDSLSSEN RSNHNSGNTG
60 70 80 90 100
KAKAERGGFD WDPSGGGGGD HRLNNQPNRV GNNMYASSLG LQRQSSGSSF
110 120 130 140 150
GESSLSGDYY MPTLSAAANE IESVGFPQDD GFRLGFGGGG GDLRIQMAAD
160 170 180 190 200
SAGGSSSGKS WAQQTEESYQ LQLALALRLS SEATCADDPN FLDPVPDESA
210 220 230 240 250
LRTSPSSAET VSHRFWVNGC LSYYDKVPDG FYMMNGLDPY IWTLCIDLHE
260 270 280 290 300
SGRIPSIESL RAVDSGVDSS LEAIIVDRRS DPAFKELHNR VHDISCSCIT
310 320 330 340 350
TKEVVDQLAK LICNRMGGPV IMGEDELVPM WKECIDGLKE IFKVVVPIGS
360 370 380 390 400
LSVGLCRHRA LLFKVLADII DLPCRIAKGC KYCNRDDAAS CLVRFGLDRE
410 420 430 440 450
YLVDLVGKPG HLWEPDSLLN GPSSISISSP LRFPRPKPVE PAVDFRLLAK
460 470 480 490 500
QYFSDSQSLN LVFDPASDDM GFSMFHRQYD NPGGENDALA ENGGGSLPPS
510 520 530 540 550
ANMPPQNMMR ASNQIEAAPM NAPPISQPVP NRANRELGLD GDDMDIPWCD
560 570 580 590 600
LNIKEKIGAG SFGTVHRAEW HGSDVAVKIL MEQDFHAERV NEFLREVAIM
610 620 630 640 650
KRLRHPNIVL FMGAVTQPPN LSIVTEYLSR GSLYRLLHKS GAREQLDERR
660 670 680 690 700
RLSMAYDVAK GMNYLHNRNP PIVHRDLKSP NLLVDKKYTV KVCDFGLSRL
710 720 730 740 750
KASTFLSSKS AAGTPEWMAP EVLRDEPSNE KSDVYSFGVI LWELATLQQP
760 770 780 790 800
WGNLNPAQVV AAVGFKCKRL EIPRNLNPQV AAIIEGCWTN EPWKRPSFAT
810 820
IMDLLRPLIK SAVPPPNRSD L
Length:821
Mass (Da):90,306
Last modified:November 1, 1995 - v1
Checksum:i2922D3DCD0CC15BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08789 mRNA Translation: AAA32779.1
L08790 Genomic DNA Translation: AAA32780.1
AL162506 Genomic DNA Translation: CAB82938.1
CP002688 Genomic DNA Translation: AED90647.1
CP002688 Genomic DNA Translation: AED90648.1
PIRiT48400
RefSeqiNP_195993.1, NM_120454.4
NP_850760.1, NM_180429.4
UniGeneiAt.300

Genome annotation databases

EnsemblPlantsiAT5G03730.1; AT5G03730.1; AT5G03730
AT5G03730.2; AT5G03730.2; AT5G03730
GeneIDi831748
GrameneiAT5G03730.1; AT5G03730.1; AT5G03730
AT5G03730.2; AT5G03730.2; AT5G03730
KEGGiath:AT5G03730

Similar proteinsi

Entry informationi

Entry nameiCTR1_ARATH
AccessioniPrimary (citable) accession number: Q05609
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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