Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q05586 (NMDZ1_HUMAN)

Entry version 241 (23 Feb 2022)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
Add a publicationFeedback
Protein

Glutamate receptor ionotropic, NMDA 1

Gene

GRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).

5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei523GlycineCombined sources3 Publications1
Binding sitei688GlycineCombined sources3 Publications1
Binding sitei732GlycineCombined sources3 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q05586

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6794361, Neurexins and neuroligins
R-HSA-8849932, Synaptic adhesion-like molecules
R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
R-HSA-9617324, Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244, Long-term potentiation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q05586

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q05586

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.10.1.20, the glutamate-gated ion channel (gic) family of neurotransmitter receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 1
Short name:
GluN1
Alternative name(s):
Glutamate [NMDA] receptor subunit zeta-1
N-methyl-D-aspartate receptor subunit NR1
Short name:
NMD-R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRIN1
Synonyms:NMDAR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4584, GRIN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138249, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q05586

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000176884

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 559ExtracellularBy similarityAdd BLAST541
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei560 – 580HelicalBy similarityAdd BLAST21
Topological domaini581 – 602CytoplasmicBy similarityAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei603 – 624Discontinuously helicalBy similarityAdd BLAST22
Topological domaini625 – 630CytoplasmicBy similarity6
Transmembranei631 – 647HelicalBy similarityAdd BLAST17
Topological domaini648 – 812ExtracellularBy similarityAdd BLAST165
Transmembranei813 – 833HelicalBy similarityAdd BLAST21
Topological domaini834 – 938CytoplasmicBy similarityAdd BLAST105

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant (NDHMSD)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by severe mental retardation and developmental delay, absent speech, muscular hypotonia, dyskinesia, and hyperkinetic movements. Cortical blindness, cerebral atrophy, and seizures are present in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079989552D → E in NDHMSD; changed localization to the cell membrane; decreased glutamate-gated calcium ion channel activity. 3 PublicationsCorresponds to variant dbSNP:rs1554770054EnsemblClinVar.1
Natural variantiVAR_079991557P → R in NDHMSD; changed localization to the cell membrane; loss of glutamate-gated calcium ion channel activity. 3 PublicationsCorresponds to variant dbSNP:rs878853143EnsemblClinVar.1
Natural variantiVAR_066597560S → SS in NDHMSD; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication1
Natural variantiVAR_079992618G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 1 Publication1
Natural variantiVAR_079993620G → R in NDHMSD; decreased localization to the plasma membrane of GRIN1/GRIN2B NMDA receptor complexes; changed glutamate-gated calcium ion channel activity; decreased activation by glutamate and glycine; decreased sensitivity to magnesium block; loss of function in calcium ion transmembrane import into cytosol. 2 PublicationsCorresponds to variant dbSNP:rs797045047EnsemblClinVar.1
Natural variantiVAR_079994641M → I in NDHMSD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1060500046EnsemblClinVar.1
Natural variantiVAR_079995645A → S in NDHMSD; unknown pathological significance; no effect on glutamate-gated calcium ion channel activity. 1 Publication1
Natural variantiVAR_079996647Y → S in NDHMSD; loss of glutamate-gated calcium ion channel activity. 1 Publication1
Natural variantiVAR_079997650N → K in NDHMSD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs771610568EnsemblClinVar.1
Natural variantiVAR_066598662E → K in NDHMSD; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 PublicationCorresponds to variant dbSNP:rs387906635EnsemblClinVar.1
Natural variantiVAR_079998688S → Y in NDHMSD. 1 Publication1
Natural variantiVAR_079999815G → R in NDHMSD; loss of glutamate-gated calcium ion channel activity. 2 PublicationsCorresponds to variant dbSNP:rs797044925EnsemblClinVar.1
Natural variantiVAR_080000815G → V in NDHMSD. 1 Publication1
Natural variantiVAR_080001817F → L in NDHMSD; decreased glutamate-gated calcium ion channel activity. 1 PublicationCorresponds to variant dbSNP:rs1554770624EnsemblClinVar.1
Natural variantiVAR_080002827G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 2 PublicationsCorresponds to variant dbSNP:rs1451230055EnsemblClinVar.1
Natural variantiVAR_080003844R → C in NDHMSD; no effect on glutamate-gated calcium ion channel activity. 1 PublicationCorresponds to variant dbSNP:rs1554770667EnsemblClinVar.1
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive (NDHMSR)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by severe mental retardation and psychomotor developmental delay, involuntary and stereotypic movements, spasticity, and inability to walk without support. Intractable seizures manifest in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079984217R → W in NDHMSR; changed glutamate-gated calcium ion channel activity; increased inhibition by zinc. 1 PublicationCorresponds to variant dbSNP:rs200777850EnsemblClinVar.1
Natural variantiVAR_079985227D → H in NDHMSR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869312865Ensembl.1
Natural variantiVAR_079990556 – 938Missing in NDHMSR; loss of function in calcium ion transmembrane import into cytosol. 1 PublicationAdd BLAST383

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi813M → V: Slight decrease in glycine agonist potency; no effect on glutamate agonist potency. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		2902

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		GRIN1

MalaCards human disease database

More...MalaCardsi		GRIN1
MIMi614254, phenotype
617820, phenotype

Open Targets

More...OpenTargetsi		ENSG00000176884

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469, Autosomal dominant non-syndromic intellectual disability
208447, Bilateral generalized polymicrogyria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28978

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q05586, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2015

Drug and drug target database

More...DrugBanki		DB01931, 5,7-Dichlorokynurenic acid
DB00659, Acamprosate
DB06151, Acetylcysteine
DB08838, Agmatine
DB01238, Aripiprazole
DB00289, Atomoxetine
DB05824, CNS-5161
DB04620, Cycloleucine
DB03929, D-Serine
DB00843, Donepezil
DB00228, Enflurane
DB11823, Esketamine
DB13146, Fluciclovine (18F)
DB06741, Gavestinel
DB00142, Glutamic acid
DB00874, Guaifenesin
DB08954, Ifenprodil
DB06738, Ketobemidone
DB09409, Magnesium acetate tetrahydrate
DB09481, Magnesium carbonate
DB01043, Memantine
DB00454, Meperidine
DB00333, Methadone
DB04896, Milnacipran
DB01173, Orphenadrine
DB00312, Pentobarbital
DB01174, Phenobarbital
DB01708, Prasterone
DB00418, Secobarbital
DB00193, Tramadol

DrugCentral

More...DrugCentrali		Q05586

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		455

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GRIN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		548377

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001158719 – 938Glutamate receptor ionotropic, NMDA 1Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi79 ↔ 308By similarity
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi420 ↔ 454Combined sources3 Publications
Disulfide bondi436 ↔ 455Combined sources3 Publications
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi744 ↔ 798Combined sources3 Publications
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei889Phosphoserine; by PKC1 Publication1
Modified residuei890Phosphoserine; by PKC1 Publication1
Modified residuei896Phosphoserine; by PKC1 Publication1
Modified residuei897Phosphoserine; by PKC1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q05586

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q05586

PeptideAtlas

More...PeptideAtlasi		Q05586

PRoteomics IDEntifications database

More...PRIDEi		Q05586

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58336 [Q05586-1]
58337 [Q05586-2]
58338 [Q05586-3]
58339 [Q05586-4]
58340 [Q05586-5]
65258
65259

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q05586, 13 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q05586

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q05586

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176884, Expressed in anterior cingulate cortex and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q05586, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q05586, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000176884, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), an epsilon subunit, plus GRIN3A or GRIN3B (in vitro). In vivo, the subunit composition may vary in function of the expression levels of the different subunits.

Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (By similarity).

Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity).

Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity).

Interacts with DLG4 and MPDZ.

Interacts with LRFN1 and LRFN2 (By similarity).

Interacts with MYZAP (PubMed:18849881).

Found in a complex with DLG4 and PRR7 (By similarity).

Found in a complex with GRIN2B and PRR7 (PubMed:27458189).

Interacts with PRR7; the interaction is reduced following NMDA receptor activity (PubMed:27458189).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109159, 53 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2202, NMDA receptor complex, GluN1-GluN2A
CPX-285, NMDA receptor complex, GluN1-GluN2B
CPX-286, NMDA receptor complex, GluN1-GluN2C
CPX-289, NMDA receptor complex, GluN1-GluN2D
CPX-294, NMDA receptor complex, GluN1-GluN2A-GluN2B

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q05586

Protein interaction database and analysis system

More...IntActi		Q05586, 11 interactors

Molecular INTeraction database

More...MINTi		Q05586

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360608

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q05586

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q05586, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1938
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q05586

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q05586

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni516 – 518Glycine bindingCombined sources3 Publications3
Regioni603 – 624Pore-formingBy similarityAdd BLAST22
Regioni889 – 938DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi917 – 938Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. [View classification]Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4440, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158016

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007257_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q05586

Identification of Orthologs from Complete Genome Data

More...OMAi		SGFYHIP

Database of Orthologous Groups

More...OrthoDBi		188544at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q05586

TreeFam database of animal gene trees

More...TreeFami		TF351405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR018882, CaM-bd_C0_NMDA_rcpt_NR1
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR028082, Peripla_BP_I

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF10562, CaM_bdg_C0, 1 hit
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00177, NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q05586-1) [UniParc]FASTAAdd to basket
Also known as: Long, NR1-3

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG 
       210        220        230        240        250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG 
       260        270        280        290        300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
       310        320        330        340        350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN 
       360        370        380        390        400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI 
       410        420        430        440        450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT 
       460        470        480        490        500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG 
       510        520        530        540        550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST 
       560        570        580        590        600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
       610        620        630        640        650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN 
       660        670        680        690        700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS 
       710        720        730        740        750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG 
       760        770        780        790        800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS 
       810        820        830        840        850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL 
       860        870        880        890        900
AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT 
       910        920        930 
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES
Length:938
Mass (Da):105,373
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDF5402769E530AB
GO
Isoform 1 (identifier: Q05586-2) [UniParc]FASTAAdd to basket
Also known as: Short, NR1-1

The sequence of this isoform differs from the canonical sequence as follows:
     864-885: DRKSGRAEPDPKKKATFRAITS → QYHPTDITGPLNLSDPSVSTVV
     886-938: Missing.

Show »
Length:885
Mass (Da):99,315
Checksum:i28C383037998DA20
GO
Isoform 2 (identifier: Q05586-3) [UniParc]FASTAAdd to basket
Also known as: Medium, NR1-2

The sequence of this isoform differs from the canonical sequence as follows:
     864-900: Missing.

Show »
Length:901
Mass (Da):101,209
Checksum:iE0C37E8C9F686155
GO
Isoform 4 (identifier: Q05586-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

Show »
Length:922
Mass (Da):103,479
Checksum:iF704AD9A244BD78E
GO
Isoform 5 (identifier: Q05586-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK

Show »
Length:959
Mass (Da):107,909
Checksum:iC7F52E8535F521EE
GO
Isoform 6 (identifier: Q05586-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

Show »
Length:943
Mass (Da):106,015
Checksum:i20DBA38A2B9E3ED0
GO
Isoform 7 (identifier: Q05586-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     864-938: DRKSGRAEPD...LQLCSRHRES → QYHPTDITGPLNLSDPSVSTVV

Show »
Length:906
Mass (Da):101,851
Checksum:iB275FBD4126F4F15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VSF9Q5VSF9_HUMAN
Glutamate receptor
GRIN1
922Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AVK2A2AVK2_HUMAN
Glutamate receptor ionotropic, NMDA...
GRIN1
356Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389P → S in AAB25917 (PubMed:7681588).Curated1
Sequence conflicti488E → K in AAB59361 (PubMed:8406025).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079984217R → W in NDHMSR; changed glutamate-gated calcium ion channel activity; increased inhibition by zinc. 1 PublicationCorresponds to variant dbSNP:rs200777850EnsemblClinVar.1
Natural variantiVAR_079985227D → H in NDHMSR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869312865Ensembl.1
Natural variantiVAR_079986306R → Q Found in a patient with schizophrenia; unknown pathological significance. 1 Publication1
Natural variantiVAR_079987349A → S1 PublicationCorresponds to variant dbSNP:rs148008303EnsemblClinVar.1
Natural variantiVAR_079988419T → A1 PublicationCorresponds to variant dbSNP:rs763133592EnsemblClinVar.1
Natural variantiVAR_049187540I → M1 PublicationCorresponds to variant dbSNP:rs3181457Ensembl.1
Natural variantiVAR_079989552D → E in NDHMSD; changed localization to the cell membrane; decreased glutamate-gated calcium ion channel activity. 3 PublicationsCorresponds to variant dbSNP:rs1554770054EnsemblClinVar.1
Natural variantiVAR_079990556 – 938Missing in NDHMSR; loss of function in calcium ion transmembrane import into cytosol. 1 PublicationAdd BLAST383
Natural variantiVAR_079991557P → R in NDHMSD; changed localization to the cell membrane; loss of glutamate-gated calcium ion channel activity. 3 PublicationsCorresponds to variant dbSNP:rs878853143EnsemblClinVar.1
Natural variantiVAR_066597560S → SS in NDHMSD; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication1
Natural variantiVAR_079992618G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 1 Publication1
Natural variantiVAR_079993620G → R in NDHMSD; decreased localization to the plasma membrane of GRIN1/GRIN2B NMDA receptor complexes; changed glutamate-gated calcium ion channel activity; decreased activation by glutamate and glycine; decreased sensitivity to magnesium block; loss of function in calcium ion transmembrane import into cytosol. 2 PublicationsCorresponds to variant dbSNP:rs797045047EnsemblClinVar.1
Natural variantiVAR_079994641M → I in NDHMSD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1060500046EnsemblClinVar.1
Natural variantiVAR_079995645A → S in NDHMSD; unknown pathological significance; no effect on glutamate-gated calcium ion channel activity. 1 Publication1
Natural variantiVAR_079996647Y → S in NDHMSD; loss of glutamate-gated calcium ion channel activity. 1 Publication1
Natural variantiVAR_079997650N → K in NDHMSD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs771610568EnsemblClinVar.1
Natural variantiVAR_066598662E → K in NDHMSD; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 PublicationCorresponds to variant dbSNP:rs387906635EnsemblClinVar.1
Natural variantiVAR_069057682A → S1 PublicationCorresponds to variant dbSNP:rs1126448Ensembl.1
Natural variantiVAR_079998688S → Y in NDHMSD. 1 Publication1
Natural variantiVAR_079999815G → R in NDHMSD; loss of glutamate-gated calcium ion channel activity. 2 PublicationsCorresponds to variant dbSNP:rs797044925EnsemblClinVar.1
Natural variantiVAR_080000815G → V in NDHMSD. 1 Publication1
Natural variantiVAR_080001817F → L in NDHMSD; decreased glutamate-gated calcium ion channel activity. 1 PublicationCorresponds to variant dbSNP:rs1554770624EnsemblClinVar.1
Natural variantiVAR_080002827G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 2 PublicationsCorresponds to variant dbSNP:rs1451230055EnsemblClinVar.1
Natural variantiVAR_080003844R → C in NDHMSD; no effect on glutamate-gated calcium ion channel activity. 1 PublicationCorresponds to variant dbSNP:rs1554770667EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011777190K → KSKKRNYENLDQLSYDNKRG PK in isoform 5, isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_045464864 – 938DRKSG…RHRES → QYHPTDITGPLNLSDPSVST VV in isoform 7. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_000139864 – 900Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_000137864 – 885DRKSG…RAITS → QYHPTDITGPLNLSDPSVST VV in isoform 1. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_000138886 – 938Missing in isoform 1. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_011778901 – 922STGGG…PRRAI → QYHPTDITGPLNLSDPSVST VV in isoform 4 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_011779923 – 938Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L13266 mRNA Translation: AAB59360.1
L13267 mRNA Translation: AAA36198.1
L13268 mRNA Translation: AAB59361.1
D13515 mRNA Translation: BAA02732.1
L05666 mRNA Translation: AAA21180.1
AF015730 mRNA Translation: AAB67723.1
AF015731 mRNA Translation: AAB67724.1
Z32772 Genomic DNA No translation available.
Z32773 Genomic DNA No translation available.
Z32774 Genomic DNA No translation available.
AL929554 Genomic DNA No translation available.
U08106 mRNA Translation: AAA62111.1
U08107 mRNA Translation: AAA62112.1
S57708 mRNA Translation: AAB25917.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43910.1 [Q05586-2]
CCDS55354.1 [Q05586-6]
CCDS55355.1 [Q05586-7]
CCDS7031.1 [Q05586-1]
CCDS7032.1 [Q05586-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A46612
A47551

NCBI Reference Sequences

More...RefSeqi		NP_000823.4, NM_000832.6 [Q05586-2]
NP_001172019.1, NM_001185090.1 [Q05586-6]
NP_001172020.1, NM_001185091.1 [Q05586-7]
NP_015566.1, NM_007327.3 [Q05586-1]
NP_067544.1, NM_021569.3 [Q05586-3]
XP_005266128.1, XM_005266071.3 [Q05586-4]
XP_005266130.1, XM_005266073.4 [Q05586-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371546; ENSP00000360601; ENSG00000176884 [Q05586-5]
ENST00000371550; ENSP00000360605; ENSG00000176884 [Q05586-3]
ENST00000371553; ENSP00000360608; ENSG00000176884 [Q05586-6]
ENST00000371559; ENSP00000360614; ENSG00000176884 [Q05586-2]
ENST00000371560; ENSP00000360615; ENSG00000176884 [Q05586-7]
ENST00000371561; ENSP00000360616; ENSG00000176884

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2902

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000371561.8; ENSP00000360616.3; NM_007327.4; NP_015566.1

UCSC genome browser

More...UCSCi		uc004clk.4, human [Q05586-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

NMDA receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13266 mRNA Translation: AAB59360.1
L13267 mRNA Translation: AAA36198.1
L13268 mRNA Translation: AAB59361.1
D13515 mRNA Translation: BAA02732.1
L05666 mRNA Translation: AAA21180.1
AF015730 mRNA Translation: AAB67723.1
AF015731 mRNA Translation: AAB67724.1
Z32772 Genomic DNA No translation available.
Z32773 Genomic DNA No translation available.
Z32774 Genomic DNA No translation available.
AL929554 Genomic DNA No translation available.
U08106 mRNA Translation: AAA62111.1
U08107 mRNA Translation: AAA62112.1
S57708 mRNA Translation: AAB25917.1
CCDSiCCDS43910.1 [Q05586-2]
CCDS55354.1 [Q05586-6]
CCDS55355.1 [Q05586-7]
CCDS7031.1 [Q05586-1]
CCDS7032.1 [Q05586-3]
PIRiA46612
A47551
RefSeqiNP_000823.4, NM_000832.6 [Q05586-2]
NP_001172019.1, NM_001185090.1 [Q05586-6]
NP_001172020.1, NM_001185091.1 [Q05586-7]
NP_015566.1, NM_007327.3 [Q05586-1]
NP_067544.1, NM_021569.3 [Q05586-3]
XP_005266128.1, XM_005266071.3 [Q05586-4]
XP_005266130.1, XM_005266073.4 [Q05586-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HQWX-ray1.90B875-898[»]
2NR1NMR-A599-621[»]
3BYAX-ray1.85B875-898[»]
5H8FX-ray1.81B394-544[»]
B663-800[»]
5H8HX-ray2.23B394-544[»]
B663-800[»]
5H8NX-ray2.50B394-544[»]
B663-800[»]
5H8QX-ray1.90B394-544[»]
B663-800[»]
5I2KX-ray2.86B394-544[»]
B663-800[»]
5I2NX-ray2.12B394-544[»]
B663-800[»]
5KCJX-ray2.09B394-544[»]
B663-800[»]
5KDTX-ray2.44B394-544[»]
B663-800[»]
5TP9X-ray2.40B394-544[»]
B663-800[»]
5TPAX-ray2.48B394-544[»]
B663-800[»]
6IRAelectron microscopy4.50A/C1-847[»]
6IRFelectron microscopy5.10A/C1-847[»]
6IRGelectron microscopy5.50A/C1-847[»]
6IRHelectron microscopy7.80A/C1-847[»]
7EOQelectron microscopy4.10B/D1-847[»]
7EORelectron microscopy4.00B/D1-847[»]
7EOSelectron microscopy3.90B/D1-847[»]
7EOTelectron microscopy3.80B/D1-847[»]
7EOUelectron microscopy4.30B/D1-847[»]
7EU7electron microscopy3.50A/C1-847[»]
7EU8electron microscopy4.07A/C1-847[»]
SMRiQ05586
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109159, 53 interactors
ComplexPortaliCPX-2202, NMDA receptor complex, GluN1-GluN2A
CPX-285, NMDA receptor complex, GluN1-GluN2B
CPX-286, NMDA receptor complex, GluN1-GluN2C
CPX-289, NMDA receptor complex, GluN1-GluN2D
CPX-294, NMDA receptor complex, GluN1-GluN2A-GluN2B
CORUMiQ05586
IntActiQ05586, 11 interactors
MINTiQ05586
STRINGi9606.ENSP00000360608

Chemistry databases

BindingDBiQ05586
ChEMBLiCHEMBL2015
DrugBankiDB01931, 5,7-Dichlorokynurenic acid
DB00659, Acamprosate
DB06151, Acetylcysteine
DB08838, Agmatine
DB01238, Aripiprazole
DB00289, Atomoxetine
DB05824, CNS-5161
DB04620, Cycloleucine
DB03929, D-Serine
DB00843, Donepezil
DB00228, Enflurane
DB11823, Esketamine
DB13146, Fluciclovine (18F)
DB06741, Gavestinel
DB00142, Glutamic acid
DB00874, Guaifenesin
DB08954, Ifenprodil
DB06738, Ketobemidone
DB09409, Magnesium acetate tetrahydrate
DB09481, Magnesium carbonate
DB01043, Memantine
DB00454, Meperidine
DB00333, Methadone
DB04896, Milnacipran
DB01173, Orphenadrine
DB00312, Pentobarbital
DB01174, Phenobarbital
DB01708, Prasterone
DB00418, Secobarbital
DB00193, Tramadol
DrugCentraliQ05586
GuidetoPHARMACOLOGYi455

Protein family/group databases

TCDBi1.A.10.1.20, the glutamate-gated ion channel (gic) family of neurotransmitter receptors

PTM databases

GlyGeniQ05586, 13 sites, 1 O-linked glycan (1 site)
iPTMnetiQ05586
PhosphoSitePlusiQ05586

Genetic variation databases

BioMutaiGRIN1
DMDMi548377

Proteomic databases

MassIVEiQ05586
PaxDbiQ05586
PeptideAtlasiQ05586
PRIDEiQ05586
ProteomicsDBi58336 [Q05586-1]
58337 [Q05586-2]
58338 [Q05586-3]
58339 [Q05586-4]
58340 [Q05586-5]
65258
65259

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q05586, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3475, 1292 antibodies from 49 providers

The DNASU plasmid repository

More...DNASUi		2902

Genome annotation databases

EnsembliENST00000371546; ENSP00000360601; ENSG00000176884 [Q05586-5]
ENST00000371550; ENSP00000360605; ENSG00000176884 [Q05586-3]
ENST00000371553; ENSP00000360608; ENSG00000176884 [Q05586-6]
ENST00000371559; ENSP00000360614; ENSG00000176884 [Q05586-2]
ENST00000371560; ENSP00000360615; ENSG00000176884 [Q05586-7]
ENST00000371561; ENSP00000360616; ENSG00000176884
GeneIDi2902
KEGGihsa:2902
MANE-SelectiENST00000371561.8; ENSP00000360616.3; NM_007327.4; NP_015566.1
UCSCiuc004clk.4, human [Q05586-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2902
DisGeNETi2902

GeneCards: human genes, protein and diseases

More...GeneCardsi		GRIN1
GeneReviewsiGRIN1
HGNCiHGNC:4584, GRIN1
HPAiENSG00000176884, Tissue enriched (brain)
MalaCardsiGRIN1
MIMi138249, gene
614254, phenotype
617820, phenotype
neXtProtiNX_Q05586
OpenTargetsiENSG00000176884
Orphaneti178469, Autosomal dominant non-syndromic intellectual disability
208447, Bilateral generalized polymicrogyria
PharmGKBiPA28978
VEuPathDBiHostDB:ENSG00000176884

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4440, Eukaryota
GeneTreeiENSGT00940000158016
HOGENOMiCLU_007257_2_0_1
InParanoidiQ05586
OMAiSGFYHIP
OrthoDBi188544at2759
PhylomeDBiQ05586
TreeFamiTF351405

Enzyme and pathway databases

PathwayCommonsiQ05586
ReactomeiR-HSA-3928662, EPHB-mediated forward signaling
R-HSA-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6794361, Neurexins and neuroligins
R-HSA-8849932, Synaptic adhesion-like molecules
R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
R-HSA-9617324, Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244, Long-term potentiation
SignaLinkiQ05586
SIGNORiQ05586

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2902, 5 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GRIN1, human
EvolutionaryTraceiQ05586

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GRIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2902
PharosiQ05586, Tclin

Protein Ontology

More...PROi		PR:Q05586
RNActiQ05586, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000176884, Expressed in anterior cingulate cortex and 200 other tissues
ExpressionAtlasiQ05586, baseline and differential
GenevisibleiQ05586, HS

Family and domain databases

InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR018882, CaM-bd_C0_NMDA_rcpt_NR1
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR028082, Peripla_BP_I
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF10562, CaM_bdg_C0, 1 hit
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177, NMDARECEPTOR
SMARTiView protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMDZ1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05586
Secondary accession number(s): A6NLK7
, A6NLR1, C9K0X1, P35437, Q12867, Q12868, Q5VSF3, Q5VSF4, Q5VSF5, Q5VSF6, Q5VSF7, Q5VSF8, Q9UPF8, Q9UPF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 23, 2022
This is version 241 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again