GRIN1

Functionⁱ

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg²⁺ (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).5 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	523	GlycineCombined sources3 Publications	1
Binding siteⁱ	688	GlycineCombined sources3 Publications	1
Binding siteⁱ	732	GlycineCombined sources3 Publications	1

GO - Molecular functionⁱ

calcium ion binding Source: UniProtKB
calmodulin binding Source: UniProtKB
glutamate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7685113
glutamate-gated calcium ion channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26875626
glycine binding
Source: UniProtKB
Inferred from direct assayⁱ
- 28105280
- 7685113
neurotransmitter binding Source: BHF-UCL
NMDA glutamate receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26919761
- 28105280
protein-containing complex binding Source: ARUK-UCL
Ras guanyl-nucleotide exchange factor activity Source: Reactome
signaling receptor binding Source: Ensembl
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
brain development
Source: ARUK-UCL
Non-traceable author statementⁱ
- 17526495
calcium ion homeostasis Source: UniProtKB
calcium ion transmembrane import into cytosol
Source: UniProtKB
Inferred from direct assayⁱ
- 26875626
cation transport
Source: UniProtKB
Inferred from direct assayⁱ
- 7685113
cerebral cortex development Source: Ensembl
conditioned taste aversion Source: Ensembl
ephrin receptor signaling pathway Source: Reactome
excitatory chemical synaptic transmission
Source: ARUK-UCL
Non-traceable author statementⁱ
- 17526495
excitatory postsynaptic potential Source: UniProtKB
ionotropic glutamate receptor signaling pathway Source: UniProtKB
long-term memory Source: Ensembl
male mating behavior Source: Ensembl
MAPK cascade Source: Reactome
negative regulation of neuron apoptotic process Source: Ensembl
olfactory learning Source: Ensembl
pons maturation Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of calcium ion transport into cytosol Source: ARUK-UCL
positive regulation of cysteine-type endopeptidase activity
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 17526495
positive regulation of excitatory postsynaptic potential Source: BHF-UCL
positive regulation of reactive oxygen species biosynthetic process Source: ARUK-UCL
positive regulation of transcription by RNA polymerase II Source: UniProtKB
prepulse inhibition Source: Ensembl
propylene metabolic process Source: BHF-UCL
protein heterotetramerization Source: UniProtKB
protein localization to postsynaptic membrane Source: Ensembl
regulation of axonogenesis Source: Ensembl
regulation of dendrite morphogenesis Source: Ensembl
regulation of long-term neuronal synaptic plasticity Source: Ensembl
regulation of membrane potential
Source: UniProtKB
Inferred from direct assayⁱ
regulation of respiratory gaseous exchange Source: Ensembl
regulation of synapse assembly Source: Ensembl
regulation of synaptic plasticity
Source: ARUK-UCL
Non-traceable author statementⁱ
- 17526495
respiratory gaseous exchange Source: Ensembl
response to amphetamine Source: Ensembl
response to ethanol
Source: UniProtKB
Inferred from direct assayⁱ
- 18445116
response to glycine
Source: UniProtKB
Inferred from direct assayⁱ
- 28105280
response to morphine Source: Ensembl
sensory perception of pain Source: Ensembl
social behavior Source: Ensembl
suckling behavior Source: Ensembl
synaptic transmission, glutamatergic Source: Ensembl
visual learning Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport
Ligand	Calcium, Magnesium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3928662 EPHB-mediated forward signaling R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation R-HSA-442729 CREB phosphorylation through the activation of CaMKII R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6794361 Neurexins and neuroligins R-HSA-8849932 Synaptic adhesion-like molecules
SignaLinkⁱ	Q05586

Protein family/group databases

TCDBⁱ	1.A.10.1.20 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

TCDBⁱ

1.A.10.1.20 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamate receptor ionotropic, NMDA 1 Short name: GluN1 Alternative name(s): Glutamate [NMDA] receptor subunit zeta-1 N-methyl-D-aspartate receptor subunit NR1 Short name: NMD-R1
Gene namesⁱ	Name:GRIN1 Synonyms:NMDAR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176884.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4584 GRIN1
MIMⁱ	138249 gene
neXtProtⁱ	NX_Q05586

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 559	ExtracellularBy similarityAdd BLAST	541
Transmembraneⁱ	560 – 580	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	581 – 602	CytoplasmicBy similarityAdd BLAST	22
Intramembraneⁱ	603 – 624	Discontinuously helicalBy similarityAdd BLAST	22
Topological domainⁱ	625 – 630	CytoplasmicBy similarity	6
Transmembraneⁱ	631 – 647	HelicalBy similarityAdd BLAST	17
Topological domainⁱ	648 – 812	ExtracellularBy similarityAdd BLAST	165
Transmembraneⁱ	813 – 833	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	834 – 938	CytoplasmicBy similarityAdd BLAST	105

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant (NDHMSD)7 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by severe mental retardation and developmental delay, absent speech, muscular hypotonia, dyskinesia, and hyperkinetic movements. Cortical blindness, cerebral atrophy, and seizures are present in some patients.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_079989	552	D → E in NDHMSD; changed localization to the cell membrane; decreased glutamate-gated calcium ion channel activity. 3 Publications	1
Natural variantⁱVAR_079991	557	P → R in NDHMSD; changed localization to the cell membrane; loss of glutamate-gated calcium ion channel activity. 3 PublicationsCorresponds to variant dbSNP:rs878853143EnsemblClinVar.	1
Natural variantⁱVAR_066597	560	S → SS in NDHMSD; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication	1
Natural variantⁱVAR_079992	618	G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 1 Publication	1
Natural variantⁱVAR_079993	620	G → R in NDHMSD; decreased localization to the plasma membrane of GRIN1/GRIN2B NMDA receptor complexes; changed glutamate-gated calcium ion channel activity; decreased activation by glutamate and glycine; decreased sensitivity to magnesium block; loss of function in calcium ion transmembrane import into cytosol. 2 PublicationsCorresponds to variant dbSNP:rs797045047EnsemblClinVar.	1
Natural variantⁱVAR_079994	641	M → I in NDHMSD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1060500046Ensembl.	1
Natural variantⁱVAR_079995	645	A → S in NDHMSD; unknown pathological significance; no effect on glutamate-gated calcium ion channel activity. 1 Publication	1
Natural variantⁱVAR_079996	647	Y → S in NDHMSD; loss of glutamate-gated calcium ion channel activity. 1 Publication	1
Natural variantⁱVAR_079997	650	N → K in NDHMSD; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_066598	662	E → K in NDHMSD; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 PublicationCorresponds to variant dbSNP:rs387906635EnsemblClinVar.	1
Natural variantⁱVAR_079998	688	S → Y in NDHMSD. 1 Publication	1
Natural variantⁱVAR_079999	815	G → R in NDHMSD; loss of glutamate-gated calcium ion channel activity. 2 PublicationsCorresponds to variant dbSNP:rs797044925EnsemblClinVar.	1
Natural variantⁱVAR_080000	815	G → V in NDHMSD. 1 Publication	1
Natural variantⁱVAR_080001	817	F → L in NDHMSD; decreased glutamate-gated calcium ion channel activity. 1 Publication	1
Natural variantⁱVAR_080002	827	G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 2 Publications	1
Natural variantⁱVAR_080003	844	R → C in NDHMSD; no effect on glutamate-gated calcium ion channel activity. 1 Publication	1

Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive (NDHMSR)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by severe mental retardation and psychomotor developmental delay, involuntary and stereotypic movements, spasticity, and inability to walk without support. Intractable seizures manifest in some patients.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	813	M → V: Slight decrease in glycine agonist potency; no effect on glutamate agonist potency. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2902
MalaCards human disease database More...MalaCardsⁱ	GRIN1
MIMⁱ	614254 phenotype 617820 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000176884
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA28978

Chemistry databases

ChEMBLⁱ	CHEMBL2015
Drug and drug target database More...DrugBankⁱ	DB00659 Acamprosate DB06151 Acetylcysteine DB08838 Agmatine DB00289 Atomoxetine DB05824 CNS-5161 DB04620 Cycloleucine DB03929 D-Serine DB00996 Gabapentin DB06741 Gavestinel DB08954 Ifenprodil DB06738 Ketobemidone DB00142 L-Glutamic Acid DB01043 Memantine DB04896 Milnacipran DB01173 Orphenadrine DB00312 Pentobarbital DB00454 Pethidine DB01174 Phenobarbital DB01708 Prasterone DB00418 Secobarbital
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	455

Polymorphism and mutation databases

BioMutaⁱ	GRIN1
DMDMⁱ	548377

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000011587	19 – 938	Glutamate receptor ionotropic, NMDA 1Add BLAST		920

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	61	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	79 ↔ 308	By similarity
Glycosylationⁱ	203	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	239	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	276	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	350	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	368	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	420 ↔ 454	Combined sources3 Publications
Disulfide bondⁱ	436 ↔ 455	Combined sources3 Publications
Glycosylationⁱ	440	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	471	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	491	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	744 ↔ 798	Combined sources3 Publications
Modified residueⁱ	889	Phosphoserine; by PKC1 Publication	1
Modified residueⁱ	890	Phosphoserine; by PKC1 Publication	1
Modified residueⁱ	896	Phosphoserine; by PKC1 Publication	1
Modified residueⁱ	897	Phosphoserine; by PKC1 Publication	1

Post-translational modificationⁱ

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q05586
PeptideAtlas More...PeptideAtlasⁱ	Q05586
PRIDEⁱ	Q05586
ProteomicsDBⁱ	58336 58337 [Q05586-2] 58338 [Q05586-3] 58339 [Q05586-4] 58340 [Q05586-5]

PTM databases

iPTMnetⁱ	Q05586
PhosphoSitePlusⁱ	Q05586

Miscellaneous databases

PMAP-CutDBⁱ	Q5VSF3

PMAP-CutDBⁱ

Q5VSF3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000176884 Expressed in 185 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_GRIN1
ExpressionAtlasⁱ	Q05586 baseline and differential
Genevisibleⁱ	Q05586 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006831

HPAⁱ

CAB006831

Interactionⁱ

Subunit structureⁱ

Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), an epsilon subunit, plus GRIN3A or GRIN3B (in vitro). In vivo, the subunit composition may vary in function of the expression levels of the different subunits. Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (By similarity). Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP (PubMed:18849881). Found in a complex with DLG4 and PRR7 (By similarity). Found in a complex with GRIN2B and PRR7 (PubMed:27458189). Interacts with PRR7; the interaction is reduced following NMDA receptor activity (PubMed:27458189).By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Dlg3	Q62936	3	EBI-8286218,EBI-349596	From Rattus norvegicus.

With

Entry

#Exp.

IntAct

Notes

Dlg3

Q62936

3

EBI-8286218,EBI-349596

From Rattus norvegicus.

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB
Ras guanyl-nucleotide exchange factor activity Source: Reactome
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109159, 12 interactors
ComplexPortalⁱ	CPX-2202 NMDA receptor complex, GluN1-GluN2A CPX-285 NMDA receptor complex, GluN1-GluN2B CPX-286 NMDA receptor complex, GluN1-GluN2C CPX-289 NMDA receptor complex, GluN1-GluN2D CPX-294 NMDA receptor complex, GluN1-GluN2A-GluN2B
CORUMⁱ	Q05586
IntActⁱ	Q05586, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q05586
STRINGⁱ	9606.ENSP00000360608

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	398 – 402	Combined sources	5
Turnⁱ	406 – 408	Combined sources	3
Beta strandⁱ	409 – 413	Combined sources	5
Beta strandⁱ	426 – 428	Combined sources	3
Beta strandⁱ	434 – 441	Combined sources	8
Beta strandⁱ	450 – 457	Combined sources	8
Helixⁱ	458 – 470	Combined sources	13
Beta strandⁱ	474 – 478	Combined sources	5
Beta strandⁱ	487 – 489	Combined sources	3
Beta strandⁱ	496 – 498	Combined sources	3
Helixⁱ	500 – 506	Combined sources	7
Beta strandⁱ	511 – 513	Combined sources	3
Helixⁱ	521 – 524	Combined sources	4
Beta strandⁱ	527 – 529	Combined sources	3
Beta strandⁱ	533 – 543	Combined sources	11
Helixⁱ	600 – 620	Combined sources	21
Helixⁱ	670 – 673	Combined sources	4
Beta strandⁱ	677 – 679	Combined sources	3
Helixⁱ	688 – 695	Combined sources	8
Helixⁱ	697 – 699	Combined sources	3
Helixⁱ	700 – 707	Combined sources	8
Beta strandⁱ	711 – 713	Combined sources	3
Helixⁱ	714 – 722	Combined sources	9
Beta strandⁱ	727 – 732	Combined sources	6
Helixⁱ	733 – 742	Combined sources	10
Beta strandⁱ	746 – 758	Combined sources	13
Beta strandⁱ	761 – 763	Combined sources	3
Helixⁱ	769 – 781	Combined sources	13
Helixⁱ	784 – 792	Combined sources	9
Helixⁱ	877 – 892	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	Q05586
SMRⁱ	Q05586
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q05586

EvolutionaryTraceⁱ

Q05586

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	516 – 518	Glycine bindingCombined sources3 Publications		3
Regionⁱ	603 – 624	Pore-formingBy similarityAdd BLAST		22

Domainⁱ

A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.By similarity

Sequence similaritiesⁱ

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1053 Eukaryota ENOG410XNUR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143978
HOGENOMⁱ	HOG000231491
HOVERGENⁱ	HBG052638
InParanoidⁱ	Q05586
KEGG Orthology (KO) More...KOⁱ	K05208
OMAⁱ	SGFYHIP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M5H
PhylomeDBⁱ	Q05586
TreeFamⁱ	TF351405

Family and domain databases

InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR018882 CaM-bd_C0_NMDA_rcpt_NR1 IPR019594 Glu/Gly-bd IPR001508 Iono_rcpt_met IPR001320 Iontro_rcpt IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF10562 CaM_bdg_C0, 1 hit PF00060 Lig_chan, 1 hit PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSⁱ	PR00177 NMDARECEPTOR
SMARTⁱ	View protein in SMART SM00918 Lig_chan-Glu_bd, 1 hit SM00079 PBPe, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 3 (identifier: Q05586-1) [UniParc]FASTA Add to basket

Also known as: Long, NR1-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG 
       210        220        230        240        250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG 
       260        270        280        290        300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
       310        320        330        340        350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN 
       360        370        380        390        400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI 
       410        420        430        440        450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT 
       460        470        480        490        500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG 
       510        520        530        540        550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST 
       560        570        580        590        600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
       610        620        630        640        650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN 
       660        670        680        690        700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS 
       710        720        730        740        750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG 
       760        770        780        790        800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS 
       810        820        830        840        850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL 
       860        870        880        890        900
AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT 
       910        920        930 
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES

Length:938

Mass (Da):105,373

Last modified:June 1, 1994 - v1

Checksum:ⁱCDF5402769E530AB

GO

Isoform 1 (identifier: Q05586-2) [UniParc]FASTA Add to basket

Also known as: Short, NR1-1

The sequence of this isoform differs from the canonical sequence as follows:
864-885: DRKSGRAEPDPKKKATFRAITS → QYHPTDITGPLNLSDPSVSTVV
886-938: Missing.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG 
       210        220        230        240        250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG 
       260        270        280        290        300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
       310        320        330        340        350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN 
       360        370        380        390        400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI 
       410        420        430        440        450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT 
       460        470        480        490        500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG 
       510        520        530        540        550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST 
       560        570        580        590        600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
       610        620        630        640        650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN 
       660        670        680        690        700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS 
       710        720        730        740        750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG 
       760        770        780        790        800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS 
       810        820        830        840        850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL 
       860        870        880 
AFAAVNVWRK NLQQYHPTDI TGPLNLSDPS VSTVV

Show »

Length:885

Mass (Da):99,315

Checksum:ⁱ28C383037998DA20

GO

Isoform 2 (identifier: Q05586-3) [UniParc]FASTA Add to basket

Also known as: Medium, NR1-2

The sequence of this isoform differs from the canonical sequence as follows:
864-900: Missing.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG 
       210        220        230        240        250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG 
       260        270        280        290        300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
       310        320        330        340        350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN 
       360        370        380        390        400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI 
       410        420        430        440        450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT 
       460        470        480        490        500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG 
       510        520        530        540        550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST 
       560        570        580        590        600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
       610        620        630        640        650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN 
       660        670        680        690        700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS 
       710        720        730        740        750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG 
       760        770        780        790        800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS 
       810        820        830        840        850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL 
       860        870        880        890        900
AFAAVNVWRK NLQSTGGGRG ALQNQKDTVL PRRAIEREEG QLQLCSRHRE 

S

Show »

Length:901

Mass (Da):101,209

Checksum:ⁱE0C37E8C9F686155

GO

Isoform 4 (identifier: Q05586-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
923-938: Missing.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG 
       210        220        230        240        250
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG 
       260        270        280        290        300
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
       310        320        330        340        350
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN 
       360        370        380        390        400
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI 
       410        420        430        440        450
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT 
       460        470        480        490        500
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG 
       510        520        530        540        550
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST 
       560        570        580        590        600
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
       610        620        630        640        650
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN 
       660        670        680        690        700
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS 
       710        720        730        740        750
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG 
       760        770        780        790        800
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS 
       810        820        830        840        850
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL 
       860        870        880        890        900
AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT 
       910        920 
QYHPTDITGP LNLSDPSVST VV

Show »

Length:922

Mass (Da):103,479

Checksum:ⁱF704AD9A244BD78E

GO

Isoform 5 (identifier: Q05586-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
190-190: K → KSKKRNYENLDQLSYDNKRGPK

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK SKKRNYENLD 
       210        220        230        240        250
QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EAKELEARVI ILSASEDDAA 
       260        270        280        290        300
TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGILGL QLINGKNESA 
       310        320        330        340        350
HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK 
       360        370        380        390        400
YADGVTGRVE FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI 
       410        420        430        440        450
IWPGGETEKP RGYQMSTRLK IVTIHQEPFV YVKPTLSDGT CKEEFTVNGD 
       460        470        480        490        500
PVKKVICTGP NDTSPGSPRH TVPQCCYGFC IDLLIKLART MNFTYEVHLV 
       510        520        530        540        550
ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI NNERAQYIEF 
       560        570        580        590        600
SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL 
       610        620        630        640        650
LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA 
       660        670        680        690        700
RILGMVWAGF AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF 
       710        720        730        740        750
IYATVKQSSV DIYFRRQVEL STMYRHMEKH NYESAAEAIQ AVRDNKLHAF 
       760        770        780        790        800
IWDSAVLEFE ASQKCDLVTT GELFFRSGFG IGMRKDSPWK QNVSLSILKS 
       810        820        830        840        850
HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML VAGGIVAGIF 
       860        870        880        890        900
LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQDRKSGR AEPDPKKKAT 
       910        920        930        940        950
FRAITSTLAS SFKRRRSSKD TSTGGGRGAL QNQKDTVLPR RAIEREEGQL 

QLCSRHRES

Show »

Length:959

Mass (Da):107,909

Checksum:ⁱC7F52E8535F521EE

GO

Isoform 6 (identifier: Q05586-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: K → KSKKRNYENLDQLSYDNKRGPK
     901-922: STGGGRGALQNQKDTVLPRRAI → QYHPTDITGPLNLSDPSVSTVV
     923-938: Missing.

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK SKKRNYENLD 
       210        220        230        240        250
QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EAKELEARVI ILSASEDDAA 
       260        270        280        290        300
TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGILGL QLINGKNESA 
       310        320        330        340        350
HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK 
       360        370        380        390        400
YADGVTGRVE FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI 
       410        420        430        440        450
IWPGGETEKP RGYQMSTRLK IVTIHQEPFV YVKPTLSDGT CKEEFTVNGD 
       460        470        480        490        500
PVKKVICTGP NDTSPGSPRH TVPQCCYGFC IDLLIKLART MNFTYEVHLV 
       510        520        530        540        550
ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI NNERAQYIEF 
       560        570        580        590        600
SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL 
       610        620        630        640        650
LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA 
       660        670        680        690        700
RILGMVWAGF AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF 
       710        720        730        740        750
IYATVKQSSV DIYFRRQVEL STMYRHMEKH NYESAAEAIQ AVRDNKLHAF 
       760        770        780        790        800
IWDSAVLEFE ASQKCDLVTT GELFFRSGFG IGMRKDSPWK QNVSLSILKS 
       810        820        830        840        850
HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML VAGGIVAGIF 
       860        870        880        890        900
LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQDRKSGR AEPDPKKKAT 
       910        920        930        940 
FRAITSTLAS SFKRRRSSKD TQYHPTDITG PLNLSDPSVS TVV

Show »

Length:943

Mass (Da):106,015

Checksum:ⁱ20DBA38A2B9E3ED0

GO

Isoform 7 (identifier: Q05586-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
190-190: K → KSKKRNYENLDQLSYDNKRGPK
864-938: DRKSGRAEPD...LQLCSRHRES → QYHPTDITGPLNLSDPSVSTVV

« Hide

        10         20         30         40         50
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
        60         70         80         90        100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
       110        120        130        140        150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
       160        170        180        190        200
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK SKKRNYENLD 
       210        220        230        240        250
QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EAKELEARVI ILSASEDDAA 
       260        270        280        290        300
TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGILGL QLINGKNESA 
       310        320        330        340        350
HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK 
       360        370        380        390        400
YADGVTGRVE FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI 
       410        420        430        440        450
IWPGGETEKP RGYQMSTRLK IVTIHQEPFV YVKPTLSDGT CKEEFTVNGD 
       460        470        480        490        500
PVKKVICTGP NDTSPGSPRH TVPQCCYGFC IDLLIKLART MNFTYEVHLV 
       510        520        530        540        550
ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI NNERAQYIEF 
       560        570        580        590        600
SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL 
       610        620        630        640        650
LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA 
       660        670        680        690        700
RILGMVWAGF AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF 
       710        720        730        740        750
IYATVKQSSV DIYFRRQVEL STMYRHMEKH NYESAAEAIQ AVRDNKLHAF 
       760        770        780        790        800
IWDSAVLEFE ASQKCDLVTT GELFFRSGFG IGMRKDSPWK QNVSLSILKS 
       810        820        830        840        850
HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML VAGGIVAGIF 
       860        870        880        890        900
LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQQYHPTD ITGPLNLSDP 

SVSTVV

Show »

Length:906

Mass (Da):101,851

Checksum:ⁱB275FBD4126F4F15

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	Q5VSF9	Q5VSF9_HUMAN		Glutamate receptor ionotropic, NMDA... Glutamate receptor ionotropic, NMDA 1	GRIN1	922	Annotation score:
	A2AVK2	A2AVK2_HUMAN		Glutamate receptor ionotropic, NMDA... Glutamate receptor ionotropic, NMDA 1	GRIN1	356	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	389	P → S in AAB25917 (PubMed:7681588).Curated		1
Sequence conflictⁱ	488	E → K in AAB59361 (PubMed:8406025).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_079984	217	R → W in NDHMSR; changed glutamate-gated calcium ion channel activity; increased inhibition by zinc. 1 Publication	1
Natural variantⁱVAR_079985	227	D → H in NDHMSR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869312865EnsemblClinVar.	1
Natural variantⁱVAR_079986	306	R → Q Found in a patient with schizophrenia; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_079987	349	A → S1 PublicationCorresponds to variant dbSNP:rs148008303EnsemblClinVar.	1
Natural variantⁱVAR_079988	419	T → A1 PublicationCorresponds to variant dbSNP:rs763133592Ensembl.	1
Natural variantⁱVAR_049187	540	I → M1 PublicationCorresponds to variant dbSNP:rs3181457Ensembl.	1
Natural variantⁱVAR_079989	552	D → E in NDHMSD; changed localization to the cell membrane; decreased glutamate-gated calcium ion channel activity. 3 Publications	1
Natural variantⁱVAR_079990	556 – 938	Missing in NDHMSR; loss of function in calcium ion transmembrane import into cytosol. 1 PublicationAdd BLAST	383
Natural variantⁱVAR_079991	557	P → R in NDHMSD; changed localization to the cell membrane; loss of glutamate-gated calcium ion channel activity. 3 PublicationsCorresponds to variant dbSNP:rs878853143EnsemblClinVar.	1
Natural variantⁱVAR_066597	560	S → SS in NDHMSD; there is near abolition of the activity of the NMDA receptor in Xenopus oocytes; alters the 3-dimensional structure at the receptor's channel pore entrance. 1 Publication	1
Natural variantⁱVAR_079992	618	G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 1 Publication	1
Natural variantⁱVAR_079993	620	G → R in NDHMSD; decreased localization to the plasma membrane of GRIN1/GRIN2B NMDA receptor complexes; changed glutamate-gated calcium ion channel activity; decreased activation by glutamate and glycine; decreased sensitivity to magnesium block; loss of function in calcium ion transmembrane import into cytosol. 2 PublicationsCorresponds to variant dbSNP:rs797045047EnsemblClinVar.	1
Natural variantⁱVAR_079994	641	M → I in NDHMSD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1060500046Ensembl.	1
Natural variantⁱVAR_079995	645	A → S in NDHMSD; unknown pathological significance; no effect on glutamate-gated calcium ion channel activity. 1 Publication	1
Natural variantⁱVAR_079996	647	Y → S in NDHMSD; loss of glutamate-gated calcium ion channel activity. 1 Publication	1
Natural variantⁱVAR_079997	650	N → K in NDHMSD; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_066598	662	E → K in NDHMSD; this mutation produces a significant increase in NMDA receptor-induced calcium currents; excessive calcium influx through NMDA receptor could lead to excitotoxic neuronal cell damage. 1 PublicationCorresponds to variant dbSNP:rs387906635EnsemblClinVar.	1
Natural variantⁱVAR_069057	682	A → S1 PublicationCorresponds to variant dbSNP:rs1126448Ensembl.	1
Natural variantⁱVAR_079998	688	S → Y in NDHMSD. 1 Publication	1
Natural variantⁱVAR_079999	815	G → R in NDHMSD; loss of glutamate-gated calcium ion channel activity. 2 PublicationsCorresponds to variant dbSNP:rs797044925EnsemblClinVar.	1
Natural variantⁱVAR_080000	815	G → V in NDHMSD. 1 Publication	1
Natural variantⁱVAR_080001	817	F → L in NDHMSD; decreased glutamate-gated calcium ion channel activity. 1 Publication	1
Natural variantⁱVAR_080002	827	G → R in NDHMSD; loss of function in calcium ion transmembrane import into cytosol. 2 Publications	1
Natural variantⁱVAR_080003	844	R → C in NDHMSD; no effect on glutamate-gated calcium ion channel activity. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_011777	190	K → KSKKRNYENLDQLSYDNKRG PK in isoform 5, isoform 6 and isoform 7. 2 Publications	1
Alternative sequenceⁱVSP_045464	864 – 938	DRKSG…RHRES → QYHPTDITGPLNLSDPSVST VV in isoform 7. 1 PublicationAdd BLAST	75
Alternative sequenceⁱVSP_000139	864 – 900	Missing in isoform 2. 1 PublicationAdd BLAST	37
Alternative sequenceⁱVSP_000137	864 – 885	DRKSG…RAITS → QYHPTDITGPLNLSDPSVST VV in isoform 1. 2 PublicationsAdd BLAST	22
Alternative sequenceⁱVSP_000138	886 – 938	Missing in isoform 1. 2 PublicationsAdd BLAST	53
Alternative sequenceⁱVSP_011778	901 – 922	STGGG…PRRAI → QYHPTDITGPLNLSDPSVST VV in isoform 4 and isoform 6. 2 PublicationsAdd BLAST	22
Alternative sequenceⁱVSP_011779	923 – 938	Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST	16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13266 mRNA Translation: AAB59360.1 L13267 mRNA Translation: AAA36198.1 L13268 mRNA Translation: AAB59361.1 D13515 mRNA Translation: BAA02732.1 L05666 mRNA Translation: AAA21180.1 AF015730 mRNA Translation: AAB67723.1 AF015731 mRNA Translation: AAB67724.1 Z32772 Genomic DNA No translation available. Z32773 Genomic DNA No translation available. Z32774 Genomic DNA No translation available. AL929554 Genomic DNA No translation available. U08106 mRNA Translation: AAA62111.1 U08107 mRNA Translation: AAA62112.1 S57708 mRNA Translation: AAB25917.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43910.1 [Q05586-2] CCDS55354.1 [Q05586-6] CCDS55355.1 [Q05586-7] CCDS7031.1 [Q05586-1] CCDS7032.1 [Q05586-3]
PIRⁱ	A46612 A47551
NCBI Reference Sequences More...RefSeqⁱ	NP_000823.4, NM_000832.6 [Q05586-2] NP_001172019.1, NM_001185090.1 [Q05586-6] NP_001172020.1, NM_001185091.1 [Q05586-7] NP_015566.1, NM_007327.3 [Q05586-1] NP_067544.1, NM_021569.3 [Q05586-3] XP_005266128.1, XM_005266071.3 [Q05586-4] XP_005266130.1, XM_005266073.4 [Q05586-5]
UniGeneⁱ	Hs.558334

Genome annotation databases

Ensemblⁱ	ENST00000371546; ENSP00000360601; ENSG00000176884 [Q05586-5] ENST00000371550; ENSP00000360605; ENSG00000176884 [Q05586-3] ENST00000371553; ENSP00000360608; ENSG00000176884 [Q05586-6] ENST00000371559; ENSP00000360614; ENSG00000176884 [Q05586-2] ENST00000371560; ENSP00000360615; ENSG00000176884 [Q05586-7] ENST00000371561; ENSP00000360616; ENSG00000176884 [Q05586-1]
GeneIDⁱ	2902
KEGGⁱ	hsa:2902
UCSC genome browser More...UCSCⁱ	uc004clk.4 human [Q05586-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q05586	Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3		MACMU		938	UniRef100_Q05586
GRIN1 isoform 1		PANTR		938
GRIN1 isoform 1		PONAB		938
Glutamate ionotropic receptor NMDA type subunit 1		CERAT		938
Glutamate ionotropic receptor NMDA type subunit 1		MACFA		938
Q05586-2	Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-1		MACMU		885	UniRef100_H9EPG1
GRIN1 isoform 5		PONAB		885
GRIN1 isoform 5		PANTR		885
Glutamate ionotropic receptor NMDA type subunit 1		RHIBE		885
Glutamate ionotropic receptor NMDA type subunit 1		MACNE		885
+6
Q05586-3	Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-2		MACMU		901	UniRef100_F7G6M2
GRIN1 isoform 7		PONAB		901
GRIN1 isoform 8		PANTR		901
Q05586-5	Glutamate receptor, ionotropic, N-methyl D-aspartate 1, isoform CRA_c		HUMAN		702	UniRef100_A0A024R8G5
Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3		MACMU		959
GRIN1 isoform 3		PONAB		959
GRIN1 isoform 3		PANTR		959
Glutamate ionotropic receptor NMDA type subunit 1		CERAT		959
+4
Q05586-6	GRIN1 isoform 4		PONAB		943	UniRef100_A0A2J8RMH7
GRIN1 isoform 4		PANTR		943
Q05586-7	GRIN1 isoform 6		PONAB		906	UniRef100_A0A2J8RMJ2
GRIN1 isoform 6		PANTR		906

Protein	Similar proteins		Species	Score	Length	Source
Q05586	Glutamate receptor ionotropic, NMDA 1		MOUSE		938	UniRef90_P35438
Glutamate receptor ionotropic, NMDA 1	)	RAT		938
Glutamate ionotropic receptor NMDA type subunit 1		PROCO		939
Glutamate ionotropic receptor NMDA type subunit 1		PANPA		939
Glutamate ionotropic receptor NMDA type subunit 1		PAPAN		939
+225
Q05586-5	Isoform B of Glutamate receptor ionotropic, NMDA 1		RAT		959	UniRef90_P35439-2
Glutamate receptor ionotropic, NMDA 1		CANLF		943
Glutamate ionotropic receptor NMDA type subunit 1		MACNE		996
Uncharacterized protein		AILME		969
Glutamate ionotropic receptor NMDA type subunit 1		PROCO		960
+246
Q05586-6	Isoform B of Glutamate receptor ionotropic, NMDA 1		RAT		959	UniRef90_P35439-2
Glutamate receptor ionotropic, NMDA 1		CANLF		943
Glutamate ionotropic receptor NMDA type subunit 1		MACNE		996
Uncharacterized protein		AILME		969
Glutamate ionotropic receptor NMDA type subunit 1		PROCO		960
+246
Q05586-7	Isoform B of Glutamate receptor ionotropic, NMDA 1		RAT		959	UniRef90_P35439-2
Glutamate receptor ionotropic, NMDA 1		CANLF		943
Glutamate ionotropic receptor NMDA type subunit 1		MACNE		996
Uncharacterized protein		AILME		969
Glutamate ionotropic receptor NMDA type subunit 1		PROCO		960
+246

Protein	Similar proteins		Species	Score	Length	Source
Q05586	Glutamate receptor ionotropic, NMDA 1		MOUSE		938	UniRef50_P35438
Glutamate receptor ionotropic, NMDA 1	)	RAT		938
Glutamate receptor ionotropic, NMDA 1	)	XENLA		903
Glutamate receptor ionotropic, NMDA 1		CANLF		943
Glutamate ionotropic receptor NMDA type subunit 1		PROCO		939
+978

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

NMDA receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13266 mRNA Translation: AAB59360.1 L13267 mRNA Translation: AAA36198.1 L13268 mRNA Translation: AAB59361.1 D13515 mRNA Translation: BAA02732.1 L05666 mRNA Translation: AAA21180.1 AF015730 mRNA Translation: AAB67723.1 AF015731 mRNA Translation: AAB67724.1 Z32772 Genomic DNA No translation available. Z32773 Genomic DNA No translation available. Z32774 Genomic DNA No translation available. AL929554 Genomic DNA No translation available. U08106 mRNA Translation: AAA62111.1 U08107 mRNA Translation: AAA62112.1 S57708 mRNA Translation: AAB25917.1
CCDSⁱ	CCDS43910.1 [Q05586-2] CCDS55354.1 [Q05586-6] CCDS55355.1 [Q05586-7] CCDS7031.1 [Q05586-1] CCDS7032.1 [Q05586-3]
PIRⁱ	A46612 A47551
RefSeqⁱ	NP_000823.4, NM_000832.6 [Q05586-2] NP_001172019.1, NM_001185090.1 [Q05586-6] NP_001172020.1, NM_001185091.1 [Q05586-7] NP_015566.1, NM_007327.3 [Q05586-1] NP_067544.1, NM_021569.3 [Q05586-3] XP_005266128.1, XM_005266071.3 [Q05586-4] XP_005266130.1, XM_005266073.4 [Q05586-5]
UniGeneⁱ	Hs.558334

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HQW	X-ray	1.90	B	875-898	[»]
	2NR1	NMR	-	A	599-621	[»]
	3BYA	X-ray	1.85	B	875-898	[»]
	5H8F	X-ray	1.81	B	394-544	[»]
				B	663-800	[»]
	5H8H	X-ray	2.23	B	394-544	[»]
				B	663-800	[»]
	5H8N	X-ray	2.50	B	394-544	[»]
				B	663-800	[»]
	5H8Q	X-ray	1.90	B	394-544	[»]
				B	663-800	[»]
	5I2K	X-ray	2.86	B	394-544	[»]
				B	663-800	[»]
	5I2N	X-ray	2.12	B	394-544	[»]
				B	663-800	[»]
	5KCJ	X-ray	2.09	B	394-544	[»]
				B	663-800	[»]
	5KDT	X-ray	2.44	B	394-544	[»]
				B	663-800	[»]
	5TP9	X-ray	2.40	B	394-544	[»]
				B	663-800	[»]
	5TPA	X-ray	2.48	B	394-544	[»]
				B	663-800	[»]
ProteinModelPortalⁱ	Q05586
SMRⁱ	Q05586
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109159, 12 interactors
ComplexPortalⁱ	CPX-2202 NMDA receptor complex, GluN1-GluN2A CPX-285 NMDA receptor complex, GluN1-GluN2B CPX-286 NMDA receptor complex, GluN1-GluN2C CPX-289 NMDA receptor complex, GluN1-GluN2D CPX-294 NMDA receptor complex, GluN1-GluN2A-GluN2B
CORUMⁱ	Q05586
IntActⁱ	Q05586, 7 interactors
MINTⁱ	Q05586
STRINGⁱ	9606.ENSP00000360608

Chemistry databases

ChEMBLⁱ	CHEMBL2015
DrugBankⁱ	DB00659 Acamprosate DB06151 Acetylcysteine DB08838 Agmatine DB00289 Atomoxetine DB05824 CNS-5161 DB04620 Cycloleucine DB03929 D-Serine DB00996 Gabapentin DB06741 Gavestinel DB08954 Ifenprodil DB06738 Ketobemidone DB00142 L-Glutamic Acid DB01043 Memantine DB04896 Milnacipran DB01173 Orphenadrine DB00312 Pentobarbital DB00454 Pethidine DB01174 Phenobarbital DB01708 Prasterone DB00418 Secobarbital
GuidetoPHARMACOLOGYⁱ	455

Protein family/group databases

TCDBⁱ	1.A.10.1.20 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

TCDBⁱ

1.A.10.1.20 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

PTM databases

iPTMnetⁱ	Q05586
PhosphoSitePlusⁱ	Q05586

Polymorphism and mutation databases

BioMutaⁱ	GRIN1
DMDMⁱ	548377

Proteomic databases

PaxDbⁱ	Q05586
PeptideAtlasⁱ	Q05586
PRIDEⁱ	Q05586
ProteomicsDBⁱ	58336 58337 [Q05586-2] 58338 [Q05586-3] 58339 [Q05586-4] 58340 [Q05586-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000371546; ENSP00000360601; ENSG00000176884 [Q05586-5] ENST00000371550; ENSP00000360605; ENSG00000176884 [Q05586-3] ENST00000371553; ENSP00000360608; ENSG00000176884 [Q05586-6] ENST00000371559; ENSP00000360614; ENSG00000176884 [Q05586-2] ENST00000371560; ENSP00000360615; ENSG00000176884 [Q05586-7] ENST00000371561; ENSP00000360616; ENSG00000176884 [Q05586-1]
GeneIDⁱ	2902
KEGGⁱ	hsa:2902
UCSCⁱ	uc004clk.4 human [Q05586-1]

Organism-specific databases

CTDⁱ	2902
DisGeNETⁱ	2902
EuPathDBⁱ	HostDB:ENSG00000176884.14
GeneCardsⁱ	GRIN1
HGNCⁱ	HGNC:4584 GRIN1
HPAⁱ	CAB006831
MalaCardsⁱ	GRIN1
MIMⁱ	138249 gene 614254 phenotype 617820 phenotype
neXtProtⁱ	NX_Q05586
OpenTargetsⁱ	ENSG00000176884
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA28978
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1053 Eukaryota ENOG410XNUR LUCA
GeneTreeⁱ	ENSGT00910000143978
HOGENOMⁱ	HOG000231491
HOVERGENⁱ	HBG052638
InParanoidⁱ	Q05586
KOⁱ	K05208
OMAⁱ	SGFYHIP
OrthoDBⁱ	EOG091G0M5H
PhylomeDBⁱ	Q05586
TreeFamⁱ	TF351405

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3928662 EPHB-mediated forward signaling R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation R-HSA-442729 CREB phosphorylation through the activation of CaMKII R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6794361 Neurexins and neuroligins R-HSA-8849932 Synaptic adhesion-like molecules
SignaLinkⁱ	Q05586

Miscellaneous databases

ChiTaRSⁱ	GRIN1 human
EvolutionaryTraceⁱ	Q05586
GeneWikiⁱ	GRIN1
GenomeRNAiⁱ	2902
PMAP-CutDBⁱ	Q5VSF3
Protein Ontology More...PROⁱ	PR:Q05586
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000176884 Expressed in 185 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_GRIN1
ExpressionAtlasⁱ	Q05586 baseline and differential
Genevisibleⁱ	Q05586 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR018882 CaM-bd_C0_NMDA_rcpt_NR1 IPR019594 Glu/Gly-bd IPR001508 Iono_rcpt_met IPR001320 Iontro_rcpt IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF10562 CaM_bdg_C0, 1 hit PF00060 Lig_chan, 1 hit PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSⁱ	PR00177 NMDARECEPTOR
SMARTⁱ	View protein in SMART SM00918 Lig_chan-Glu_bd, 1 hit SM00079 PBPe, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NMDZ1_HUMAN
Accessionⁱ	Q05586Primary (citable) accession number: Q05586 Secondary accession number(s): A6NLK7 Q9UPF9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	September 12, 2018
	This is version 217 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - Q05586 (NMDZ1_HUMAN)

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Glutamate receptor ionotropic, NMDA 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ