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UniProtKB - Q05543 (RT103_YEAST)
Protein
Regulator of Ty1 transposition protein 103
Gene
RTT103
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in transcription termination by RNA polymerase II and in regulation of Ty1 transposition.
2 PublicationsMiscellaneous
Present with 3930 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- RNA polymerase II complex binding Source: SGD
GO - Biological processi
- mRNA 3'-end processing Source: SGD
- negative regulation of transposition, RNA-mediated Source: SGD
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SCE-6807505, RNA polymerase II transcribes snRNA genes |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of Ty1 transposition protein 103 |
Gene namesi | Name:RTT103 Ordered Locus Names:YDR289C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002697, RTT103 |
VEuPathDBi | FungiDB:YDR289C |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- RNA polymerase II, holoenzyme Source: GO_Central
Other locations
- chromatin Source: SGD
- site of double-strand break Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268707 | 1 – 409 | Regulator of Ty1 transposition protein 103Add BLAST | 409 |
Proteomic databases
MaxQBi | Q05543 |
PaxDbi | Q05543 |
PRIDEi | Q05543 |
PTM databases
iPTMneti | Q05543 |
Interactioni
Subunit structurei
Interacts with PCF11, RAI1, RAT1, RPO21 AND RBP2.
1 PublicationGO - Molecular functioni
- RNA polymerase II complex binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 32342, 532 interactors |
DIPi | DIP-2583N |
IntActi | Q05543, 6 interactors |
MINTi | Q05543 |
STRINGi | 4932.YDR289C |
Miscellaneous databases
RNActi | Q05543, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q05543 |
SASBDBi | Q05543 |
SMRi | Q05543 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q05543 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 135 | CIDPROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 249 – 409 | DisorderedSequence analysisAdd BLAST | 161 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 262 – 290 | Acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 309 – 325 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 337 – 384 | Basic and acidic residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 390 – 409 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the UPF0400 (RTT103) family.Curated
Phylogenomic databases
eggNOGi | KOG2669, Eukaryota |
GeneTreei | ENSGT00950000183094 |
HOGENOMi | CLU_053395_0_0_1 |
InParanoidi | Q05543 |
OMAi | KWLLSQY |
Family and domain databases
Gene3Di | 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR006569, CID_dom IPR008942, ENTH_VHS |
Pfami | View protein in Pfam PF04818, CID, 1 hit |
SMARTi | View protein in SMART SM00582, RPR, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS51391, CID, 1 hit |
i Sequence
Sequence statusi: Complete.
Q05543-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFSSEQFTT KLNTLEDSQE SISSASKWLL LQYRDAPKVA EMWKEYMLRP
60 70 80 90 100
SVNTRRKLLG LYLMNHVVQQ AKGQKIIQFQ DSFGKVAAEV LGRINQEFPR
110 120 130 140 150
DLKKKLSRVV NILKERNIFS KQVVNDIERS LKTESSPVEA LVLPQKLKDF
160 170 180 190 200
AKDYEKLVKM HHNVCAMKMR FDKSSDELDP SSSVYEENFK TISKIGNMAK
210 220 230 240 250
DIINESILKR ESGIHKLQST LDDEKRHLDE EQNMLSEIEF VLSAKDPSRL
260 270 280 290 300
NKNVDEDNII PTYEVGDGDD DDDDGDNDDD DDDDDDDKNY DDRSNDSNYG
310 320 330 340 350
VTNISTTDKK NEVVEKTDSE HKNSTHNPSD NQFGMKRTHD MIGHDDANDI
360 370 380 390 400
PEKKVHLDSK TSEDGTFNSE DGHYELDIEG HVGAQTDEGV ENSGGVSSSI
QDLLSKLAN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51031 Genomic DNA Translation: AAB64467.1 AY557793 Genomic DNA Translation: AAS56119.1 BK006938 Genomic DNA Translation: DAA12129.1 |
PIRi | S70119 |
RefSeqi | NP_010575.1, NM_001180597.1 |
Genome annotation databases
EnsemblFungii | YDR289C_mRNA; YDR289C; YDR289C |
GeneIDi | 851884 |
KEGGi | sce:YDR289C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51031 Genomic DNA Translation: AAB64467.1 AY557793 Genomic DNA Translation: AAS56119.1 BK006938 Genomic DNA Translation: DAA12129.1 |
PIRi | S70119 |
RefSeqi | NP_010575.1, NM_001180597.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KM4 | NMR | - | A | 1-131 | [»] | |
2L0I | NMR | - | A | 3-131 | [»] | |
5M48 | X-ray | 2.59 | A | 141-246 | [»] | |
5WOZ | NMR | - | A | 5-131 | [»] | |
BMRBi | Q05543 | |||||
SASBDBi | Q05543 | |||||
SMRi | Q05543 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32342, 532 interactors |
DIPi | DIP-2583N |
IntActi | Q05543, 6 interactors |
MINTi | Q05543 |
STRINGi | 4932.YDR289C |
PTM databases
iPTMneti | Q05543 |
Proteomic databases
MaxQBi | Q05543 |
PaxDbi | Q05543 |
PRIDEi | Q05543 |
Genome annotation databases
EnsemblFungii | YDR289C_mRNA; YDR289C; YDR289C |
GeneIDi | 851884 |
KEGGi | sce:YDR289C |
Organism-specific databases
SGDi | S000002697, RTT103 |
VEuPathDBi | FungiDB:YDR289C |
Phylogenomic databases
eggNOGi | KOG2669, Eukaryota |
GeneTreei | ENSGT00950000183094 |
HOGENOMi | CLU_053395_0_0_1 |
InParanoidi | Q05543 |
OMAi | KWLLSQY |
Enzyme and pathway databases
Reactomei | R-SCE-6807505, RNA polymerase II transcribes snRNA genes |
Miscellaneous databases
EvolutionaryTracei | Q05543 |
PROi | PR:Q05543 |
RNActi | Q05543, protein |
Family and domain databases
Gene3Di | 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR006569, CID_dom IPR008942, ENTH_VHS |
Pfami | View protein in Pfam PF04818, CID, 1 hit |
SMARTi | View protein in SMART SM00582, RPR, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS51391, CID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RT103_YEAST | |
Accessioni | Q05543Primary (citable) accession number: Q05543 Secondary accession number(s): D6VSR9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families