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Protein

Serine/arginine-rich splicing factor 11

Gene

SRSF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in pre-mRNA splicing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 11
Alternative name(s):
Arginine-rich 54 kDa nuclear protein
Short name:
p54
Splicing factor, arginine/serine-rich 11
Gene namesi
Name:SRSF11
Synonyms:SFRS11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116754.13
HGNCiHGNC:10782 SRSF11
MIMi602010 gene
neXtProtiNX_Q05519

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9295
OpenTargetsiENSG00000116754
PharmGKBiPA35698

Polymorphism and mutation databases

BioMutaiSRSF11
DMDMi8134672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000819392 – 484Serine/arginine-rich splicing factor 11Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei207PhosphoserineCombined sources1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei212PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei325PhosphothreonineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ05519
MaxQBiQ05519
PaxDbiQ05519
PeptideAtlasiQ05519
PRIDEiQ05519
ProteomicsDBi58334
58335 [Q05519-2]

PTM databases

iPTMnetiQ05519
PhosphoSitePlusiQ05519
SwissPalmiQ05519

Expressioni

Gene expression databases

BgeeiENSG00000116754 Expressed in 233 organ(s), highest expression level in endometrium
CleanExiHS_SFRS11
ExpressionAtlasiQ05519 baseline and differential
GenevisibleiQ05519 HS

Organism-specific databases

HPAiHPA008762

Interactioni

Subunit structurei

Interacts with PUF60.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114709, 93 interactors
CORUMiQ05519
IntActiQ05519, 33 interactors
MINTiQ05519
STRINGi9606.ENSP00000359988

Structurei

3D structure databases

ProteinModelPortaliQ05519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 113RRMPROSITE-ProRule annotationAdd BLAST81
Repeati247 – 25519
Repeati258 – 26528
Repeati267 – 27438
Repeati275 – 28248
Repeati285 – 29258
Repeati293 – 30068
Repeati302 – 30978
Repeati321 – 32888
Repeati334 – 34198
Repeati346 – 353108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 35310 X 8 AA approximate repeats of R-R-S-R-S-R-S-RAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 31Poly-GlyAdd BLAST15
Compositional biasi252 – 259Poly-Arg8
Compositional biasi291 – 294Poly-Arg4
Compositional biasi341 – 349Poly-Arg9
Compositional biasi397 – 404Poly-Lys8

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4676 Eukaryota
ENOG410YJ1Y LUCA
GeneTreeiENSGT00730000110872
HOGENOMiHOG000121772
HOVERGENiHBG058422
InParanoidiQ05519
KOiK12899
OrthoDBiEOG091G0QKH
PhylomeDBiQ05519
TreeFamiTF106266

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034447 SRSF11
PANTHERiPTHR32343:SF6 PTHR32343:SF6, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNTTVVPST AGPGPSGGPG GGGGGGGGGG GTEVIQVTNV SPSASSEQMR
60 70 80 90 100
TLFGFLGKID ELRLFPPDDS PLPVSSRVCF VKFHDPDSAV VAQHLTNTVF
110 120 130 140 150
VDRALIVVPY AEGVIPDEAK ALSLLAPANA VAGLLPGGGL LPTPNPLTQI
160 170 180 190 200
GAVPLAALGA PTLDPALAAL GLPGANLNSQ SLAADQLLKL MSTVDPKLNH
210 220 230 240 250
VAAGLVSPSL KSDTSSKEIE EAMKRVREAQ SLISAAIEPD KKEEKRRHSR
260 270 280 290 300
SRSRSRRRRT PSSSRHRRSR SRSRRRSHSK SRSRRRSKSP RRRRSHSRER
310 320 330 340 350
GRRSRSTSKT RDKKKEDKEK KRSKTPPKSY STARRSRSAS RERRRRRSRS
360 370 380 390 400
GTRSPKKPRS PKRKLSRSPS PRRHKKEKKK DKDKERSRDE RERSTSKKKK
410 420 430 440 450
SKDKEKDRER KSESDKDVKQ VTRDYDEEEQ GYDSEKEKKE EKKPIETGSP
460 470 480
KTKECSVEKG TGDSLRESKV NGDDHHEEDM DMSD
Length:484
Mass (Da):53,542
Last modified:November 1, 1996 - v1
Checksum:i1211E96DDC0A3182
GO
Isoform 2 (identifier: Q05519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,414
Checksum:i5A40AFD8B7599976
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T757Q5T757_HUMAN
Serine/arginine-rich-splicing facto...
SRSF11
424Annotation score:
Q5T760Q5T760_HUMAN
Serine/arginine-rich-splicing facto...
SRSF11
389Annotation score:
B4DWT1B4DWT1_HUMAN
Serine/arginine-rich-splicing facto...
SRSF11
128Annotation score:
S4R3C4S4R3C4_HUMAN
Serine/arginine-rich-splicing facto...
SRSF11
80Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043376420Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74002 mRNA Translation: AAA35554.1
AL353771 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06459.1
BC040436 mRNA Translation: AAH40436.1
CCDSiCCDS53332.1 [Q05519-2]
CCDS647.1 [Q05519-1]
PIRiA40988
RefSeqiNP_001177916.1, NM_001190987.1 [Q05519-2]
NP_004759.1, NM_004768.3 [Q05519-1]
XP_011540729.1, XM_011542427.2
XP_016858301.1, XM_017002812.1
XP_016858302.1, XM_017002813.1
UniGeneiHs.479693

Genome annotation databases

EnsembliENST00000370950; ENSP00000359988; ENSG00000116754 [Q05519-1]
ENST00000370951; ENSP00000359989; ENSG00000116754 [Q05519-2]
GeneIDi9295
KEGGihsa:9295
UCSCiuc001des.4 human [Q05519-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74002 mRNA Translation: AAA35554.1
AL353771 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06459.1
BC040436 mRNA Translation: AAH40436.1
CCDSiCCDS53332.1 [Q05519-2]
CCDS647.1 [Q05519-1]
PIRiA40988
RefSeqiNP_001177916.1, NM_001190987.1 [Q05519-2]
NP_004759.1, NM_004768.3 [Q05519-1]
XP_011540729.1, XM_011542427.2
XP_016858301.1, XM_017002812.1
XP_016858302.1, XM_017002813.1
UniGeneiHs.479693

3D structure databases

ProteinModelPortaliQ05519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114709, 93 interactors
CORUMiQ05519
IntActiQ05519, 33 interactors
MINTiQ05519
STRINGi9606.ENSP00000359988

PTM databases

iPTMnetiQ05519
PhosphoSitePlusiQ05519
SwissPalmiQ05519

Polymorphism and mutation databases

BioMutaiSRSF11
DMDMi8134672

Proteomic databases

EPDiQ05519
MaxQBiQ05519
PaxDbiQ05519
PeptideAtlasiQ05519
PRIDEiQ05519
ProteomicsDBi58334
58335 [Q05519-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370950; ENSP00000359988; ENSG00000116754 [Q05519-1]
ENST00000370951; ENSP00000359989; ENSG00000116754 [Q05519-2]
GeneIDi9295
KEGGihsa:9295
UCSCiuc001des.4 human [Q05519-1]

Organism-specific databases

CTDi9295
DisGeNETi9295
EuPathDBiHostDB:ENSG00000116754.13
GeneCardsiSRSF11
HGNCiHGNC:10782 SRSF11
HPAiHPA008762
MIMi602010 gene
neXtProtiNX_Q05519
OpenTargetsiENSG00000116754
PharmGKBiPA35698
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4676 Eukaryota
ENOG410YJ1Y LUCA
GeneTreeiENSGT00730000110872
HOGENOMiHOG000121772
HOVERGENiHBG058422
InParanoidiQ05519
KOiK12899
OrthoDBiEOG091G0QKH
PhylomeDBiQ05519
TreeFamiTF106266

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiSRSF11 human
GeneWikiiSFRS11
GenomeRNAii9295
PROiPR:Q05519
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116754 Expressed in 233 organ(s), highest expression level in endometrium
CleanExiHS_SFRS11
ExpressionAtlasiQ05519 baseline and differential
GenevisibleiQ05519 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034447 SRSF11
PANTHERiPTHR32343:SF6 PTHR32343:SF6, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRS11_HUMAN
AccessioniPrimary (citable) accession number: Q05519
Secondary accession number(s): Q5T758, Q8IWE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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