UniProtKB - Q05516 (ZBT16_HUMAN)
Zinc finger and BTB domain-containing protein 16
ZBTB16
Functioni
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566).
Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654).
May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
3 Publications: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 404 – 426 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 432 – 454 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 490 – 512 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 518 – 540 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 546 – 568 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 574 – 596 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 602 – 624 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 630 – 652 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- transcription corepressor binding Source: UniProtKB
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- apoptotic process Source: UniProtKB
- cartilage development Source: UniProtKB
- central nervous system development Source: UniProtKB
- embryonic digit morphogenesis Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- embryonic pattern specification Source: Ensembl
- forelimb morphogenesis Source: Ensembl
- hemopoiesis Source: UniProtKB
- male germ-line stem cell asymmetric division Source: Ensembl
- mesonephros development Source: UniProtKB
- myeloid cell differentiation Source: UniProtKB
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of myeloid cell differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- ossification involved in bone maturation Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cartilage development Source: UniProtKB
- positive regulation of chondrocyte differentiation Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of NK T cell differentiation Source: Ensembl
- positive regulation of ossification Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein localization to nucleus Source: Ensembl
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q05516 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q05516 |
SIGNORi | Q05516 |
UniPathwayi | UPA00143 |
Protein family/group databases
MoonDBi | Q05516, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 16Alternative name(s): Promyelocytic leukemia zinc finger protein Zinc finger protein 145 Zinc finger protein PLZF |
Gene namesi | Name:ZBTB16 Synonyms:PLZF, ZNF145 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12930, ZBTB16 |
MIMi | 176797, gene |
neXtProti | NX_Q05516 |
VEuPathDBi | HostDB:ENSG00000109906 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- nuclear body 1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear body Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleus Source: UniProtKB
- PML body Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- protein-containing complex Source: UniProtKB
- transcription repressor complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Skeletal defects, genital hypoplasia, and mental retardation (SGYMR)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054912 | 617 | M → V in SGYMR. 1 PublicationCorresponds to variant dbSNP:rs121434606EnsemblClinVar. | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 394 – 395 | Breakpoint for translocation to form PLZF-RAR-alpha oncogene | 2 |
Keywords - Diseasei
Disease variant, Mental retardation, Proto-oncogeneOrganism-specific databases
DisGeNETi | 7704 |
MalaCardsi | ZBTB16 |
MIMi | 612447, phenotype |
OpenTargetsi | ENSG00000109906 |
Orphaneti | 520, Acute promyelocytic leukemia 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA37517 |
Miscellaneous databases
Pharosi | Q05516, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105726 |
Genetic variation databases
BioMutai | ZBTB16 |
DMDMi | 90109930 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047729 | 1 – 673 | Zinc finger and BTB domain-containing protein 16Add BLAST | 673 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | Phosphoserine; by PDPK1Sequence analysis | 1 | |
Modified residuei | 184 | Phosphoserine; by PDPK1Sequence analysis | 1 | |
Modified residuei | 197 | Phosphoserine; by PDPK1Sequence analysis | 1 | |
Modified residuei | 256 | Phosphoserine; by PDPK1Sequence analysis | 1 | |
Modified residuei | 282 | Phosphothreonine; by PDPK1Sequence analysis | 1 | |
Modified residuei | 628 | Phosphoserine; by PDPK1Sequence analysis | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q05516 |
MassIVEi | Q05516 |
PaxDbi | Q05516 |
PeptideAtlasi | Q05516 |
PRIDEi | Q05516 |
ProteomicsDBi | 58332 [Q05516-1] 58333 [Q05516-2] |
PTM databases
iPTMneti | Q05516 |
PhosphoSitePlusi | Q05516 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000109906, Expressed in upper lobe of lung and 235 other tissues |
ExpressionAtlasi | Q05516, baseline and differential |
Genevisiblei | Q05516, HS |
Organism-specific databases
HPAi | ENSG00000109906, Tissue enhanced (tongue) |
Interactioni
Subunit structurei
Binds EPN1 (PubMed:11161217).
Interacts with ZBTB32 and CUL3 (PubMed:10572087, PubMed:14528312).
Interacts with ATP7B (PubMed:16676348).
Interacts with transcriptional corepressor RUNX1T1 (via its N-terminus); the interaction increases the transcription repression activity of ZBTB16 (PubMed:10688654).
Interacts (via C2H2-type zinc finger domains 1 and 2) with RNF112 (PubMed:24359566).
6 PublicationsBinary interactionsi
Q05516
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- transcription corepressor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113498, 170 interactors |
DIPi | DIP-2654N |
IntActi | Q05516, 124 interactors |
MINTi | Q05516 |
STRINGi | 9606.ENSP00000338157 |
Chemistry databases
BindingDBi | Q05516 |
Miscellaneous databases
RNActi | Q05516, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q05516 |
SMRi | Q05516 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q05516 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 96 | BTBPROSITE-ProRule annotationAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 200 – 300 | Interaction with RUNX1T11 PublicationAdd BLAST | 101 | |
Regioni | 215 – 236 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 249 – 332 | DisorderedSequence analysisAdd BLAST | 84 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 404 – 426 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 432 – 454 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 490 – 512 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 518 – 540 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 546 – 568 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 574 – 596 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 602 – 624 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 630 – 652 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154616 |
HOGENOMi | CLU_026420_0_0_1 |
InParanoidi | Q05516 |
OMAi | MGLIQLQ |
PhylomeDBi | Q05516 |
TreeFami | TF350825 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT
60 70 80 90 100
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD
110 120 130 140 150
DLLYAAEILE IEYLEEQCLK MLETIQASDD NDTEATMADG GAEEEEDRKA
160 170 180 190 200
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK
210 220 230 240 250
AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKTEMMQVDE
260 270 280 290 300
VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE
310 320 330 340 350
ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS
360 370 380 390 400
SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR
410 420 430 440 450
TIGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH
460 470 480 490 500
LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ
510 520 530 540 550
AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF
560 570 580 590 600
CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK
610 620 630 640 650
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK
660 670
GHKPEEIPPD WRIEKTYLYL CYV
The sequence of this isoform differs from the canonical sequence as follows:
255-377: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0S2Z4J5 | A0A0S2Z4J5_HUMAN | Zinc finger and BTB domain containi... | ZBTB16 | 644 | Annotation score: | ||
A0A804HIC1 | A0A804HIC1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB16 | 527 | Annotation score: | ||
A0A804HJ45 | A0A804HJ45_HUMAN | Zinc finger and BTB domain-containi... | ZBTB16 | 697 | Annotation score: | ||
F5H6C3 | F5H6C3_HUMAN | Zinc finger and BTB domain-containi... | ZBTB16 | 115 | Annotation score: | ||
H0YGW2 | H0YGW2_HUMAN | Zinc finger and BTB domain-containi... | ZBTB16 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 580 | G → D in CAA79489 (PubMed:8384553).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054912 | 617 | M → V in SGYMR. 1 PublicationCorresponds to variant dbSNP:rs121434606EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006896 | 255 – 377 | Missing in isoform PLZFA. CuratedAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19002 mRNA Translation: CAA79489.1 AF060568 Genomic DNA Translation: AAD03619.1 BC026902 mRNA Translation: AAH26902.1 BC029812 mRNA Translation: AAH29812.1 S60093 Genomic DNA Translation: AAC60590.2 |
CCDSi | CCDS8367.1 [Q05516-1] |
PIRi | S36336 |
RefSeqi | NP_001018011.1, NM_001018011.1 [Q05516-1] NP_005997.2, NM_006006.4 [Q05516-1] XP_016873746.1, XM_017018257.1 XP_016873747.1, XM_017018258.1 XP_016873748.1, XM_017018259.1 [Q05516-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19002 mRNA Translation: CAA79489.1 AF060568 Genomic DNA Translation: AAD03619.1 BC026902 mRNA Translation: AAH26902.1 BC029812 mRNA Translation: AAH29812.1 S60093 Genomic DNA Translation: AAC60590.2 |
CCDSi | CCDS8367.1 [Q05516-1] |
PIRi | S36336 |
RefSeqi | NP_001018011.1, NM_001018011.1 [Q05516-1] NP_005997.2, NM_006006.4 [Q05516-1] XP_016873746.1, XM_017018257.1 XP_016873747.1, XM_017018258.1 XP_016873748.1, XM_017018259.1 [Q05516-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BUO | X-ray | 1.90 | A | 6-126 | [»] | |
1CS3 | X-ray | 2.00 | A | 7-122 | [»] | |
AlphaFoldDBi | Q05516 | |||||
SMRi | Q05516 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113498, 170 interactors |
DIPi | DIP-2654N |
IntActi | Q05516, 124 interactors |
MINTi | Q05516 |
STRINGi | 9606.ENSP00000338157 |
Chemistry databases
BindingDBi | Q05516 |
ChEMBLi | CHEMBL4105726 |
Protein family/group databases
MoonDBi | Q05516, Predicted |
PTM databases
iPTMneti | Q05516 |
PhosphoSitePlusi | Q05516 |
Genetic variation databases
BioMutai | ZBTB16 |
DMDMi | 90109930 |
Proteomic databases
EPDi | Q05516 |
MassIVEi | Q05516 |
PaxDbi | Q05516 |
PeptideAtlasi | Q05516 |
PRIDEi | Q05516 |
ProteomicsDBi | 58332 [Q05516-1] 58333 [Q05516-2] |
Protocols and materials databases
ABCDi | Q05516, 3 sequenced antibodies |
Antibodypediai | 897, 402 antibodies from 38 providers |
DNASUi | 7704 |
Genome annotation databases
Organism-specific databases
CTDi | 7704 |
DisGeNETi | 7704 |
GeneCardsi | ZBTB16 |
HGNCi | HGNC:12930, ZBTB16 |
HPAi | ENSG00000109906, Tissue enhanced (tongue) |
MalaCardsi | ZBTB16 |
MIMi | 176797, gene 612447, phenotype |
neXtProti | NX_Q05516 |
OpenTargetsi | ENSG00000109906 |
Orphaneti | 520, Acute promyelocytic leukemia 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA37517 |
VEuPathDBi | HostDB:ENSG00000109906 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154616 |
HOGENOMi | CLU_026420_0_0_1 |
InParanoidi | Q05516 |
OMAi | MGLIQLQ |
PhylomeDBi | Q05516 |
TreeFami | TF350825 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q05516 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q05516 |
SIGNORi | Q05516 |
Miscellaneous databases
BioGRID-ORCSi | 7704, 11 hits in 1135 CRISPR screens |
ChiTaRSi | ZBTB16, human |
EvolutionaryTracei | Q05516 |
GeneWikii | Zinc_finger_and_BTB_domain-containing_protein_16 |
GenomeRNAii | 7704 |
Pharosi | Q05516, Tbio |
PROi | PR:Q05516 |
RNActi | Q05516, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109906, Expressed in upper lobe of lung and 235 other tissues |
ExpressionAtlasi | Q05516, baseline and differential |
Genevisiblei | Q05516, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT16_HUMAN | |
Accessioni | Q05516Primary (citable) accession number: Q05516 Secondary accession number(s): Q8TAL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | March 7, 2006 | |
Last modified: | May 25, 2022 | |
This is version 226 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families