ZBTB16

Functionⁱ

Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).2 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	404 – 426	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	432 – 454	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	461 – 483	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	490 – 512	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	518 – 540	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	546 – 568	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	574 – 596	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	602 – 624	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	630 – 652	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12802276
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
metal ion binding Source: UniProtKB-KW
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8622986
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12802276
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12802276

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 9294197
cartilage development
Source: UniProtKB
Inferred from direct assayⁱ
- 21547890
central nervous system development
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 8541544
embryonic digit morphogenesis Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
embryonic pattern specification Source: Ensembl
forelimb morphogenesis Source: Ensembl
hemopoiesis
Source: UniProtKB
Inferred from direct assayⁱ
- 8541544
male germ-line stem cell asymmetric division Source: Ensembl
mesonephros development
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 8541544
myeloid cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 9294197
negative regulation of cell proliferation Source: Ensembl
negative regulation of myeloid cell differentiation
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 8541544
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 24359566
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12802276
positive regulation of apoptotic process Source: Ensembl
positive regulation of cartilage development
Source: UniProtKB
Inferred from direct assayⁱ
- 21547890
positive regulation of chondrocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21547890
positive regulation of fat cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21547890
positive regulation of NK T cell differentiation Source: Ensembl
positive regulation of ossification
Source: UniProtKB
Inferred from direct assayⁱ
- 21547890
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 21547890
post-translational protein modification Source: Reactome
protein localization to nucleus Source: Ensembl
protein ubiquitination Source: UniProtKB-UniPathway
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q05516
SIGNORⁱ	Q05516
UniPathwayⁱ	UPA00143

Protein family/group databases

MoonDBⁱ	Q05516 Predicted

MoonDBⁱ

Q05516 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 16 Alternative name(s): Promyelocytic leukemia zinc finger protein Zinc finger protein 145 Zinc finger protein PLZF
Gene namesⁱ	Name:ZBTB16 Synonyms:PLZF, ZNF145
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109906.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12930 ZBTB16
MIMⁱ	176797 gene
neXtProtⁱ	NX_Q05516

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Skeletal defects, genital hypoplasia, and mental retardation (SGYMR)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	394 – 395	Breakpoint for translocation to form PLZF-RAR-alpha oncogene		2

Keywords - Diseaseⁱ

Disease mutation, Mental retardation, Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7704
MalaCards human disease database More...MalaCardsⁱ	ZBTB16
MIMⁱ	612447 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000109906
Orphanetⁱ	520 Acute promyelocytic leukemia
PharmGKBⁱ	PA37517

Polymorphism and mutation databases

BioMutaⁱ	ZBTB16
DMDMⁱ	90109930

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047729	1 – 673	Zinc finger and BTB domain-containing protein 16Add BLAST		673

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	76	Phosphoserine; by PDPK1Sequence analysis	1
Modified residueⁱ	184	Phosphoserine; by PDPK1Sequence analysis	1
Modified residueⁱ	197	Phosphoserine; by PDPK1Sequence analysis	1
Modified residueⁱ	256	Phosphoserine; by PDPK1Sequence analysis	1
Modified residueⁱ	282	Phosphothreonine; by PDPK1Sequence analysis	1
Modified residueⁱ	628	Phosphoserine; by PDPK1Sequence analysis	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q05516
PaxDbⁱ	Q05516
PeptideAtlas More...PeptideAtlasⁱ	Q05516
PRIDEⁱ	Q05516
ProteomicsDBⁱ	58332 58333 [Q05516-2]

PTM databases

iPTMnetⁱ	Q05516
PhosphoSitePlusⁱ	Q05516

Expressionⁱ

Tissue specificityⁱ

Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Inductionⁱ

By retinoic acid.

Gene expression databases

Bgeeⁱ	ENSG00000109906 Expressed in 223 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_ZBTB16
ExpressionAtlasⁱ	Q05516 baseline and differential
Genevisibleⁱ	Q05516 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004540 HPA001499

HPAⁱ

CAB004540
HPA001499

Interactionⁱ

Subunit structureⁱ

Binds EPN1 (PubMed:11161217). Interacts with ZBTB32 and CUL3 (PubMed:10572087, PubMed:14528312). Interacts with ATP7B (PubMed:16676348). Interacts (via C2H2-type zinc finger domains 1 and 2) with RNF112 (PubMed:24359566).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		7	EBI-711925,EBI-711925
CEP70	Q8NHQ1	3	EBI-711925,EBI-739624
COG6	Q9Y2V7	4	EBI-711925,EBI-3866319
EEF1A1	P68104	4	EBI-711925,EBI-352162
Gne	O35826	2	EBI-711925,EBI-7109445	From Rattus norvegicus.
GOLGA2	Q08379	7	EBI-711925,EBI-618309
Hoxa1	P09022	3	EBI-711925,EBI-3957603	From Mus musculus.
IL6	P05231	2	EBI-711925,EBI-720533
KRT40	Q6A162	8	EBI-711925,EBI-10171697
LAMTOR5	A0A0C4DGV4	5	EBI-711925,EBI-10173304
LDOC1	O95751	3	EBI-711925,EBI-740738
PML	P29590	7	EBI-711925,EBI-295890
PML	P29590-5	2	EBI-711925,EBI-304008
SH2D4A	Q9H788-2	3	EBI-711925,EBI-10308083
TAB2	Q9NYJ8	3	EBI-711925,EBI-358708
TRAF1	Q13077	4	EBI-711925,EBI-359224
TRAF2	Q12933	4	EBI-711925,EBI-355744
TRIM27	P14373	5	EBI-711925,EBI-719493
TRIM54	Q9BYV2	5	EBI-711925,EBI-2130429
VTA1	Q9NP79	3	EBI-711925,EBI-740160

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8622986

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113498, 124 interactors
Database of interacting proteins More...DIPⁱ	DIP-2654N
IntActⁱ	Q05516, 116 interactors
Molecular INTeraction database More...MINTⁱ	Q05516
STRINGⁱ	9606.ENSP00000338157

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	16 – 30	Combined sources	15
Turnⁱ	31 – 33	Combined sources	3
Beta strandⁱ	36 – 42	Combined sources	7
Beta strandⁱ	44 – 47	Combined sources	4
Helixⁱ	49 – 55	Combined sources	7
Helixⁱ	57 – 62	Combined sources	6
Helixⁱ	63 – 65	Combined sources	3
Beta strandⁱ	68 – 72	Combined sources	5
Helixⁱ	77 – 89	Combined sources	13
Helixⁱ	96 – 98	Combined sources	3
Helixⁱ	99 – 109	Combined sources	11
Helixⁱ	112 – 125	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	Q05516
SMRⁱ	Q05516
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q05516

EvolutionaryTraceⁱ

Q05516

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 96	BTBPROSITE-ProRule annotationAdd BLAST		63

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	404 – 426	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	432 – 454	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	461 – 483	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	490 – 512	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	518 – 540	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	546 – 568	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	574 – 596	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	602 – 624	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	630 – 652	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063338
HOGENOMⁱ	HOG000130800
HOVERGENⁱ	HBG057844
InParanoidⁱ	Q05516
KEGG Orthology (KO) More...KOⁱ	K10055
OMAⁱ	DMAIFCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11X6
PhylomeDBⁱ	Q05516
TreeFamⁱ	TF350825

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform PLZFB (identifier: Q05516-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT 
        60         70         80         90        100
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD 
       110        120        130        140        150
DLLYAAEILE IEYLEEQCLK MLETIQASDD NDTEATMADG GAEEEEDRKA 
       160        170        180        190        200
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK 
       210        220        230        240        250
AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKTEMMQVDE 
       260        270        280        290        300
VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE 
       310        320        330        340        350
ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS 
       360        370        380        390        400
SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR 
       410        420        430        440        450
TIGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH 
       460        470        480        490        500
LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ 
       510        520        530        540        550
AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF 
       560        570        580        590        600
CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK 
       610        620        630        640        650
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK 
       660        670 
GHKPEEIPPD WRIEKTYLYL CYV

Length:673

Mass (Da):74,274

Last modified:March 7, 2006 - v2

Checksum:ⁱ51F8E361FA31239E

GO

Isoform PLZFA (identifier: Q05516-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
255-377: Missing.

« Hide

        10         20         30         40         50
MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT 
        60         70         80         90        100
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD 
       110        120        130        140        150
DLLYAAEILE IEYLEEQCLK MLETIQASDD NDTEATMADG GAEEEEDRKA 
       160        170        180        190        200
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK 
       210        220        230        240        250
AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKTEMMQVDE 
       260        270        280        290        300
VPSQGFIQRE LFSKLGELAV GMKSESRTIG EQCSVCGVEL PDNEAVEQHR 
       310        320        330        340        350
KLHSGMKTYG CELCGKRFLD SLRLRMHLLA HSAGAKAFVC DQCGAQFSKE 
       360        370        380        390        400
DALETHRQTH TGTDMAVFCL LCGKRFQAQS ALQQHMEVHA GVRSYICSEC 
       410        420        430        440        450
NRTFPSHTAL KRHLRSHTGD HPYECEFCGS CFRDESTLKS HKRIHTGEKP 
       460        470        480        490        500
YECNGCGKKF SLKHQLETHY RVHTGEKPFE CKLCHQRSRD YSAMIKHLRT 
       510        520        530        540        550
HNGASPYQCT ICTEYCPSLS SMQKHMKGHK PEEIPPDWRI EKTYLYLCYV

Show »

Length:550

Mass (Da):61,601

Checksum:ⁱ1051E16C91FDC089

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H6C3	F5H6C3_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 16	ZBTB16	115	Annotation score:
F5H5Y7	F5H5Y7_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 16	ZBTB16	148	Annotation score:
H0YGW2	H0YGW2_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 16	ZBTB16	55	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	580	G → D in CAA79489 (PubMed:8384553).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_054912	617	M → V in SGYMR. 1 PublicationCorresponds to variant dbSNP:rs121434606EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006896	255 – 377	Missing in isoform PLZFA. CuratedAdd BLAST		123

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z19002 mRNA Translation: CAA79489.1 AF060568 Genomic DNA Translation: AAD03619.1 BC026902 mRNA Translation: AAH26902.1 BC029812 mRNA Translation: AAH29812.1 S60093 Genomic DNA Translation: AAC60590.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8367.1 [Q05516-1]
PIRⁱ	S36336
NCBI Reference Sequences More...RefSeqⁱ	NP_001018011.1, NM_001018011.1 [Q05516-1] NP_005997.2, NM_006006.4 [Q05516-1] XP_016873746.1, XM_017018257.1 XP_016873747.1, XM_017018258.1 XP_016873748.1, XM_017018259.1 [Q05516-1]
UniGeneⁱ	Hs.591945 Hs.682144

Genome annotation databases

Ensemblⁱ	ENST00000335953; ENSP00000338157; ENSG00000109906 [Q05516-1] ENST00000392996; ENSP00000376721; ENSG00000109906 [Q05516-1]
GeneIDⁱ	7704
KEGGⁱ	hsa:7704
UCSC genome browser More...UCSCⁱ	uc001pop.4 human [Q05516-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q05516	Zinc finger and BTB domain containing 16 isoform 1		HUMAN		673	UniRef100_Q05516
Promyelocytic leukemia zinc finger (Fragment)		HUMAN		422
Zinc finger and BTB domain-containing protein 16 (Fragment)		HUMAN		148
UPI000387D392		HUMAN		485
UPI0000110A5C		HUMAN		121
+1

Protein	Similar proteins		Species	Score	Length	Source
Q05516	Zinc finger and BTB domain containing 16 isoform 1		HUMAN		673	UniRef90_Q05516
Uncharacterized protein		MYOLU		675
zinc finger and BTB domain-containing protein 16		DELLE		673
ZBTB16 isoform 1		PANTR		673
Uncharacterized protein		PANPA		673
+109

Protein	Similar proteins		Species	Score	Length	Source
Q05516	Zinc finger and BTB domain-containing protein 16-A		DANRE		671	UniRef50_Q05516
Zinc finger and BTB domain containing 16 isoform 1		HUMAN		673
Uncharacterized protein		MYOLU		675
Zinc finger and BTB domain containing 16		SAIBB		673
Zinc finger and BTB domain containing 16		CALJA		673
+287
Q05516-2	Zinc finger and BTB domain-containing 16b		DANRE		659	UniRef50_Q05516-2
zinc finger and BTB domain-containing protein 16-A-like		ICTPU		654
Uncharacterized protein		ASTMX		658
Zinc finger and SCAN domain-containing protein 2		FUNHE		561
Uncharacterized protein		NEOLE		439
+26

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z19002 mRNA Translation: CAA79489.1 AF060568 Genomic DNA Translation: AAD03619.1 BC026902 mRNA Translation: AAH26902.1 BC029812 mRNA Translation: AAH29812.1 S60093 Genomic DNA Translation: AAC60590.2
CCDSⁱ	CCDS8367.1 [Q05516-1]
PIRⁱ	S36336
RefSeqⁱ	NP_001018011.1, NM_001018011.1 [Q05516-1] NP_005997.2, NM_006006.4 [Q05516-1] XP_016873746.1, XM_017018257.1 XP_016873747.1, XM_017018258.1 XP_016873748.1, XM_017018259.1 [Q05516-1]
UniGeneⁱ	Hs.591945 Hs.682144

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BUO	X-ray	1.90	A	6-126	[»]
	1CS3	X-ray	2.00	A	7-122	[»]
ProteinModelPortalⁱ	Q05516
SMRⁱ	Q05516
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113498, 124 interactors
DIPⁱ	DIP-2654N
IntActⁱ	Q05516, 116 interactors
MINTⁱ	Q05516
STRINGⁱ	9606.ENSP00000338157

Protein family/group databases

MoonDBⁱ	Q05516 Predicted

MoonDBⁱ

Q05516 Predicted

PTM databases

iPTMnetⁱ	Q05516
PhosphoSitePlusⁱ	Q05516

Polymorphism and mutation databases

BioMutaⁱ	ZBTB16
DMDMⁱ	90109930

Proteomic databases

EPDⁱ	Q05516
PaxDbⁱ	Q05516
PeptideAtlasⁱ	Q05516
PRIDEⁱ	Q05516
ProteomicsDBⁱ	58332 58333 [Q05516-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7704
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000335953; ENSP00000338157; ENSG00000109906 [Q05516-1] ENST00000392996; ENSP00000376721; ENSG00000109906 [Q05516-1]
GeneIDⁱ	7704
KEGGⁱ	hsa:7704
UCSCⁱ	uc001pop.4 human [Q05516-1]

Organism-specific databases

CTDⁱ	7704
DisGeNETⁱ	7704
EuPathDBⁱ	HostDB:ENSG00000109906.13
GeneCardsⁱ	ZBTB16
HGNCⁱ	HGNC:12930 ZBTB16
HPAⁱ	CAB004540 HPA001499
MalaCardsⁱ	ZBTB16
MIMⁱ	176797 gene 612447 phenotype
neXtProtⁱ	NX_Q05516
OpenTargetsⁱ	ENSG00000109906
Orphanetⁱ	520 Acute promyelocytic leukemia
PharmGKBⁱ	PA37517
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063338
HOGENOMⁱ	HOG000130800
HOVERGENⁱ	HBG057844
InParanoidⁱ	Q05516
KOⁱ	K10055
OMAⁱ	DMAIFCL
OrthoDBⁱ	EOG091G11X6
PhylomeDBⁱ	Q05516
TreeFamⁱ	TF350825

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q05516
SIGNORⁱ	Q05516

Miscellaneous databases

ChiTaRSⁱ	ZBTB16 human
EvolutionaryTraceⁱ	Q05516
GeneWikiⁱ	Zinc_finger_and_BTB_domain-containing_protein_16
GenomeRNAiⁱ	7704
Protein Ontology More...PROⁱ	PR:Q05516
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109906 Expressed in 223 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_ZBTB16
ExpressionAtlasⁱ	Q05516 baseline and differential
Genevisibleⁱ	Q05516 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT16_HUMAN
Accessionⁱ	Q05516Primary (citable) accession number: Q05516 Secondary accession number(s): Q8TAL4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	March 7, 2006
	Last modified:	October 10, 2018
	This is version 202 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniProtKB - Q05516 (ZBT16_HUMAN)

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Zinc finger and BTB domain-containing protein 16

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Nucleus

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Other locations

Keywords - Cellular componenti

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Sites

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ