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UniProtKB - Q05513 (KPCZ_HUMAN)

Entry version 230 (10 Feb 2021)
Sequence version 4 (21 Jun 2005)
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Protein

Protein kinase C zeta type

Gene

PRKCZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).7 Publications
Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (By similarity). Isoform 2: Constitutively active (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei281ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei376Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri130 – 180Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi258 – 266ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processInflammatory response
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.13, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q05513

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114604, GPVI-mediated activation cascade
R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-5218921, VEGFR2 mediated cell proliferation
R-HSA-5668599, RHO GTPases Activate NADPH Oxidases
R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q05513

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q05513

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q05513, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase C zeta type (EC:2.7.11.133 Publications)
Alternative name(s):
nPKC-zeta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKCZ
Synonyms:PKC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9412, PRKCZ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176982, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q05513

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000067606.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19K → A: No effect on interaction with SQSTM1 and PARD6B. 1 Publication1
Mutagenesisi62D → A: Loss of interaction with SQSTM1 and PARD6B. 1 Publication1
Mutagenesisi66D → A: Loss of interaction with SQSTM1 and PARD6B. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5590

Open Targets

More...OpenTargetsi		ENSG00000067606

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33775

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q05513, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3438

Drug and drug target database

More...DrugBanki		DB00675, Tamoxifen

DrugCentral

More...DrugCentrali		Q05513

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1491

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRKCZ

Domain mapping of disease mutations (DMDM)

More...DMDMi		68067736

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000557011 – 592Protein kinase C zeta typeAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei410Phosphothreonine; by PDPK1 and PI3K3 Publications1
Modified residuei560PhosphothreonineCombined sources1
Modified residuei591PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q05513

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q05513

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q05513

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q05513

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q05513

PeptideAtlas

More...PeptideAtlasi		Q05513

PRoteomics IDEntifications database

More...PRIDEi		Q05513

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19529
58330 [Q05513-1]
58331 [Q05513-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q05513

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q05513

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, and to a lesser extent in lung, kidney and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000067606, Expressed in chorionic villus and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q05513, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q05513, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000067606, Tissue enhanced (brain, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ternary complex with SQSTM1 and KCNAB2.

Forms another ternary complex with SQSTM1 and GABRR3.

Forms a complex with SQSTM1 and MAP2K5 (By similarity).

Interacts with PARD6A, PARD6B, PARD6G and SQSTM1.

Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1.

Interacts with ADAP1/CENTA1.

Forms a ternary complex composed of SQSTM1 and PAWR.

Interacts directly with SQSTM1 (Probable).

Interacts with IKBKB.

Interacts (via the protein kinase domain) with WWC1.

Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen.

Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1.

Interacts with PDPK1 (via N-terminal region).

Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529).

Interacts with VAMP2 (PubMed:17313651).

Forms a complex with WDFY2 and VAMP2 (PubMed:17313651).

Interacts with APPL1 (PubMed:26583432).

By similarityCurated13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111576, 249 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6195, PAR cell polarity complex, PARD6G-PRKCZ variant
CPX-6196, PAR cell polarity complex, PARD6B-PRKCZ variant
CPX-6197, PAR cell polarity complex, PARD6A-PRKCZ variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q05513

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q05513

Protein interaction database and analysis system

More...IntActi		Q05513, 113 interactors

Molecular INTeraction database

More...MINTi		Q05513

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367830

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q05513

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q05513, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q05513

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 98PB1PROSITE-ProRule annotationAdd BLAST84
Domaini252 – 518Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini519 – 590AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 145Interaction with SQSTM1By similarityAdd BLAST67

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.1 Publication
The C1 domain does not bind the diacylglycerol (DAG).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 180Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0695, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_63_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q05513

Identification of Orthologs from Complete Genome Data

More...OMAi		ACQHRDE

Database of Orthologous Groups

More...OrthoDBi		614710at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q05513

TreeFam database of animal gene trees

More...TreeFami		TF102004

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit
cd06404, PB1_aPKC, 1 hit
cd05617, STKc_aPKC_zeta, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000961, AGC-kinase_C
IPR034662, aPKC_zeta
IPR020454, DAG/PE-bd
IPR011009, Kinase-like_dom_sf
IPR034877, PB1_aPKC
IPR000270, PB1_dom
IPR002219, PE/DAG-bd
IPR012233, PKC
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 1 hit
PF00564, PB1, 1 hit
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000554, PKC_zeta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00008, DAGPEDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 1 hit
SM00666, PB1, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS51745, PB1, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05513-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL 
        60         70         80         90        100
HQQHPLTLKW VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP 
       110        120        130        140        150
EQPGLPCPGE DKSIYRRGAR RWRKLYRANG HLFQAKRFNR RAYCGQCSER 
       160        170        180        190        200
IWGLARQGYR CINCKLLVHK RCHGLVPLTC RKHMDSVMPS QEPPVDDKNE 
       210        220        230        240        250
DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG IKISQGLGLQ 
       260        270        280        290        300
DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE 
       310        320        330        340        350
KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE 
       360        370        380        390        400
EHARFYAAEI CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE 
       410        420        430        440        450
GLGPGDTTST FCGTPNYIAP EILRGEEYGF SVDWWALGVL MFEMMAGRSP 
       460        470        480        490        500
FDIITDNPDM NTEDYLFQVI LEKPIRIPRF LSVKASHVLK GFLNKDPKER 
       510        520        530        540        550
LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT DDYGLDNFDT 
       560        570        580        590 
QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV
Length:592
Mass (Da):67,660
Last modified:June 21, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88CCD0577E6A596C
GO
Isoform 2 (identifier: Q05513-2) [UniParc]FASTAAdd to basket
Also known as: PKMzetaBy similarity

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Note: Produced by alternative promoter usage.By similarity
Show »
Length:409
Mass (Da):46,622
Checksum:i21C316A4A2B418BD
GO
Isoform 3 (identifier: Q05513-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: MPSRTGPKME...PGLPCPGEDK → MLTPRTDE

Show »
Length:488
Mass (Da):56,136
Checksum:i219A7C60FCEF0905
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBE1E9PBE1_HUMAN
Protein kinase C zeta type
PRKCZ
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAU1D6RAU1_HUMAN
Protein kinase C zeta type
PRKCZ
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGG1D6RGG1_HUMAN
Protein kinase C zeta type
PRKCZ
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2H9F2Z2H9_HUMAN
Protein kinase C zeta type
PRKCZ
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBD4D6RBD4_HUMAN
Protein kinase C zeta type
PRKCZ
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRP7J3KRP7_HUMAN
Protein kinase C zeta type
PRKCZ
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3C5F2Z3C5_HUMAN
Protein kinase C zeta type
PRKCZ
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC84D6RC84_HUMAN
Protein kinase C zeta type
PRKCZ
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDM0D6RDM0_HUMAN
Protein kinase C zeta type
PRKCZ
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RG01D6RG01_HUMAN
Protein kinase C zeta type
PRKCZ
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA78813 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6G → D in AAA36488 (PubMed:8224878).Curated1
Sequence conflicti198K → R in BAF83684 (PubMed:14702039).Curated1
Sequence conflicti262S → T in AAA36488 (PubMed:8224878).Curated1
Sequence conflicti281K → R in BAH11883 (PubMed:14702039).Curated1
Sequence conflicti366F → L in BAF83684 (PubMed:14702039).Curated1
Sequence conflicti500R → G in BAF83684 (PubMed:14702039).Curated1
Sequence conflicti522D → G in BAF83684 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05056049R → H. Corresponds to variant dbSNP:rs35271800EnsemblClinVar.1
Natural variantiVAR_04231084R → H1 PublicationCorresponds to variant dbSNP:rs56017162Ensembl.1
Natural variantiVAR_035467514S → F in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042311519R → C in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376894109Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0419041 – 183Missing in isoform 2. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_0463471 – 112MPSRT…PGEDK → MLTPRTDE in isoform 3. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L14283 mRNA Translation: AAA36488.1
BT007082 mRNA Translation: AAP35745.1
AK290995 mRNA Translation: BAF83684.1
AK294649 mRNA Translation: BAH11833.1
AK294782 mRNA Translation: BAH11883.1
AL162271 Genomic DNA No translation available.
AL391845 Genomic DNA No translation available.
AL590822 Genomic DNA No translation available.
AL645703 Genomic DNA No translation available.
BC008058 mRNA Translation: AAH08058.1
BC014270 mRNA Translation: AAH14270.1
Z15108 mRNA Translation: CAA78813.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37.1 [Q05513-1]
CCDS41229.1 [Q05513-2]
CCDS55563.1 [Q05513-3]

Protein sequence database of the Protein Information Resource

More...PIRi		JN0877

NCBI Reference Sequences

More...RefSeqi		NP_001028753.1, NM_001033581.1 [Q05513-2]
NP_001028754.1, NM_001033582.1 [Q05513-2]
NP_001229803.1, NM_001242874.1 [Q05513-3]
NP_002735.3, NM_002744.4 [Q05513-1]
XP_016857288.1, XM_017001799.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000378567; ENSP00000367830; ENSG00000067606 [Q05513-1]
ENST00000400921; ENSP00000383712; ENSG00000067606 [Q05513-2]
ENST00000461106; ENSP00000426412; ENSG00000067606 [Q05513-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5590

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5590

UCSC genome browser

More...UCSCi		uc001aiq.3, human [Q05513-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14283 mRNA Translation: AAA36488.1
BT007082 mRNA Translation: AAP35745.1
AK290995 mRNA Translation: BAF83684.1
AK294649 mRNA Translation: BAH11833.1
AK294782 mRNA Translation: BAH11883.1
AL162271 Genomic DNA No translation available.
AL391845 Genomic DNA No translation available.
AL590822 Genomic DNA No translation available.
AL645703 Genomic DNA No translation available.
BC008058 mRNA Translation: AAH08058.1
BC014270 mRNA Translation: AAH14270.1
Z15108 mRNA Translation: CAA78813.1 Different initiation.
CCDSiCCDS37.1 [Q05513-1]
CCDS41229.1 [Q05513-2]
CCDS55563.1 [Q05513-3]
PIRiJN0877
RefSeqiNP_001028753.1, NM_001033581.1 [Q05513-2]
NP_001028754.1, NM_001033582.1 [Q05513-2]
NP_001229803.1, NM_001242874.1 [Q05513-3]
NP_002735.3, NM_002744.4 [Q05513-1]
XP_016857288.1, XM_017001799.1

3D structure databases

SMRiQ05513
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111576, 249 interactors
ComplexPortaliCPX-6195, PAR cell polarity complex, PARD6G-PRKCZ variant
CPX-6196, PAR cell polarity complex, PARD6B-PRKCZ variant
CPX-6197, PAR cell polarity complex, PARD6A-PRKCZ variant
CORUMiQ05513
ELMiQ05513
IntActiQ05513, 113 interactors
MINTiQ05513
STRINGi9606.ENSP00000367830

Chemistry databases

BindingDBiQ05513
ChEMBLiCHEMBL3438
DrugBankiDB00675, Tamoxifen
DrugCentraliQ05513
GuidetoPHARMACOLOGYi1491

Protein family/group databases

MoonDBiQ05513, Predicted

PTM databases

iPTMnetiQ05513
PhosphoSitePlusiQ05513

Genetic variation databases

BioMutaiPRKCZ
DMDMi68067736

Proteomic databases

EPDiQ05513
jPOSTiQ05513
MassIVEiQ05513
MaxQBiQ05513
PaxDbiQ05513
PeptideAtlasiQ05513
PRIDEiQ05513
ProteomicsDBi19529
58330 [Q05513-1]
58331 [Q05513-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3869, 803 antibodies

The DNASU plasmid repository

More...DNASUi		5590

Genome annotation databases

EnsembliENST00000378567; ENSP00000367830; ENSG00000067606 [Q05513-1]
ENST00000400921; ENSP00000383712; ENSG00000067606 [Q05513-2]
ENST00000461106; ENSP00000426412; ENSG00000067606 [Q05513-3]
GeneIDi5590
KEGGihsa:5590
UCSCiuc001aiq.3, human [Q05513-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5590
DisGeNETi5590

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRKCZ
HGNCiHGNC:9412, PRKCZ
HPAiENSG00000067606, Tissue enhanced (brain, placenta)
MIMi176982, gene
neXtProtiNX_Q05513
OpenTargetsiENSG00000067606
PharmGKBiPA33775
VEuPathDBiHostDB:ENSG00000067606.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0695, Eukaryota
GeneTreeiENSGT00940000153497
HOGENOMiCLU_000288_63_5_1
InParanoidiQ05513
OMAiACQHRDE
OrthoDBi614710at2759
PhylomeDBiQ05513
TreeFamiTF102004

Enzyme and pathway databases

BRENDAi2.7.11.13, 2681
PathwayCommonsiQ05513
ReactomeiR-HSA-114604, GPVI-mediated activation cascade
R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-5218921, VEGFR2 mediated cell proliferation
R-HSA-5668599, RHO GTPases Activate NADPH Oxidases
R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ
SignaLinkiQ05513
SIGNORiQ05513

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5590, 13 hits in 915 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRKCZ, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Protein_kinase_M_zeta/Protein_kinase_C_zeta

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5590
PharosiQ05513, Tchem

Protein Ontology

More...PROi		PR:Q05513
RNActiQ05513, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000067606, Expressed in chorionic villus and 206 other tissues
ExpressionAtlasiQ05513, baseline and differential
GenevisibleiQ05513, HS

Family and domain databases

CDDicd00029, C1, 1 hit
cd06404, PB1_aPKC, 1 hit
cd05617, STKc_aPKC_zeta, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR034662, aPKC_zeta
IPR020454, DAG/PE-bd
IPR011009, Kinase-like_dom_sf
IPR034877, PB1_aPKC
IPR000270, PB1_dom
IPR002219, PE/DAG-bd
IPR012233, PKC
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00564, PB1, 1 hit
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit
PIRSFiPIRSF000554, PKC_zeta, 1 hit
PRINTSiPR00008, DAGPEDOMAIN
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00666, PB1, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS51745, PB1, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKPCZ_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05513
Secondary accession number(s): A8K4N0
, A8MU64, B7Z2J7, E9PCW2, Q15207, Q5SYT5, Q969S4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 21, 2005
Last modified: February 10, 2021
This is version 230 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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