UniProtKB - Q05513 (KPCZ_HUMAN)
Protein kinase C zeta type
PRKCZ
Functioni
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 281 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 376 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 130 – 180 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 | |
Nucleotide bindingi | 258 – 266 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- 14-3-3 protein binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- insulin receptor substrate binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- phospholipase binding Source: Ensembl
- potassium channel regulator activity Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein kinase activity Source: UniProtKB
- protein kinase binding Source: Ensembl
- protein serine/threonine kinase activity Source: BHF-UCL
GO - Biological processi
- activation of phospholipase D activity Source: Ensembl
- activation of protein kinase B activity Source: Ensembl
- cell migration Source: Ensembl
- cellular response to insulin stimulus Source: Ensembl
- establishment of cell polarity Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- intracellular signal transduction Source: GO_Central
- long-term memory Source: Ensembl
- long-term synaptic potentiation Source: UniProtKB
- membrane depolarization Source: Ensembl
- membrane hyperpolarization Source: Ensembl
- microtubule cytoskeleton organization Source: Ensembl
- negative regulation of apoptotic process Source: ProtInc
- negative regulation of hydrolase activity Source: Ensembl
- negative regulation of insulin receptor signaling pathway Source: BHF-UCL
- negative regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- negative regulation of protein-containing complex assembly Source: BHF-UCL
- neuron projection extension Source: Ensembl
- peptidyl-serine phosphorylation Source: BHF-UCL
- positive regulation of cell-matrix adhesion Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of excitatory postsynaptic potential Source: UniProtKB
- positive regulation of insulin receptor signaling pathway Source: UniProtKB
- positive regulation of interleukin-10 production Source: UniProtKB
- positive regulation of interleukin-13 production Source: UniProtKB
- positive regulation of interleukin-4 production Source: UniProtKB
- positive regulation of interleukin-5 production Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of protein transport Source: Ensembl
- positive regulation of T-helper 2 cell cytokine production Source: UniProtKB
- positive regulation of T-helper 2 cell differentiation Source: UniProtKB
- protein kinase C signaling Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- protein phosphorylation Source: UniProtKB
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: Ensembl
- signal transduction Source: ProtInc
- transforming growth factor beta receptor signaling pathway Source: Reactome
- vesicle transport along microtubule Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Inflammatory response |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | Q05513 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5668599, RHO GTPases Activate NADPH Oxidases R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ |
SignaLinki | Q05513 |
SIGNORi | Q05513 |
Protein family/group databases
MoonDBi | Q05513, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase C zeta type (EC:2.7.11.133 Publications)Alternative name(s): nPKC-zeta |
Gene namesi | Name:PRKCZ Synonyms:PKC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9412, PRKCZ |
MIMi | 176982, gene |
neXtProti | NX_Q05513 |
VEuPathDBi | HostDB:ENSG00000067606.15 |
Subcellular locationi
Endosome
- Endosome 1 Publication
Other locations
- Cytoplasm 2 Publications
- Cell junction 1 Publication
- Membrane By similarity; Peripheral membrane protein Curated
Note: In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes (PubMed:9566925). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity).By similarity3 Publications
Other locations
- Cytoplasm By similarity
Cytoskeleton
- microtubule organizing center Source: Ensembl
- stress fiber Source: Ensembl
Cytosol
- cytosol Source: HPA
Endosome
- endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear envelope Source: Ensembl
- nuclear matrix Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- plasma membrane Source: HPA
Other locations
- apical cortex Source: Ensembl
- axon hillock Source: Ensembl
- bicellular tight junction Source: Ensembl
- cell junction Source: Reactome
- cell leading edge Source: Ensembl
- cell-cell junction Source: UniProtKB
- cytoplasm Source: ProtInc
- glutamatergic synapse Source: Ensembl
- membrane Source: ProtInc
- membrane raft Source: Ensembl
- myelin sheath abaxonal region Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
- postsynaptic density Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cytoplasm, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | K → A: No effect on interaction with SQSTM1 and PARD6B. 1 Publication | 1 | |
Mutagenesisi | 62 | D → A: Loss of interaction with SQSTM1 and PARD6B. 1 Publication | 1 | |
Mutagenesisi | 66 | D → A: Loss of interaction with SQSTM1 and PARD6B. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5590 |
OpenTargetsi | ENSG00000067606 |
PharmGKBi | PA33775 |
Miscellaneous databases
Pharosi | Q05513, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3438 |
DrugBanki | DB00675, Tamoxifen |
DrugCentrali | Q05513 |
GuidetoPHARMACOLOGYi | 1491 |
Genetic variation databases
BioMutai | PRKCZ |
DMDMi | 68067736 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055701 | 1 – 592 | Protein kinase C zeta typeAdd BLAST | 592 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 410 | Phosphothreonine; by PDPK1 and PI3K3 Publications | 1 | |
Modified residuei | 560 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 591 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q05513 |
jPOSTi | Q05513 |
MassIVEi | Q05513 |
MaxQBi | Q05513 |
PaxDbi | Q05513 |
PeptideAtlasi | Q05513 |
PRIDEi | Q05513 |
ProteomicsDBi | 19529 58330 [Q05513-1] 58331 [Q05513-2] |
PTM databases
iPTMneti | Q05513 |
PhosphoSitePlusi | Q05513 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000067606, Expressed in chorionic villus and 206 other tissues |
ExpressionAtlasi | Q05513, baseline and differential |
Genevisiblei | Q05513, HS |
Organism-specific databases
HPAi | ENSG00000067606, Tissue enhanced (brain, placenta) |
Interactioni
Subunit structurei
Forms a ternary complex with SQSTM1 and KCNAB2.
Forms another ternary complex with SQSTM1 and GABRR3.
Forms a complex with SQSTM1 and MAP2K5 (By similarity).
Interacts with PARD6A, PARD6B, PARD6G and SQSTM1.
Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1.
Interacts with ADAP1/CENTA1.
Forms a ternary complex composed of SQSTM1 and PAWR.
Interacts directly with SQSTM1 (Probable).
Interacts with IKBKB.
Interacts (via the protein kinase domain) with WWC1.
Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen.
Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1.
Interacts with PDPK1 (via N-terminal region).
Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529).
Interacts with VAMP2 (PubMed:17313651).
Forms a complex with WDFY2 and VAMP2 (PubMed:17313651).
Interacts with APPL1 (PubMed:26583432).
By similarityCurated13 PublicationsBinary interactionsi
Hide detailsQ05513
GO - Molecular functioni
- 14-3-3 protein binding Source: Ensembl
- insulin receptor substrate binding Source: BHF-UCL
- phospholipase binding Source: Ensembl
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111576, 249 interactors |
ComplexPortali | CPX-6195, PAR cell polarity complex, PARD6G-PRKCZ variant CPX-6196, PAR cell polarity complex, PARD6B-PRKCZ variant CPX-6197, PAR cell polarity complex, PARD6A-PRKCZ variant |
CORUMi | Q05513 |
ELMi | Q05513 |
IntActi | Q05513, 113 interactors |
MINTi | Q05513 |
STRINGi | 9606.ENSP00000367830 |
Chemistry databases
BindingDBi | Q05513 |
Miscellaneous databases
RNActi | Q05513, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 98 | PB1PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 252 – 518 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 267 | |
Domaini | 519 – 590 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 79 – 145 | Interaction with SQSTM1By similarityAdd BLAST | 67 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 130 – 180 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0695, Eukaryota |
GeneTreei | ENSGT00940000153497 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | Q05513 |
OMAi | ACQHRDE |
OrthoDBi | 614710at2759 |
PhylomeDBi | Q05513 |
TreeFami | TF102004 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd06404, PB1_aPKC, 1 hit cd05617, STKc_aPKC_zeta, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034662, aPKC_zeta IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034877, PB1_aPKC IPR000270, PB1_dom IPR002219, PE/DAG-bd IPR012233, PKC IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00564, PB1, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000554, PKC_zeta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00666, PB1, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS51745, PB1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL
60 70 80 90 100
HQQHPLTLKW VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP
110 120 130 140 150
EQPGLPCPGE DKSIYRRGAR RWRKLYRANG HLFQAKRFNR RAYCGQCSER
160 170 180 190 200
IWGLARQGYR CINCKLLVHK RCHGLVPLTC RKHMDSVMPS QEPPVDDKNE
210 220 230 240 250
DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG IKISQGLGLQ
260 270 280 290 300
DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE
310 320 330 340 350
KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE
360 370 380 390 400
EHARFYAAEI CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE
410 420 430 440 450
GLGPGDTTST FCGTPNYIAP EILRGEEYGF SVDWWALGVL MFEMMAGRSP
460 470 480 490 500
FDIITDNPDM NTEDYLFQVI LEKPIRIPRF LSVKASHVLK GFLNKDPKER
510 520 530 540 550
LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT DDYGLDNFDT
560 570 580 590
QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PBE1 | E9PBE1_HUMAN | Protein kinase C zeta type | PRKCZ | 347 | Annotation score: | ||
D6RAU1 | D6RAU1_HUMAN | Protein kinase C zeta type | PRKCZ | 136 | Annotation score: | ||
D6RGG1 | D6RGG1_HUMAN | Protein kinase C zeta type | PRKCZ | 109 | Annotation score: | ||
F2Z2H9 | F2Z2H9_HUMAN | Protein kinase C zeta type | PRKCZ | 105 | Annotation score: | ||
D6RBD4 | D6RBD4_HUMAN | Protein kinase C zeta type | PRKCZ | 98 | Annotation score: | ||
J3KRP7 | J3KRP7_HUMAN | Protein kinase C zeta type | PRKCZ | 61 | Annotation score: | ||
F2Z3C5 | F2Z3C5_HUMAN | Protein kinase C zeta type | PRKCZ | 181 | Annotation score: | ||
D6RC84 | D6RC84_HUMAN | Protein kinase C zeta type | PRKCZ | 46 | Annotation score: | ||
D6RDM0 | D6RDM0_HUMAN | Protein kinase C zeta type | PRKCZ | 73 | Annotation score: | ||
D6RG01 | D6RG01_HUMAN | Protein kinase C zeta type | PRKCZ | 82 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | G → D in AAA36488 (PubMed:8224878).Curated | 1 | |
Sequence conflicti | 198 | K → R in BAF83684 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 262 | S → T in AAA36488 (PubMed:8224878).Curated | 1 | |
Sequence conflicti | 281 | K → R in BAH11883 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 366 | F → L in BAF83684 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 500 | R → G in BAF83684 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 522 | D → G in BAF83684 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050560 | 49 | R → H. Corresponds to variant dbSNP:rs35271800EnsemblClinVar. | 1 | |
Natural variantiVAR_042310 | 84 | R → H1 PublicationCorresponds to variant dbSNP:rs56017162Ensembl. | 1 | |
Natural variantiVAR_035467 | 514 | S → F in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042311 | 519 | R → C in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376894109Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041904 | 1 – 183 | Missing in isoform 2. 1 PublicationAdd BLAST | 183 | |
Alternative sequenceiVSP_046347 | 1 – 112 | MPSRT…PGEDK → MLTPRTDE in isoform 3. 1 PublicationAdd BLAST | 112 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14283 mRNA Translation: AAA36488.1 BT007082 mRNA Translation: AAP35745.1 AK290995 mRNA Translation: BAF83684.1 AK294649 mRNA Translation: BAH11833.1 AK294782 mRNA Translation: BAH11883.1 AL162271 Genomic DNA No translation available. AL391845 Genomic DNA No translation available. AL590822 Genomic DNA No translation available. AL645703 Genomic DNA No translation available. BC008058 mRNA Translation: AAH08058.1 BC014270 mRNA Translation: AAH14270.1 Z15108 mRNA Translation: CAA78813.1 Different initiation. |
CCDSi | CCDS37.1 [Q05513-1] CCDS41229.1 [Q05513-2] CCDS55563.1 [Q05513-3] |
PIRi | JN0877 |
RefSeqi | NP_001028753.1, NM_001033581.1 [Q05513-2] NP_001028754.1, NM_001033582.1 [Q05513-2] NP_001229803.1, NM_001242874.1 [Q05513-3] NP_002735.3, NM_002744.4 [Q05513-1] XP_016857288.1, XM_017001799.1 |
Genome annotation databases
Ensembli | ENST00000378567; ENSP00000367830; ENSG00000067606 [Q05513-1] ENST00000400921; ENSP00000383712; ENSG00000067606 [Q05513-2] ENST00000461106; ENSP00000426412; ENSG00000067606 [Q05513-3] |
GeneIDi | 5590 |
KEGGi | hsa:5590 |
UCSCi | uc001aiq.3, human [Q05513-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14283 mRNA Translation: AAA36488.1 BT007082 mRNA Translation: AAP35745.1 AK290995 mRNA Translation: BAF83684.1 AK294649 mRNA Translation: BAH11833.1 AK294782 mRNA Translation: BAH11883.1 AL162271 Genomic DNA No translation available. AL391845 Genomic DNA No translation available. AL590822 Genomic DNA No translation available. AL645703 Genomic DNA No translation available. BC008058 mRNA Translation: AAH08058.1 BC014270 mRNA Translation: AAH14270.1 Z15108 mRNA Translation: CAA78813.1 Different initiation. |
CCDSi | CCDS37.1 [Q05513-1] CCDS41229.1 [Q05513-2] CCDS55563.1 [Q05513-3] |
PIRi | JN0877 |
RefSeqi | NP_001028753.1, NM_001033581.1 [Q05513-2] NP_001028754.1, NM_001033582.1 [Q05513-2] NP_001229803.1, NM_001242874.1 [Q05513-3] NP_002735.3, NM_002744.4 [Q05513-1] XP_016857288.1, XM_017001799.1 |
3D structure databases
SMRi | Q05513 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111576, 249 interactors |
ComplexPortali | CPX-6195, PAR cell polarity complex, PARD6G-PRKCZ variant CPX-6196, PAR cell polarity complex, PARD6B-PRKCZ variant CPX-6197, PAR cell polarity complex, PARD6A-PRKCZ variant |
CORUMi | Q05513 |
ELMi | Q05513 |
IntActi | Q05513, 113 interactors |
MINTi | Q05513 |
STRINGi | 9606.ENSP00000367830 |
Chemistry databases
BindingDBi | Q05513 |
ChEMBLi | CHEMBL3438 |
DrugBanki | DB00675, Tamoxifen |
DrugCentrali | Q05513 |
GuidetoPHARMACOLOGYi | 1491 |
Protein family/group databases
MoonDBi | Q05513, Predicted |
PTM databases
iPTMneti | Q05513 |
PhosphoSitePlusi | Q05513 |
Genetic variation databases
BioMutai | PRKCZ |
DMDMi | 68067736 |
Proteomic databases
EPDi | Q05513 |
jPOSTi | Q05513 |
MassIVEi | Q05513 |
MaxQBi | Q05513 |
PaxDbi | Q05513 |
PeptideAtlasi | Q05513 |
PRIDEi | Q05513 |
ProteomicsDBi | 19529 58330 [Q05513-1] 58331 [Q05513-2] |
Protocols and materials databases
Antibodypediai | 3869, 803 antibodies |
DNASUi | 5590 |
Genome annotation databases
Ensembli | ENST00000378567; ENSP00000367830; ENSG00000067606 [Q05513-1] ENST00000400921; ENSP00000383712; ENSG00000067606 [Q05513-2] ENST00000461106; ENSP00000426412; ENSG00000067606 [Q05513-3] |
GeneIDi | 5590 |
KEGGi | hsa:5590 |
UCSCi | uc001aiq.3, human [Q05513-1] |
Organism-specific databases
CTDi | 5590 |
DisGeNETi | 5590 |
GeneCardsi | PRKCZ |
HGNCi | HGNC:9412, PRKCZ |
HPAi | ENSG00000067606, Tissue enhanced (brain, placenta) |
MIMi | 176982, gene |
neXtProti | NX_Q05513 |
OpenTargetsi | ENSG00000067606 |
PharmGKBi | PA33775 |
VEuPathDBi | HostDB:ENSG00000067606.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0695, Eukaryota |
GeneTreei | ENSGT00940000153497 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | Q05513 |
OMAi | ACQHRDE |
OrthoDBi | 614710at2759 |
PhylomeDBi | Q05513 |
TreeFami | TF102004 |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | Q05513 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5668599, RHO GTPases Activate NADPH Oxidases R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ |
SignaLinki | Q05513 |
SIGNORi | Q05513 |
Miscellaneous databases
BioGRID-ORCSi | 5590, 13 hits in 915 CRISPR screens |
ChiTaRSi | PRKCZ, human |
GeneWikii | Protein_kinase_M_zeta/Protein_kinase_C_zeta |
GenomeRNAii | 5590 |
Pharosi | Q05513, Tchem |
PROi | PR:Q05513 |
RNActi | Q05513, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000067606, Expressed in chorionic villus and 206 other tissues |
ExpressionAtlasi | Q05513, baseline and differential |
Genevisiblei | Q05513, HS |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd06404, PB1_aPKC, 1 hit cd05617, STKc_aPKC_zeta, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034662, aPKC_zeta IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034877, PB1_aPKC IPR000270, PB1_dom IPR002219, PE/DAG-bd IPR012233, PKC IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00564, PB1, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000554, PKC_zeta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00666, PB1, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS51745, PB1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPCZ_HUMAN | |
Accessioni | Q05513Primary (citable) accession number: Q05513 Secondary accession number(s): A8K4N0 Q969S4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | June 21, 2005 | |
Last modified: | February 10, 2021 | |
This is version 230 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index