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Entry version 193 (02 Jun 2021)
Sequence version 2 (30 Nov 2010)
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Protein

Zinc finger protein 91

Gene

ZNF91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305).

May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo (PubMed:11470777).

1 Publication1 Publication

Miscellaneous

ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the protein's ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).2 Publications1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri154 – 176C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri208 – 232C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri238 – 260C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 680C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 708C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri714 – 736C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 764C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri770 – 792C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri798 – 820C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri826 – 848C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri854 – 876C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri885 – 904C2H2-type 27; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri910 – 932C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri938 – 960C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri966 – 988C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri994 – 1016C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1022 – 1044C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1050 – 1072C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1078 – 1100C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1106 – 1128C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1134 – 1156C2H2-type 36PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q05481

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 91
Alternative name(s):
Zinc finger protein HPF7
Zinc finger protein HTF10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF91
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13166, ZNF91

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603971, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05481

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000167232.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7644

Open Targets

More...
OpenTargetsi
ENSG00000167232

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37739

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q05481, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF91

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104067

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474001 – 1191Zinc finger protein 91Add BLAST1191

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q05481

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q05481

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05481

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05481

PeptideAtlas

More...
PeptideAtlasi
Q05481

PRoteomics IDEntifications database

More...
PRIDEi
Q05481

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58328 [Q05481-1]
58329 [Q05481-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05481

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167232, Expressed in frontal cortex and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q05481, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q05481, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167232, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113460, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q05481, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300619

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q05481, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05481

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri208 – 232C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri238 – 260C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 680C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 708C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri714 – 736C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 764C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri770 – 792C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri798 – 820C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri826 – 848C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri854 – 876C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri885 – 904C2H2-type 27; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri910 – 932C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri938 – 960C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri966 – 988C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri994 – 1016C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1022 – 1044C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1050 – 1072C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1078 – 1100C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1106 – 1128C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1134 – 1156C2H2-type 36PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05481

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCFPDNS

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05481

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 29 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 34 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 19 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 31 hits
PS50157, ZINC_FINGER_C2H2_2, 35 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05481-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA
60 70 80 90 100
FLGIALSKPD LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM
110 120 130 140 150
EDSFQKVLLR KYEKCGHENL QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ
160 170 180 190 200
SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK CFKCKKCVKS FCIRLHKTQH
210 220 230 240 250
KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC EECGKAFKQL
260 270 280 290 300
STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG
310 320 330 340 350
KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY
360 370 380 390 400
KCKECGKAFS NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH
410 420 430 440 450
AGEKLYKCEE CGKAFNRSSN LTIHKFIHTG EKPYKCEECG KAFNWSSSLT
460 470 480 490 500
KHKRFHTREK PFKCKECGKA FIWSSTLTRH KRIHTGEKPY KCEECGKAFR
510 520 530 540 550
QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH SREKPYKCKE
560 570 580 590 600
CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK
610 620 630 640 650
SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR
660 670 680 690 700
IHTGEKPYKC KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST
710 720 730 740 750
LTKHKIIHAG EKLYKCEECG KAFNRSSNLT IHKFIHTGEK PYKCEECGKA
760 770 780 790 800
FNWSSSLTKH KRIHTREKPF KCKECGKAFI WSSTLTRHKR IHTGEKPYKC
810 820 830 840 850
EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA LAKHKIIHAG
860 870 880 890 900
EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH
910 920 930 940 950
KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS
960 970 980 990 1000
STLTTHKIIH TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG
1010 1020 1030 1040 1050
KAFSQSSTLT RHTRMHTGEK PYKCEECGKA FNRSSKLTTH KIIHTGEKPY
1060 1070 1080 1090 1100
KCEECGKAFI SSSTLNGHKR IHTREKPYKC EECGKAFSQS STLTRHKRLH
1110 1120 1130 1140 1150
TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG KAFNQSSILT
1160 1170 1180 1190
NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y
Length:1,191
Mass (Da):137,217
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8F5F0327A79EE3B
GO
Isoform 2 (identifier: Q05481-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Show »
Length:1,159
Mass (Da):133,536
Checksum:i988520EB0A88BE5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX31M0QX31_HUMAN
Zinc finger protein 91
ZNF91
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R186M0R186_HUMAN
Zinc finger protein 91
ZNF91
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58672 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142L → F in BAH13252 (PubMed:14702039).Curated1
Sequence conflicti333R → H in AAA59469 (PubMed:8467795).Curated1
Sequence conflicti470A → G in AAA59469 (PubMed:8467795).Curated1
Sequence conflicti493E → V in BAF83945 (PubMed:14702039).Curated1
Sequence conflicti663C → R in BAF83945 (PubMed:14702039).Curated1
Sequence conflicti760H → R in BAH13252 (PubMed:14702039).Curated1
Sequence conflicti907E → G in BAH13252 (PubMed:14702039).Curated1
Sequence conflicti909T → P in AAA59469 (PubMed:8467795).Curated1
Sequence conflicti1140G → C in AAA59469 (PubMed:8467795).Curated1
Sequence conflicti1164L → A in BAF83945 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057393112Y → H. Corresponds to variant dbSNP:rs296091Ensembl.1
Natural variantiVAR_060417336T → A1 PublicationCorresponds to variant dbSNP:rs449447Ensembl.1
Natural variantiVAR_060418386A → T2 PublicationsCorresponds to variant dbSNP:rs403356Ensembl.1
Natural variantiVAR_059897455F → I. Corresponds to variant dbSNP:rs440638Ensembl.1
Natural variantiVAR_060419521E → K. Corresponds to variant dbSNP:rs12976753Ensembl.1
Natural variantiVAR_057394896T → A. Corresponds to variant dbSNP:rs296093Ensembl.1
Natural variantiVAR_0604201011R → I. Corresponds to variant dbSNP:rs1821844Ensembl.1
Natural variantiVAR_0604211033R → Q. Corresponds to variant dbSNP:rs1821846Ensembl.1
Natural variantiVAR_0598981164L → P. Corresponds to variant dbSNP:rs428549Ensembl.1
Natural variantiVAR_0598991164L → V. Corresponds to variant dbSNP:rs385750Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04028855 – 86Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L11672 mRNA Translation: AAA59469.1
AK300294 mRNA Translation: BAH13252.1
AK291256 mRNA Translation: BAF83945.1
AC010300 Genomic DNA No translation available.
AC016628 Genomic DNA No translation available.
AC022409 Genomic DNA No translation available.
AC093058 Genomic DNA No translation available.
M61871 mRNA Translation: AAA58672.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS42541.1 [Q05481-1]
CCDS74322.1 [Q05481-2]

Protein sequence database of the Protein Information Resource

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PIRi
F39384
PQ0636
S35305

NCBI Reference Sequences

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RefSeqi
NP_001287880.1, NM_001300951.1 [Q05481-2]
NP_003421.2, NM_003430.3 [Q05481-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300619; ENSP00000300619; ENSG00000167232 [Q05481-1]
ENST00000397082; ENSP00000380272; ENSG00000167232 [Q05481-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7644

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7644

UCSC genome browser

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UCSCi
uc002nre.4, human [Q05481-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11672 mRNA Translation: AAA59469.1
AK300294 mRNA Translation: BAH13252.1
AK291256 mRNA Translation: BAF83945.1
AC010300 Genomic DNA No translation available.
AC016628 Genomic DNA No translation available.
AC022409 Genomic DNA No translation available.
AC093058 Genomic DNA No translation available.
M61871 mRNA Translation: AAA58672.1 Frameshift.
CCDSiCCDS42541.1 [Q05481-1]
CCDS74322.1 [Q05481-2]
PIRiF39384
PQ0636
S35305
RefSeqiNP_001287880.1, NM_001300951.1 [Q05481-2]
NP_003421.2, NM_003430.3 [Q05481-1]

3D structure databases

SMRiQ05481
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113460, 7 interactors
IntActiQ05481, 7 interactors
STRINGi9606.ENSP00000300619

PTM databases

iPTMnetiQ05481
PhosphoSitePlusiQ05481

Genetic variation databases

BioMutaiZNF91
DMDMi313104067

Proteomic databases

jPOSTiQ05481
MassIVEiQ05481
MaxQBiQ05481
PaxDbiQ05481
PeptideAtlasiQ05481
PRIDEiQ05481
ProteomicsDBi58328 [Q05481-1]
58329 [Q05481-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28756, 106 antibodies

The DNASU plasmid repository

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DNASUi
7644

Genome annotation databases

EnsembliENST00000300619; ENSP00000300619; ENSG00000167232 [Q05481-1]
ENST00000397082; ENSP00000380272; ENSG00000167232 [Q05481-2]
GeneIDi7644
KEGGihsa:7644
UCSCiuc002nre.4, human [Q05481-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7644
DisGeNETi7644

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF91
HGNCiHGNC:13166, ZNF91
HPAiENSG00000167232, Low tissue specificity
MIMi603971, gene
neXtProtiNX_Q05481
OpenTargetsiENSG00000167232
PharmGKBiPA37739
VEuPathDBiHostDB:ENSG00000167232.13

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161942
HOGENOMiCLU_002678_17_1_1
InParanoidiQ05481
OMAiKCFPDNS
OrthoDBi1318335at2759
PhylomeDBiQ05481
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ05481

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7644, 41 hits in 948 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF91, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7644
PharosiQ05481, Tbio

Protein Ontology

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PROi
PR:Q05481
RNActiQ05481, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167232, Expressed in frontal cortex and 250 other tissues
ExpressionAtlasiQ05481, baseline and differential
GenevisibleiQ05481, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 29 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 34 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 19 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 31 hits
PS50157, ZINC_FINGER_C2H2_2, 35 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF91_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05481
Secondary accession number(s): A8K5E1, B7Z6G6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 30, 2010
Last modified: June 2, 2021
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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