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Entry version 151 (07 Apr 2021)
Sequence version 3 (28 Jul 2009)
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Protein

Polyketide synthase PksL

Gene

pksL

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 5 phosphopantetheines covalently.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei609For beta-ketoacyl synthase 1 activityPROSITE-ProRule annotation1
Active sitei2103For beta-ketoacyl synthase 2 activityPROSITE-ProRule annotation1
Active sitei3040For beta-ketoacyl synthase 3 activityPROSITE-ProRule annotation1
Active sitei4237For beta-ketoacyl synthase 4 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
Biological processAntibiotic biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU17190-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA01003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyketide synthase PksL
Short name:
PKS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pksL
Synonyms:outG, pksA, pksX
Ordered Locus Names:BSU17190
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001802991 – 4538Polyketide synthase PksLAdd BLAST4538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei354O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1834O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2634O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2775O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3997O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05470

PRoteomics IDEntifications database

More...
PRIDEi
Q05470

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU17190

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05470

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini320 – 394Carrier 1PROSITE-ProRule annotationAdd BLAST75
Domaini1800 – 1873Carrier 2PROSITE-ProRule annotationAdd BLAST74
Domaini2597 – 2674Carrier 3PROSITE-ProRule annotationAdd BLAST78
Domaini2738 – 2815Carrier 4PROSITE-ProRule annotationAdd BLAST78
Domaini3960 – 4037Carrier 5PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni436 – 874Beta-ketoacyl synthase 1Add BLAST439
Regioni1048 – 1226DehydrataseAdd BLAST179
Regioni1520 – 1713Beta-ketoacyl reductase 1Add BLAST194
Regioni1929 – 2368Beta-ketoacyl synthase 2Add BLAST440
Regioni2876 – 3297Beta-ketoacyl synthase 3Add BLAST422
Regioni3686 – 3887Beta-ketoacyl reductase 2Add BLAST202
Regioni4085 – 4488Beta-ketoacyl synthase 4Add BLAST404

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0236, Bacteria
COG0300, Bacteria
COG3321, Bacteria
COG4221, Bacteria

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q05470

Identification of Orthologs from Complete Genome Data

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OMAi
ITGLEWI

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 5 hits
3.10.129.110, 2 hits
3.40.47.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036736, ACP-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR011254, Prismane-like_sf
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16197, KAsynt_C_assoc, 3 hits
PF00109, ketoacyl-synt, 4 hits
PF02801, Ketoacyl-synt_C, 4 hits
PF08659, KR, 2 hits
PF00550, PP-binding, 5 hits
PF14765, PS-DH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 4 hits
SM00823, PKS_PP, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 3 hits
SSF53901, SSF53901, 4 hits
SSF56821, SSF56821, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05470-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWRSNVKKI TKQLTLSLKN PFIYHHVVYG QNVLPGLAYI DIIYQIFREH
60 70 80 90 100
GFSCSELQLR NLSIYQPLTA EQDAVIVLNI QCAEKKEGQW QITAKGIEKR
110 120 130 140 150
DGKEASEEKL YMKADMHADS PAIFEETLDL SQIKASAQNV VQLDDVYEQC
160 170 180 190 200
RRQELVHSEY MKAKGCIYEE EDGVLLELSL GSEAMLHAEG FMFHPTLIDG
210 220 230 240 250
SGVGANHLLT SLLKGEQRLY LPLFYESFSA SALLQTDCMT RIKRSSVRRE
260 270 280 290 300
KELIYVTLEF FNASGEKVAE LKNFTSKLVR EAELISGKHQ DAQETQMTRA
310 320 330 340 350
DTAERDKPAD MVSSPVNSYS EAEQFVSQLI AEKINKPVEQ VEKQVGYYQM
360 370 380 390 400
GLNSSGLLEV VETISDKIGE SLSPTLLFEH TTIAELSAFL AEEYAEHFSA
410 420 430 440 450
AGSLGQNERA RVSDSINDHK TVEGSRPAPI EAAGDIAIIG LAGRYPKAAN
460 470 480 490 500
IHEFWNNLKE GKDCVSEIPE SRWDWQRLEG ITSPSGKDIS KWGGFIDDPD
510 520 530 540 550
CFDPQFFRIT PREAETMDPQ ERLFLETCWE TIEDAGYTPK TLAKPKGRNK
560 570 580 590 600
RQHVGVFAGV MHKDYTLVGA EEASAENVFP LSLNYAQIAN RVSYFCNFHG
610 620 630 640 650
PSMAVDTVCS SSLTAVHLAL ESIRHGECDV ALAGGVNLSL HPNKYMTYGV
660 670 680 690 700
WDMFSTDGHC RTFGKDGDGY VPAEGIGAVL LKPLRQAEED GDRIYAVIKG
710 720 730 740 750
SAVNHVGTVS GISVPSPVSQ ADLIETCLEK TGIDPRTISY VEAHGTGTSL
760 770 780 790 800
GDPIEIQGLV KAFRQYTQDR QFCSIGSVKS NIGHAESAAG ISGLSKVALQ
810 820 830 840 850
LHHQKLVPSL HSEELNPYVD FEKSPFYVQH ETETWKQPVI KENGEDVPYP
860 870 880 890 900
RRAGISSFGA TGSNAHIILE EHIPQAAEQD VSLSSDSDIS AVIPLSARNQ
910 920 930 940 950
ERLRVYAKRL LDFLHDGIQI RDLAYTLQVG REPMEERVSF LASGIQELSD
960 970 980 990 1000
QLKAFIEGRK AIQHCWKGRV SRGSEPSRPA ESVHKLLEQR KLDQIAEQWA
1010 1020 1030 1040 1050
NGSGVDWKLL YEGSKPKRIS LPTYPFERVR YWVPKAEKKT DRSKQERHIL
1060 1070 1080 1090 1100
HPLLHQNVSD ISGVRFRSAF TGREFFLKDH VIKGEHVLPG AALLEMVRAA
1110 1120 1130 1140 1150
VERAAADQFP TGFRLRNIVW VRPFAVTEQQ KDIDVRLYPE ENGEITFEIC
1160 1170 1180 1190 1200
RDPESAEESP IVYGQGSAVL CEAGENPVIN IEELKASYNG RTLSPFDCYE
1210 1220 1230 1240 1250
AYTEMGIHYG DSHRAIDSLY AGENGVLVKL TMPPVISDTE DHYILHPSMI
1260 1270 1280 1290 1300
DSAFQASIGL RLGGATSLED RKAMLPFAIQ DVRIFKGCEA SMWARITYSE
1310 1320 1330 1340 1350
GSTAGDRMQK LDIDLCNEEG QVCVRLTSYS ARVLETDQEG PSEANDTLLF
1360 1370 1380 1390 1400
EHIWEERAAE RQELIEYDTY KVVVCDVGEQ MESLQNHLDC TVLQHDTETI
1410 1420 1430 1440 1450
DERFEGYAIQ LFEEIKQLMH SKTGGHTFIQ VAVPALDEPQ LLSGLTGLLK
1460 1470 1480 1490 1500
TAELENPKLT GQLIEIETGM SAGELFEILE ENRRYPRDTH IRHWQGKRFV
1510 1520 1530 1540 1550
SKWKEVSGEH LSADMPWKDK GVYLITGGAG GLGFIFATEI ANQTNDAVVI
1560 1570 1580 1590 1600
LTGRSPLDER KKKKLKALQK LGIQAIYRQA DLADKQTVDA LLKETQNVYG
1610 1620 1630 1640 1650
DLDGIIHSAG LIKDNFIMKK KKEEVQTVLA PKVAGLIHLD EATKDIPLDF
1660 1670 1680 1690 1700
FILFSSGAGA VGSAGQADYA MANAFMNAFS EYRNGQAELH KRYGKTLSVC
1710 1720 1730 1740 1750
WPLWKDGGMQ IDAETARMLK RETGMVAMET DRGIQALYHG WTSGKPQVLV
1760 1770 1780 1790 1800
ASGVTDRIRA FLHETGHGKG QSHNIKKSSL NQEAEKADMI GEIDEEILRE
1810 1820 1830 1840 1850
KAENYFKQVL SSVIKLPAGQ IDAEAPLEDY GIDSIMIMHV TGQLEKVFGS
1860 1870 1880 1890 1900
LSKTLFFEYQ DIRSLTRYFI DSRREKLLDI LGFETGKPSV ERKSEPEKQE
1910 1920 1930 1940 1950
IPVIPRKSGF LPLQDKEQKQ VREKETEEIA IIGISGRYPQ ADNIDELWEK
1960 1970 1980 1990 2000
LRDGRDCITE IPADRWDHSL YYDEDKDKPG KTYSKWGGFM KDVDKFDPQF
2010 2020 2030 2040 2050
FHISPREAKL MDPQERLFLQ CVYETMEDAG YTREHLGRKR DAELGGSVGV
2060 2070 2080 2090 2100
YVGVMYEEYQ LYGAQEQVRG RSLALTGNPS SIANRVSYYF DFHGPSIALD
2110 2120 2130 2140 2150
TMCSSSLTAI HLACQSLQRG ECEAAFAGGV NVSIHPNKYL MLGQNKFMSS
2160 2170 2180 2190 2200
KGRCESFGQG GDGYVPGEGV GAVLLKPLSK AVEDGDHIYG IIKGTAINHG
2210 2220 2230 2240 2250
GKTNGYSVPN PNAQADVIKK AFVEAKVDPR TVSYIEAHGT GTSLGDPIEI
2260 2270 2280 2290 2300
TGLSKVFTQE TDDKQFCAIG SAKSNIGHCE SAAGIAGVTK VLLQMKYRQL
2310 2320 2330 2340 2350
APSLHSNVLN PNIDFLNSPF KVQQELEEWK RPIISVNGKD IELPRIAGVS
2360 2370 2380 2390 2400
SFGAGGVNAH ILIEEYAPEP VEERLPARKQ PAVIVLSAKN EERLQKRAER
2410 2420 2430 2440 2450
LLHAIREQTY VEADLHRIAY TLQVGREAMK ERLAFVAETM QELEEKLYEC
2460 2470 2480 2490 2500
ISGTENREYV YRGQVKSNKE AIAAFAADED MSKTIEAWLQ KGKYAKVLDL
2510 2520 2530 2540 2550
WVRGLRIDWS TLYQDQKPRR ISLPAYPFAR DRYWIDVNAK AEEKRTEEPF
2560 2570 2580 2590 2600
APVQPVIPKP SVDREASGKP ANITLQPLMT NQDRLERVPS DTETETITAE
2610 2620 2630 2640 2650
ALCDELTAGL AEVLYMDQNE IDPDEAFIDI GMDSITGLEW IKAINKQYGT
2660 2670 2680 2690 2700
SLNVTKVYDY PTTRDFAVYL AHELSTQAGE KKQTETYTPI RQKTVVPAAK
2710 2720 2730 2740 2750
PANISLQPLE HHQPVQEEAE ETIQYAAAEI SASRQYTVAI ETLHENLRES
2760 2770 2780 2790 2800
IADVLYMEPY EVDIDEAFID IGMDSITGLE WIKAVNKQYG TSFTVTRVYD
2810 2820 2830 2840 2850
YPTIRDFAEM LKSELGTHLD RKIEHTDSFE AAQQKPAASS HPKPAERPLQ
2860 2870 2880 2890 2900
PVQHPIKKEH EKKTVPVLQD RPEDAIAIVG MSGRYPGARN VREYWDNLVH
2910 2920 2930 2940 2950
ARNAIRDIPT SRWDVDKYYD PVLNKKGKVY CKSMGMLDDI EHFDPLFFNI
2960 2970 2980 2990 3000
PPSEAELMDP QHRIFLQEGY KAFEDAGYNA RTLNEKKCGV YLGIMSNEYG
3010 3020 3030 3040 3050
VMLNRQSRAN ATGNSFAIAA ARIPYFLNLK GPAIPIDTAC SSSLVGTHLA
3060 3070 3080 3090 3100
RQALINKEID MALVGGVSLY LTPESYMSMC EAGMLSPDGQ CKAFDNGANG
3110 3120 3130 3140 3150
FVPGEGAGAL VLKRLKDAEA DRDHIYGIII GSGINQDGKT NGITAPSAKS
3160 3170 3180 3190 3200
QMDLERDIYE TYGIHPESIS YVEMHGTGTK QGDPIELEAL STVFQEKTDK
3210 3220 3230 3240 3250
KQFCAIGSVK SNIGHTSAAA GVAGVQKVLL CMNHKTLVPT LNFTTPNEHF
3260 3270 3280 3290 3300
EFEHSPLYVN TELKPWETAD GKPRRACVSS FGYSGTNAHI VIEEYQPEKR
3310 3320 3330 3340 3350
NDRLTKQHRS ALFVLSAKKE KQLKAYAEAM KDFVTSNEDI DLEDMAYTLQ
3360 3370 3380 3390 3400
TGREAMDYRM AFLADSREML IKALDDYLAE MPNGSIFAAH VKTKKSEIKL
3410 3420 3430 3440 3450
FETDHDAKAL LQTWIEKKRL EKVAELWVKG LQIDWNKLYG EYTPRRISLP
3460 3470 3480 3490 3500
AYPFAEEYYW LPTQEGEPET IATAMPQFEL MPKRCFLRKQ WQPCPIEPAE
3510 3520 3530 3540 3550
MTNQTVAILA NEETMALAEE LSAYFSTYRI FDSQELDRVS AADYEHVAGA
3560 3570 3580 3590 3600
IDLIGCGTSH EHSMGWINWL QKLIEQGRAS KHHLTVLGVT KGLEAYANEG
3610 3620 3630 3640 3650
VLLSGASRAG LYRMLQSEYS HLTSRHADME CEASHEELAR LIAVEYYAKS
3660 3670 3680 3690 3700
TESEVCYRNG QRYRAYLTEQ PAEAALSHKQ VSFSTDKVLL ITGGTRGLGL
3710 3720 3730 3740 3750
LCARHFVKTY GVKRLVLIGR EELPPRDQWN SVKISSLAEK IKAVQELEDM
3760 3770 3780 3790 3800
GAQVQVLSLD LTDRVAVEQS LKTIHETMGA IGGVIHCAGM VNKQNPAFIR
3810 3820 3830 3840 3850
KSLEEIGQVL EPKVEGLQTL FDLLQDEPLA FFTLFSSVSA AIPALAAGQA
3860 3870 3880 3890 3900
DYAMANAFMD YFAEAHQDKC PIVSIQWPNW KETGLGEVRS KALEQTGLIS
3910 3920 3930 3940 3950
LTNDEGLQLL DQILSDRQYA VVLPAVPDTN VWKPDKLMQP SLPVEALSHP
3960 3970 3980 3990 4000
ETKEQTSTRN LFPETVDWLV TLFSDELKIA AEDFETDEPF QEYGIDSIIL
4010 4020 4030 4040 4050
AQLVQQMNQQ LNGDIDPSIL FEYPTIESFA HWLISKYDIS AVLQPSVPEK
4060 4070 4080 4090 4100
QTPLKPQSAM KQKLVPEQRP QQISHEKTAL LAEDIAIIGL SCRFPGAETL
4110 4120 4130 4140 4150
EEYWDLIRDG RSAIAPVPPE RFGNSSSNYA GLIDEMNRFD HDFFMMSESD
4160 4170 4180 4190 4200
VRAMDPQALA VLEESLKLWY HAGYTEKEVK GMRAGVYIGG RSQHKPDPAS
4210 4220 4230 4240 4250
LSKAKNPIVA GGQNYLAANI SQFFDLKGPS IVLDTACSSA LVGLNMAIQA
4260 4270 4280 4290 4300
LRSGDIEAAV VGGVSLLDAD AHRMFHERGL LCDKPSFHIF DKRADGVILG
4310 4320 4330 4340 4350
EGVGMVLVKT VNQAVEDGDS IYAVIKAAAI NNDGRTAGPS SPNLEAQKDV
4360 4370 4380 4390 4400
MLSALEKSGK KTEEISYLEA NGSGSAVTDL LELKAIQSIY RSESKAPLGL
4410 4420 4430 4440 4450
GSVKPNIGHP LCAEGIASLI KVALMLKHRQ LVPFLSGNEN MPYFDIEKTD
4460 4470 4480 4490 4500
LYFSRSQAEW KETTPAAAIN CFADGGTNAH LIIEGWRDSA ERPIRRKPLP
4510 4520 4530
LPELNRQPVL IKPSAQNVQK KVHSDTGASK DMFWKTFK
Length:4,538
Mass (Da):506,182
Last modified:July 28, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i398353DEC864EBF2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA85145 differs from that shown. Reason: Frameshift.Curated
The sequence CAA78479 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2299 – 2300QL → HV in AAA85145 (PubMed:8344529).Curated2
Sequence conflicti2299 – 2300QL → HV in CAA78479 (PubMed:8344529).Curated2
Sequence conflicti2398A → P in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti2398A → P in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti3384G → A in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti3384G → A in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti4041A → R in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti4041A → R in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti4041A → R in CAA84504 (Ref. 5) Curated1
Sequence conflicti4232V → L in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti4232V → L in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti4232V → L in CAA84504 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U11039 Genomic DNA Translation: AAA85145.1 Frameshift.
AL009126 Genomic DNA Translation: CAB13602.3
Z14098 Genomic DNA Translation: CAA78479.1 Frameshift.
Z35133 Genomic DNA Translation: CAA84504.1

Protein sequence database of the Protein Information Resource

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PIRi
S25021, PN0637

NCBI Reference Sequences

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RefSeqi
NP_389600.3, NC_000964.3
WP_010886513.1, NZ_JNCM01000035.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB13602; CAB13602; BSU_17190

Database of genes from NCBI RefSeq genomes

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GeneIDi
940032

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
bsu:BSU17190

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|224308.43.peg.1815

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11039 Genomic DNA Translation: AAA85145.1 Frameshift.
AL009126 Genomic DNA Translation: CAB13602.3
Z14098 Genomic DNA Translation: CAA78479.1 Frameshift.
Z35133 Genomic DNA Translation: CAA84504.1
PIRiS25021, PN0637
RefSeqiNP_389600.3, NC_000964.3
WP_010886513.1, NZ_JNCM01000035.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E1VX-ray1.87A/B6-279[»]
5E5NX-ray2.00A/B/C/D2870-3466[»]
5E6KX-ray2.16A/B2870-3466[»]
5ENYX-ray4.00A/B/C/D/E/F/G/H2719-3462[»]
5ERFX-ray3.10A/B2870-3466[»]
SMRiQ05470
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU17190

Proteomic databases

PaxDbiQ05470
PRIDEiQ05470

Genome annotation databases

EnsemblBacteriaiCAB13602; CAB13602; BSU_17190
GeneIDi940032
KEGGibsu:BSU17190
PATRICifig|224308.43.peg.1815

Phylogenomic databases

eggNOGiCOG0236, Bacteria
COG0300, Bacteria
COG3321, Bacteria
COG4221, Bacteria
InParanoidiQ05470
OMAiITGLEWI

Enzyme and pathway databases

UniPathwayiUPA01003
BioCyciBSUB:BSU17190-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 5 hits
3.10.129.110, 2 hits
3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR036736, ACP-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR011254, Prismane-like_sf
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF16197, KAsynt_C_assoc, 3 hits
PF00109, ketoacyl-synt, 4 hits
PF02801, Ketoacyl-synt_C, 4 hits
PF08659, KR, 2 hits
PF00550, PP-binding, 5 hits
PF14765, PS-DH, 2 hits
SMARTiView protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 4 hits
SM00823, PKS_PP, 5 hits
SUPFAMiSSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 3 hits
SSF53901, SSF53901, 4 hits
SSF56821, SSF56821, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKSL_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05470
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 28, 2009
Last modified: April 7, 2021
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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