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UniProtKB - Q05470 (PKSL_BACSU)

Entry version 154 (23 Feb 2022)
Sequence version 3 (28 Jul 2009)
Previous versions | rss
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Protein

Polyketide synthase PksL

Gene

pksL

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.

1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 5 phosphopantetheines covalently.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei609For beta-ketoacyl synthase 1 activityPROSITE-ProRule annotation1
Active sitei2103For beta-ketoacyl synthase 2 activityPROSITE-ProRule annotation1
Active sitei3040For beta-ketoacyl synthase 3 activityPROSITE-ProRule annotation1
Active sitei4237For beta-ketoacyl synthase 4 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
Biological processAntibiotic biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		BSUB:BSU17190-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA01003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyketide synthase PksL
Short name:
PKS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pksL
Synonyms:outG, pksA, pksX
Ordered Locus Names:BSU17190
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001802991 – 4538Polyketide synthase PksLAdd BLAST4538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei354O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1834O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2634O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2775O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3997O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q05470

PRoteomics IDEntifications database

More...PRIDEi		Q05470

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		224308.BSU17190

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q05470

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini320 – 394Carrier 1PROSITE-ProRule annotationAdd BLAST75
Domaini1800 – 1873Carrier 2PROSITE-ProRule annotationAdd BLAST74
Domaini2597 – 2674Carrier 3PROSITE-ProRule annotationAdd BLAST78
Domaini2738 – 2815Carrier 4PROSITE-ProRule annotationAdd BLAST78
Domaini3960 – 4037Carrier 5PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 314DisorderedSequence analysisAdd BLAST26
Regioni436 – 874Beta-ketoacyl synthase 1Add BLAST439
Regioni1048 – 1226DehydrataseAdd BLAST179
Regioni1520 – 1713Beta-ketoacyl reductase 1Add BLAST194
Regioni1929 – 2368Beta-ketoacyl synthase 2Add BLAST440
Regioni2546 – 2568DisorderedSequence analysisAdd BLAST23
Regioni2828 – 2854DisorderedSequence analysisAdd BLAST27
Regioni2876 – 3297Beta-ketoacyl synthase 3Add BLAST422
Regioni3686 – 3887Beta-ketoacyl reductase 2Add BLAST202
Regioni4085 – 4488Beta-ketoacyl synthase 4Add BLAST404

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi289 – 308Basic and acidic residuesSequence analysisAdd BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0236, Bacteria
COG0300, Bacteria
COG3321, Bacteria
COG4221, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q05470

Identification of Orthologs from Complete Genome Data

More...OMAi		ITGLEWI

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 5 hits
3.10.129.110, 2 hits
3.40.47.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036736, ACP-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR011254, Prismane-like_sf
IPR016039, Thiolase-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16197, KAsynt_C_assoc, 3 hits
PF00109, ketoacyl-synt, 4 hits
PF02801, Ketoacyl-synt_C, 4 hits
PF08659, KR, 2 hits
PF00550, PP-binding, 5 hits
PF14765, PS-DH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 4 hits
SM00823, PKS_PP, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 3 hits
SSF53901, SSF53901, 4 hits
SSF56821, SSF56821, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05470-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWRSNVKKI TKQLTLSLKN PFIYHHVVYG QNVLPGLAYI DIIYQIFREH 
        60         70         80         90        100
GFSCSELQLR NLSIYQPLTA EQDAVIVLNI QCAEKKEGQW QITAKGIEKR 
       110        120        130        140        150
DGKEASEEKL YMKADMHADS PAIFEETLDL SQIKASAQNV VQLDDVYEQC 
       160        170        180        190        200
RRQELVHSEY MKAKGCIYEE EDGVLLELSL GSEAMLHAEG FMFHPTLIDG 
       210        220        230        240        250
SGVGANHLLT SLLKGEQRLY LPLFYESFSA SALLQTDCMT RIKRSSVRRE 
       260        270        280        290        300
KELIYVTLEF FNASGEKVAE LKNFTSKLVR EAELISGKHQ DAQETQMTRA 
       310        320        330        340        350
DTAERDKPAD MVSSPVNSYS EAEQFVSQLI AEKINKPVEQ VEKQVGYYQM 
       360        370        380        390        400
GLNSSGLLEV VETISDKIGE SLSPTLLFEH TTIAELSAFL AEEYAEHFSA 
       410        420        430        440        450
AGSLGQNERA RVSDSINDHK TVEGSRPAPI EAAGDIAIIG LAGRYPKAAN 
       460        470        480        490        500
IHEFWNNLKE GKDCVSEIPE SRWDWQRLEG ITSPSGKDIS KWGGFIDDPD 
       510        520        530        540        550
CFDPQFFRIT PREAETMDPQ ERLFLETCWE TIEDAGYTPK TLAKPKGRNK 
       560        570        580        590        600
RQHVGVFAGV MHKDYTLVGA EEASAENVFP LSLNYAQIAN RVSYFCNFHG 
       610        620        630        640        650
PSMAVDTVCS SSLTAVHLAL ESIRHGECDV ALAGGVNLSL HPNKYMTYGV 
       660        670        680        690        700
WDMFSTDGHC RTFGKDGDGY VPAEGIGAVL LKPLRQAEED GDRIYAVIKG 
       710        720        730        740        750
SAVNHVGTVS GISVPSPVSQ ADLIETCLEK TGIDPRTISY VEAHGTGTSL 
       760        770        780        790        800
GDPIEIQGLV KAFRQYTQDR QFCSIGSVKS NIGHAESAAG ISGLSKVALQ 
       810        820        830        840        850
LHHQKLVPSL HSEELNPYVD FEKSPFYVQH ETETWKQPVI KENGEDVPYP 
       860        870        880        890        900
RRAGISSFGA TGSNAHIILE EHIPQAAEQD VSLSSDSDIS AVIPLSARNQ 
       910        920        930        940        950
ERLRVYAKRL LDFLHDGIQI RDLAYTLQVG REPMEERVSF LASGIQELSD 
       960        970        980        990       1000
QLKAFIEGRK AIQHCWKGRV SRGSEPSRPA ESVHKLLEQR KLDQIAEQWA 
      1010       1020       1030       1040       1050
NGSGVDWKLL YEGSKPKRIS LPTYPFERVR YWVPKAEKKT DRSKQERHIL 
      1060       1070       1080       1090       1100
HPLLHQNVSD ISGVRFRSAF TGREFFLKDH VIKGEHVLPG AALLEMVRAA 
      1110       1120       1130       1140       1150
VERAAADQFP TGFRLRNIVW VRPFAVTEQQ KDIDVRLYPE ENGEITFEIC 
      1160       1170       1180       1190       1200
RDPESAEESP IVYGQGSAVL CEAGENPVIN IEELKASYNG RTLSPFDCYE 
      1210       1220       1230       1240       1250
AYTEMGIHYG DSHRAIDSLY AGENGVLVKL TMPPVISDTE DHYILHPSMI 
      1260       1270       1280       1290       1300
DSAFQASIGL RLGGATSLED RKAMLPFAIQ DVRIFKGCEA SMWARITYSE 
      1310       1320       1330       1340       1350
GSTAGDRMQK LDIDLCNEEG QVCVRLTSYS ARVLETDQEG PSEANDTLLF 
      1360       1370       1380       1390       1400
EHIWEERAAE RQELIEYDTY KVVVCDVGEQ MESLQNHLDC TVLQHDTETI 
      1410       1420       1430       1440       1450
DERFEGYAIQ LFEEIKQLMH SKTGGHTFIQ VAVPALDEPQ LLSGLTGLLK 
      1460       1470       1480       1490       1500
TAELENPKLT GQLIEIETGM SAGELFEILE ENRRYPRDTH IRHWQGKRFV 
      1510       1520       1530       1540       1550
SKWKEVSGEH LSADMPWKDK GVYLITGGAG GLGFIFATEI ANQTNDAVVI 
      1560       1570       1580       1590       1600
LTGRSPLDER KKKKLKALQK LGIQAIYRQA DLADKQTVDA LLKETQNVYG 
      1610       1620       1630       1640       1650
DLDGIIHSAG LIKDNFIMKK KKEEVQTVLA PKVAGLIHLD EATKDIPLDF 
      1660       1670       1680       1690       1700
FILFSSGAGA VGSAGQADYA MANAFMNAFS EYRNGQAELH KRYGKTLSVC 
      1710       1720       1730       1740       1750
WPLWKDGGMQ IDAETARMLK RETGMVAMET DRGIQALYHG WTSGKPQVLV 
      1760       1770       1780       1790       1800
ASGVTDRIRA FLHETGHGKG QSHNIKKSSL NQEAEKADMI GEIDEEILRE 
      1810       1820       1830       1840       1850
KAENYFKQVL SSVIKLPAGQ IDAEAPLEDY GIDSIMIMHV TGQLEKVFGS 
      1860       1870       1880       1890       1900
LSKTLFFEYQ DIRSLTRYFI DSRREKLLDI LGFETGKPSV ERKSEPEKQE 
      1910       1920       1930       1940       1950
IPVIPRKSGF LPLQDKEQKQ VREKETEEIA IIGISGRYPQ ADNIDELWEK 
      1960       1970       1980       1990       2000
LRDGRDCITE IPADRWDHSL YYDEDKDKPG KTYSKWGGFM KDVDKFDPQF 
      2010       2020       2030       2040       2050
FHISPREAKL MDPQERLFLQ CVYETMEDAG YTREHLGRKR DAELGGSVGV 
      2060       2070       2080       2090       2100
YVGVMYEEYQ LYGAQEQVRG RSLALTGNPS SIANRVSYYF DFHGPSIALD 
      2110       2120       2130       2140       2150
TMCSSSLTAI HLACQSLQRG ECEAAFAGGV NVSIHPNKYL MLGQNKFMSS 
      2160       2170       2180       2190       2200
KGRCESFGQG GDGYVPGEGV GAVLLKPLSK AVEDGDHIYG IIKGTAINHG 
      2210       2220       2230       2240       2250
GKTNGYSVPN PNAQADVIKK AFVEAKVDPR TVSYIEAHGT GTSLGDPIEI 
      2260       2270       2280       2290       2300
TGLSKVFTQE TDDKQFCAIG SAKSNIGHCE SAAGIAGVTK VLLQMKYRQL 
      2310       2320       2330       2340       2350
APSLHSNVLN PNIDFLNSPF KVQQELEEWK RPIISVNGKD IELPRIAGVS 
      2360       2370       2380       2390       2400
SFGAGGVNAH ILIEEYAPEP VEERLPARKQ PAVIVLSAKN EERLQKRAER 
      2410       2420       2430       2440       2450
LLHAIREQTY VEADLHRIAY TLQVGREAMK ERLAFVAETM QELEEKLYEC 
      2460       2470       2480       2490       2500
ISGTENREYV YRGQVKSNKE AIAAFAADED MSKTIEAWLQ KGKYAKVLDL 
      2510       2520       2530       2540       2550
WVRGLRIDWS TLYQDQKPRR ISLPAYPFAR DRYWIDVNAK AEEKRTEEPF 
      2560       2570       2580       2590       2600
APVQPVIPKP SVDREASGKP ANITLQPLMT NQDRLERVPS DTETETITAE 
      2610       2620       2630       2640       2650
ALCDELTAGL AEVLYMDQNE IDPDEAFIDI GMDSITGLEW IKAINKQYGT 
      2660       2670       2680       2690       2700
SLNVTKVYDY PTTRDFAVYL AHELSTQAGE KKQTETYTPI RQKTVVPAAK 
      2710       2720       2730       2740       2750
PANISLQPLE HHQPVQEEAE ETIQYAAAEI SASRQYTVAI ETLHENLRES 
      2760       2770       2780       2790       2800
IADVLYMEPY EVDIDEAFID IGMDSITGLE WIKAVNKQYG TSFTVTRVYD 
      2810       2820       2830       2840       2850
YPTIRDFAEM LKSELGTHLD RKIEHTDSFE AAQQKPAASS HPKPAERPLQ 
      2860       2870       2880       2890       2900
PVQHPIKKEH EKKTVPVLQD RPEDAIAIVG MSGRYPGARN VREYWDNLVH 
      2910       2920       2930       2940       2950
ARNAIRDIPT SRWDVDKYYD PVLNKKGKVY CKSMGMLDDI EHFDPLFFNI 
      2960       2970       2980       2990       3000
PPSEAELMDP QHRIFLQEGY KAFEDAGYNA RTLNEKKCGV YLGIMSNEYG 
      3010       3020       3030       3040       3050
VMLNRQSRAN ATGNSFAIAA ARIPYFLNLK GPAIPIDTAC SSSLVGTHLA 
      3060       3070       3080       3090       3100
RQALINKEID MALVGGVSLY LTPESYMSMC EAGMLSPDGQ CKAFDNGANG 
      3110       3120       3130       3140       3150
FVPGEGAGAL VLKRLKDAEA DRDHIYGIII GSGINQDGKT NGITAPSAKS 
      3160       3170       3180       3190       3200
QMDLERDIYE TYGIHPESIS YVEMHGTGTK QGDPIELEAL STVFQEKTDK 
      3210       3220       3230       3240       3250
KQFCAIGSVK SNIGHTSAAA GVAGVQKVLL CMNHKTLVPT LNFTTPNEHF 
      3260       3270       3280       3290       3300
EFEHSPLYVN TELKPWETAD GKPRRACVSS FGYSGTNAHI VIEEYQPEKR 
      3310       3320       3330       3340       3350
NDRLTKQHRS ALFVLSAKKE KQLKAYAEAM KDFVTSNEDI DLEDMAYTLQ 
      3360       3370       3380       3390       3400
TGREAMDYRM AFLADSREML IKALDDYLAE MPNGSIFAAH VKTKKSEIKL 
      3410       3420       3430       3440       3450
FETDHDAKAL LQTWIEKKRL EKVAELWVKG LQIDWNKLYG EYTPRRISLP 
      3460       3470       3480       3490       3500
AYPFAEEYYW LPTQEGEPET IATAMPQFEL MPKRCFLRKQ WQPCPIEPAE 
      3510       3520       3530       3540       3550
MTNQTVAILA NEETMALAEE LSAYFSTYRI FDSQELDRVS AADYEHVAGA 
      3560       3570       3580       3590       3600
IDLIGCGTSH EHSMGWINWL QKLIEQGRAS KHHLTVLGVT KGLEAYANEG 
      3610       3620       3630       3640       3650
VLLSGASRAG LYRMLQSEYS HLTSRHADME CEASHEELAR LIAVEYYAKS 
      3660       3670       3680       3690       3700
TESEVCYRNG QRYRAYLTEQ PAEAALSHKQ VSFSTDKVLL ITGGTRGLGL 
      3710       3720       3730       3740       3750
LCARHFVKTY GVKRLVLIGR EELPPRDQWN SVKISSLAEK IKAVQELEDM 
      3760       3770       3780       3790       3800
GAQVQVLSLD LTDRVAVEQS LKTIHETMGA IGGVIHCAGM VNKQNPAFIR 
      3810       3820       3830       3840       3850
KSLEEIGQVL EPKVEGLQTL FDLLQDEPLA FFTLFSSVSA AIPALAAGQA 
      3860       3870       3880       3890       3900
DYAMANAFMD YFAEAHQDKC PIVSIQWPNW KETGLGEVRS KALEQTGLIS 
      3910       3920       3930       3940       3950
LTNDEGLQLL DQILSDRQYA VVLPAVPDTN VWKPDKLMQP SLPVEALSHP 
      3960       3970       3980       3990       4000
ETKEQTSTRN LFPETVDWLV TLFSDELKIA AEDFETDEPF QEYGIDSIIL 
      4010       4020       4030       4040       4050
AQLVQQMNQQ LNGDIDPSIL FEYPTIESFA HWLISKYDIS AVLQPSVPEK 
      4060       4070       4080       4090       4100
QTPLKPQSAM KQKLVPEQRP QQISHEKTAL LAEDIAIIGL SCRFPGAETL 
      4110       4120       4130       4140       4150
EEYWDLIRDG RSAIAPVPPE RFGNSSSNYA GLIDEMNRFD HDFFMMSESD 
      4160       4170       4180       4190       4200
VRAMDPQALA VLEESLKLWY HAGYTEKEVK GMRAGVYIGG RSQHKPDPAS 
      4210       4220       4230       4240       4250
LSKAKNPIVA GGQNYLAANI SQFFDLKGPS IVLDTACSSA LVGLNMAIQA 
      4260       4270       4280       4290       4300
LRSGDIEAAV VGGVSLLDAD AHRMFHERGL LCDKPSFHIF DKRADGVILG 
      4310       4320       4330       4340       4350
EGVGMVLVKT VNQAVEDGDS IYAVIKAAAI NNDGRTAGPS SPNLEAQKDV 
      4360       4370       4380       4390       4400
MLSALEKSGK KTEEISYLEA NGSGSAVTDL LELKAIQSIY RSESKAPLGL 
      4410       4420       4430       4440       4450
GSVKPNIGHP LCAEGIASLI KVALMLKHRQ LVPFLSGNEN MPYFDIEKTD 
      4460       4470       4480       4490       4500
LYFSRSQAEW KETTPAAAIN CFADGGTNAH LIIEGWRDSA ERPIRRKPLP 
      4510       4520       4530 
LPELNRQPVL IKPSAQNVQK KVHSDTGASK DMFWKTFK
Length:4,538
Mass (Da):506,182
Last modified:July 28, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i398353DEC864EBF2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA85145 differs from that shown. Reason: Frameshift.Curated
The sequence CAA78479 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2299 – 2300QL → HV in AAA85145 (PubMed:8344529).Curated2
Sequence conflicti2299 – 2300QL → HV in CAA78479 (PubMed:8344529).Curated2
Sequence conflicti2398A → P in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti2398A → P in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti3384G → A in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti3384G → A in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti4041A → R in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti4041A → R in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti4041A → R in CAA84504 (Ref. 5) Curated1
Sequence conflicti4232V → L in AAA85145 (PubMed:8344529).Curated1
Sequence conflicti4232V → L in CAA78479 (PubMed:8344529).Curated1
Sequence conflicti4232V → L in CAA84504 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U11039 Genomic DNA Translation: AAA85145.1 Frameshift.
AL009126 Genomic DNA Translation: CAB13602.3
Z14098 Genomic DNA Translation: CAA78479.1 Frameshift.
Z35133 Genomic DNA Translation: CAA84504.1

Protein sequence database of the Protein Information Resource

More...PIRi		S25021, PN0637

NCBI Reference Sequences

More...RefSeqi		NP_389600.3, NC_000964.3
WP_010886513.1, NZ_JNCM01000035.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAB13602; CAB13602; BSU_17190

Database of genes from NCBI RefSeq genomes

More...GeneIDi		940032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bsu:BSU17190

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|224308.43.peg.1815

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11039 Genomic DNA Translation: AAA85145.1 Frameshift.
AL009126 Genomic DNA Translation: CAB13602.3
Z14098 Genomic DNA Translation: CAA78479.1 Frameshift.
Z35133 Genomic DNA Translation: CAA84504.1
PIRiS25021, PN0637
RefSeqiNP_389600.3, NC_000964.3
WP_010886513.1, NZ_JNCM01000035.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E1VX-ray1.87A/B6-279[»]
5E5NX-ray2.00A/B/C/D2870-3466[»]
5E6KX-ray2.16A/B2870-3466[»]
5ENYX-ray4.00A/B/C/D/E/F/G/H2719-3462[»]
5ERFX-ray3.10A/B2870-3466[»]
SMRiQ05470
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU17190

Proteomic databases

PaxDbiQ05470
PRIDEiQ05470

Genome annotation databases

EnsemblBacteriaiCAB13602; CAB13602; BSU_17190
GeneIDi940032
KEGGibsu:BSU17190
PATRICifig|224308.43.peg.1815

Phylogenomic databases

eggNOGiCOG0236, Bacteria
COG0300, Bacteria
COG3321, Bacteria
COG4221, Bacteria
InParanoidiQ05470
OMAiITGLEWI

Enzyme and pathway databases

UniPathwayiUPA01003
BioCyciBSUB:BSU17190-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 5 hits
3.10.129.110, 2 hits
3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR036736, ACP-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR011254, Prismane-like_sf
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF16197, KAsynt_C_assoc, 3 hits
PF00109, ketoacyl-synt, 4 hits
PF02801, Ketoacyl-synt_C, 4 hits
PF08659, KR, 2 hits
PF00550, PP-binding, 5 hits
PF14765, PS-DH, 2 hits
SMARTiView protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 4 hits
SM00823, PKS_PP, 5 hits
SUPFAMiSSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 3 hits
SSF53901, SSF53901, 4 hits
SSF56821, SSF56821, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKSL_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05470
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 28, 2009
Last modified: February 23, 2022
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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