UniProtKB - Q05397 (FAK1_HUMAN)
Focal adhesion kinase 1
PTK2
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation3 PublicationsEC:2.7.10.2PROSITE-ProRule annotation3 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 454 | ATPPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 546 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 428 – 434 | ATPPROSITE-ProRule annotation1 Publication | 7 | |
Nucleotide bindingi | 500 – 502 | ATPPROSITE-ProRule annotation1 Publication | 3 |
GO - Molecular functioni
- actin binding Source: BHF-UCL
- ATP binding Source: UniProtKB-KW
- integrin binding Source: ARUK-UCL
- JUN kinase binding Source: BHF-UCL
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
- protein kinase activity Source: Reactome
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: BHF-UCL
- protein tyrosine kinase activity Source: Reactome
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
GO - Biological processi
- angiogenesis Source: GO_Central
- axon guidance Source: UniProtKB
- cell differentiation Source: GO_Central
- cell motility Source: UniProtKB
- detection of muscle stretch Source: BHF-UCL
- ephrin receptor signaling pathway Source: UniProtKB
- epidermal growth factor receptor signaling pathway Source: GO_Central
- establishment of cell polarity Source: UniProtKB
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- growth hormone receptor signaling pathway Source: BHF-UCL
- heart morphogenesis Source: UniProtKB
- innate immune response Source: GO_Central
- integrin-mediated signaling pathway Source: UniProtKB
- MAPK cascade Source: Reactome
- negative regulation of anoikis Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell-cell adhesion Source: BHF-UCL
- netrin-activated signaling pathway Source: UniProtKB
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- placenta development Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of fibroblast migration Source: ARUK-UCL
- positive regulation of macrophage chemotaxis Source: ARUK-UCL
- positive regulation of macrophage proliferation Source: ARUK-UCL
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein kinase activity Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of ubiquitin-dependent protein catabolic process Source: UniProtKB
- positive regulation of wound healing Source: ARUK-UCL
- protein autophosphorylation Source: UniProtKB
- regulation of cell adhesion Source: GO_Central
- regulation of cell adhesion mediated by integrin Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- regulation of cytoskeleton organization Source: UniProtKB
- regulation of endothelial cell migration Source: UniProtKB
- regulation of epithelial cell migration Source: UniProtKB
- regulation of focal adhesion assembly Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
- regulation of osteoblast differentiation Source: UniProtKB
- regulation of protein phosphorylation Source: UniProtKB
- regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- signal complex assembly Source: InterPro
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vascular endothelial growth factor receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein, Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Angiogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q05397 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-391160, Signal regulatory protein family interactions R-HSA-3928662, EPHB-mediated forward signaling R-HSA-418885, DCC mediated attractive signaling R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8874081, MET activates PTK2 signaling R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | Q05397 |
SIGNORi | Q05397 |
Names & Taxonomyi
Protein namesi | Recommended name: Focal adhesion kinase 1Curated (EC:2.7.10.2)Short name: FADK 1 Alternative name(s): Focal adhesion kinase-related nonkinase Short name: FRNK Protein phosphatase 1 regulatory subunit 71 Short name: PPP1R71 Protein-tyrosine kinase 2 p125FAK pp125FAK |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9611, PTK2 |
MIMi | 600758, gene |
neXtProti | NX_Q05397 |
VEuPathDBi | HostDB:ENSG00000169398.19 |
Subcellular locationi
Nucleus
Cytoskeleton
- cytoskeleton
- centrosome By similarity
- cilium basal body 1 Publication
Plasma membrane
Other locations
Note: Constituent of focal adhesions. Detected at microtubules.
Cytoskeleton
- ciliary basal body Source: UniProtKB
- cytoskeleton Source: ProtInc
- stress fiber Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell cortex Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- dendritic spine Source: GO_Central
- focal adhesion Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 397 | Y → F: Abolishes autophosphorylation. Abolishes interaction with SRC and activation of BMX. 1 Publication | 1 | |
Mutagenesisi | 928 | V → G: Loss of interaction with TGFB1I1. 1 Publication | 1 | |
Mutagenesisi | 1034 | L → S: Loss of interaction with TGFB1I1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5747 |
OpenTargetsi | ENSG00000169398 |
PharmGKBi | PA33955 |
Miscellaneous databases
Pharosi | Q05397, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2695 |
DrugBanki | DB07460, 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE DB07248, 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE DB06423, Endostatin DB12010, Fostamatinib |
DrugCentrali | Q05397 |
GuidetoPHARMACOLOGYi | 2180 |
Genetic variation databases
BioMutai | PTK2 |
DMDMi | 3183518 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000088077 | 2 – 1052 | Focal adhesion kinase 1Add BLAST | 1051 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 5 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 13 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Modified residuei | 54 | PhosphoserineBy similarity | 1 | |
Cross-linki | 152 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Modified residuei | 397 | Phosphotyrosine; by autocatalysisCombined sources6 Publications | 1 | |
Modified residuei | 407 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 570 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 576 | Phosphotyrosine; by RET and SRC3 Publications | 1 | |
Modified residuei | 577 | Phosphotyrosine; by RET and SRC3 Publications | 1 | |
Modified residuei | 580 | PhosphoserineCombined sources | 1 | |
Modified residuei | 722 | Phosphoserine1 Publication | 1 | |
Modified residuei | 732 | Phosphoserine; by CDK5By similarity | 1 | |
Modified residuei | 843 | PhosphoserineCombined sources | 1 | |
Modified residuei | 861 | Phosphotyrosine3 Publications | 1 | |
Modified residuei | 887 | PhosphoserineCombined sources | 1 | |
Modified residuei | 910 | PhosphoserineCombined sources | 1 | |
Modified residuei | 914 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 925 | Phosphotyrosine2 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1785 |
EPDi | Q05397 |
jPOSTi | Q05397 |
MassIVEi | Q05397 |
MaxQBi | Q05397 |
PaxDbi | Q05397 |
PeptideAtlasi | Q05397 |
PRIDEi | Q05397 |
ProteomicsDBi | 58320 [Q05397-1] 58321 [Q05397-2] 58322 [Q05397-3] 58323 [Q05397-4] 58324 [Q05397-5] 58325 [Q05397-6] 71210 |
PTM databases
CarbonylDBi | Q05397 |
iPTMneti | Q05397 |
PhosphoSitePlusi | Q05397 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000169398, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | Q05397, baseline and differential |
Genevisiblei | Q05397, HS |
Organism-specific databases
HPAi | ENSG00000169398, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via first Pro-rich region) with CAS family members (via SH3 domain), including BCAR1, BCAR3, CASS4 and NEDD9.
Interacts with GIT1.
Interacts with SORBS1.
Interacts with ARHGEF28.
Interacts with SHB.
Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (PubMed:29069646).
Interacts with PXN and TLN1.
Interacts with STAT1.
Interacts with DCC.
Interacts with WASL.
Interacts with ARHGEF7.
Interacts with GRB2 and GRB7 (By similarity).
Component of a complex that contains at least FER, CTTN and PTK2/FAK1.
Interacts with BMX.
Interacts with TGFB1I1.
Interacts with STEAP4.
Interacts with ZFYVE21.
Interacts with ESR1.
Interacts with PIK3R1 or PIK3R2.
Interacts with SRC, FGR, FLT4 and RET.
Interacts with EPHA2 in resting cells; activation of EPHA2 recruits PTPN11, leading to dephosphorylation of PTK2/FAK1 and dissociation of the complex.
Interacts with EPHA1 (kinase activity-dependent).
Interacts with CD4; this interaction requires the presence of HIV-1 gp120.
Interacts with PIAS1.
Interacts with ARHGAP26 and SHC1.
Interacts with RB1CC1; this inhibits PTK2/FAK1 activity and activation of downstream signaling pathways.
Interacts with P53/TP53 and MDM2.
Interacts with LPXN (via LD motif 3).
Interacts with MISP.
Interacts with CIB1 isoform 2.
Interacts with CD36.
Interacts with EMP2; regulates PTK2 activation and localization (PubMed:19494199).
Interacts with DSCAM (By similarity).
By similarity28 PublicationsBinary interactionsi
Hide detailsQ05397
GO - Molecular functioni
- actin binding Source: BHF-UCL
- integrin binding Source: ARUK-UCL
- JUN kinase binding Source: BHF-UCL
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: BHF-UCL
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111719, 146 interactors |
CORUMi | Q05397 |
ELMi | Q05397 |
IntActi | Q05397, 88 interactors |
MINTi | Q05397 |
STRINGi | 9606.ENSP00000341189 |
Chemistry databases
BindingDBi | Q05397 |
Miscellaneous databases
RNActi | Q05397, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q05397 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q05397 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 355 | FERMPROSITE-ProRule annotationAdd BLAST | 321 | |
Domaini | 422 – 680 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 707 – 1052 | Interaction with TGFB1I1Add BLAST | 346 | |
Regioni | 912 – 1052 | Interaction with ARHGEF28By similarityAdd BLAST | 141 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 712 – 733 | Pro-richAdd BLAST | 22 | |
Compositional biasi | 863 – 913 | Pro-richAdd BLAST | 51 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4257, Eukaryota |
GeneTreei | ENSGT00940000155113 |
HOGENOMi | CLU_002646_0_0_1 |
InParanoidi | Q05397 |
OrthoDBi | 43729at2759 |
PhylomeDBi | Q05397 |
TreeFami | TF316643 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13190, FERM_C_FAK1, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR041390, FADK_N IPR041784, FAK1/PYK2_FERM_C IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF18038, FERM_N_2, 1 hit PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 32 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAYLDPNL NHTPNSSTKT HLGTGMERSP GAMERVLKVF HYFESNSEPT
60 70 80 90 100
TWASIIRHGD ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV
110 120 130 140 150
DMGVSSVREK YELAHPPEEW KYELRIRYLP KGFLNQFTED KPTLNFFYQQ
160 170 180 190 200
VKSDYMLEIA DQVDQEIALK LGCLEIRRSY WEMRGNALEK KSNYEVLEKD
210 220 230 240 250
VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI LKFFEILSPV
260 270 280 290 300
YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFTQVQ
310 320 330 340 350
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL
360 370 380 390 400
VNGTSQSFII RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI
410 420 430 440 450
IDEEDTYTMP STRDYEIQRE RIELGRCIGE GQFGDVHQGI YMSPENPALA
460 470 480 490 500
VAIKTCKNCT SDSVREKFLQ EALTMRQFDH PHIVKLIGVI TENPVWIIME
510 520 530 540 550
LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK RFVHRDIAAR
560 570 580 590 600
NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT
610 620 630 640 650
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT
660 670 680 690 700
LYSLMTKCWA YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT
710 720 730 740 750
VSWDSGGSDE APPKPSRPGY PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS
760 770 780 790 800
HGITAMAGSI YPGQASLLDQ TDSWNHRPQE IAMWQPNVED STVLDLRGIG
810 820 830 840 850
QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS RGSIDREDGS
860 870 880 890 900
LQGPIGNQHI YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE
910 920 930 940 950
GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY
960 970 980 990 1000
VPMVKEVGLA LRTLLATVDE TIPLLPASTH REIEMAQKLL NSDLGELINK
1010 1020 1030 1040 1050
MKLAQQYVMT SLQQEYKKQM LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR
PH
The sequence of this isoform differs from the canonical sequence as follows:
1-181: Missing.
182-189: EMRGNALE → MSDYWVVG
472-472: A → ACHYTSLHWNWCRYISDPNVDACPDPRNAE
677-706: STILEEEKAQQEERMRMESRRQATVSWDSG → FQNPAQMLPASGRLPNQPCPERENYSFATF
707-1052: Missing.
Computationally mapped potential isoform sequencesi
There are 32 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ESA6 | E7ESA6_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 1,096 | Annotation score: | ||
H0YBP1 | H0YBP1_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 1,017 | Annotation score: | ||
H0YB16 | H0YB16_HUMAN | Focal adhesion kinase 1 | PTK2 | 724 | Annotation score: | ||
H0YB99 | H0YB99_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 319 | Annotation score: | ||
H0YBZ1 | H0YBZ1_HUMAN | Focal adhesion kinase 1 | PTK2 | 753 | Annotation score: | ||
E9PEI4 | E9PEI4_HUMAN | Focal adhesion kinase 1 | PTK2 | 680 | Annotation score: | ||
B4DWJ1 | B4DWJ1_HUMAN | Focal adhesion kinase 1 | PTK2 | 362 | Annotation score: | ||
E5RGA6 | E5RGA6_HUMAN | Focal adhesion kinase 1 | PTK2 | 156 | Annotation score: | ||
E5RJP0 | E5RJP0_HUMAN | Focal adhesion kinase 1 | PTK2 | 122 | Annotation score: | ||
E5RFW9 | E5RFW9_HUMAN | Focal adhesion kinase 1 | PTK2 | 121 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | R → L in BAG65198 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 211 | L → I in BAG65198 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 778 | P → S in AAA35819 (PubMed:8422239).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041682 | 292 | H → P1 Publication | 1 | |
Natural variantiVAR_041683 | 292 | H → Q1 Publication | 1 | |
Natural variantiVAR_041684 | 793 | V → A in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041685 | 1030 | D → E1 Publication | 1 | |
Natural variantiVAR_041686 | 1044 | K → E in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042168 | 1 – 692 | Missing in isoform 6. CuratedAdd BLAST | 692 | |
Alternative sequenceiVSP_004967 | 1 – 181 | Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST | 181 | |
Alternative sequenceiVSP_004968 | 182 – 189 | EMRGNALE → MSDYWVVG in isoform 2, isoform 3 and isoform 4. 1 Publication | 8 | |
Alternative sequenceiVSP_004969 | 472 | A → ACHYTSLHWNWCRYISDPNV DACPDPRNAE in isoform 2, isoform 3 and isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_004971 | 579 – 583 | ASKGK → GKKSG in isoform 4. 1 Publication | 5 | |
Alternative sequenceiVSP_004972 | 584 – 1052 | Missing in isoform 4. 1 PublicationAdd BLAST | 469 | |
Alternative sequenceiVSP_004973 | 677 – 706 | STILE…SWDSG → FQNPAQMLPASGRLPNQPCP ERENYSFATF in isoform 3. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_004974 | 707 – 1052 | Missing in isoform 3. 1 PublicationAdd BLAST | 346 | |
Alternative sequenceiVSP_057268 | 744 – 789 | Missing in isoform 7. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_004970 | 834 – 854 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_042169 | 868 | D → GKEEKNWAERN in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_042170 | 903 | K → KPWR in isoform 5. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13616 mRNA Translation: AAA58469.1 L05186 mRNA Translation: AAA35819.1 AK304356 mRNA Translation: BAG65198.1 AC067931 Genomic DNA No translation available. AC100860 Genomic DNA No translation available. AC105009 Genomic DNA No translation available. AC105235 Genomic DNA No translation available. KF458878 Genomic DNA No translation available. KF458882 Genomic DNA No translation available. BC035404 mRNA Translation: AAH35404.1 |
CCDSi | CCDS56557.1 [Q05397-5] CCDS6381.1 [Q05397-1] |
PIRi | I53012 PC1225 |
RefSeqi | NP_001186578.1, NM_001199649.1 [Q05397-5] NP_722560.1, NM_153831.3 [Q05397-1] XP_016869162.1, XM_017013673.1 |
Genome annotation databases
Ensembli | ENST00000340930; ENSP00000341189; ENSG00000169398 [Q05397-5] ENST00000395218; ENSP00000378644; ENSG00000169398 [Q05397-7] ENST00000521059; ENSP00000429474; ENSG00000169398 [Q05397-1] ENST00000522684; ENSP00000429911; ENSG00000169398 [Q05397-1] |
GeneIDi | 5747 |
KEGGi | hsa:5747 |
UCSCi | uc003yvu.4, human [Q05397-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13616 mRNA Translation: AAA58469.1 L05186 mRNA Translation: AAA35819.1 AK304356 mRNA Translation: BAG65198.1 AC067931 Genomic DNA No translation available. AC100860 Genomic DNA No translation available. AC105009 Genomic DNA No translation available. AC105235 Genomic DNA No translation available. KF458878 Genomic DNA No translation available. KF458882 Genomic DNA No translation available. BC035404 mRNA Translation: AAH35404.1 |
CCDSi | CCDS56557.1 [Q05397-5] CCDS6381.1 [Q05397-1] |
PIRi | I53012 PC1225 |
RefSeqi | NP_001186578.1, NM_001199649.1 [Q05397-5] NP_722560.1, NM_153831.3 [Q05397-1] XP_016869162.1, XM_017013673.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K04 | X-ray | 1.95 | A | 891-1052 | [»] | |
1K05 | X-ray | 2.90 | A/B/C | 891-1052 | [»] | |
1MP8 | X-ray | 1.60 | A | 411-686 | [»] | |
1OW6 | X-ray | 2.35 | A/B/C | 892-1052 | [»] | |
1OW7 | X-ray | 2.60 | A/B/C | 892-1052 | [»] | |
1OW8 | X-ray | 2.85 | A/B/C | 892-1052 | [»] | |
2ETM | X-ray | 2.30 | A/B | 411-689 | [»] | |
2IJM | X-ray | 2.19 | A/B | 411-689 | [»] | |
3B71 | X-ray | 2.82 | A/B/C | 891-1052 | [»] | |
3BZ3 | X-ray | 2.20 | A | 414-689 | [»] | |
3PXK | X-ray | 1.79 | A/B | 411-689 | [»] | |
3S9O | X-ray | 2.60 | A/B/C | 891-1052 | [»] | |
4EBV | X-ray | 1.67 | A | 411-686 | [»] | |
4EBW | X-ray | 2.65 | A | 411-686 | [»] | |
4GU6 | X-ray | 1.95 | A/B | 411-689 | [»] | |
4GU9 | X-ray | 2.40 | A/B | 410-686 | [»] | |
4I4E | X-ray | 1.55 | A | 411-686 | [»] | |
4I4F | X-ray | 1.75 | A | 411-686 | [»] | |
4K8A | X-ray | 2.91 | A/B | 410-686 | [»] | |
4K9Y | X-ray | 2.00 | A | 410-686 | [»] | |
4KAB | X-ray | 2.71 | A/B | 410-686 | [»] | |
4KAO | X-ray | 2.39 | A/B | 410-689 | [»] | |
4NY0 | X-ray | 2.80 | A/B/C/D | 31-405 | [»] | |
4Q9S | X-ray | 2.07 | A | 411-686 | [»] | |
6I8Z | X-ray | 1.99 | A | 411-689 | [»] | |
6LES | X-ray | 2.00 | A/B/X/Y | 805-832 | [»] | |
6PW8 | X-ray | 1.95 | A | 922-1047 | [»] | |
SMRi | Q05397 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111719, 146 interactors |
CORUMi | Q05397 |
ELMi | Q05397 |
IntActi | Q05397, 88 interactors |
MINTi | Q05397 |
STRINGi | 9606.ENSP00000341189 |
Chemistry databases
BindingDBi | Q05397 |
ChEMBLi | CHEMBL2695 |
DrugBanki | DB07460, 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE DB07248, 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE DB06423, Endostatin DB12010, Fostamatinib |
DrugCentrali | Q05397 |
GuidetoPHARMACOLOGYi | 2180 |
PTM databases
CarbonylDBi | Q05397 |
iPTMneti | Q05397 |
PhosphoSitePlusi | Q05397 |
Genetic variation databases
BioMutai | PTK2 |
DMDMi | 3183518 |
Proteomic databases
CPTACi | CPTAC-1785 |
EPDi | Q05397 |
jPOSTi | Q05397 |
MassIVEi | Q05397 |
MaxQBi | Q05397 |
PaxDbi | Q05397 |
PeptideAtlasi | Q05397 |
PRIDEi | Q05397 |
ProteomicsDBi | 58320 [Q05397-1] 58321 [Q05397-2] 58322 [Q05397-3] 58323 [Q05397-4] 58324 [Q05397-5] 58325 [Q05397-6] 71210 |
Protocols and materials databases
Antibodypediai | 725, 2764 antibodies |
DNASUi | 5747 |
Genome annotation databases
Ensembli | ENST00000340930; ENSP00000341189; ENSG00000169398 [Q05397-5] ENST00000395218; ENSP00000378644; ENSG00000169398 [Q05397-7] ENST00000521059; ENSP00000429474; ENSG00000169398 [Q05397-1] ENST00000522684; ENSP00000429911; ENSG00000169398 [Q05397-1] |
GeneIDi | 5747 |
KEGGi | hsa:5747 |
UCSCi | uc003yvu.4, human [Q05397-1] |
Organism-specific databases
CTDi | 5747 |
DisGeNETi | 5747 |
GeneCardsi | PTK2 |
HGNCi | HGNC:9611, PTK2 |
HPAi | ENSG00000169398, Low tissue specificity |
MIMi | 600758, gene |
neXtProti | NX_Q05397 |
OpenTargetsi | ENSG00000169398 |
PharmGKBi | PA33955 |
VEuPathDBi | HostDB:ENSG00000169398.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4257, Eukaryota |
GeneTreei | ENSGT00940000155113 |
HOGENOMi | CLU_002646_0_0_1 |
InParanoidi | Q05397 |
OrthoDBi | 43729at2759 |
PhylomeDBi | Q05397 |
TreeFami | TF316643 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q05397 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-391160, Signal regulatory protein family interactions R-HSA-3928662, EPHB-mediated forward signaling R-HSA-418885, DCC mediated attractive signaling R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8874081, MET activates PTK2 signaling R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | Q05397 |
SIGNORi | Q05397 |
Miscellaneous databases
BioGRID-ORCSi | 5747, 378 hits in 915 CRISPR screens |
ChiTaRSi | PTK2, human |
EvolutionaryTracei | Q05397 |
GeneWikii | PTK2 |
GenomeRNAii | 5747 |
Pharosi | Q05397, Tchem |
PROi | PR:Q05397 |
RNActi | Q05397, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169398, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | Q05397, baseline and differential |
Genevisiblei | Q05397, HS |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13190, FERM_C_FAK1, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR041390, FADK_N IPR041784, FAK1/PYK2_FERM_C IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF18038, FERM_N_2, 1 hit PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FAK1_HUMAN | |
Accessioni | Q05397Primary (citable) accession number: Q05397 Secondary accession number(s): B4E2N6 Q9UD85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 243 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human and mouse protein kinases
Human and mouse protein kinases: classification and index