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UniProtKB - Q05315 (LEG10_HUMAN)

Entry version 179 (08 May 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Galectin-10

Gene

CLC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).1 Publication

Miscellaneous

Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias.

Caution

Was originally thought to possess lysophospholipase activity but the absence of this activity has been shown by PubMed:11834744.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.5 2681

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...UniLectini		Q05315

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galectin-10
Short name:
Gal-10
Alternative name(s):
Charcot-Leyden crystal protein
Short name:
CLC
Eosinophil lysophospholipase
Lysolecithin acylhydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLC
Synonyms:LGALS10, LGALS10A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2014 CLC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		153310 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q05315

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1178

Open Targets

More...OpenTargetsi		ENSG00000105205

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26541

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02967 N-Ethylmaleimide
DB02983 Para-Mercury-Benzenesulfonic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLC

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373429

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769602 – 142Galectin-10Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei136Not glycosylated1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q05315

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q05315

PeptideAtlas

More...PeptideAtlasi		Q05315

PRoteomics IDEntifications database

More...PRIDEi		Q05315

ProteomicsDB human proteome resource

More...ProteomicsDBi		58318

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q05315

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q05315

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q05315

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105205 Expressed in 95 organ(s), highest expression level in bone marrow

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q05315 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041751

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CEL.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10485101,EBI-10485101

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107592, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q05315, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000221804

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G86X-ray1.80A1-142[»]
1HDKX-ray1.80A2-142[»]
1LCLX-ray1.80A1-142[»]
1QKQX-ray1.80A1-142[»]
5XRGX-ray1.55A1-142[»]
5XRHX-ray1.55A1-142[»]
5XRIX-ray1.68A1-142[»]
5XRJX-ray1.90A1-142[»]
5XRKX-ray1.70A1-142[»]
5XRLX-ray2.00A1-142[»]
5XRMX-ray2.00A1-142[»]
5XRNX-ray1.60A1-142[»]
5XROX-ray1.60A1-142[»]
5XRPX-ray2.00A1-142[»]
5YT4X-ray2.00A2-139[»]
6A1SX-ray1.63A1-142[»]
6A1TX-ray1.97A1-142[»]
6A1UX-ray1.62A1-142[»]
6A1VX-ray1.98A1-142[»]
6A1XX-ray1.99A1-142[»]
6A1YX-ray1.63A1-142[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q05315

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q05315

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 138GalectinPROSITE-ProRule annotationAdd BLAST133

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3587 Eukaryota
ENOG4111EA0 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163192

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000015090

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q05315

KEGG Orthology (KO)

More...KOi		K13334

Identification of Orthologs from Complete Genome Data

More...OMAi		DKYQVMV

Database of Orthologous Groups

More...OrthoDBi		829777at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q05315

TreeFam database of animal gene trees

More...TreeFami		TF315551

Family and domain databases

Conserved Domains Database

More...CDDi		cd00070 GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00337 Gal-bind_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51304 GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q05315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI 
        60         70         80         90        100
VFHFQVCFGR RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY 
       110        120        130        140 
QVMVNGQSSY TFDHRIKPEA VKMVQVWRDI SLTKFNVSYL KR
Length:142
Mass (Da):16,453
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2744F0C082C6446E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01476528A → V6 PublicationsCorresponds to variant dbSNP:rs17608Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L01664 mRNA Translation: AAA36190.1
L01665 Genomic DNA Translation: AAC37530.1
U68398
, U68393, U68395, U68396 Genomic DNA Translation: AAC51157.1
FJ613334 mRNA Translation: ACR09636.1
FJ613335 mRNA Translation: ACR09637.1
AC005393 Genomic DNA Translation: AAC28912.1
AC006133 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56914.1
BC119711 mRNA Translation: AAI19712.1
BC119712 mRNA Translation: AAI19713.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33025.1

Protein sequence database of the Protein Information Resource

More...PIRi		A46523

NCBI Reference Sequences

More...RefSeqi		NP_001819.2, NM_001828.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000221804; ENSP00000221804; ENSG00000105205

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1178

UCSC genome browser

More...UCSCi		uc002omh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01664 mRNA Translation: AAA36190.1
L01665 Genomic DNA Translation: AAC37530.1
U68398
, U68393, U68395, U68396 Genomic DNA Translation: AAC51157.1
FJ613334 mRNA Translation: ACR09636.1
FJ613335 mRNA Translation: ACR09637.1
AC005393 Genomic DNA Translation: AAC28912.1
AC006133 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56914.1
BC119711 mRNA Translation: AAI19712.1
BC119712 mRNA Translation: AAI19713.1
CCDSiCCDS33025.1
PIRiA46523
RefSeqiNP_001819.2, NM_001828.5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G86X-ray1.80A1-142[»]
1HDKX-ray1.80A2-142[»]
1LCLX-ray1.80A1-142[»]
1QKQX-ray1.80A1-142[»]
5XRGX-ray1.55A1-142[»]
5XRHX-ray1.55A1-142[»]
5XRIX-ray1.68A1-142[»]
5XRJX-ray1.90A1-142[»]
5XRKX-ray1.70A1-142[»]
5XRLX-ray2.00A1-142[»]
5XRMX-ray2.00A1-142[»]
5XRNX-ray1.60A1-142[»]
5XROX-ray1.60A1-142[»]
5XRPX-ray2.00A1-142[»]
5YT4X-ray2.00A2-139[»]
6A1SX-ray1.63A1-142[»]
6A1TX-ray1.97A1-142[»]
6A1UX-ray1.62A1-142[»]
6A1VX-ray1.98A1-142[»]
6A1XX-ray1.99A1-142[»]
6A1YX-ray1.63A1-142[»]
SMRiQ05315
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107592, 1 interactor
IntActiQ05315, 1 interactor
STRINGi9606.ENSP00000221804

Chemistry databases

DrugBankiDB02967 N-Ethylmaleimide
DB02983 Para-Mercury-Benzenesulfonic Acid

Protein family/group databases

UniLectiniQ05315

PTM databases

iPTMnetiQ05315
PhosphoSitePlusiQ05315

Polymorphism and mutation databases

BioMutaiCLC
DMDMi317373429

Proteomic databases

jPOSTiQ05315
PaxDbiQ05315
PeptideAtlasiQ05315
PRIDEiQ05315
ProteomicsDBi58318
TopDownProteomicsiQ05315

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221804; ENSP00000221804; ENSG00000105205
GeneIDi1178
KEGGihsa:1178
UCSCiuc002omh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1178
DisGeNETi1178

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLC

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0040154
HGNCiHGNC:2014 CLC
HPAiHPA041751
MIMi153310 gene
neXtProtiNX_Q05315
OpenTargetsiENSG00000105205
PharmGKBiPA26541

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00940000163192
HOGENOMiHOG000015090
InParanoidiQ05315
KOiK13334
OMAiDKYQVMV
OrthoDBi829777at2759
PhylomeDBiQ05315
TreeFamiTF315551

Enzyme and pathway databases

BRENDAi3.1.1.5 2681

Miscellaneous databases

EvolutionaryTraceiQ05315

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLC_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1178

Protein Ontology

More...PROi		PR:Q05315

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105205 Expressed in 95 organ(s), highest expression level in bone marrow
GenevisibleiQ05315 HS

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEG10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05315
Secondary accession number(s): C5HZ13, C5HZ14, Q0VDE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2011
Last modified: May 8, 2019
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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