UniProtKB - Q05315 (LEG10_HUMAN)
Protein
Galectin-10
Gene
CLC
Organism
Homo sapiens (Human)
Status
Functioni
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).1 Publication
Miscellaneous
Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias.
Caution
Was originally thought to possess lysophospholipase activity but the absence of this activity has been shown by PubMed:11834744.Curated
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- identical protein binding Source: IntAct
GO - Biological processi
- multicellular organism development Source: ProtInc
- regulation of activated T cell proliferation Source: UniProtKB
- regulation of T cell anergy Source: UniProtKB
- regulation of T cell cytokine production Source: UniProtKB
- T cell apoptotic process Source: UniProtKB
Keywordsi
Ligand | Lectin |
Enzyme and pathway databases
BRENDAi | 3.1.1.5, 2681 |
PathwayCommonsi | Q05315 |
Protein family/group databases
UniLectini | Q05315 |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-10Short name: Gal-10 Alternative name(s): Charcot-Leyden crystal protein Short name: CLC Eosinophil lysophospholipase Lysolecithin acylhydrolase |
Gene namesi | Name:CLC Synonyms:LGALS10, LGALS10A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2014, CLC |
MIMi | 153310, gene |
neXtProti | NX_Q05315 |
VEuPathDBi | HostDB:ENSG00000105205.6 |
Subcellular locationi
Cytosol
- cytosol 1 Publication
Other locations
- Cytoplasmic granule 1 Publication
Note: Localized in granules from where it may be secreted or transported to other locations in the cell.
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 1178 |
OpenTargetsi | ENSG00000105205 |
PharmGKBi | PA26541 |
Miscellaneous databases
Pharosi | Q05315, Tbio |
Chemistry databases
DrugBanki | DB02967, N-Ethylmaleimide DB02983, Para-Mercury-Benzenesulfonic Acid |
Genetic variation databases
BioMutai | CLC |
DMDMi | 317373429 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000076960 | 2 – 142 | Galectin-10Add BLAST | 141 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 136 | Not glycosylated1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | Q05315 |
MassIVEi | Q05315 |
PaxDbi | Q05315 |
PeptideAtlasi | Q05315 |
PRIDEi | Q05315 |
ProteomicsDBi | 58318 |
TopDownProteomicsi | Q05315 |
PTM databases
iPTMneti | Q05315 |
PhosphoSitePlusi | Q05315 |
Expressioni
Tissue specificityi
Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).4 Publications
Gene expression databases
Bgeei | ENSG00000105205, Expressed in bone marrow and 125 other tissues |
Genevisiblei | Q05315, HS |
Organism-specific databases
HPAi | ENSG00000105205, Tissue enriched (blood) |
Interactioni
Subunit structurei
Interacts with CEL.
1 PublicationBinary interactionsi
Q05315
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-10485101,EBI-10485101 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 107592, 1 interactor |
STRINGi | 9606.ENSP00000221804 |
Miscellaneous databases
RNActi | Q05315, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | Q05315 |
SMRi | Q05315 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q05315 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 138 | GalectinPROSITE-ProRule annotationAdd BLAST | 133 |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000163192 |
HOGENOMi | CLU_037794_4_0_1 |
InParanoidi | Q05315 |
OMAi | VCFFNEP |
OrthoDBi | 829777at2759 |
PhylomeDBi | Q05315 |
TreeFami | TF315551 |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR030648, Galectin_10 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit PTHR11346:SF15, PTHR11346:SF15, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q05315-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI
60 70 80 90 100
VFHFQVCFGR RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY
110 120 130 140
QVMVNGQSSY TFDHRIKPEA VKMVQVWRDI SLTKFNVSYL KR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014765 | 28 | A → V6 PublicationsCorresponds to variant dbSNP:rs17608Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01664 mRNA Translation: AAA36190.1 L01665 Genomic DNA Translation: AAC37530.1 U68398 , U68393, U68395, U68396 Genomic DNA Translation: AAC51157.1 FJ613334 mRNA Translation: ACR09636.1 FJ613335 mRNA Translation: ACR09637.1 AC005393 Genomic DNA Translation: AAC28912.1 AC006133 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW56914.1 BC119711 mRNA Translation: AAI19712.1 BC119712 mRNA Translation: AAI19713.1 |
CCDSi | CCDS33025.1 |
PIRi | A46523 |
RefSeqi | NP_001819.2, NM_001828.5 |
Genome annotation databases
Ensembli | ENST00000221804; ENSP00000221804; ENSG00000105205 |
GeneIDi | 1178 |
KEGGi | hsa:1178 |
UCSCi | uc002omh.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Galectin-10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01664 mRNA Translation: AAA36190.1 L01665 Genomic DNA Translation: AAC37530.1 U68398 , U68393, U68395, U68396 Genomic DNA Translation: AAC51157.1 FJ613334 mRNA Translation: ACR09636.1 FJ613335 mRNA Translation: ACR09637.1 AC005393 Genomic DNA Translation: AAC28912.1 AC006133 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW56914.1 BC119711 mRNA Translation: AAI19712.1 BC119712 mRNA Translation: AAI19713.1 |
CCDSi | CCDS33025.1 |
PIRi | A46523 |
RefSeqi | NP_001819.2, NM_001828.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G86 | X-ray | 1.80 | A | 1-142 | [»] | |
1HDK | X-ray | 1.80 | A | 2-142 | [»] | |
1LCL | X-ray | 1.80 | A | 1-142 | [»] | |
1QKQ | X-ray | 1.80 | A | 1-142 | [»] | |
5XRG | X-ray | 1.55 | A | 1-142 | [»] | |
5XRH | X-ray | 1.55 | A | 1-142 | [»] | |
5XRI | X-ray | 1.68 | A | 1-142 | [»] | |
5XRJ | X-ray | 1.90 | A | 1-142 | [»] | |
5XRK | X-ray | 1.70 | A | 1-142 | [»] | |
5XRL | X-ray | 2.00 | A | 1-142 | [»] | |
5XRM | X-ray | 2.00 | A | 1-142 | [»] | |
5XRN | X-ray | 1.60 | A | 1-142 | [»] | |
5XRO | X-ray | 1.60 | A | 1-142 | [»] | |
5XRP | X-ray | 2.00 | A | 1-142 | [»] | |
5YT4 | X-ray | 2.00 | A | 2-139 | [»] | |
6A1S | X-ray | 1.63 | A | 1-142 | [»] | |
6A1T | X-ray | 1.97 | A | 1-142 | [»] | |
6A1U | X-ray | 1.62 | A | 1-142 | [»] | |
6A1V | X-ray | 1.98 | A | 1-142 | [»] | |
6A1X | X-ray | 1.99 | A | 1-142 | [»] | |
6A1Y | X-ray | 1.63 | A | 1-142 | [»] | |
6GKQ | X-ray | 2.30 | A | 1-142 | [»] | |
6GKS | X-ray | 1.38 | A | 1-142 | [»] | |
6GKT | X-ray | 2.10 | A/B/C/D/E/F | 1-142 | [»] | |
6GKU | X-ray | 1.91 | A | 1-142 | [»] | |
6GLW | X-ray | 1.90 | A/B | 1-142 | [»] | |
6GLX | X-ray | 3.40 | A/B | 1-142 | [»] | |
6L64 | X-ray | 2.08 | A | 1-142 | [»] | |
6L67 | X-ray | 1.97 | A | 1-142 | [»] | |
6L68 | X-ray | 1.92 | A | 1-142 | [»] | |
6L6A | X-ray | 1.81 | A | 1-142 | [»] | |
6L6B | X-ray | 1.80 | A | 1-142 | [»] | |
6L6C | X-ray | 1.77 | A | 1-142 | [»] | |
6L6D | X-ray | 1.93 | A | 1-142 | [»] | |
6QRN | X-ray | 1.40 | A | 1-142 | [»] | |
SASBDBi | Q05315 | |||||
SMRi | Q05315 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107592, 1 interactor |
STRINGi | 9606.ENSP00000221804 |
Chemistry databases
DrugBanki | DB02967, N-Ethylmaleimide DB02983, Para-Mercury-Benzenesulfonic Acid |
Protein family/group databases
UniLectini | Q05315 |
PTM databases
iPTMneti | Q05315 |
PhosphoSitePlusi | Q05315 |
Genetic variation databases
BioMutai | CLC |
DMDMi | 317373429 |
Proteomic databases
jPOSTi | Q05315 |
MassIVEi | Q05315 |
PaxDbi | Q05315 |
PeptideAtlasi | Q05315 |
PRIDEi | Q05315 |
ProteomicsDBi | 58318 |
TopDownProteomicsi | Q05315 |
Protocols and materials databases
ABCDi | Q05315, 3 sequenced antibodies |
Antibodypediai | 30409, 273 antibodies |
Genome annotation databases
Ensembli | ENST00000221804; ENSP00000221804; ENSG00000105205 |
GeneIDi | 1178 |
KEGGi | hsa:1178 |
UCSCi | uc002omh.4, human |
Organism-specific databases
CTDi | 1178 |
DisGeNETi | 1178 |
GeneCardsi | CLC |
HGNCi | HGNC:2014, CLC |
HPAi | ENSG00000105205, Tissue enriched (blood) |
MIMi | 153310, gene |
neXtProti | NX_Q05315 |
OpenTargetsi | ENSG00000105205 |
PharmGKBi | PA26541 |
VEuPathDBi | HostDB:ENSG00000105205.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000163192 |
HOGENOMi | CLU_037794_4_0_1 |
InParanoidi | Q05315 |
OMAi | VCFFNEP |
OrthoDBi | 829777at2759 |
PhylomeDBi | Q05315 |
TreeFami | TF315551 |
Enzyme and pathway databases
BRENDAi | 3.1.1.5, 2681 |
PathwayCommonsi | Q05315 |
Miscellaneous databases
BioGRID-ORCSi | 1178, 5 hits in 875 CRISPR screens |
EvolutionaryTracei | Q05315 |
GeneWikii | CLC_(gene) |
GenomeRNAii | 1178 |
Pharosi | Q05315, Tbio |
PROi | PR:Q05315 |
RNActi | Q05315, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105205, Expressed in bone marrow and 125 other tissues |
Genevisiblei | Q05315, HS |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR030648, Galectin_10 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit PTHR11346:SF15, PTHR11346:SF15, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LEG10_HUMAN | |
Accessioni | Q05315Primary (citable) accession number: Q05315 Secondary accession number(s): C5HZ13, C5HZ14, Q0VDE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references