EGR4

Functionⁱ

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences cannot be extended.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	483 – 507	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	513 – 535	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	541 – 563	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription factor activity
Source: ProtInc
Non-traceable author statementⁱ
- 1584812
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 23332764

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to growth factor stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 1658795
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12560487
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Early growth response protein 4 Short name: EGR-4 Alternative name(s): AT133
Gene namesⁱ	Name:EGR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135625.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3241 EGR4
MIMⁱ	128992 gene
neXtProtⁱ	NX_Q05215

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1961
Open Targets More...OpenTargetsⁱ	ENSG00000135625
PharmGKBⁱ	PA27676

Polymorphism and mutation databases

BioMutaⁱ	EGR4
DMDMⁱ	485956294

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047128	1 – 589	Early growth response protein 4Add BLAST		589

Proteomic databases

PaxDbⁱ	Q05215
PeptideAtlas More...PeptideAtlasⁱ	Q05215
PRIDEⁱ	Q05215
ProteomicsDBⁱ	58317

PTM databases

iPTMnetⁱ	Q05215
PhosphoSitePlusⁱ	Q05215

Expressionⁱ

Inductionⁱ

By PHA/PMA or by serum.

Gene expression databases

Bgeeⁱ	ENSG00000135625 Expressed in 114 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_EGR4
ExpressionAtlasⁱ	Q05215 baseline and differential
Genevisibleⁱ	Q05215 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028983

HPAⁱ

HPA028983

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108281, 1 interactor
IntActⁱ	Q05215, 2 interactors
STRINGⁱ	9606.ENSP00000445626

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q05215
SMRⁱ	Q05215
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	175 – 455	Pro-richAdd BLAST		281

Sequence similaritiesⁱ

Belongs to the EGR C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	483 – 507	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	513 – 535	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	541 – 563	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000112347
HOVERGENⁱ	HBG005574
InParanoidⁱ	Q05215
KEGG Orthology (KO) More...KOⁱ	K12498
OMAⁱ	CFCPRPH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VX
PhylomeDBⁱ	Q05215
TreeFamⁱ	TF318980

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q05215-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR 
        60         70         80         90        100
LPDSFPRGEC PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR 
       110        120        130        140        150
RRAMLHLSEF SEPDALLVKS TEGCCAEPSA ELPRLPARDA PAATGYPGAG 
       160        170        180        190        200
DFLSWALNSC GASGDLADSC FLEGPAPTPP PGLSYSGSFF IQAVPEHPHD 
       210        220        230        240        250
PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL LPGPPDLYSP 
       260        270        280        290        300
DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA 
       310        320        330        340        350
VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS 
       360        370        380        390        400
CPAELPAVPA NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS 
       410        420        430        440        450
GDGGEFLAST QPQLSPLGLR SAAAADFPKP LVADIPGSSG VAAPPVPPPP 
       460        470        480        490        500
PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA KAFACPVESC VRSFARSDEL 
       510        520        530        540        550
NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP FACDVCGRRF 
       560        570        580 
ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL

Length:589

Mass (Da):61,623

Last modified:May 1, 2013 - v3

Checksum:ⁱEFB5A743541A07D7

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0C4DG96	A0A0C4DG96_HUMAN		Early growth response protein 4 Early growth response protein 4	EGR4	486	Annotation score:

Sequence cautionⁱ

The sequence AAX88903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAG36840 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA42698 differs from that shown. Reason: Frameshift at position 66.Curated

The sequence CAA49214 differs from that shown. Reason: Frameshift at position 66.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	211	I → V in CAA42698 (PubMed:1658795).Curated	1
Sequence conflictⁱ	211	I → V in CAA49214 (PubMed:8504297).Curated	1
Sequence conflictⁱ	291	A → R in CAA42698 (PubMed:1658795).Curated	1
Sequence conflictⁱ	291	A → R in CAA49214 (PubMed:8504297).Curated	1
Sequence conflictⁱ	446	V → M in BAG36840 (PubMed:14702039).Curated	1
Sequence conflictⁱ	530	T → S in CAA49214 (PubMed:8504297).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69438 Genomic DNA Translation: CAA49214.1 Frameshift. AK314154 mRNA Translation: BAG36840.1 Different initiation. AC010913 Genomic DNA Translation: AAX88903.1 Different initiation. CH471053 Genomic DNA Translation: EAW99734.1 X60104 mRNA Translation: CAA42698.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1925.2
PIRⁱ	A41537
NCBI Reference Sequences More...RefSeqⁱ	NP_001956.3, NM_001965.3
UniGeneⁱ	Hs.3052

Genome annotation databases

Ensemblⁱ	ENST00000545030; ENSP00000445626; ENSG00000135625
GeneIDⁱ	1961
KEGGⁱ	hsa:1961
UCSC genome browser More...UCSCⁱ	uc010yrj.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q05215	Early growth response protein 4		HUMAN		486	UniRef100_Q05215

Protein	Similar proteins		Species	Score	Length	Source
Q05215	Early growth response protein 4		HUMAN		486	UniRef90_Q05215
EGR4 isoform 2		PANTR		589
Early growth response 4		SAIBB		589
Uncharacterized protein		COLAP		589
EGR4 isoform 2		PONAB		589
+67

Protein	Similar proteins		Species	Score	Length	Source
Q05215	Early growth response protein 4		BOVIN		482	UniRef50_Q05215
Early growth response protein 4		RAT		478
Early growth response protein 4		MOUSE		478
Early growth response protein 4		HUMAN		486
Uncharacterized protein		MANLE		589
+156

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69438 Genomic DNA Translation: CAA49214.1 Frameshift. AK314154 mRNA Translation: BAG36840.1 Different initiation. AC010913 Genomic DNA Translation: AAX88903.1 Different initiation. CH471053 Genomic DNA Translation: EAW99734.1 X60104 mRNA Translation: CAA42698.1 Frameshift.
CCDSⁱ	CCDS1925.2
PIRⁱ	A41537
RefSeqⁱ	NP_001956.3, NM_001965.3
UniGeneⁱ	Hs.3052

3D structure databases

ProteinModelPortalⁱ	Q05215
SMRⁱ	Q05215
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108281, 1 interactor
IntActⁱ	Q05215, 2 interactors
STRINGⁱ	9606.ENSP00000445626

PTM databases

iPTMnetⁱ	Q05215
PhosphoSitePlusⁱ	Q05215

Polymorphism and mutation databases

BioMutaⁱ	EGR4
DMDMⁱ	485956294

Proteomic databases

PaxDbⁱ	Q05215
PeptideAtlasⁱ	Q05215
PRIDEⁱ	Q05215
ProteomicsDBⁱ	58317

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000545030; ENSP00000445626; ENSG00000135625
GeneIDⁱ	1961
KEGGⁱ	hsa:1961
UCSCⁱ	uc010yrj.3 human

Organism-specific databases

CTDⁱ	1961
DisGeNETⁱ	1961
EuPathDBⁱ	HostDB:ENSG00000135625.7
GeneCardsⁱ	EGR4
HGNCⁱ	HGNC:3241 EGR4
HPAⁱ	HPA028983
MIMⁱ	128992 gene
neXtProtⁱ	NX_Q05215
OpenTargetsⁱ	ENSG00000135625
PharmGKBⁱ	PA27676
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000112347
HOVERGENⁱ	HBG005574
InParanoidⁱ	Q05215
KOⁱ	K12498
OMAⁱ	CFCPRPH
OrthoDBⁱ	EOG091G06VX
PhylomeDBⁱ	Q05215
TreeFamⁱ	TF318980

Miscellaneous databases

GeneWikiⁱ	EGR4
GenomeRNAiⁱ	1961
Protein Ontology More...PROⁱ	PR:Q05215
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135625 Expressed in 114 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_EGR4
ExpressionAtlasⁱ	Q05215 baseline and differential
Genevisibleⁱ	Q05215 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EGR4_HUMAN
Accessionⁱ	Q05215Primary (citable) accession number: Q05215 Secondary accession number(s): B2RAE3, G3V1T5, Q2Z1P5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	May 1, 2013
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q05215 (EGR4_HUMAN)

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Early growth response protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ