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Protein

Early growth response protein 4

Gene

EGR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences cannot be extended.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri483 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Alternative name(s):
AT133
Gene namesi
Name:EGR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135625.7
HGNCiHGNC:3241 EGR4
MIMi128992 gene
neXtProtiNX_Q05215

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1961
OpenTargetsiENSG00000135625
PharmGKBiPA27676

Polymorphism and mutation databases

BioMutaiEGR4
DMDMi485956294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471281 – 589Early growth response protein 4Add BLAST589

Proteomic databases

PaxDbiQ05215
PeptideAtlasiQ05215
PRIDEiQ05215
ProteomicsDBi58317

PTM databases

iPTMnetiQ05215
PhosphoSitePlusiQ05215

Expressioni

Inductioni

By PHA/PMA or by serum.

Gene expression databases

BgeeiENSG00000135625 Expressed in 114 organ(s), highest expression level in caudate nucleus
CleanExiHS_EGR4
ExpressionAtlasiQ05215 baseline and differential
GenevisibleiQ05215 HS

Organism-specific databases

HPAiHPA028983

Interactioni

Protein-protein interaction databases

BioGridi108281, 1 interactor
IntActiQ05215, 2 interactors
STRINGi9606.ENSP00000445626

Structurei

3D structure databases

ProteinModelPortaliQ05215
SMRiQ05215
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi175 – 455Pro-richAdd BLAST281

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri483 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000112347
HOVERGENiHBG005574
InParanoidiQ05215
KOiK12498
OMAiCFCPRPH
OrthoDBiEOG091G06VX
PhylomeDBiQ05215
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q05215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR
60 70 80 90 100
LPDSFPRGEC PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR
110 120 130 140 150
RRAMLHLSEF SEPDALLVKS TEGCCAEPSA ELPRLPARDA PAATGYPGAG
160 170 180 190 200
DFLSWALNSC GASGDLADSC FLEGPAPTPP PGLSYSGSFF IQAVPEHPHD
210 220 230 240 250
PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL LPGPPDLYSP
260 270 280 290 300
DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA
310 320 330 340 350
VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS
360 370 380 390 400
CPAELPAVPA NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS
410 420 430 440 450
GDGGEFLAST QPQLSPLGLR SAAAADFPKP LVADIPGSSG VAAPPVPPPP
460 470 480 490 500
PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA KAFACPVESC VRSFARSDEL
510 520 530 540 550
NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP FACDVCGRRF
560 570 580
ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL
Length:589
Mass (Da):61,623
Last modified:May 1, 2013 - v3
Checksum:iEFB5A743541A07D7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG96A0A0C4DG96_HUMAN
Early growth response protein 4
EGR4
486Annotation score:

Sequence cautioni

The sequence AAX88903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG36840 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42698 differs from that shown. Reason: Frameshift at position 66.Curated
The sequence CAA49214 differs from that shown. Reason: Frameshift at position 66.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211I → V in CAA42698 (PubMed:1658795).Curated1
Sequence conflicti211I → V in CAA49214 (PubMed:8504297).Curated1
Sequence conflicti291A → R in CAA42698 (PubMed:1658795).Curated1
Sequence conflicti291A → R in CAA49214 (PubMed:8504297).Curated1
Sequence conflicti446V → M in BAG36840 (PubMed:14702039).Curated1
Sequence conflicti530T → S in CAA49214 (PubMed:8504297).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69438 Genomic DNA Translation: CAA49214.1 Frameshift.
AK314154 mRNA Translation: BAG36840.1 Different initiation.
AC010913 Genomic DNA Translation: AAX88903.1 Different initiation.
CH471053 Genomic DNA Translation: EAW99734.1
X60104 mRNA Translation: CAA42698.1 Frameshift.
CCDSiCCDS1925.2
PIRiA41537
RefSeqiNP_001956.3, NM_001965.3
UniGeneiHs.3052

Genome annotation databases

EnsembliENST00000545030; ENSP00000445626; ENSG00000135625
GeneIDi1961
KEGGihsa:1961
UCSCiuc010yrj.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69438 Genomic DNA Translation: CAA49214.1 Frameshift.
AK314154 mRNA Translation: BAG36840.1 Different initiation.
AC010913 Genomic DNA Translation: AAX88903.1 Different initiation.
CH471053 Genomic DNA Translation: EAW99734.1
X60104 mRNA Translation: CAA42698.1 Frameshift.
CCDSiCCDS1925.2
PIRiA41537
RefSeqiNP_001956.3, NM_001965.3
UniGeneiHs.3052

3D structure databases

ProteinModelPortaliQ05215
SMRiQ05215
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108281, 1 interactor
IntActiQ05215, 2 interactors
STRINGi9606.ENSP00000445626

PTM databases

iPTMnetiQ05215
PhosphoSitePlusiQ05215

Polymorphism and mutation databases

BioMutaiEGR4
DMDMi485956294

Proteomic databases

PaxDbiQ05215
PeptideAtlasiQ05215
PRIDEiQ05215
ProteomicsDBi58317

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545030; ENSP00000445626; ENSG00000135625
GeneIDi1961
KEGGihsa:1961
UCSCiuc010yrj.3 human

Organism-specific databases

CTDi1961
DisGeNETi1961
EuPathDBiHostDB:ENSG00000135625.7
GeneCardsiEGR4
HGNCiHGNC:3241 EGR4
HPAiHPA028983
MIMi128992 gene
neXtProtiNX_Q05215
OpenTargetsiENSG00000135625
PharmGKBiPA27676
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000112347
HOVERGENiHBG005574
InParanoidiQ05215
KOiK12498
OMAiCFCPRPH
OrthoDBiEOG091G06VX
PhylomeDBiQ05215
TreeFamiTF318980

Miscellaneous databases

GeneWikiiEGR4
GenomeRNAii1961
PROiPR:Q05215
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135625 Expressed in 114 organ(s), highest expression level in caudate nucleus
CleanExiHS_EGR4
ExpressionAtlasiQ05215 baseline and differential
GenevisibleiQ05215 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR4_HUMAN
AccessioniPrimary (citable) accession number: Q05215
Secondary accession number(s): B2RAE3, G3V1T5, Q2Z1P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 1, 2013
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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