UniProtKB - Q05215 (EGR4_HUMAN)
Protein
Early growth response protein 4
Gene
EGR4
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity
Caution
It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences cannot be extended.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 483 – 507 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 513 – 535 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 541 – 563 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q05215 |
Reactomei | R-HSA-9031628, NGF-stimulated transcription |
Names & Taxonomyi
Protein namesi | Recommended name: Early growth response protein 4Short name: EGR-4 Alternative name(s): AT133 |
Gene namesi | Name:EGR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135625.7 |
HGNCi | HGNC:3241, EGR4 |
MIMi | 128992, gene |
neXtProti | NX_Q05215 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1961 |
OpenTargetsi | ENSG00000135625 |
PharmGKBi | PA27676 |
Miscellaneous databases
Pharosi | Q05215, Tbio |
Polymorphism and mutation databases
BioMutai | EGR4 |
DMDMi | 485956294 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047128 | 1 – 589 | Early growth response protein 4Add BLAST | 589 |
Proteomic databases
PaxDbi | Q05215 |
PeptideAtlasi | Q05215 |
PRIDEi | Q05215 |
ProteomicsDBi | 32436 58317 |
PTM databases
iPTMneti | Q05215 |
PhosphoSitePlusi | Q05215 |
Expressioni
Inductioni
By PHA/PMA or by serum.
Gene expression databases
Bgeei | ENSG00000135625, Expressed in caudate nucleus and 118 other tissues |
ExpressionAtlasi | Q05215, baseline and differential |
Genevisiblei | Q05215, HS |
Organism-specific databases
HPAi | ENSG00000135625, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Hide detailsQ05215
With | #Exp. | IntAct |
---|---|---|
ABI2 - isoform 2 [Q9NYB9-2] | 3 | EBI-19949420,EBI-11096309 |
BAG3 [O95817] | 3 | EBI-19949420,EBI-747185 |
Protein-protein interaction databases
BioGRIDi | 108281, 4 interactors |
IntActi | Q05215, 2 interactors |
STRINGi | 9606.ENSP00000445626 |
Miscellaneous databases
RNActi | Q05215, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 175 – 455 | Pro-richAdd BLAST | 281 |
Sequence similaritiesi
Belongs to the EGR C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 483 – 507 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 513 – 535 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 541 – 563 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162199 |
InParanoidi | Q05215 |
OMAi | PEHPHDP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q05215 |
TreeFami | TF318980 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q05215-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR
60 70 80 90 100
LPDSFPRGEC PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR
110 120 130 140 150
RRAMLHLSEF SEPDALLVKS TEGCCAEPSA ELPRLPARDA PAATGYPGAG
160 170 180 190 200
DFLSWALNSC GASGDLADSC FLEGPAPTPP PGLSYSGSFF IQAVPEHPHD
210 220 230 240 250
PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL LPGPPDLYSP
260 270 280 290 300
DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA
310 320 330 340 350
VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS
360 370 380 390 400
CPAELPAVPA NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS
410 420 430 440 450
GDGGEFLAST QPQLSPLGLR SAAAADFPKP LVADIPGSSG VAAPPVPPPP
460 470 480 490 500
PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA KAFACPVESC VRSFARSDEL
510 520 530 540 550
NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP FACDVCGRRF
560 570 580
ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG96 | A0A0C4DG96_HUMAN | Early growth response protein 4 | EGR4 | 486 | Annotation score: |
Sequence cautioni
The sequence AAX88903 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG36840 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA42698 differs from that shown. Reason: Frameshift.Curated
The sequence CAA49214 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 211 | I → V in CAA42698 (PubMed:1658795).Curated | 1 | |
Sequence conflicti | 211 | I → V in CAA49214 (PubMed:8504297).Curated | 1 | |
Sequence conflicti | 291 | A → R in CAA42698 (PubMed:1658795).Curated | 1 | |
Sequence conflicti | 291 | A → R in CAA49214 (PubMed:8504297).Curated | 1 | |
Sequence conflicti | 446 | V → M in BAG36840 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 530 | T → S in CAA49214 (PubMed:8504297).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69438 Genomic DNA Translation: CAA49214.1 Frameshift. AK314154 mRNA Translation: BAG36840.1 Different initiation. AC010913 Genomic DNA Translation: AAX88903.1 Different initiation. CH471053 Genomic DNA Translation: EAW99734.1 X60104 mRNA Translation: CAA42698.1 Frameshift. |
PIRi | A41537 |
RefSeqi | NP_001956.3, NM_001965.3 |
Genome annotation databases
Ensembli | ENST00000545030; ENSP00000445626; ENSG00000135625 |
GeneIDi | 1961 |
KEGGi | hsa:1961 |
UCSCi | uc010yrj.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69438 Genomic DNA Translation: CAA49214.1 Frameshift. AK314154 mRNA Translation: BAG36840.1 Different initiation. AC010913 Genomic DNA Translation: AAX88903.1 Different initiation. CH471053 Genomic DNA Translation: EAW99734.1 X60104 mRNA Translation: CAA42698.1 Frameshift. |
PIRi | A41537 |
RefSeqi | NP_001956.3, NM_001965.3 |
3D structure databases
SMRi | Q05215 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108281, 4 interactors |
IntActi | Q05215, 2 interactors |
STRINGi | 9606.ENSP00000445626 |
PTM databases
iPTMneti | Q05215 |
PhosphoSitePlusi | Q05215 |
Polymorphism and mutation databases
BioMutai | EGR4 |
DMDMi | 485956294 |
Proteomic databases
PaxDbi | Q05215 |
PeptideAtlasi | Q05215 |
PRIDEi | Q05215 |
ProteomicsDBi | 32436 58317 |
Protocols and materials databases
Antibodypediai | 16536, 111 antibodies |
Genome annotation databases
Ensembli | ENST00000545030; ENSP00000445626; ENSG00000135625 |
GeneIDi | 1961 |
KEGGi | hsa:1961 |
UCSCi | uc010yrj.3, human |
Organism-specific databases
CTDi | 1961 |
DisGeNETi | 1961 |
EuPathDBi | HostDB:ENSG00000135625.7 |
GeneCardsi | EGR4 |
HGNCi | HGNC:3241, EGR4 |
HPAi | ENSG00000135625, Tissue enriched (brain) |
MIMi | 128992, gene |
neXtProti | NX_Q05215 |
OpenTargetsi | ENSG00000135625 |
PharmGKBi | PA27676 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162199 |
InParanoidi | Q05215 |
OMAi | PEHPHDP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q05215 |
TreeFami | TF318980 |
Enzyme and pathway databases
PathwayCommonsi | Q05215 |
Reactomei | R-HSA-9031628, NGF-stimulated transcription |
Miscellaneous databases
BioGRID-ORCSi | 1961, 10 hits in 859 CRISPR screens |
GeneWikii | EGR4 |
GenomeRNAii | 1961 |
Pharosi | Q05215, Tbio |
PROi | PR:Q05215 |
RNActi | Q05215, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135625, Expressed in caudate nucleus and 118 other tissues |
ExpressionAtlasi | Q05215, baseline and differential |
Genevisiblei | Q05215, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EGR4_HUMAN | |
Accessioni | Q05215Primary (citable) accession number: Q05215 Secondary accession number(s): B2RAE3, G3V1T5, Q2Z1P5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | May 1, 2013 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM