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Entry version 185 (13 Feb 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Tyrosine-protein phosphatase non-receptor type 12

Gene

PTPN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36Substrate1 Publication1
Binding sitei199Substrate1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei231Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei278Substrate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc
  • phosphoprotein phosphatase activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: Reactome
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-182971 EGFR downregulation
R-HSA-186797 Signaling by PDGF
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9008059 Interleukin-37 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q05209

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 12 (EC:3.1.3.482 Publications)
Alternative name(s):
PTP-PEST1 Publication
Protein-tyrosine phosphatase G1
Short name:
PTPG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127947.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9645 PTPN12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600079 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q05209

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19S → E: Loss of phosphorylation site. 1 Publication1
Mutagenesisi36R → A: Decreases enzyme activity. 1 Publication1
Mutagenesisi63R → A: Decreases enzyme activity. 1 Publication1
Mutagenesisi64Y → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi66D → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi67I → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi199D → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi200H → A: Decreases enzyme activity. 1 Publication1
Mutagenesisi270R → A: Decreases enzyme activity. 1 Publication1
Mutagenesisi278Q → A: Nearly abolishes enzyme activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5782

MalaCards human disease database

More...
MalaCardsi
PTPN12

Open Targets

More...
OpenTargetsi
ENSG00000127947

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33987

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3236

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPN12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373522

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000947711 – 780Tyrosine-protein phosphatase non-receptor type 12Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei19PhosphoserineCombined sources1 Publication1
Modified residuei332PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei509PhosphothreonineCombined sources1
Modified residuei519PhosphothreonineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei569PhosphothreonineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei596PhosphoserineBy similarity1
Modified residuei598PhosphothreonineBy similarity1
Modified residuei603PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei693PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by STK24/MST3 and this results in inhibition of its activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q05209

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q05209

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q05209

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05209

PeptideAtlas

More...
PeptideAtlasi
Q05209

PRoteomics IDEntifications database

More...
PRIDEi
Q05209

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58316

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q05209

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05209

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q05209

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127947 Expressed in 236 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q05209 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q05209 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007097

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1 (PubMed:9857189). Interacts with PTK2B/PYK2 (PubMed:17329398). Interacts with LPXN (By similarity). Interacts with SORBS2; this interaction greatly enhances WASF1 dephosphorylation and might mediate partial translocation to focal adhesion sites (PubMed:18559503).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111746, 63 interactors

Protein interaction database and analysis system

More...
IntActi
Q05209, 48 interactors

Molecular INTeraction database

More...
MINTi
Q05209

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000248594

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q05209

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1780
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HDEX-ray1.62A1-301[»]
5J8RX-ray2.04A/B/C/D1-305[»]
5O2PNMR-A328-344[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q05209

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q05209

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 293Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 67Substrate binding1 Publication5
Regioni231 – 237Substrate bindingBy similarity7
Regioni345 – 438Interaction with TGFB1I1By similarityAdd BLAST94

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0789 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156909

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252955

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007666

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05209

KEGG Orthology (KO)

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KOi
K18024

Identification of Orthologs from Complete Genome Data

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OMAi
EKCDHPA

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05209

TreeFam database of animal gene trees

More...
TreeFami
TF351977

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012266 Ptpn_12
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00102 Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000932 Tyr-Ptase_nr12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05209-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQVEILRKF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT
60 70 80 90 100
ATGEKEENVK KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP
110 120 130 140 150
KAYVATQGPL ANTVIDFWRM IWEYNVVIIV MACREFEMGR KKCERYWPLY
160 170 180 190 200
GEDPITFAPF KISCEDEQAR TDYFIRTLLL EFQNESRRLY QFHYVNWPDH
210 220 230 240 250
DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA ICAIDYTWNL
260 270 280 290 300
LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL
310 320 330 340 350
YEIHGAQKIA DGVNEINTEN MVSSIEPEKQ DSPPPKPPRT RSCLVEGDAK
360 370 380 390 400
EEILQPPEPH PVPPILTPSP PSAFPTVTTV WQDNDRYHPK PVLHMVSSEQ
410 420 430 440 450
HSADLNRNYS KSTELPGKNE STIEQIDKKL ERNLSFEIKK VPLQEGPKSF
460 470 480 490 500
DGNTLLNRGH AIKIKSASPC IADKISKPQE LSSDLNVGDT SQNSCVDCSV
510 520 530 540 550
TQSNKVSVTP PEESQNSDTP PRPDRLPLDE KGHVTWSFHG PENAIPIPDL
560 570 580 590 600
SEGNSSDINY QTRKTVSLTP SPTTQVETPD LVDHDNTSPL FRTPLSFTNP
610 620 630 640 650
LHSDDSDSDE RNSDGAVTQN KTNISTASAT VSAATSTESI STRKVLPMSI
660 670 680 690 700
ARHNIAGTTH SGAEKDVDVS EDSPPPLPER TPESFVLASE HNTPVRSEWS
710 720 730 740 750
ELQSQERSEQ KKSEGLITSE NEKCDHPAGG IHYEMCIECP PTFSDKREQI
760 770 780
SENPTEATDI GFGNRCGKPK GPRDPPSEWT
Length:780
Mass (Da):88,106
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i663DB3E5176FD7FD
GO
Isoform 2 (identifier: Q05209-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Note: No experimental confirmation available.
Show »
Length:650
Mass (Da):72,778
Checksum:i217EF3041B7E5EDB
GO
Isoform 3 (identifier: Q05209-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:661
Mass (Da):74,138
Checksum:i74E2947477636633
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WB51F8WB51_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC15H0YC15_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1X8C9J1X8_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJC1C9JJC1_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB59H0YB59_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM04H3BM04_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYA4C9JYA4_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN12
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121I → V in BAA02648 (PubMed:1472029).Curated1
Sequence conflicti121I → V in AAB30047 (PubMed:7509295).Curated1
Sequence conflicti612N → D in BAG59344 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00638561K → R in colon cancer. 1 PublicationCorresponds to variant dbSNP:rs121434623EnsemblClinVar.1
Natural variantiVAR_019512322V → ICombined sources3 PublicationsCorresponds to variant dbSNP:rs9640663Ensembl.1
Natural variantiVAR_020297573T → A1 PublicationCorresponds to variant dbSNP:rs3750050Ensembl.1
Natural variantiVAR_057129706E → K. Corresponds to variant dbSNP:rs2230602Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462741 – 130Missing in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_0541681 – 119Missing in isoform 3. CuratedAdd BLAST119

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D13380 mRNA Translation: BAA02648.1
M93425 mRNA Translation: AAA36529.1
AK289573 mRNA Translation: BAF82262.1
AK296764 mRNA Translation: BAG59344.1
AB209524 mRNA Translation: BAD92761.1 Different initiation.
AC006451 Genomic DNA Translation: AAQ96881.1
CH236949 Genomic DNA Translation: EAL24198.1
CH471091 Genomic DNA Translation: EAW77036.1
CH471091 Genomic DNA Translation: EAW77037.1
BC050008 mRNA Translation: AAH50008.2
S69184 mRNA Translation: AAB30047.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47619.1 [Q05209-3]
CCDS47620.1 [Q05209-2]
CCDS5592.1 [Q05209-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC1368

NCBI Reference Sequences

More...
RefSeqi
NP_001124480.1, NM_001131008.1 [Q05209-3]
NP_001124481.1, NM_001131009.1 [Q05209-2]
NP_002826.3, NM_002835.3 [Q05209-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.61812

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000248594; ENSP00000248594; ENSG00000127947 [Q05209-1]
ENST00000415482; ENSP00000392429; ENSG00000127947 [Q05209-3]
ENST00000435495; ENSP00000397991; ENSG00000127947 [Q05209-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5782

UCSC genome browser

More...
UCSCi
uc003ugh.3 human [Q05209-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13380 mRNA Translation: BAA02648.1
M93425 mRNA Translation: AAA36529.1
AK289573 mRNA Translation: BAF82262.1
AK296764 mRNA Translation: BAG59344.1
AB209524 mRNA Translation: BAD92761.1 Different initiation.
AC006451 Genomic DNA Translation: AAQ96881.1
CH236949 Genomic DNA Translation: EAL24198.1
CH471091 Genomic DNA Translation: EAW77036.1
CH471091 Genomic DNA Translation: EAW77037.1
BC050008 mRNA Translation: AAH50008.2
S69184 mRNA Translation: AAB30047.2
CCDSiCCDS47619.1 [Q05209-3]
CCDS47620.1 [Q05209-2]
CCDS5592.1 [Q05209-1]
PIRiJC1368
RefSeqiNP_001124480.1, NM_001131008.1 [Q05209-3]
NP_001124481.1, NM_001131009.1 [Q05209-2]
NP_002826.3, NM_002835.3 [Q05209-1]
UniGeneiHs.61812

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HDEX-ray1.62A1-301[»]
5J8RX-ray2.04A/B/C/D1-305[»]
5O2PNMR-A328-344[»]
ProteinModelPortaliQ05209
SMRiQ05209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111746, 63 interactors
IntActiQ05209, 48 interactors
MINTiQ05209
STRINGi9606.ENSP00000248594

Chemistry databases

BindingDBiQ05209
ChEMBLiCHEMBL3236

PTM databases

DEPODiQ05209
iPTMnetiQ05209
PhosphoSitePlusiQ05209

Polymorphism and mutation databases

BioMutaiPTPN12
DMDMi317373522

Proteomic databases

EPDiQ05209
jPOSTiQ05209
MaxQBiQ05209
PaxDbiQ05209
PeptideAtlasiQ05209
PRIDEiQ05209
ProteomicsDBi58316

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248594; ENSP00000248594; ENSG00000127947 [Q05209-1]
ENST00000415482; ENSP00000392429; ENSG00000127947 [Q05209-3]
ENST00000435495; ENSP00000397991; ENSG00000127947 [Q05209-2]
GeneIDi5782
KEGGihsa:5782
UCSCiuc003ugh.3 human [Q05209-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5782
DisGeNETi5782
EuPathDBiHostDB:ENSG00000127947.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPN12

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0033626
HGNCiHGNC:9645 PTPN12
HPAiHPA007097
MalaCardsiPTPN12
MIMi600079 gene
neXtProtiNX_Q05209
OpenTargetsiENSG00000127947
PharmGKBiPA33987

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000156909
HOGENOMiHOG000252955
HOVERGENiHBG007666
InParanoidiQ05209
KOiK18024
OMAiEKCDHPA
OrthoDBi411281at2759
PhylomeDBiQ05209
TreeFamiTF351977

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-182971 EGFR downregulation
R-HSA-186797 Signaling by PDGF
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9008059 Interleukin-37 signaling
SIGNORiQ05209

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPN12 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPN12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5782

Protein Ontology

More...
PROi
PR:Q05209

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127947 Expressed in 236 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ05209 baseline and differential
GenevisibleiQ05209 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012266 Ptpn_12
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000932 Tyr-Ptase_nr12, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05209
Secondary accession number(s): A4D1C5
, B4DKY2, E9PBR5, E9PEH9, Q16130, Q59FD6, Q75MN8, Q86XU4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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