UniProtKB - Q05204 (LAMP1_BOVIN)
Protein
Lysosome-associated membrane glycoprotein 1
Gene
LAMP1
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- protein domain specific binding Source: Ensembl
GO - Biological processi
- establishment of protein localization to organelle Source: GO_Central
- Golgi to lysosome transport Source: Ensembl
- granzyme-mediated programmed cell death signaling pathway Source: Ensembl
- positive regulation of natural killer cell degranulation Source: Ensembl
- protein stabilization Source: UniProtKB
- regulation of organelle transport along microtubule Source: Ensembl
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Lysosome-associated membrane glycoprotein 1Short name: LAMP-1 Short name: Lysosome-associated membrane protein 1 Alternative name(s): CD107 antigen-like family member A Chromaffin granule-associated membrane glycoprotein IIA CD_antigen: CD107a |
Gene namesi | Name:LAMP1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:30775, LAMP1 |
Subcellular locationi
Lysosome
- Lysosome membrane By similarity; Single-pass type I membrane protein By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Endosome
- Endosome membrane By similarity; Single-pass type I membrane protein By similarity
- Late endosome By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.By similarity
Cytosol
- cytosol Source: GOC
Endosome
- endosome membrane Source: UniProtKB
- late endosome membrane Source: GO_Central
- multivesicular body Source: Ensembl
Lysosome
- autolysosome Source: Ensembl
- cytolytic granule Source: Ensembl
- lysosomal membrane Source: AgBase
- phagolysosome membrane Source: Ensembl
Plasma Membrane
- caveola Source: AgBase
- external side of plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
- sarcolemma Source: Ensembl
Other locations
- autophagosome membrane Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- melanosome Source: Ensembl
- membrane raft Source: AgBase
- perinuclear region of cytoplasm Source: Ensembl
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 374 | LumenalSequence analysisAdd BLAST | 349 | |
Transmembranei | 375 – 398 | HelicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Topological domaini | 399 – 409 | CytoplasmicPROSITE-ProRule annotationAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | By similarityAdd BLAST | 25 | |
ChainiPRO_0000017107 | 26 – 409 | Lysosome-associated membrane glycoprotein 1Add BLAST | 384 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 38 ↔ 76 | PROSITE-ProRule annotation | ||
Glycosylationi | 59 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 146 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 151 ↔ 187 | PROSITE-ProRule annotation | ||
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 223 ↔ 261 | PROSITE-ProRule annotation | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 253 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 299 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 330 ↔ 367 | PROSITE-ProRule annotation |
Post-translational modificationi
O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q05204 |
PeptideAtlasi | Q05204 |
PRIDEi | Q05204 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000010242, Expressed in spermatid and 18 other tissues |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042536 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 187 | First lumenal domainAdd BLAST | 162 | |
Regioni | 188 – 219 | HingeAdd BLAST | 32 | |
Regioni | 220 – 374 | Second lumenal domainAdd BLAST | 155 |
Sequence similaritiesi
Belongs to the LAMP family.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4818, Eukaryota |
GeneTreei | ENSGT00950000182899 |
HOGENOMi | CLU_055379_2_0_1 |
InParanoidi | Q05204 |
OMAi | RLQVQPF |
OrthoDBi | 1042920at2759 |
TreeFami | TF316339 |
Family and domain databases
InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
PANTHERi | PTHR11506, PTHR11506, 1 hit |
Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
PRINTSi | PR00336, LYSASSOCTDMP |
PROSITEi | View protein in PROSITE PS00310, LAMP_1, 2 hits PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q05204-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPGGARRR PLLLLLFAGL VHGASAVFVV KNGNGTACIM ADFSATFLTS
60 70 80 90 100
YDTRSGPQNK SFELPAGAEV SNSSSCGKEN ASDSSLVITF GRGHTLTLIF
110 120 130 140 150
TRNATRYEVQ LMRFAYNLSD TDTFPNSSST GVKTVESATD IKADINKTYR
160 170 180 190 200
CVSETQVNMD NVTVTLRDAA IQAYLSSSNF SREETRCEQD LPTPTTPPQP
210 220 230 240 250
APTPAPASPA VFRYNVSGSN GTCLLASMGL QLNVTYRRVD NKTVTREFNV
260 270 280 290 300
NPNKTTFGGN CSATLATLEL HSENLLLLAL QFVMNESSSR VFLQGVQLNL
310 320 330 340 350
TLPDAKEGSF TATNSSLRAL QATAGNSYKC NAEQRLRVTS SFSLNMFRVW
360 370 380 390 400
LQAFRVDGDK FGPVEECQLD ENSMLIPIAV GGALAGLVLI VLLAYLIGRK
RSHAGYQTI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 – 7 | AAPGGA → RPPAAP in AAA30548 (PubMed:8496169).Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118436 mRNA Translation: AAI18437.1 BC133619 mRNA Translation: AAI33620.1 BC140610 mRNA Translation: AAI40611.1 L09113 mRNA Translation: AAA30548.1 |
PIRi | A46712 |
RefSeqi | NP_001068592.1, NM_001075124.2 |
Genome annotation databases
Ensembli | ENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242 |
GeneIDi | 281897 |
KEGGi | bta:281897 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC118436 mRNA Translation: AAI18437.1 BC133619 mRNA Translation: AAI33620.1 BC140610 mRNA Translation: AAI40611.1 L09113 mRNA Translation: AAA30548.1 |
PIRi | A46712 |
RefSeqi | NP_001068592.1, NM_001075124.2 |
3D structure databases
SMRi | Q05204 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042536 |
Proteomic databases
PaxDbi | Q05204 |
PeptideAtlasi | Q05204 |
PRIDEi | Q05204 |
Genome annotation databases
Ensembli | ENSBTAT00000045121; ENSBTAP00000042536; ENSBTAG00000010242 |
GeneIDi | 281897 |
KEGGi | bta:281897 |
Organism-specific databases
CTDi | 3916 |
VGNCi | VGNC:30775, LAMP1 |
Phylogenomic databases
eggNOGi | KOG4818, Eukaryota |
GeneTreei | ENSGT00950000182899 |
HOGENOMi | CLU_055379_2_0_1 |
InParanoidi | Q05204 |
OMAi | RLQVQPF |
OrthoDBi | 1042920at2759 |
TreeFami | TF316339 |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation |
Gene expression databases
Bgeei | ENSBTAG00000010242, Expressed in spermatid and 18 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
PANTHERi | PTHR11506, PTHR11506, 1 hit |
Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
PRINTSi | PR00336, LYSASSOCTDMP |
PROSITEi | View protein in PROSITE PS00310, LAMP_1, 2 hits PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMP1_BOVIN | |
Accessioni | Q05204Primary (citable) accession number: Q05204 Secondary accession number(s): A2VE82, A5D7M2, Q17QC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families