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Protein

Dynamin-1

Gene

DNM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi136 – 140GTPBy similarity5
Nucleotide bindingi205 – 208GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5 2681
ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-437239 Recycling pathway of L1
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiQ05193

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Gene namesi
Name:DNM1
Synonyms:DNM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106976.19
HGNCiHGNC:2972 DNM1
MIMi602377 gene
neXtProtiNX_Q05193

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, early infantile, 31 (EIEE31)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
See also OMIM:616346
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073710177A → P in EIEE31. 1 PublicationCorresponds to variant dbSNP:rs587777860EnsemblClinVar.1
Natural variantiVAR_073711206K → N in EIEE31. 1 PublicationCorresponds to variant dbSNP:rs587777861EnsemblClinVar.1
Natural variantiVAR_073712237R → W in EIEE31. 2 PublicationsCorresponds to variant dbSNP:rs760270633EnsemblClinVar.1
Natural variantiVAR_073713359G → A in EIEE31. 1 PublicationCorresponds to variant dbSNP:rs587777862EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44K → A: Inhibits receptor-mediated endocytosis. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNETi1759
MalaCardsiDNM1
MIMi616346 phenotype
OpenTargetsiENSG00000106976
Orphaneti2382 Lennox-Gastaut syndrome
442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA27440

Chemistry databases

ChEMBLiCHEMBL4958

Polymorphism and mutation databases

DMDMi172046078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065631 – 864Dynamin-1Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphotyrosineBy similarity1
Modified residuei125Nitrated tyrosine; alternateBy similarity1
Modified residuei125Phosphotyrosine; alternateBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei354PhosphotyrosineBy similarity1
Modified residuei512PhosphoserineBy similarity1
Modified residuei774PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1
Modified residuei796Omega-N-methylarginineBy similarity1
Modified residuei822PhosphoserineBy similarity1
Modified residuei851PhosphoserineBy similarity1
Modified residuei857PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

EPDiQ05193
MaxQBiQ05193
PaxDbiQ05193
PeptideAtlasiQ05193
PRIDEiQ05193
ProteomicsDBi58309
58310 [Q05193-2]
58311 [Q05193-3]
58313 [Q05193-5]

PTM databases

iPTMnetiQ05193
PhosphoSitePlusiQ05193

Expressioni

Gene expression databases

BgeeiENSG00000106976 Expressed in 205 organ(s), highest expression level in frontal cortex
CleanExiHS_DNM1
ExpressionAtlasiQ05193 baseline and differential
GenevisibleiQ05193 HS

Organism-specific databases

HPAiCAB005920
HPA049910
HPA061801

Interactioni

Subunit structurei

Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1 (PubMed:23325789).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108099, 67 interactors
CORUMiQ05193
DIPiDIP-36242N
IntActiQ05193, 33 interactors
MINTiQ05193
STRINGi9606.ENSP00000362014

Chemistry databases

BindingDBiQ05193

Structurei

Secondary structure

1864
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ05193
SMRiQ05193
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05193

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini519 – 625PHPROSITE-ProRule annotationAdd BLAST107
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000161069
HOVERGENiHBG107833
InParanoidiQ05193
KOiK01528
OrthoDBiEOG091G0EIQ
PhylomeDBiQ05193
TreeFamiTF300362

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027741 DNM1
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF32 PTHR11566:SF32, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q05193-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVNATTEY AEFLHCKGKK FTDFEEVRLE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP
160 170 180 190 200
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKVA KEVDPQGQRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
260 270 280 290 300
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL
310 320 330 340 350
QSQLLSIEKE VEEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP
460 470 480 490 500
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ
510 520 530 540 550
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL
560 570 580 590 600
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY
610 620 630 640 650
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE
710 720 730 740 750
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV
760 770 780 790 800
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP
810 820 830 840 850
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA
860
SPSRPESPRP PFDL
Length:864
Mass (Da):97,408
Last modified:March 18, 2008 - v2
Checksum:i7FCD8CB572FFEAEF
GO
Isoform 2 (identifier: Q05193-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTATIRKCSE

Show »
Length:864
Mass (Da):97,263
Checksum:iDC9E3D5259D891DF
GO
Isoform 3 (identifier: Q05193-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Show »
Length:851
Mass (Da):96,041
Checksum:i89040FCDDAC2870C
GO
Isoform 4 (identifier: Q05193-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTATIRKCSE
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Show »
Length:851
Mass (Da):95,895
Checksum:i4230B9970D097B20
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SFE4A0A0D9SFE4_HUMAN
Dynamin-1
DNM1
864Annotation score:
A0A0D9SFB1A0A0D9SFB1_HUMAN
Dynamin-1
DNM1
835Annotation score:
A0A0U1RQP1A0A0U1RQP1_HUMAN
Dynamin-1
DNM1
856Annotation score:
A0A1B0GU67A0A1B0GU67_HUMAN
Dynamin-1
DNM1
356Annotation score:
A0A1B0GUX5A0A1B0GUX5_HUMAN
Dynamin-1
DNM1
320Annotation score:
H7C5U0H7C5U0_HUMAN
Dynamin-1
DNM1
131Annotation score:
A0A0D9SFP1A0A0D9SFP1_HUMAN
Dynamin-1
DNM1
53Annotation score:
A0A1B0GVK6A0A1B0GVK6_HUMAN
Dynamin-1
DNM1
34Annotation score:

Sequence cautioni

The sequence AAA02805 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188K → E in AAH50279 (PubMed:15489334).Curated1
Sequence conflicti287N → D in AAH50279 (PubMed:15489334).Curated1
Sequence conflicti809L → M in AAH50279 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073710177A → P in EIEE31. 1 PublicationCorresponds to variant dbSNP:rs587777860EnsemblClinVar.1
Natural variantiVAR_073711206K → N in EIEE31. 1 PublicationCorresponds to variant dbSNP:rs587777861EnsemblClinVar.1
Natural variantiVAR_073712237R → W in EIEE31. 2 PublicationsCorresponds to variant dbSNP:rs760270633EnsemblClinVar.1
Natural variantiVAR_073713359G → A in EIEE31. 1 PublicationCorresponds to variant dbSNP:rs587777862EnsemblClinVar.1
Natural variantiVAR_048904744D → N1 PublicationCorresponds to variant dbSNP:rs1042007Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031518407 – 444MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTATIRKCSE in isoform 2 and isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_031519845 – 864SRSGQ…PPFDL → RITISDP in isoform 3 and isoform 4. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07807 mRNA Translation: AAA02803.1
L07808 mRNA Translation: AAA02804.1
L07809 mRNA Translation: AAA02805.1 Sequence problems.
L07810 mRNA Translation: AAA02806.1
AL590708 Genomic DNA No translation available.
BC050279 mRNA Translation: AAH50279.2
BC063850 mRNA Translation: AAH63850.1
CCDSiCCDS43882.1 [Q05193-3]
CCDS6895.1 [Q05193-1]
CCDS75911.1 [Q05193-5]
CCDS75912.1 [Q05193-2]
PIRiA40671
RefSeqiNP_001005336.1, NM_001005336.2 [Q05193-3]
NP_001275666.1, NM_001288737.1 [Q05193-5]
NP_001275667.1, NM_001288738.1 [Q05193-5]
NP_001275668.1, NM_001288739.1 [Q05193-2]
NP_004399.2, NM_004408.3 [Q05193-1]
XP_005251825.1, XM_005251768.2 [Q05193-5]
XP_005251826.1, XM_005251769.2 [Q05193-3]
XP_016869860.1, XM_017014371.1 [Q05193-3]
UniGeneiHs.522413

Genome annotation databases

EnsembliENST00000341179; ENSP00000345680; ENSG00000106976 [Q05193-3]
ENST00000372923; ENSP00000362014; ENSG00000106976 [Q05193-1]
ENST00000393594; ENSP00000377219; ENSG00000106976 [Q05193-5]
ENST00000475805; ENSP00000419225; ENSG00000106976 [Q05193-5]
ENST00000486160; ENSP00000420045; ENSG00000106976 [Q05193-2]
ENST00000627543; ENSP00000487310; ENSG00000106976 [Q05193-3]
GeneIDi1759
KEGGihsa:1759
UCSCiuc064wcg.1 human [Q05193-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07807 mRNA Translation: AAA02803.1
L07808 mRNA Translation: AAA02804.1
L07809 mRNA Translation: AAA02805.1 Sequence problems.
L07810 mRNA Translation: AAA02806.1
AL590708 Genomic DNA No translation available.
BC050279 mRNA Translation: AAH50279.2
BC063850 mRNA Translation: AAH63850.1
CCDSiCCDS43882.1 [Q05193-3]
CCDS6895.1 [Q05193-1]
CCDS75911.1 [Q05193-5]
CCDS75912.1 [Q05193-2]
PIRiA40671
RefSeqiNP_001005336.1, NM_001005336.2 [Q05193-3]
NP_001275666.1, NM_001288737.1 [Q05193-5]
NP_001275667.1, NM_001288738.1 [Q05193-5]
NP_001275668.1, NM_001288739.1 [Q05193-2]
NP_004399.2, NM_004408.3 [Q05193-1]
XP_005251825.1, XM_005251768.2 [Q05193-5]
XP_005251826.1, XM_005251769.2 [Q05193-3]
XP_016869860.1, XM_017014371.1 [Q05193-3]
UniGeneiHs.522413

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DYNX-ray2.20A/B510-633[»]
2DYNX-ray2.30A/B509-630[»]
2X2EX-ray2.00A/D6-320[»]
A/D726-750[»]
2X2FX-ray2.00A/D6-320[»]
A/D726-750[»]
3SNHX-ray3.70A6-746[»]
3ZYCX-ray2.20A/D6-320[»]
A/D726-750[»]
3ZYSelectron microscopy12.20A/D6-320[»]
A/D726-750[»]
C/F518-630[»]
4UUDelectron microscopy12.50A/B/C/D/E/F/G/H/I/J/K/L1-864[»]
4UUKelectron microscopy12.50A/B/C/D/E/F/G/H/I/J/K/L1-864[»]
5D3QX-ray1.70A/B5-320[»]
A/B726-746[»]
6DLUelectron microscopy3.75B/P1-748[»]
6DLVelectron microscopy10.10b/c/f/g1-748[»]
ProteinModelPortaliQ05193
SMRiQ05193
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108099, 67 interactors
CORUMiQ05193
DIPiDIP-36242N
IntActiQ05193, 33 interactors
MINTiQ05193
STRINGi9606.ENSP00000362014

Chemistry databases

BindingDBiQ05193
ChEMBLiCHEMBL4958

PTM databases

iPTMnetiQ05193
PhosphoSitePlusiQ05193

Polymorphism and mutation databases

DMDMi172046078

Proteomic databases

EPDiQ05193
MaxQBiQ05193
PaxDbiQ05193
PeptideAtlasiQ05193
PRIDEiQ05193
ProteomicsDBi58309
58310 [Q05193-2]
58311 [Q05193-3]
58313 [Q05193-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341179; ENSP00000345680; ENSG00000106976 [Q05193-3]
ENST00000372923; ENSP00000362014; ENSG00000106976 [Q05193-1]
ENST00000393594; ENSP00000377219; ENSG00000106976 [Q05193-5]
ENST00000475805; ENSP00000419225; ENSG00000106976 [Q05193-5]
ENST00000486160; ENSP00000420045; ENSG00000106976 [Q05193-2]
ENST00000627543; ENSP00000487310; ENSG00000106976 [Q05193-3]
GeneIDi1759
KEGGihsa:1759
UCSCiuc064wcg.1 human [Q05193-1]

Organism-specific databases

CTDi1759
DisGeNETi1759
EuPathDBiHostDB:ENSG00000106976.19
GeneCardsiDNM1
H-InvDBiHIX0026786
HIX0211497
HGNCiHGNC:2972 DNM1
HPAiCAB005920
HPA049910
HPA061801
MalaCardsiDNM1
MIMi602377 gene
616346 phenotype
neXtProtiNX_Q05193
OpenTargetsiENSG00000106976
Orphaneti2382 Lennox-Gastaut syndrome
442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA27440
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000161069
HOVERGENiHBG107833
InParanoidiQ05193
KOiK01528
OrthoDBiEOG091G0EIQ
PhylomeDBiQ05193
TreeFamiTF300362

Enzyme and pathway databases

BRENDAi3.6.5.5 2681
ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-437239 Recycling pathway of L1
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiQ05193

Miscellaneous databases

EvolutionaryTraceiQ05193
GeneWikiiDNM1
GenomeRNAii1759
PROiPR:Q05193
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106976 Expressed in 205 organ(s), highest expression level in frontal cortex
CleanExiHS_DNM1
ExpressionAtlasiQ05193 baseline and differential
GenevisibleiQ05193 HS

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027741 DNM1
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF32 PTHR11566:SF32, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYN1_HUMAN
AccessioniPrimary (citable) accession number: Q05193
Secondary accession number(s): A6NLM6
, Q5SYX0, Q5SYX2, Q6P3T6, Q86VD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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