Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).
Entry version 190 (07 Apr 2021)
Sequence version 3 (25 Oct 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Nuclear hormone receptor FTZ-F1 beta

Gene

Hr39

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi373 – 448Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri376 – 396NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri412 – 436NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-383280, Nuclear Receptor transcription pathway
R-DME-4090294, SUMOylation of intracellular receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear hormone receptor FTZ-F1 beta
Alternative name(s):
Nuclear hormone receptor HR39
Short name:
dHR39
Nuclear receptor subfamily 5 group B member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hr39
Synonyms:FTZ-F1-beta, FTZF1-beta, NR5-beta-1, NR5B1
ORF Names:CG8676
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261239, Hr39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000537401 – 808Nuclear hormone receptor FTZ-F1 betaAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90Phosphoserine1 Publication1
Modified residuei98Phosphoserine1 Publication1
Modified residuei100Phosphoserine1 Publication1
Modified residuei106Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei276Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05192

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05192

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed throughout the blastodermal layer in early embryos. At later stages, strong expression is observed in the brain, ventral cord and hindgut.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at all stages.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261239, Expressed in saliva-secreting gland and 47 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q05192, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer; forms a complex with ftz.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61349, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q05192, 17 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081008

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini580 – 808NR LBDPROSITE-ProRule annotationAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 39Poly-Thr4
Compositional biasi230 – 299Ser-richAdd BLAST70
Compositional biasi478 – 488Poly-AlaAdd BLAST11
Compositional biasi572 – 589Ser-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri376 – 396NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri412 – 436NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015032_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05192

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVKVREC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05192

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035500, NHR-like_dom_sf
IPR016355, NR5_fam
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA

The PANTHER Classification System

More...
PANTHERi
PTHR24086, PTHR24086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00398, STRDHORMONER
PR00047, STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508, SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q05192-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNMSSIKAE QQSGPLGGSS GYQVPVNMCT TTVANTTTTL GSSAGGATGS
60 70 80 90 100
RHNVSVTNIK CELDELPSPN GNMVPVIANY VHGSLRIPLS GHSNHRESDS
110 120 130 140 150
EEELASIENL KVRRRTAADK NGPRPMSWEG ELSDTEVNGG EELMEMEPTI
160 170 180 190 200
KSEVVPAVAP PQPVCALQPI KTELENIAGE MQIQEKCYPQ SNTQHHAATK
210 220 230 240 250
LKVAPTQSDP INLKFEPPLG DNSPLLAARS KSSSGGHLPL PTNPSPDSAI
260 270 280 290 300
HSVYTHSSPS QSPLTSRHAP YTPSLSRNNS DASHSSCYSY SSEFSPTHSP
310 320 330 340 350
IQARHAPPAG TLYGNHHGIY RQMKVEASST VPSSGQEAQN LSMDSASSNL
360 370 380 390 400
DTVGLGSSHP ASPAGISRQQ LINSPCPICG DKISGFHYGI FSCESCKGFF
410 420 430 440 450
KRTVQNRKNY VCVRGGPCQV SISTRKKCPA CRFEKCLQKG MKLEAIREDR
460 470 480 490 500
TRGGRSTYQC SYTLPNSMLS PLLSPDQAAA AAAAAAVASQ QQPHQRLHQL
510 520 530 540 550
NGFGGVPIPC STSLPASPSL AGTSVKSEEM AETGKQSLRT GSVPPLLQEI
560 570 580 590 600
MDVEHLWQYT DAELARINQP LSAFASGSSS SSSSSGTSSG AHAQLTNPLL
610 620 630 640 650
ASAGLSSNGE NANPDLIAHL CNVADHRLYK IVKWCKSLPL FKNISIDDQI
660 670 680 690 700
CLLINSWCEL LLFSCCFRSI DTPGEIKMSQ GRKITLSQAK SNGLQTCIER
710 720 730 740 750
MLNLTDHLRR LRVDRYEYVA MKVIVLLQSD TTELQEAVKV RECQEKALQS
760 770 780 790 800
LQAYTLAHYP DTPSKFGELL LRIPDLQRTC QLGKEMLTIK TRDGADFNLL

MELLRGEH
Length:808
Mass (Da):87,314
Last modified:October 25, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02390BC2D4B35A48
GO
Isoform C (identifier: Q05192-2) [UniParc]FASTAAdd to basket
Also known as: DHR39-short

The sequence of this isoform differs from the canonical sequence as follows:
     696-701: TCIERM → VSLCEL
     702-808: Missing.

Show »
Length:701
Mass (Da):74,785
Checksum:i76C41AE5E0D7E531
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185E → G in AAA28543 (PubMed:8382937).Curated1
Sequence conflicti185E → G in AAA28462 (PubMed:8479913).Curated1
Sequence conflicti185E → G in AAA28463 (PubMed:8479913).Curated1
Sequence conflicti185E → G in AAA28464 (PubMed:8479913).Curated1
Sequence conflicti203V → L in AAA28543 (PubMed:8382937).Curated1
Sequence conflicti389G → F in AAA28462 (PubMed:8479913).Curated1
Sequence conflicti389G → F in AAA28463 (PubMed:8479913).Curated1
Sequence conflicti389G → F in AAA28464 (PubMed:8479913).Curated1
Sequence conflicti763P → Q in AAA28462 (PubMed:8479913).Curated1
Sequence conflicti763P → Q in AAA28464 (PubMed:8479913).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003718696 – 701TCIERM → VSLCEL in isoform C. 1 Publication6
Alternative sequenceiVSP_003719702 – 808Missing in isoform C. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L06423 mRNA Translation: AAA28543.1
L07551 mRNA Translation: AAA28464.1
L07549 mRNA Translation: AAA28462.1
L07550 mRNA Translation: AAA28463.1
AE014134 Genomic DNA Translation: AAN11107.1
AE014134 Genomic DNA Translation: AAN11108.1
AE014134 Genomic DNA Translation: AAN11109.1
AY069676 mRNA Translation: AAL39821.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S33708
S33709

NCBI Reference Sequences

More...
RefSeqi
NP_476932.1, NM_057584.5 [Q05192-1]
NP_476933.1, NM_057585.3 [Q05192-2]
NP_599123.1, NM_134296.3 [Q05192-1]
NP_724322.1, NM_165364.2 [Q05192-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081478; FBpp0081007; FBgn0261239 [Q05192-2]
FBtr0081479; FBpp0081008; FBgn0261239 [Q05192-1]
FBtr0081480; FBpp0081009; FBgn0261239 [Q05192-1]
FBtr0081481; FBpp0081010; FBgn0261239 [Q05192-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35398

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8676

UCSC genome browser

More...
UCSCi
CG8676-RD, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06423 mRNA Translation: AAA28543.1
L07551 mRNA Translation: AAA28464.1
L07549 mRNA Translation: AAA28462.1
L07550 mRNA Translation: AAA28463.1
AE014134 Genomic DNA Translation: AAN11107.1
AE014134 Genomic DNA Translation: AAN11108.1
AE014134 Genomic DNA Translation: AAN11109.1
AY069676 mRNA Translation: AAL39821.1
PIRiS33708
S33709
RefSeqiNP_476932.1, NM_057584.5 [Q05192-1]
NP_476933.1, NM_057585.3 [Q05192-2]
NP_599123.1, NM_134296.3 [Q05192-1]
NP_724322.1, NM_165364.2 [Q05192-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi61349, 21 interactors
IntActiQ05192, 17 interactors
STRINGi7227.FBpp0081008

PTM databases

iPTMnetiQ05192

Proteomic databases

PaxDbiQ05192

Genome annotation databases

EnsemblMetazoaiFBtr0081478; FBpp0081007; FBgn0261239 [Q05192-2]
FBtr0081479; FBpp0081008; FBgn0261239 [Q05192-1]
FBtr0081480; FBpp0081009; FBgn0261239 [Q05192-1]
FBtr0081481; FBpp0081010; FBgn0261239 [Q05192-1]
GeneIDi35398
KEGGidme:Dmel_CG8676
UCSCiCG8676-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35398
FlyBaseiFBgn0261239, Hr39

Phylogenomic databases

eggNOGiKOG3575, Eukaryota
GeneTreeiENSGT00940000153391
HOGENOMiCLU_015032_0_0_1
InParanoidiQ05192
OMAiAVKVREC
PhylomeDBiQ05192

Enzyme and pathway databases

ReactomeiR-DME-383280, Nuclear Receptor transcription pathway
R-DME-4090294, SUMOylation of intracellular receptors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35398, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hr39, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35398

Protein Ontology

More...
PROi
PR:Q05192

Gene expression databases

BgeeiFBgn0261239, Expressed in saliva-secreting gland and 47 other tissues
GenevisibleiQ05192, DM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500, NHR-like_dom_sf
IPR016355, NR5_fam
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA
PANTHERiPTHR24086, PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit
PRINTSiPR00398, STRDHORMONER
PR00047, STROIDFINGER
SMARTiView protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit
SUPFAMiSSF48508, SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTF1B_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05192
Secondary accession number(s): A4V0Z2
, Q0E8N5, Q8INT8, Q9VID8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 25, 2004
Last modified: April 7, 2021
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again