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Entry version 138 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Voltage-dependent N-type calcium channel subunit alpha-1B

Gene

CACNA1B

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (By similarity).

They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei314Calcium ion selectivity and permeabilityBy similarity1
Sitei663Calcium ion selectivity and permeabilityBy similarity1
Sitei1370Calcium ion selectivity and permeabilityBy similarity1
Sitei1658Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi452 – 459ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi1740 – 1751PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alpha-1B
Alternative name(s):
Brain calcium channel III
Short name:
BIII
Calcium channel, L type, alpha-1 polypeptide isoform 5
Voltage-gated calcium channel subunit alpha Cav2.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1B
Synonyms:CACH5, CACNL1A5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei96 – 114Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini115 – 132ExtracellularSequence analysisAdd BLAST18
Transmembranei133 – 152Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini153 – 163CytoplasmicSequence analysisAdd BLAST11
Transmembranei164 – 183Helical; Name=S3 of repeat ISequence analysisAdd BLAST20
Topological domaini184 – 187ExtracellularSequence analysis4
Transmembranei188 – 206Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini207 – 225CytoplasmicSequence analysisAdd BLAST19
Transmembranei226 – 245Helical; Name=S5 of repeat ISequence analysisAdd BLAST20
Topological domaini246 – 331ExtracellularSequence analysisAdd BLAST86
Transmembranei332 – 356Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini357 – 483CytoplasmicSequence analysisAdd BLAST127
Transmembranei484 – 502Helical; Name=S1 of repeat IISequence analysisAdd BLAST19
Topological domaini503 – 517ExtracellularSequence analysisAdd BLAST15
Transmembranei518 – 537Helical; Name=S2 of repeat IISequence analysisAdd BLAST20
Topological domaini538 – 545CytoplasmicSequence analysis8
Transmembranei546 – 563Helical; Name=S3 of repeat IISequence analysisAdd BLAST18
Topological domaini564 – 574ExtracellularSequence analysisAdd BLAST11
Transmembranei575 – 593Helical; Name=S4 of repeat IISequence analysisAdd BLAST19
Topological domaini594 – 612CytoplasmicSequence analysisAdd BLAST19
Transmembranei613 – 632Helical; Name=S5 of repeat IISequence analysisAdd BLAST20
Topological domaini633 – 685ExtracellularSequence analysisAdd BLAST53
Transmembranei686 – 710Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini711 – 1156CytoplasmicSequence analysisAdd BLAST446
Transmembranei1157 – 1174Helical; Name=S1 of repeat IIISequence analysisAdd BLAST18
Topological domaini1175 – 1190ExtracellularSequence analysisAdd BLAST16
Transmembranei1191 – 1210Helical; Name=S2 of repeat IIISequence analysisAdd BLAST20
Topological domaini1211 – 1222CytoplasmicSequence analysisAdd BLAST12
Transmembranei1223 – 1241Helical; Name=S3 of repeat IIISequence analysisAdd BLAST19
Topological domaini1242 – 1251ExtracellularSequence analysis10
Transmembranei1252 – 1270Helical; Name=S4 of repeat IIISequence analysisAdd BLAST19
Topological domaini1271 – 1289CytoplasmicSequence analysisAdd BLAST19
Transmembranei1290 – 1309Helical; Name=S5 of repeat IIISequence analysisAdd BLAST20
Topological domaini1310 – 1396ExtracellularSequence analysisAdd BLAST87
Transmembranei1397 – 1421Helical; Name=S6 of repeat IIISequence analysisAdd BLAST25
Topological domaini1422 – 1476CytoplasmicSequence analysisAdd BLAST55
Transmembranei1477 – 1495Helical; Name=S1 of repeat IVSequence analysisAdd BLAST19
Topological domaini1496 – 1510ExtracellularSequence analysisAdd BLAST15
Transmembranei1511 – 1530Helical; Name=S2 of repeat IVSequence analysisAdd BLAST20
Topological domaini1531 – 1538CytoplasmicSequence analysis8
Transmembranei1539 – 1557Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1558 – 1566ExtracellularSequence analysis9
Transmembranei1567 – 1585Helical; Name=S4 of repeat IVSequence analysisAdd BLAST19
Topological domaini1586 – 1604CytoplasmicSequence analysisAdd BLAST19
Transmembranei1605 – 1624Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini1625 – 1686ExtracellularSequence analysisAdd BLAST62
Transmembranei1687 – 1711Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1712 – 2339CytoplasmicSequence analysisAdd BLAST628

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539231 – 2339Voltage-dependent N-type calcium channel subunit alpha-1BAdd BLAST2339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22Omega-N-methylarginineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei411PhosphoserineBy similarity1
Modified residuei746PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1
Modified residuei1074PhosphoserineBy similarity1
Glycosylationi1566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1678N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2067PhosphoserineBy similarity1
Modified residuei2224PhosphoserineBy similarity1
Modified residuei2233PhosphoserineBy similarity1
Modified residuei2256PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q05152

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05152

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widespread expression throughout the brain. Highest levels in corpus striatum and midbrain.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Interacts with RIMS1.

Interacts with FMR1 (via C-terminus); this interaction induces a decrease in the number of presynaptic functional CACNA1B channels at the cell surface.

Interacts with the omega-conotoxin-GVIA (AC P01522) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q05152
With#Exp.IntAct
CALM3 [P62158] From a different organism.2EBI-15685496,EBI-397435

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
1172002, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-29592N

Protein interaction database and analysis system

More...
IntActi
Q05152, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000010930

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05152

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q05152

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati82 – 359IAdd BLAST278
Repeati469 – 713IIAdd BLAST245
Repeati1142 – 1424IIIAdd BLAST283
Repeati1461 – 1714IVAdd BLAST254
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1727 – 1762EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 37DisorderedSequence analysisAdd BLAST23
Regioni379 – 396Binding to the beta subunitBy similarityAdd BLAST18
Regioni809 – 1026DisorderedSequence analysisAdd BLAST218
Regioni1056 – 1084DisorderedSequence analysisAdd BLAST29
Regioni1983 – 2312DisorderedSequence analysisAdd BLAST330

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi873 – 963Basic and acidic residuesSequence analysisAdd BLAST91
Compositional biasi970 – 1026Basic and acidic residuesSequence analysisAdd BLAST57
Compositional biasi1066 – 1084Polar residuesSequence analysisAdd BLAST19
Compositional biasi2049 – 2065Basic residuesSequence analysisAdd BLAST17
Compositional biasi2097 – 2133Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi2169 – 2212Polar residuesSequence analysisAdd BLAST44
Compositional biasi2284 – 2306Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05152

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRACDER

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005447, VDCC_N_a1su
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit
PTHR10037:SF289, PTHR10037:SF289, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01631, NVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q05152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRFGDELGG RYGGAGGAER ARGGGAGGAG GPGPGGLPPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKIL
160 170 180 190 200
ALGFVLHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDP DPVGDFPCGK EAPARLCEGD TECREYWAGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDRNAEEK SPLDAVLKRA AAKKSRSDLI QAEEGEGRLT GLCAPGSPFA
460 470 480 490 500
RASLKSGKTE SSSYFRRKEK MFRFFIRRMV KAQSFYWTVL CVVALNTLCV
510 520 530 540 550
AMVHYNQPQR LTTALYFAEF VFLGLFLTEM SLKMYGLGPR SYFRSSFNCF
560 570 580 590 600
DFGVIVGSIF EVVWAAVKPG TSFGISVLRA LRLLRIFKVT KYWNSLRNLV
610 620 630 640 650
VSLLNSMKSI ISLLFLLFLF IVVFALLGMQ LFGGQFNFKD ETPTTNFDTF
660 670 680 690 700
PAAILTVFQI LTGEDWNAVM YHGIESQGGV SRGMFSSFYF IVLTLFGNYT
710 720 730 740 750
LLNVFLAIAV DNLANAQELT KDEEEMEEAA NQKLALQKAK EVAEVSPMSA
760 770 780 790 800
ANISIAARQQ NSAKARSVWE QRASQLRLQN LRASCEALYS EMDPEERLRY
810 820 830 840 850
ATARHLRPDV KTHLDRPLVV EPGRDAPRGP PGGKSRPDGS EAPEGADPPR
860 870 880 890 900
RHHRHRDKDK APATVPSAGE QDRAEALRAE GGELGPREER GRPRRSRSKE
910 920 930 940 950
APGAPEVRSD RGRGPCPEGG RRHHRRGSPE EAAEREPRRH RAHRHGPDPG
960 970 980 990 1000
KEGPASGTRG ERRARHRTGP RACPREAESS EEPARRHRAR HKAPPTQETA
1010 1020 1030 1040 1050
EKDKEAAEKG GEATEAEKDK EARNHQPKEL PCDLEAIGML GVGAVHTLPS
1060 1070 1080 1090 1100
TCLQKVEEQP EDADNQRNVT RMGSQPPDTS TTVHIPVTLT GPPGETTVVP
1110 1120 1130 1140 1150
SGNVDLESQA EGKKEVETSD VMRSGPRPIV PYSSMFCLSP TNLLRRCCHY
1160 1170 1180 1190 1200
IVTMRYFEMV ILVVIALSSI ALAAEDPVRT DSPRNNALKY MDYIFTGVFT
1210 1220 1230 1240 1250
FEMVIKMIDL GLLLHPGAYF RDLWNILDFI VVSGALVAFA FSGSKGKDIS
1260 1270 1280 1290 1300
TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI LIVYMLFMFI
1310 1320 1330 1340 1350
FAVIAVQLFK GKFFYCTDES KELERDCRGQ YLDYEKEEVE AQPRQWKKYD
1360 1370 1380 1390 1400
FHYDNVLWAL LTLFTVSTGE GWPMVLKHSV DATYEEQGPS PGYRMELSIF
1410 1420 1430 1440 1450
YVVYFVVFPF FFVNIFVALI IITFQEQGDK VMSECSLEKN ERACIDFAIS
1460 1470 1480 1490 1500
ARPLTRYMPQ NKQSFQYKTW TFVVSPPFEY FIMAMIALNT VVLMMKFYDA
1510 1520 1530 1540 1550
PYEYELMLKC LNIVFTSMFS MECVLKIIAF GVLNYFRDAW NVFDFVTVLG
1560 1570 1580 1590 1600
SITDILVTEI ANNFINLSFL RLFRAARLIK LLRQGYTIRI LLWTFVQSFK
1610 1620 1630 1640 1650
ALPYVCLLIA MLFFIYAIIG MQVFGNIALD DDTSINRHNN FRTFLQALML
1660 1670 1680 1690 1700
LFRSATGEAW HEIMLSCLSS RACDEHSNAS ECGSDFAYFY FVSFIFLCSF
1710 1720 1730 1740 1750
LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EFIRVWAEYD PAACGRISYS
1760 1770 1780 1790 1800
DMFEMLKHMS PPLGLGKKCP ARVAYKRLVR MNMPISSEDM TVHFTSTLMA
1810 1820 1830 1840 1850
LIRTALDIKL APAGTKQHQC DAELRKEISC VWANLPQKTL DLLVPPHKPD
1860 1870 1880 1890 1900
EMTVGKVYAA LMIFDFYKQN KTSRDQTQQA PGGLSQLGPV SLFHPLKATL
1910 1920 1930 1940 1950
EQTQPALRGA RAFLRQKSSA SLSNGGAVQT QESGIKESVS WGTQRTQDVL
1960 1970 1980 1990 2000
CEARAPLERG HSAEIPVGQP GTLAVDVQMQ NMTLSGPDAE PQPGLESQGR
2010 2020 2030 2040 2050
AASMPRLAAE TQPAPDASPM KRSISTLAPR PHTARLGSTA LDRPAPSQAP
2060 2070 2080 2090 2100
HHHHHRCHRR RDRKQRSLEK GPSLSADTDG APDSTVGPGL PTGEGPPGCR
2110 2120 2130 2140 2150
RERERRQERG RSQERRQPSS SSSEKHRFYS CDRFGGREPP QPKPSLSSHP
2160 2170 2180 2190 2200
TSPTAGQEPG PHPQGSGSVH GSPLLSTSGA STPGRGRRQL PQTPLTPRPS
2210 2220 2230 2240 2250
VTYKTANSSP VHFAGAPSGL PAFSPGRLSR GLSEHNALLQ RDPLSRPLAP
2260 2270 2280 2290 2300
GSRIGSDPYL GQRLDSEAPA RALPEDAPAF EETAASNSGR SSRTSYVSSL
2310 2320 2330
TSQPPPLRRV PNGYHCTLGL GGGGRARRGC HHPDRDRRC
Length:2,339
Mass (Da):261,181
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0413DA93794C8B34
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D14157 mRNA Translation: BAA03202.1

NCBI Reference Sequences

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RefSeqi
NP_001075660.1, NM_001082191.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100008979

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ocu:100008979

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14157 mRNA Translation: BAA03202.1
RefSeqiNP_001075660.1, NM_001082191.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DVEX-ray2.35B1855-1875[»]
3DVJX-ray2.80B1853-1873[»]
SMRiQ05152
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi1172002, 2 interactors
DIPiDIP-29592N
IntActiQ05152, 2 interactors
STRINGi9986.ENSOCUP00000010930

PTM databases

iPTMnetiQ05152

Proteomic databases

PRIDEiQ05152

Genome annotation databases

GeneIDi100008979
KEGGiocu:100008979

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
774

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
InParanoidiQ05152
OMAiHRACDER
OrthoDBi172471at2759

Miscellaneous databases

EvolutionaryTraceiQ05152

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005447, VDCC_N_a1su
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PTHR10037:SF289, PTHR10037:SF289, 1 hit
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01631, NVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1B_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05152
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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